@article{MTMT:34826851, title = {Treatment of type 2 diabetes mellitus in the elderly – Special considerations}, url = {https://m2.mtmt.hu/api/publication/34826851}, author = {Gadó, Klára and Tabák, Ádám and Vingender, István and Domján, Gyula and Bednárikné Dörnyei, Gabriella}, doi = {10.1556/2060.2024.00317}, journal-iso = {PHYSIOL INT}, journal = {PHYSIOLOGY INTERNATIONAL}, volume = {in press}, unique-id = {34826851}, issn = {2498-602X}, abstract = {Type 2 diabetes is a frequent chronic disease. Given its strong positive association with older age, it is a significant public health issue in elderly populations. Furthermore, the aging of the population, driven by increasing life expectancy in high and middle-income countries leads to an increasing prevalence of diabetes.}, year = {2024}, eissn = {2677-0164}, orcid-numbers = {Gadó, Klára/0000-0003-2253-5826; Tabák, Ádám/0000-0002-6234-3936; Domján, Gyula/0000-0003-0722-1538; Bednárikné Dörnyei, Gabriella/0000-0001-7007-6252} } @article{MTMT:34775499, title = {Frequency of office blood pressure measurements and the seasonal variability of blood pressure: results of the Hungarian Hypertension Registry}, url = {https://m2.mtmt.hu/api/publication/34775499}, author = {Nemcsik, János and Takács, Johanna and Pásztor, Dorottya Tímea and Farsang, Csaba and Simon, Attila and Páll, Dénes and Torzsa, Péter and Dolgos, Szilveszter and Koller, Ákos and Habony, Norbert and Járai, Zoltán}, doi = {10.1080/08037051.2024.2337170}, journal-iso = {BLOOD PRESSURE}, journal = {BLOOD PRESSURE}, volume = {33}, unique-id = {34775499}, issn = {0803-7051}, year = {2024}, eissn = {1651-1999}, orcid-numbers = {Nemcsik, János/0000-0002-3573-0287; Takács, Johanna/0000-0002-8709-8826; Pásztor, Dorottya Tímea/0009-0001-8399-1019; Torzsa, Péter/0000-0002-8148-4961; Koller, Ákos/0000-0003-3256-8701} } @article{MTMT:34753964, title = {Higher level of physical activity reduces mental and neurological symptoms during and two years after COVID-19 infection in young women}, url = {https://m2.mtmt.hu/api/publication/34753964}, author = {Takács, Johanna and Deák, Darina and Koller, Ákos}, doi = {10.1038/s41598-024-57646-2}, journal-iso = {SCI REP}, journal = {SCIENTIFIC REPORTS}, volume = {14}, unique-id = {34753964}, issn = {2045-2322}, abstract = {Previous studies found that regular physical activity (PA) can lower the risk of SARS-CoV-2 (COVID-19) infection and post-COVID-19 condition (PCC), yet its specific effects in young women have not yet been investigated. Thus, we aimed to examine whether regular physical activity reduces the number of symptoms during and after COVID-19 infection among young women aged between 18 and 34 (N = 802), in which the confounding effect of other morbidities could be excluded. The average time since infection was 23.5 months. Participants were classified into low, moderate, and high PA categories based on the reported minutes per week of moderate and vigorous PA. Using the Post-COVID-19 Case Report Form, 50 different symptoms were assessed. Although regular PA did not decrease the prevalence of COVID-19 infection and PCC but significantly reduced the number of mental and neurological symptoms both in acute COVID-19 and PCC. Importantly, the high level of PA had a greater impact on health improvements. In addition, the rate of reinfection decreased with an increased level of PA. In conclusion, a higher level of regular PA can reduce the risk of reinfection and the number of mental and neurological symptoms in PCC underlying the importance of regular PA, even in this and likely other viral disease conditions.}, year = {2024}, eissn = {2045-2322}, orcid-numbers = {Takács, Johanna/0000-0002-8709-8826; Koller, Ákos/0000-0003-3256-8701} } @article{MTMT:34714793, title = {Whole body vibration ameliorates anxiety-like behavior and memory functions in 30 months old senescent male rats}, url = {https://m2.mtmt.hu/api/publication/34714793}, author = {Oroszi, Tamás and Felszeghy, Klára and Luiten, Paul G.M. and Schoemaker, Regien G. and van der Zee, Eddy A. and Nyakas, Csaba}, doi = {10.1016/j.heliyon.2024.e26608}, journal-iso = {HELIYON}, journal = {HELIYON}, volume = {10}, unique-id = {34714793}, year = {2024}, eissn = {2405-8440}, orcid-numbers = {Oroszi, Tamás/0000-0003-2327-9959; Felszeghy, Klára/0000-0002-3539-1457; van der Zee, Eddy A./0000-0002-6471-7938; Nyakas, Csaba/0000-0003-3756-0186} } @article{MTMT:34493390, title = {Gravity sedimentation reveals functionally and morphologically different platelets in human blood}, url = {https://m2.mtmt.hu/api/publication/34493390}, author = {Ezer, Erzsébet and Schrick, Diana Zsuzsanna and Tőkés-Füzesi, Margit and Papp, István and Réger, Barbara and Molnár, Abigél and Ábrahám, Hajnalka and Koller, Ákos and Hársfalvi, Jolán and Kellermayer, Miklós and Molnár, Tihamér}, doi = {10.1080/09537104.2023.2298341}, journal-iso = {PLATELETS}, journal = {PLATELETS}, volume = {35}, unique-id = {34493390}, issn = {0953-7104}, year = {2024}, eissn = {1369-1635}, orcid-numbers = {Koller, Ákos/0000-0003-3256-8701; Hársfalvi, Jolán/0000-0001-9940-4846; Kellermayer, Miklós/0000-0002-5553-6553} } @article{MTMT:34425939, title = {The Semmelweis Study: a longitudinal occupational cohort study within the framework of the Semmelweis Caring University Model Program for supporting healthy aging}, url = {https://m2.mtmt.hu/api/publication/34425939}, author = {Ungvári, Zoltán István and Tabák, Ádám and Ádány, Róza and Purebl, György and Kaposvári, Csilla and Fazekas-Pongor, Vince and Csípő, Tamás and Szarvas, Zsófia and Horváth, Krisztián and Mukli, Péter and Balog, Piroska and Bódizs, Róbert and Ujma, Przemyslaw Péter and Stauder, Adrienne and Belsky, Daniel W. and Kovács, Illés and Yabluchanskiy, Andriy and Maier, Andrea B. and Moizs, Mariann and Östlin, Piroska and Yon, Yongjie and Varga, Péter and Vokó, Zoltán and Papp, Magor Csongor and Takács, István and Vásárhelyi, Barna and Torzsa, Péter and Ferdinandy, Péter and Csiszar, Anna and Benyó, Zoltán and Szabó, Attila and Bednárikné Dörnyei, Gabriella and Kivimäki, Mika and Kellermayer, Miklós and Merkely, Béla Péter}, doi = {10.1007/s11357-023-01018-7}, journal-iso = {GEROSCIENCE}, journal = {GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)}, volume = {46}, unique-id = {34425939}, issn = {2509-2715}, abstract = {The Semmelweis Study is a prospective occupational cohort study that seeks to enroll all employees of Semmelweis University (Budapest, Hungary) aged 25 years and older, with a population of 8866 people, 70.5% of whom are women. The study builds on the successful experiences of the Whitehall II study and aims to investigate the complex relationships between lifestyle, environmental, and occupational risk factors, and the development and progression of chronic age-associated diseases. An important goal of the Semmelweis Study is to identify groups of people who are aging unsuccessfully and therefore have an increased risk of developing age-associated diseases. To achieve this, the study takes a multidisciplinary approach, collecting economic, social, psychological, cognitive, health, and biological data. The Semmelweis Study comprises a baseline data collection with open healthcare data linkage, followed by repeated data collection waves every 5 years. Data are collected through computer-assisted self-completed questionnaires, followed by a physical health examination, physiological measurements, and the assessment of biomarkers. This article provides a comprehensive overview of the Semmelweis Study, including its origin, context, objectives, design, relevance, and expected contributions.}, year = {2024}, eissn = {2509-2723}, pages = {191-218}, orcid-numbers = {Ungvári, Zoltán István/0000-0002-6035-6039; Tabák, Ádám/0000-0002-6234-3936; Purebl, György/0000-0002-9750-2001; Fazekas-Pongor, Vince/0000-0002-6405-4003; Szarvas, Zsófia/0000-0002-0022-5053; Mukli, Péter/0000-0003-4355-8103; Balog, Piroska/0000-0001-5025-8649; Bódizs, Róbert/0000-0001-5341-060X; Ujma, Przemyslaw Péter/0000-0002-7981-3009; Stauder, Adrienne/0000-0002-0358-3657; Kovács, Illés/0000-0001-5763-0482; Vokó, Zoltán/0000-0002-1004-1848; Takács, István/0000-0002-7810-4833; Vásárhelyi, Barna/0000-0003-0055-7346; Torzsa, Péter/0000-0002-8148-4961; Ferdinandy, Péter/0000-0002-6424-6806; Benyó, Zoltán/0000-0001-6015-0359; Szabó, Attila/0000-0001-7321-9861; Bednárikné Dörnyei, Gabriella/0000-0001-7007-6252; Kellermayer, Miklós/0000-0002-5553-6553; Merkely, Béla Péter/0000-0001-6514-0723} } @article{MTMT:34109413, title = {AutophagyNet: high-resolution data source for the analysis of autophagy and its regulation}, url = {https://m2.mtmt.hu/api/publication/34109413}, author = {Csabai, Luca and Bohár, Balázs and Türei, Dénes and Prabhu, Sowmya and Földvári-Nagy, László and Madgwick, Matthew and Fazekas, Dávid and Módos, Dezső and Ölbei, Márton and Halka, Themis and Poletti, Martina and Kornilova, Polina and Kadlecsik, Tamás and Demeter, Amanda and Szalay-Bekő, Máté and Kapuy, Orsolya and Földvári-Nagy Lászlóné Lenti, Katalin and Vellai, Tibor and Gul, Lejla and Korcsmáros, Tamás}, doi = {10.1080/15548627.2023.2247737}, journal-iso = {AUTOPHAGY}, journal = {AUTOPHAGY}, volume = {20}, unique-id = {34109413}, issn = {1554-8627}, abstract = {Autophagy is a highly-conserved catabolic process eliminating dysfunctional cellular components and invading pathogens. Autophagy malfunction contributes to disorders such as cancer, neurodegenerative and inflammatory diseases. Understanding autophagy regulation in health and disease has been the focus of the last decades. We previously provided an integrated database for autophagy research, the Autophagy Regulatory Network (ARN). For the last seven years, this resource has been used by thousands of users. Here, we present a new and upgraded resource, AutophagyNet. It builds on the previous database but contains major improvements to address user feedback and novel needs due to the advancement in omics data availability. AutophagyNet contains updated interaction curation and integration of over 280,000 experimentally verified interactions between core autophagy proteins and their protein, transcriptional and post-transcriptional regulators as well as their potential upstream pathway connections. AutophagyNet provides annotations for each core protein about their role: 1) in different types of autophagy (mitophagy, xenophagy, etc.); 2) in distinct stages of autophagy (initiation, elongation, termination, etc); 3) with subcellular and tissue-specific localization. These annotations can be used to filter the dataset, providing customizable download options tailored to the user’s needs. The resource is available in various file formats (e.g., CSV, BioPAX and PSI-MI), and data can be analyzed and visualized directly in Cytoscape. The multi-layered regulation of autophagy can be analyzed by combining AutophagyNet with tissue- or cell type-specific using (multi-)omics datasets (e.g. transcriptomic or proteomic data). The resource is publicly accessible at http://autophagynet.org.Competing Interest StatementThe authors have declared no competing interest.ARNAutophagy Regulatory NetworkATGautophagy-related genesBCRB cell receptor pathwayBECN1beclin 1GABARAPgamma-aminobutyric acid receptor-associated proteinIIPinnate immune pathwaylncRNAlong non-coding RNAmiRNAmicroRNANHRnuclear hormone receptor pathwayPTMpost-translational modificationRTKreceptor tyrosine kinase pathwayTCRT cell receptor pathwayTLRToll-like receptor pathway}, year = {2024}, eissn = {1554-8635}, pages = {188-201}, orcid-numbers = {Földvári-Nagy, László/0000-0002-3954-721X; Fazekas, Dávid/0000-0001-7605-592X; Kapuy, Orsolya/0000-0002-8484-4504; Földvári-Nagy Lászlóné Lenti, Katalin/0000-0002-1252-822X; Vellai, Tibor/0000-0002-3520-2572} } @article{MTMT:34450420, title = {Az eleséstől való félelem a geriátriai betegek körében: narratív áttekintő közlemény}, url = {https://m2.mtmt.hu/api/publication/34450420}, author = {Kovács, Éva and Simon, András}, doi = {10.55608/nover.36.0027}, journal-iso = {NŐVÉR}, journal = {NŐVÉR}, volume = {36}, unique-id = {34450420}, issn = {0864-7003}, abstract = {Az egyre nagyobb arányt képviselő idős korosztály önálló életvitelét alapvetően meghatározza az időskori elesés, valamint az esetleges eleséstől való félelem. Az eleséstől való félelem akkor válik kórossá, ha kialakul az önbizalomvesztés, a tartós félelemérzet az elesés miatt. Továbbá ez azzal is jár, hogy az idős ember korlátozza a fizikai tevékenységét, ami rontja a jövőbeli funkcionális képességeit, valamint növeli az intézetbe kerülés kockázatát. Jelen összefoglaló tanulmány áttekinti a szakirodalomban előforduló elnevezéseit, a gyakoriságát, a vizsgálómódszereit. Kitér arra is, hogy a jelenlegi kutatási eredmények szerint hogyan lehet megelőzni a kialakulását, illetve hogyan lehet mérsékelni (esetleg megszüntetni) a már meglévő kóros félelmet.}, year = {2023}, eissn = {1588-1423}, pages = {12-18}, orcid-numbers = {Kovács, Éva/0000-0002-3250-8664; Simon, András/0000-0002-7589-1077} } @article{MTMT:34445496, title = {Participation of abdominal and chest breathing in different positions during a complete breathing cycle}, url = {https://m2.mtmt.hu/api/publication/34445496}, author = {Decker, Szonja and Deák, Darina and Horváth, Tamás and Koller, Ákos}, journal-iso = {ARCH HUNG MED ASSOC AM}, journal = {ARCHIVES OF THE HUNGARIAN MEDICAL ASSOCIATION OF AMERICA}, volume = {29}, unique-id = {34445496}, issn = {1070-0773}, year = {2023}, pages = {26}, orcid-numbers = {Horváth, Tamás/0000-0003-3038-8643; Koller, Ákos/0000-0003-3256-8701} } @article{MTMT:34407018, title = {Effects of Gender and Vitamin D on Vascular Reactivity of the Carotid Artery on a Testosterone-Induced PCOS Model}, url = {https://m2.mtmt.hu/api/publication/34407018}, author = {Süli, Anita and Magyar, Péter and Vezér, Márton Tamás and Bányai, Bálint Péter and Szekeres, Mária and Sipos, Miklós and Mátrai, Máté and Hetthéssy, Judit and Bednárikné Dörnyei, Gabriella and Ács, Nándor and Horvath, Eszter Mária and Nádasy, György László and Várbíró, Szabolcs and Török, Marianna}, doi = {10.3390/ijms242316577}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {24}, unique-id = {34407018}, issn = {1661-6596}, abstract = {The negative cardiovascular effects of polycystic ovary syndrome (PCOS) and vitamin D deficiency (VDD) have been discussed previously; however, the sex differences between PCOS females and males are not yet known. Our aim was to investigate the effect of PCOS and VDD in the carotid artery of male and female Wistar rats. Females were treated with transdermal testosterone (Androgel) for 8 weeks, which caused PCOS. VDD and vitamin D supplementation were accomplished via diet. The carotid arteries’ contraction and relaxation were examined using myography. Receptor density was investigated using immunohistochemistry. In PCOS females, angiotensin receptor density, angiotensin II-induced contraction, androgen receptor optical density, and testosterone-induced relaxation increased. The increased contractile response may increase cardiovascular vulnerability in women with PCOS. As an effect of VDD, estrogen receptor density increased in all our groups, which probably compensated for the reduced relaxation caused by VDD. Testosterone-induced relaxation was decreased as a result of VDD in males and non-PCOS females, whereas this reduction was absent in PCOS females. Male sex is associated with increased contraction ability compared with non-PCOS and PCOS females. VDD and Androgel treatment show significant gender differences in their effects on carotid artery reactivity. Both VDD and PCOS result in a dysfunctional vascular response, which can contribute to cardiovascular diseases.}, year = {2023}, eissn = {1422-0067}, orcid-numbers = {Magyar, Péter/0000-0001-7821-2159; Vezér, Márton Tamás/0000-0001-7458-2777; Bányai, Bálint Péter/0000-0001-5531-0661; Szekeres, Mária/0000-0002-6358-7270; Hetthéssy, Judit/0000-0001-8274-5257; Bednárikné Dörnyei, Gabriella/0000-0001-7007-6252; Ács, Nándor/0000-0002-1919-1869; Horvath, Eszter Mária/0000-0002-0517-1269; Nádasy, György László/0000-0003-2057-2391; Várbíró, Szabolcs/0000-0002-7109-6906; Török, Marianna/0000-0002-2832-0626} }