TY - JOUR AU - Gadó, Klára AU - Tabák, Ádám AU - Vingender, István AU - Domján, Gyula AU - Bednárikné Dörnyei, Gabriella TI - Treatment of type 2 diabetes mellitus in the elderly – Special considerations JF - PHYSIOLOGY INTERNATIONAL J2 - PHYSIOL INT VL - in press PY - 2024 IS - in press PG - 22 SN - 2498-602X DO - 10.1556/2060.2024.00317 UR - https://m2.mtmt.hu/api/publication/34826851 ID - 34826851 AB - Type 2 diabetes is a frequent chronic disease. Given its strong positive association with older age, it is a significant public health issue in elderly populations. Furthermore, the aging of the population, driven by increasing life expectancy in high and middle-income countries leads to an increasing prevalence of diabetes. LA - English DB - MTMT ER - TY - JOUR AU - Nemcsik, János AU - Takács, Johanna AU - Pásztor, Dorottya Tímea AU - Farsang, Csaba AU - Simon, Attila AU - Páll, Dénes AU - Torzsa, Péter AU - Dolgos, Szilveszter AU - Koller, Ákos AU - Habony, Norbert AU - Járai, Zoltán TI - Frequency of office blood pressure measurements and the seasonal variability of blood pressure: results of the Hungarian Hypertension Registry JF - BLOOD PRESSURE J2 - BLOOD PRESSURE VL - 33 PY - 2024 IS - 1 PG - 7 SN - 0803-7051 DO - 10.1080/08037051.2024.2337170 UR - https://m2.mtmt.hu/api/publication/34775499 ID - 34775499 LA - English DB - MTMT ER - TY - JOUR AU - Takács, Johanna AU - Deák, Darina AU - Koller, Ákos TI - Higher level of physical activity reduces mental and neurological symptoms during and two years after COVID-19 infection in young women JF - SCIENTIFIC REPORTS J2 - SCI REP VL - 14 PY - 2024 IS - 1 PG - 12 SN - 2045-2322 DO - 10.1038/s41598-024-57646-2 UR - https://m2.mtmt.hu/api/publication/34753964 ID - 34753964 AB - Previous studies found that regular physical activity (PA) can lower the risk of SARS-CoV-2 (COVID-19) infection and post-COVID-19 condition (PCC), yet its specific effects in young women have not yet been investigated. Thus, we aimed to examine whether regular physical activity reduces the number of symptoms during and after COVID-19 infection among young women aged between 18 and 34 (N = 802), in which the confounding effect of other morbidities could be excluded. The average time since infection was 23.5 months. Participants were classified into low, moderate, and high PA categories based on the reported minutes per week of moderate and vigorous PA. Using the Post-COVID-19 Case Report Form, 50 different symptoms were assessed. Although regular PA did not decrease the prevalence of COVID-19 infection and PCC but significantly reduced the number of mental and neurological symptoms both in acute COVID-19 and PCC. Importantly, the high level of PA had a greater impact on health improvements. In addition, the rate of reinfection decreased with an increased level of PA. In conclusion, a higher level of regular PA can reduce the risk of reinfection and the number of mental and neurological symptoms in PCC underlying the importance of regular PA, even in this and likely other viral disease conditions. LA - English DB - MTMT ER - TY - JOUR AU - Oroszi, Tamás AU - Felszeghy, Klára AU - Luiten, Paul G.M. AU - Schoemaker, Regien G. AU - van der Zee, Eddy A. AU - Nyakas, Csaba TI - Whole body vibration ameliorates anxiety-like behavior and memory functions in 30 months old senescent male rats JF - HELIYON J2 - HELIYON VL - 10 PY - 2024 IS - 4 PG - 11 SN - 2405-8440 DO - 10.1016/j.heliyon.2024.e26608 UR - https://m2.mtmt.hu/api/publication/34714793 ID - 34714793 N1 - Department of Molecular Neurobiology, Groningen Institute for Evolutionary Life Sciences (GELIFES), University of Groningen, Groningen, Netherlands Research Center for Molecular Exercise Science, Hungarian University of Sports Science, Budapest, Hungary Department of Morphology and Physiology, Health Science Faculty, Semmelweis University, Budapest, Hungary Export Date: 10 April 2024 Correspondence Address: Oroszi, T.; Department of Molecular Neurobiology, Netherlands; email: t.oroszi@rug.nl LA - English DB - MTMT ER - TY - JOUR AU - Ezer, Erzsébet AU - Schrick, Diana Zsuzsanna AU - Tőkés-Füzesi, Margit AU - Papp, István AU - Réger, Barbara AU - Molnár, Abigél AU - Ábrahám, Hajnalka AU - Koller, Ákos AU - Hársfalvi, Jolán AU - Kellermayer, Miklós AU - Molnár, Tihamér TI - Gravity sedimentation reveals functionally and morphologically different platelets in human blood JF - PLATELETS J2 - PLATELETS VL - 35 PY - 2024 IS - 1 PG - 10 SN - 0953-7104 DO - 10.1080/09537104.2023.2298341 UR - https://m2.mtmt.hu/api/publication/34493390 ID - 34493390 LA - English DB - MTMT ER - TY - JOUR AU - Ungvári, Zoltán István AU - Tabák, Ádám AU - Ádány, Róza AU - Purebl, György AU - Kaposvári, Csilla AU - Fazekas-Pongor, Vince AU - Csípő, Tamás AU - Szarvas, Zsófia AU - Horváth, Krisztián AU - Mukli, Péter AU - Balog, Piroska AU - Bódizs, Róbert AU - Ujma, Przemyslaw Péter AU - Stauder, Adrienne AU - Belsky, Daniel W. AU - Kovács, Illés AU - Yabluchanskiy, Andriy AU - Maier, Andrea B. AU - Moizs, Mariann AU - Östlin, Piroska AU - Yon, Yongjie AU - Varga, Péter AU - Vokó, Zoltán AU - Papp, Magor Csongor AU - Takács, István AU - Vásárhelyi, Barna AU - Torzsa, Péter AU - Ferdinandy, Péter AU - Csiszar, Anna AU - Benyó, Zoltán AU - Szabó, Attila AU - Bednárikné Dörnyei, Gabriella AU - Kivimäki, Mika AU - Kellermayer, Miklós AU - Merkely, Béla Péter TI - The Semmelweis Study: a longitudinal occupational cohort study within the framework of the Semmelweis Caring University Model Program for supporting healthy aging JF - GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE) J2 - GEROSCIENCE VL - 46 PY - 2024 IS - 1 SP - 191 EP - 218 PG - 28 SN - 2509-2715 DO - 10.1007/s11357-023-01018-7 UR - https://m2.mtmt.hu/api/publication/34425939 ID - 34425939 N1 - International Training Program in Geroscience/Healthy Aging Program, Doctoral School of Basic and Translational Medicine/Department of Public Health, Semmelweis University, Budapest, Hungary Vascular Cognitive Impairment, Neurodegeneration and Healthy Brain Aging Program, Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States Department of Health Promotion Sciences, The Hudson College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States Department of Public Health, Faculty of Medicine, Semmelweis University, Budapest, Hungary UCL Brain Sciences, University College London, London, United Kingdom Department of Internal Medicine and Oncology, Semmelweis University, Faculty of Medicine, Budapest, Hungary HUN-REN-UD Public Health Research Group, Department of Public Health and Epidemiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary Institute of Behavioral Sciences, Faculty of Medicine, Semmelweis University, Budapest, Hungary Robert N. Butler Columbia Aging Center, Columbia University, New York, NY, United States Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY, United States Department of Ophthalmology, Faculty of Medicine, Semmelweis University, Budapest, Hungary Department of Ophthalmology, Weill Cornell Medical College, New York City, NY, United States Department of Clinical Ophthalmology, Faculty of Health Sciences, Semmelweis University, Budapest, Hungary Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore Centre for Healthy Longevity, National University Health System, Singapore, Singapore Department of Human Movement Sciences, @AgeAmsterdam, Vrije Universiteit, Amsterdam Movement Sciences, Amsterdam, Netherlands Ministry of Interior of Hungary, Budapest, Hungary WHO Regional Office for Europe, Copenhagen, Denmark Clinical Center, Semmelweis University, Budapest, Hungary Center for Health Technology Assessment, Semmelweis University, Budapest, Hungary Department of Laboratory Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary Department of Family Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, Semmelweis University, Budapest, Hungary Department of Translational Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary HUN-REN-SU Cerebrovascular and Neurocognitive Diseases Research Group, Budapest, Hungary First Department of Pediatrics, Faculty of Medicine, Semmelweis University, Budapest, Hungary HUN-REN-SU Pediatrics and Nephrology Research Group, Semmelweis University, Budapest, Hungary Department of Morphology and Physiology, Faculty of Health Sciences, Semmelweis University, Budapest, Hungary Department of Biophysics and Radiation Biology, Faculty of Medicine, Semmelweis University, Budapest, Hungary Heart and Vascular Center, Semmelweis University, Budapest, Hungary Cited By :1 Export Date: 29 February 2024 Correspondence Address: Ungvari, Z.; International Training Program in Geroscience/Healthy Aging Program, Hungary; email: Zoltan-Ungvari@ouhsc.edu Correspondence Address: Adany, R.; International Training Program in Geroscience/Healthy Aging Program, Hungary AB - The Semmelweis Study is a prospective occupational cohort study that seeks to enroll all employees of Semmelweis University (Budapest, Hungary) aged 25 years and older, with a population of 8866 people, 70.5% of whom are women. The study builds on the successful experiences of the Whitehall II study and aims to investigate the complex relationships between lifestyle, environmental, and occupational risk factors, and the development and progression of chronic age-associated diseases. An important goal of the Semmelweis Study is to identify groups of people who are aging unsuccessfully and therefore have an increased risk of developing age-associated diseases. To achieve this, the study takes a multidisciplinary approach, collecting economic, social, psychological, cognitive, health, and biological data. The Semmelweis Study comprises a baseline data collection with open healthcare data linkage, followed by repeated data collection waves every 5 years. Data are collected through computer-assisted self-completed questionnaires, followed by a physical health examination, physiological measurements, and the assessment of biomarkers. This article provides a comprehensive overview of the Semmelweis Study, including its origin, context, objectives, design, relevance, and expected contributions. LA - English DB - MTMT ER - TY - JOUR AU - Csabai, Luca AU - Bohár, Balázs AU - Türei, Dénes AU - Prabhu, Sowmya AU - Földvári-Nagy, László AU - Madgwick, Matthew AU - Fazekas, Dávid AU - Módos, Dezső AU - Ölbei, Márton AU - Halka, Themis AU - Poletti, Martina AU - Kornilova, Polina AU - Kadlecsik, Tamás AU - Demeter, Amanda AU - Szalay-Bekő, Máté AU - Kapuy, Orsolya AU - Földvári-Nagy Lászlóné Lenti, Katalin AU - Vellai, Tibor AU - Gul, Lejla AU - Korcsmáros, Tamás TI - AutophagyNet: high-resolution data source for the analysis of autophagy and its regulation JF - AUTOPHAGY J2 - AUTOPHAGY VL - 20 PY - 2024 IS - 1 SP - 188 EP - 201 PG - 15 SN - 1554-8627 DO - 10.1080/15548627.2023.2247737 UR - https://m2.mtmt.hu/api/publication/34109413 ID - 34109413 N1 - Earlham Institute, Norwich, United Kingdom Department of Genetics, ELTE Eötvös Loránd University, Budapest, Hungary Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Institute for Computational Biomedicine, Heidelberg, Germany Department of Morphology and Physiology, Faculty of Health Sciences, Semmelweis University, Budapest, Hungary Quadram Institute, Norwich Research Park, Norwich, United Kingdom Department of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom Department of Molecular Biology, Semmelweis University, Budapest, Hungary ELKH/MTA-ELTE Genetics Research Group, Budapest, Hungary Export Date: 10 October 2023 Correspondence Address: Korcsmáros, T.; Earlham InstituteUnited Kingdom; email: t.korcsmaros@imperial.ac.uk AB - Autophagy is a highly-conserved catabolic process eliminating dysfunctional cellular components and invading pathogens. Autophagy malfunction contributes to disorders such as cancer, neurodegenerative and inflammatory diseases. Understanding autophagy regulation in health and disease has been the focus of the last decades. We previously provided an integrated database for autophagy research, the Autophagy Regulatory Network (ARN). For the last seven years, this resource has been used by thousands of users. Here, we present a new and upgraded resource, AutophagyNet. It builds on the previous database but contains major improvements to address user feedback and novel needs due to the advancement in omics data availability. AutophagyNet contains updated interaction curation and integration of over 280,000 experimentally verified interactions between core autophagy proteins and their protein, transcriptional and post-transcriptional regulators as well as their potential upstream pathway connections. AutophagyNet provides annotations for each core protein about their role: 1) in different types of autophagy (mitophagy, xenophagy, etc.); 2) in distinct stages of autophagy (initiation, elongation, termination, etc); 3) with subcellular and tissue-specific localization. These annotations can be used to filter the dataset, providing customizable download options tailored to the user’s needs. The resource is available in various file formats (e.g., CSV, BioPAX and PSI-MI), and data can be analyzed and visualized directly in Cytoscape. The multi-layered regulation of autophagy can be analyzed by combining AutophagyNet with tissue- or cell type-specific using (multi-)omics datasets (e.g. transcriptomic or proteomic data). The resource is publicly accessible at http://autophagynet.org.Competing Interest StatementThe authors have declared no competing interest.ARNAutophagy Regulatory NetworkATGautophagy-related genesBCRB cell receptor pathwayBECN1beclin 1GABARAPgamma-aminobutyric acid receptor-associated proteinIIPinnate immune pathwaylncRNAlong non-coding RNAmiRNAmicroRNANHRnuclear hormone receptor pathwayPTMpost-translational modificationRTKreceptor tyrosine kinase pathwayTCRT cell receptor pathwayTLRToll-like receptor pathway LA - English DB - MTMT ER - TY - JOUR AU - Kovács, Éva AU - Simon, András TI - Az eleséstől való félelem a geriátriai betegek körében: narratív áttekintő közlemény JF - NŐVÉR J2 - NŐVÉR VL - 36 PY - 2023 IS - 6 SP - 12 EP - 18 PG - 7 SN - 0864-7003 DO - 10.55608/nover.36.0027 UR - https://m2.mtmt.hu/api/publication/34450420 ID - 34450420 AB - Az egyre nagyobb arányt képviselő idős korosztály önálló életvitelét alapvetően meghatározza az időskori elesés, valamint az esetleges eleséstől való félelem. Az eleséstől való félelem akkor válik kórossá, ha kialakul az önbizalomvesztés, a tartós félelemérzet az elesés miatt. Továbbá ez azzal is jár, hogy az idős ember korlátozza a fizikai tevékenységét, ami rontja a jövőbeli funkcionális képességeit, valamint növeli az intézetbe kerülés kockázatát. Jelen összefoglaló tanulmány áttekinti a szakirodalomban előforduló elnevezéseit, a gyakoriságát, a vizsgálómódszereit. Kitér arra is, hogy a jelenlegi kutatási eredmények szerint hogyan lehet megelőzni a kialakulását, illetve hogyan lehet mérsékelni (esetleg megszüntetni) a már meglévő kóros félelmet. LA - Hungarian DB - MTMT ER - TY - JOUR AU - Decker, Szonja AU - Deák, Darina AU - Horváth, Tamás AU - Koller, Ákos TI - Participation of abdominal and chest breathing in different positions during a complete breathing cycle JF - ARCHIVES OF THE HUNGARIAN MEDICAL ASSOCIATION OF AMERICA J2 - ARCH HUNG MED ASSOC AM VL - 29 PY - 2023 IS - 1 SP - 26 SN - 1070-0773 UR - https://m2.mtmt.hu/api/publication/34445496 ID - 34445496 LA - English DB - MTMT ER - TY - JOUR AU - Süli, Anita AU - Magyar, Péter AU - Vezér, Márton Tamás AU - Bányai, Bálint Péter AU - Szekeres, Mária AU - Sipos, Miklós AU - Mátrai, Máté AU - Hetthéssy, Judit AU - Bednárikné Dörnyei, Gabriella AU - Ács, Nándor AU - Horvath, Eszter Mária AU - Nádasy, György László AU - Várbíró, Szabolcs AU - Török, Marianna TI - Effects of Gender and Vitamin D on Vascular Reactivity of the Carotid Artery on a Testosterone-Induced PCOS Model JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 24 PY - 2023 IS - 23 PG - 20 SN - 1661-6596 DO - 10.3390/ijms242316577 UR - https://m2.mtmt.hu/api/publication/34407018 ID - 34407018 N1 - Anita Süli and Peter Magyar authors contributed equally to this work. Szabolcs Varbiró and Marianna Török authors contributed equally to this work. AB - The negative cardiovascular effects of polycystic ovary syndrome (PCOS) and vitamin D deficiency (VDD) have been discussed previously; however, the sex differences between PCOS females and males are not yet known. Our aim was to investigate the effect of PCOS and VDD in the carotid artery of male and female Wistar rats. Females were treated with transdermal testosterone (Androgel) for 8 weeks, which caused PCOS. VDD and vitamin D supplementation were accomplished via diet. The carotid arteries’ contraction and relaxation were examined using myography. Receptor density was investigated using immunohistochemistry. In PCOS females, angiotensin receptor density, angiotensin II-induced contraction, androgen receptor optical density, and testosterone-induced relaxation increased. The increased contractile response may increase cardiovascular vulnerability in women with PCOS. As an effect of VDD, estrogen receptor density increased in all our groups, which probably compensated for the reduced relaxation caused by VDD. Testosterone-induced relaxation was decreased as a result of VDD in males and non-PCOS females, whereas this reduction was absent in PCOS females. Male sex is associated with increased contraction ability compared with non-PCOS and PCOS females. VDD and Androgel treatment show significant gender differences in their effects on carotid artery reactivity. Both VDD and PCOS result in a dysfunctional vascular response, which can contribute to cardiovascular diseases. LA - English DB - MTMT ER -