TY - CONF AU - Lina, Li AU - Patkó, Evelin Viktória AU - Varga, András AU - Dénes , Diána AU - Molitor, Dorottya AU - Szabó, Edina AU - Mérész, Balázs AU - Reglődi, Dóra AU - Váczy, Alexandra AU - Atlasz, Tamás ED - Kovács, Bettina ED - Glázer-Kniesz, Adrienn ED - Tislér, Ádám TI - The Protective Effect of PACAP38 in Type 2 Diabetic Retinal Disease T2 - Absztraktkötet: XII. Interdiszciplináris Doktorandusz Konferencia = Book of Abstract: XII. Interdisciplinary Doctoral Conference PB - Pécsi Tudományegyetem Doktorandusz Önkormányzat C1 - Pécs SN - 9789636262457 PY - 2024 SP - 81 EP - 81 PG - 1 UR - https://m2.mtmt.hu/api/publication/34825988 ID - 34825988 LA - English DB - MTMT ER - TY - CHAP AU - Shimazaki, Takashi AU - Hortobágyi, Tibor AU - Uematsu, Azusa AU - Kobayashi, Hirofumi AU - Nakamura, Madoka AU - Kiryu, Masataka AU - Suzuki, Shuji ED - Schinke, Robert J. TI - Long-Term QiGong Practice Is Associated with Improved Self-Perceived Health and Quality of Life T2 - Mental Health in Sport and Physical Activity PB - Routledge CY - London SN - 9781003459750 PY - 2024 SP - 268 EP - 287 PG - 20 DO - 10.4324/9781003459750-14 UR - https://m2.mtmt.hu/api/publication/34738715 ID - 34738715 LA - English DB - MTMT ER - TY - JOUR AU - Tóth, Dénes AU - Fábián, Eszter AU - Szabó, Edina AU - Patkó, Evelin Viktória AU - Vicena, Viktória AU - Váczy, Alexandra AU - Atlasz, Tamás AU - Tornóczky, Tamás AU - Reglődi, Dóra TI - Investigation of PACAP38 and PAC1 Receptor Expression in Human Retinoblastoma and the Effect of PACAP38 Administration on Human Y-79 Retinoblastoma Cells JF - LIFE-BASEL J2 - LIFE-BASEL VL - 14 PY - 2024 IS - 2 PG - 14 SN - 2075-1729 DO - 10.3390/life14020185 UR - https://m2.mtmt.hu/api/publication/34542678 ID - 34542678 N1 - Funding Agency and Grant Number: Hungarian Brain Research Program Funding text: No Statement Available AB - Retinoblastoma represents the most prevalent malignant neoplasm affecting the eyes in childhood. The clear-cut origin of retinoblastoma has not yet been determined; however, based on experiments, it has been suggested that RB1 loss in cone photoreceptors causes retinoblastoma. Pituitary adenylate-cyclase activating polypeptide (PACAP) is a pleiotropic neuropeptide which has been shown to be affected in certain tumorous transformations, such as breast, lung, kidney, pancreatic, colon, and endocrine cancers. This study aimed to investigate potential changes in both PACAP38 and PAC1 receptor (PAC1R) expression in human retinoblastoma and the effect of PACAP38 administration on the survival of a human retinoblastoma cell line (Y-79). We analyzed human enucleation specimens removed because of retinoblastoma for PACAP38 and PAC1R immunostaining and the effect of PACAP38 on the survival of the Y-79 cell line. We described for the first time that human retinoblastoma cells from patients showed only perinuclear, dot-like immunopositivity for both PACAP38 and PAC1R, irrespective of laterality, genetic background, or histopathological features. Nanomolar (100 nM and 500 nM) PACAP38 concentrations had no effect on the viability of Y-79 cells, while micromolar (2 µM and 6 µM) PACAP38 significantly decreased tumor cell viability. These findings, along with general observations from animal studies showing that PACAP38 has strong anti-apoptotic, anti-inflammatory, and antioxidant effects on ocular tissues, together suggest that PACAP38 and its analogs are promising candidates in retinoblastoma therapy. LA - English DB - MTMT ER - TY - JOUR AU - Bakker, L.B.M. AU - Lamoth, C.J.C. AU - Vetrovsky, T. AU - Gruber, M. AU - Caljouw, S.R. AU - Nieboer, W. AU - Taube, W. AU - van, Dieën J.H. AU - Granacher, U. AU - Hortobágyi, Tibor TI - Neural Correlates of Balance Skill Learning in Young and Older Individuals: A Systematic Review and Meta-analysis JF - SPORTS MEDICINE-OPEN J2 - SPORT MED-OPEN VL - 10 PY - 2024 IS - 1 PG - 30 SN - 2199-1170 DO - 10.1186/s40798-023-00668-3 UR - https://m2.mtmt.hu/api/publication/34521622 ID - 34521622 LA - English DB - MTMT ER - TY - JOUR AU - Balbim, Guilherme Moraes AU - Boa Sorte Silva, Nárlon Cássio AU - ten Brinke, Lisanne AU - Falck, Ryan S. AU - Hortobágyi, Tibor AU - Granacher, Urs AU - Erickson, Kirk I. AU - Hernández-Gamboa, Rebeca AU - Liu-Ambrose, Teresa TI - Aerobic exercise training effects on hippocampal volume in healthy older individuals: a meta-analysis of randomized controlled trials JF - GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE) J2 - GEROSCIENCE VL - 46 PY - 2024 IS - 2 SP - 2755 EP - 2764 PG - 10 SN - 2509-2715 DO - 10.1007/s11357-023-00971-7 UR - https://m2.mtmt.hu/api/publication/34327741 ID - 34327741 N1 - Online first 2023 LA - English DB - MTMT ER - TY - CONF AU - Radics, Réka AU - Dénes , Diána AU - Váczy, Alexandra AU - Li, Lina AU - Molitor, Dorottya AU - Varga, András AU - Patkó, Evelin Viktória AU - Szabó, Edina AU - Reglődi, Dóra AU - Atlasz, Tamás TI - Retinoprotektív vegyületek vizsgálata 2-es típusú diabétesz mellitusban T2 - A Magyar Anatómus Társaság 2023. évi konferenciája PY - 2023 SP - 97 EP - 98 PG - 2 UR - https://m2.mtmt.hu/api/publication/34566722 ID - 34566722 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Uematsu, Azusa AU - Mizushima, Yuta AU - Ishizaka, Hayato AU - Hortobágyi, Tibor AU - Mizushima, Takashi AU - Toyoda, Shigeru AU - Nakajima, Toshiaki AU - Debevec, Tadej TI - Blood flow restriction reduces the increases in cardiorespiratory responses and subjective burden without inhibiting muscular activity during cycling at ventilatory threshold in healthy males JF - PLOS ONE J2 - PLOS ONE VL - 18 PY - 2023 IS - 12 SP - e0294524 SN - 1932-6203 DO - 10.1371/journal.pone.0294524 UR - https://m2.mtmt.hu/api/publication/34428273 ID - 34428273 AB - Low-intensity endurance exercise with blood flow restriction (KAATSU) is under consideration for use in cardiac rehabilitation. However, the physiological responses to such exercise have not yet been fully characterized. In an initial effort in healthy males (n = 11, age: 26.3±4.6 y), we compared the physiological responses to low-intensity endurance exercise with and without a thigh KAATSU. Participants performed maximal graded exercise testing using a cycle ergometer with or without KAATSU. We examined responses to cycling exercise at ventilatory threshold (VT) in heart rate (HR), oxygen consumption (VO 2 ), dyspnea, ratings of perceived exertion (RPE), blood pressure (BP), and rectus femoris activation. Participants reached VT at a lower mechanical load, HR, VO 2 , dyspnea, and double product (HR×systolic BP) with KAATSU vs. no-KAATSU. At VT, RPE, and rectus femoris activity did not differ between the two conditions. These results suggest that KAATSU reduced exercise intensity to reach VT and the physiological responses to exercise at VT without changes in knee extensor muscle activation. Results from this pilot study in healthy males suggest that KAATSU aerobic exercise at VT intensity has the potential to be an effective and low-burden adjuvant to cycling in cardiac rehabilitation. LA - English DB - MTMT ER - TY - JOUR AU - Andrushko, Justin W AU - Carr, Joshua C AU - Farthing, Jonathan P AU - Lepley, Lindsey K AU - DeFreitas, Jason M AU - Goodall, Stuart AU - Hendy, Ashlee M AU - Howatson, Glyn AU - Grooms, Dustin R AU - Zult, Tjerk AU - Hortobágyi, Tibor AU - Harput, Gulcan AU - Papandreou, Maria AU - Nosaka, Kazunori AU - Carson, Richard G AU - Manca, Andrea AU - Deriu, Franca AU - Behm, David George AU - Kidgell, Dawson J AU - Clark, Nicholas C AU - Boyd, Lara A TI - Potential role of cross-education in early-stage rehabilitation after anterior cruciate ligament reconstruction. JF - BRITISH JOURNAL OF SPORTS MEDICINE J2 - BRIT J SPORT MED VL - 57 PY - 2023 IS - 23 SP - 1474 EP - 1475 PG - 2 SN - 0306-3674 DO - 10.1136/bjsports-2023-107456 UR - https://m2.mtmt.hu/api/publication/34198500 ID - 34198500 LA - English DB - MTMT ER - TY - JOUR AU - Patkó, Evelin Viktória AU - Szabó, Edina AU - Váczy, Alexandra AU - Molitor, Dorottya AU - Tari, Eniko AU - Li, Lina AU - Csutak, Adrienne AU - Tóth, Gábor AU - Reglődi, Dóra AU - Atlasz, Tamás TI - Protective Effects of Pituitary Adenylate-Cyclase-Activating Polypeptide on Retinal Vasculature and Molecular Responses in a Rat Model of Moderate Glaucoma JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 24 PY - 2023 IS - 17 PG - 14 SN - 1661-6596 DO - 10.3390/ijms241713256 UR - https://m2.mtmt.hu/api/publication/34117220 ID - 34117220 N1 - Export Date: 3 April 2024 AB - Despite the high probability of glaucoma-related blindness, its cause is not fully understood and there is no efficient therapeutic strategy for neuroprotection. Vascular factors have been suggested to play an important role in glaucoma development and progression. Previously, we have proven the neuroprotective effects of pituitary adenylate-cyclase-activating polypeptide (PACAP) eye drops in an inducible, microbeads model in rats that is able to reproduce many clinically relevant features of human glaucoma. In the present study, we examined the potential protective effects of PACAP1-38 on the retinal vasculature and the molecular changes in hypoxia. Ocular hypertension was induced by injection of microbeads into the anterior chamber, while control rats received PBS. PACAP dissolved in vehicle (1 µg/drop) or vehicle treatment was started one day after the injections for four weeks three times a day. Retinal degeneration was assessed with optical coherence tomography (OCT), and vascular and molecular changes were assessed by immunofluorescence labeling. HIF1-α and VEGF-A protein levels were measured by Western blot. OCT images proved severe retinal degeneration in the glaucomatous group, while PACAP1-38 eye drops had a retinoprotective effect. Vascular parameters were deteriorated and molecular analysis suggested hypoxic conditions in glaucoma. PACAP treatment exerted a positive effect against these alterations. In summary, PACAP could prevent the severe damage to the retina and its vasculature induced by ocular hypertension in a microbeads model. LA - English DB - MTMT ER - TY - JOUR AU - Abud da Silva Costa, Andréia AU - Hortobágyi, Tibor AU - den Otter, Rob AU - Sawers, Andrew AU - Moraes, Renato TI - Age, cognitive task, and arm position differently affect muscle synergy recruitment but have similar effects on walking balance JF - NEUROSCIENCE J2 - NEUROSCIENCE VL - 527 PY - 2023 SP - 11 EP - 21 PG - 11 SN - 0306-4522 DO - 10.1016/j.neuroscience.2023.07.010 UR - https://m2.mtmt.hu/api/publication/34064895 ID - 34064895 LA - English DB - MTMT ER -