@CONFERENCE{MTMT:34825988, title = {The Protective Effect of PACAP38 in Type 2 Diabetic Retinal Disease}, url = {https://m2.mtmt.hu/api/publication/34825988}, author = {Lina, Li and Patkó, Evelin Viktória and Varga, András and Dénes , Diána and Molitor, Dorottya and Szabó, Edina and Mérész, Balázs and Reglődi, Dóra and Váczy, Alexandra and Atlasz, Tamás}, booktitle = {Absztraktkötet: XII. Interdiszciplináris Doktorandusz Konferencia = Book of Abstract: XII. Interdisciplinary Doctoral Conference}, unique-id = {34825988}, year = {2024}, pages = {81-81}, orcid-numbers = {Atlasz, Tamás/0000-0002-8112-8633} } @inbook{MTMT:34738715, title = {Long-Term QiGong Practice Is Associated with Improved Self-Perceived Health and Quality of Life}, url = {https://m2.mtmt.hu/api/publication/34738715}, author = {Shimazaki, Takashi and Hortobágyi, Tibor and Uematsu, Azusa and Kobayashi, Hirofumi and Nakamura, Madoka and Kiryu, Masataka and Suzuki, Shuji}, booktitle = {Mental Health in Sport and Physical Activity}, doi = {10.4324/9781003459750-14}, unique-id = {34738715}, year = {2024}, pages = {268-287} } @article{MTMT:34542678, title = {Investigation of PACAP38 and PAC1 Receptor Expression in Human Retinoblastoma and the Effect of PACAP38 Administration on Human Y-79 Retinoblastoma Cells}, url = {https://m2.mtmt.hu/api/publication/34542678}, author = {Tóth, Dénes and Fábián, Eszter and Szabó, Edina and Patkó, Evelin Viktória and Vicena, Viktória and Váczy, Alexandra and Atlasz, Tamás and Tornóczky, Tamás and Reglődi, Dóra}, doi = {10.3390/life14020185}, journal-iso = {LIFE-BASEL}, journal = {LIFE-BASEL}, volume = {14}, unique-id = {34542678}, abstract = {Retinoblastoma represents the most prevalent malignant neoplasm affecting the eyes in childhood. The clear-cut origin of retinoblastoma has not yet been determined; however, based on experiments, it has been suggested that RB1 loss in cone photoreceptors causes retinoblastoma. Pituitary adenylate-cyclase activating polypeptide (PACAP) is a pleiotropic neuropeptide which has been shown to be affected in certain tumorous transformations, such as breast, lung, kidney, pancreatic, colon, and endocrine cancers. This study aimed to investigate potential changes in both PACAP38 and PAC1 receptor (PAC1R) expression in human retinoblastoma and the effect of PACAP38 administration on the survival of a human retinoblastoma cell line (Y-79). We analyzed human enucleation specimens removed because of retinoblastoma for PACAP38 and PAC1R immunostaining and the effect of PACAP38 on the survival of the Y-79 cell line. We described for the first time that human retinoblastoma cells from patients showed only perinuclear, dot-like immunopositivity for both PACAP38 and PAC1R, irrespective of laterality, genetic background, or histopathological features. Nanomolar (100 nM and 500 nM) PACAP38 concentrations had no effect on the viability of Y-79 cells, while micromolar (2 µM and 6 µM) PACAP38 significantly decreased tumor cell viability. These findings, along with general observations from animal studies showing that PACAP38 has strong anti-apoptotic, anti-inflammatory, and antioxidant effects on ocular tissues, together suggest that PACAP38 and its analogs are promising candidates in retinoblastoma therapy.}, keywords = {immunohistochemistry; PACAP; Cell Survival; Cell viability; retinoblastoma; enucleation}, year = {2024}, eissn = {2075-1729}, orcid-numbers = {Tóth, Dénes/0000-0002-9074-3478; Atlasz, Tamás/0000-0002-8112-8633} } @article{MTMT:34521622, title = {Neural Correlates of Balance Skill Learning in Young and Older Individuals: A Systematic Review and Meta-analysis}, url = {https://m2.mtmt.hu/api/publication/34521622}, author = {Bakker, L.B.M. and Lamoth, C.J.C. and Vetrovsky, T. and Gruber, M. and Caljouw, S.R. and Nieboer, W. and Taube, W. and van, Dieën J.H. and Granacher, U. and Hortobágyi, Tibor}, doi = {10.1186/s40798-023-00668-3}, journal-iso = {SPORT MED-OPEN}, journal = {SPORTS MEDICINE-OPEN}, volume = {10}, unique-id = {34521622}, issn = {2199-1170}, keywords = {metaanalízis}, year = {2024}, eissn = {2198-9761} } @article{MTMT:34327741, title = {Aerobic exercise training effects on hippocampal volume in healthy older individuals: a meta-analysis of randomized controlled trials}, url = {https://m2.mtmt.hu/api/publication/34327741}, author = {Balbim, Guilherme Moraes and Boa Sorte Silva, Nárlon Cássio and ten Brinke, Lisanne and Falck, Ryan S. and Hortobágyi, Tibor and Granacher, Urs and Erickson, Kirk I. and Hernández-Gamboa, Rebeca and Liu-Ambrose, Teresa}, doi = {10.1007/s11357-023-00971-7}, journal-iso = {GEROSCIENCE}, journal = {GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)}, volume = {46}, unique-id = {34327741}, issn = {2509-2715}, year = {2024}, eissn = {2509-2723}, pages = {2755-2764} } @CONFERENCE{MTMT:34566722, title = {Retinoprotektív vegyületek vizsgálata 2-es típusú diabétesz mellitusban}, url = {https://m2.mtmt.hu/api/publication/34566722}, author = {Radics, Réka and Dénes , Diána and Váczy, Alexandra and Li, Lina and Molitor, Dorottya and Varga, András and Patkó, Evelin Viktória and Szabó, Edina and Reglődi, Dóra and Atlasz, Tamás}, booktitle = {A Magyar Anatómus Társaság 2023. évi konferenciája}, unique-id = {34566722}, year = {2023}, pages = {97-98}, orcid-numbers = {Atlasz, Tamás/0000-0002-8112-8633} } @article{MTMT:34428273, title = {Blood flow restriction reduces the increases in cardiorespiratory responses and subjective burden without inhibiting muscular activity during cycling at ventilatory threshold in healthy males}, url = {https://m2.mtmt.hu/api/publication/34428273}, author = {Uematsu, Azusa and Mizushima, Yuta and Ishizaka, Hayato and Hortobágyi, Tibor and Mizushima, Takashi and Toyoda, Shigeru and Nakajima, Toshiaki and Debevec, Tadej}, doi = {10.1371/journal.pone.0294524}, journal-iso = {PLOS ONE}, journal = {PLOS ONE}, volume = {18}, unique-id = {34428273}, issn = {1932-6203}, abstract = {Low-intensity endurance exercise with blood flow restriction (KAATSU) is under consideration for use in cardiac rehabilitation. However, the physiological responses to such exercise have not yet been fully characterized. In an initial effort in healthy males (n = 11, age: 26.3±4.6 y), we compared the physiological responses to low-intensity endurance exercise with and without a thigh KAATSU. Participants performed maximal graded exercise testing using a cycle ergometer with or without KAATSU. We examined responses to cycling exercise at ventilatory threshold (VT) in heart rate (HR), oxygen consumption (VO 2 ), dyspnea, ratings of perceived exertion (RPE), blood pressure (BP), and rectus femoris activation. Participants reached VT at a lower mechanical load, HR, VO 2 , dyspnea, and double product (HR×systolic BP) with KAATSU vs. no-KAATSU. At VT, RPE, and rectus femoris activity did not differ between the two conditions. These results suggest that KAATSU reduced exercise intensity to reach VT and the physiological responses to exercise at VT without changes in knee extensor muscle activation. Results from this pilot study in healthy males suggest that KAATSU aerobic exercise at VT intensity has the potential to be an effective and low-burden adjuvant to cycling in cardiac rehabilitation.}, year = {2023}, eissn = {1932-6203}, pages = {e0294524}, orcid-numbers = {Uematsu, Azusa/0000-0002-9263-6510; Toyoda, Shigeru/0000-0002-8260-833X} } @article{MTMT:34198500, title = {Potential role of cross-education in early-stage rehabilitation after anterior cruciate ligament reconstruction.}, url = {https://m2.mtmt.hu/api/publication/34198500}, author = {Andrushko, Justin W and Carr, Joshua C and Farthing, Jonathan P and Lepley, Lindsey K and DeFreitas, Jason M and Goodall, Stuart and Hendy, Ashlee M and Howatson, Glyn and Grooms, Dustin R and Zult, Tjerk and Hortobágyi, Tibor and Harput, Gulcan and Papandreou, Maria and Nosaka, Kazunori and Carson, Richard G and Manca, Andrea and Deriu, Franca and Behm, David George and Kidgell, Dawson J and Clark, Nicholas C and Boyd, Lara A}, doi = {10.1136/bjsports-2023-107456}, journal-iso = {BRIT J SPORT MED}, journal = {BRITISH JOURNAL OF SPORTS MEDICINE}, volume = {57}, unique-id = {34198500}, issn = {0306-3674}, keywords = {Exercise; rehabilitation; anterior cruciate ligament}, year = {2023}, eissn = {1473-0480}, pages = {1474-1475} } @article{MTMT:34117220, title = {Protective Effects of Pituitary Adenylate-Cyclase-Activating Polypeptide on Retinal Vasculature and Molecular Responses in a Rat Model of Moderate Glaucoma}, url = {https://m2.mtmt.hu/api/publication/34117220}, author = {Patkó, Evelin Viktória and Szabó, Edina and Váczy, Alexandra and Molitor, Dorottya and Tari, Eniko and Li, Lina and Csutak, Adrienne and Tóth, Gábor and Reglődi, Dóra and Atlasz, Tamás}, doi = {10.3390/ijms241713256}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {24}, unique-id = {34117220}, issn = {1661-6596}, abstract = {Despite the high probability of glaucoma-related blindness, its cause is not fully understood and there is no efficient therapeutic strategy for neuroprotection. Vascular factors have been suggested to play an important role in glaucoma development and progression. Previously, we have proven the neuroprotective effects of pituitary adenylate-cyclase-activating polypeptide (PACAP) eye drops in an inducible, microbeads model in rats that is able to reproduce many clinically relevant features of human glaucoma. In the present study, we examined the potential protective effects of PACAP1-38 on the retinal vasculature and the molecular changes in hypoxia. Ocular hypertension was induced by injection of microbeads into the anterior chamber, while control rats received PBS. PACAP dissolved in vehicle (1 µg/drop) or vehicle treatment was started one day after the injections for four weeks three times a day. Retinal degeneration was assessed with optical coherence tomography (OCT), and vascular and molecular changes were assessed by immunofluorescence labeling. HIF1-α and VEGF-A protein levels were measured by Western blot. OCT images proved severe retinal degeneration in the glaucomatous group, while PACAP1-38 eye drops had a retinoprotective effect. Vascular parameters were deteriorated and molecular analysis suggested hypoxic conditions in glaucoma. PACAP treatment exerted a positive effect against these alterations. In summary, PACAP could prevent the severe damage to the retina and its vasculature induced by ocular hypertension in a microbeads model.}, year = {2023}, eissn = {1422-0067}, orcid-numbers = {Tóth, Gábor/0000-0002-3604-4385; Atlasz, Tamás/0000-0002-8112-8633} } @article{MTMT:34064895, title = {Age, cognitive task, and arm position differently affect muscle synergy recruitment but have similar effects on walking balance}, url = {https://m2.mtmt.hu/api/publication/34064895}, author = {Abud da Silva Costa, Andréia and Hortobágyi, Tibor and den Otter, Rob and Sawers, Andrew and Moraes, Renato}, doi = {10.1016/j.neuroscience.2023.07.010}, journal-iso = {NEUROSCIENCE}, journal = {NEUROSCIENCE}, volume = {527}, unique-id = {34064895}, issn = {0306-4522}, year = {2023}, eissn = {1873-7544}, pages = {11-21}, orcid-numbers = {Hortobágyi, Tibor/0000-0001-5732-7942; Moraes, Renato/0000-0001-8029-8334} }