@article{MTMT:34766036,
title = {Effects of Chrysin and Chrysin-7-sulfate on Ochratoxin A-Albumin Interactions and on the Plasma and Kidney Levels of the Mycotoxin in Rats},
url = {https://m2.mtmt.hu/api/publication/34766036},
author = {Poór, Miklós and Dombi, Ágnes and Fliszár-Nyúl, Eszter and Pedroni, Lorenzo and Dellafiora, Luca},
doi = {10.1021/acsomega.4c01738},
journal-iso = {ACS OMEGA},
journal = {ACS OMEGA},
volume = {9},
unique-id = {34766036},
issn = {2470-1343},
year = {2024},
eissn = {2470-1343},
pages = {17655-17666},
orcid-numbers = {Fliszár-Nyúl, Eszter/0000-0003-0923-0059; Dellafiora, Luca/0000-0002-1901-3317}
}
@article{MTMT:34763514,
title = {Clinical Benefits of Decreased Photo-Oxidative Stress on Human Embryo Development},
url = {https://m2.mtmt.hu/api/publication/34763514},
author = {Gödöny, Krisztina and Herczeg, Róbert and Gyenesei, Attila and Várnagy, Ákos and Bognár, Zoltán and Kovács, L. Gábor and Szekeres, Júlia and Mauchart, Péter and Nagy, Bernadett and Erostyák, János and Kovács, Kálmán András and Bódis, József},
doi = {10.1159/000536358},
journal-iso = {MED PRIN PRACT},
journal = {MEDICAL PRINCIPLES AND PRACTICE},
unique-id = {34763514},
issn = {1011-7571},
abstract = {Objective: Early embryonic development is characterized by rapid cell division and gene activation, making the embryo extremely sensitive to environmental influences. Light exposure can affect embryonic development through a direct toxic effect on the embryo via the generation of reactive oxygen species. In a previous study, we demonstrated the positive effect of improved light-protected embryo culture conditions implemented in our laboratory. This study aimed to investigate the changes in human embryo development under light protection during the conventional in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). Materials and Methods: We tested the potential beneficial effect of light filters to reduce the risk of toxic effects of light. IVF outcomes were compared between two experimental conditions, light protection with red light filters versus no light protection as a control. Results: Blastocyst development rate in IVF was significantly higher in the light-protected group than in the group treated under conventional conditions (46.6 vs. 26.7%). In the case of ICSI, we obtained a similar result (44.5 vs. 31.6%). The rate of cryopreservation with at least one embryo was higher in the light-protected phase (32.8%) than in the conventionally manipulated phase (26.8%). The abortion rate was also significantly lower during the light-protected period in IVF, resulting in a higher live birth rate. Conclusions: The implementation of light protection to reduce the embryotoxic wavelengths of light in IVF centers may improve the blastocyst development rate and embryo quality while maintaining embryo safety.},
keywords = {blastocyst; abortion; intracytoplasmic sperm injection; In vitro fertilization; Live birth rate; light protection},
year = {2024},
eissn = {1423-0151},
orcid-numbers = {Herczeg, Róbert/0000-0002-5903-0082; Kovács, L. Gábor/0000-0001-5298-5401}
}
@article{MTMT:34725855,
title = {Investigating the role of ultrasound-based shear wave elastography in kidney transplanted patients : correlation between non-invasive fibrosis detection, kidney dysfunction and biopsy results-a systematic review and meta-analysis},
url = {https://m2.mtmt.hu/api/publication/34725855},
author = {Filipov, Teodóra and Teutsch, Brigitta and Szabó, Anett and Forintos, Attila and Ács, Júlia and Váradi, Alex and Hegyi, Péter and Szarvas, Tibor and Ács, Nándor and Nyirády, Péter and Deák, Pál Ákos},
doi = {10.1007/s40620-023-01856-w},
journal-iso = {J NEPHROL},
journal = {JOURNAL OF NEPHROLOGY},
unique-id = {34725855},
issn = {1121-8428},
abstract = {Interstitial fibrosis and tubular atrophy are leading causes of renal allograft failure. Shear wave elastography could be a promising noninvasive method for providing information on the state of the kidney, with specific regard to fibrosis but currently available data in the literature are controversial. Our study aimed to analyze the correlation between shear wave elastography and various kidney dysfunction measures.This review was registered on PROSPERO (CRD42021283152). We systematically searched three major databases (MEDLINE, Embase, and CENTRAL) for articles concerning renal transplant recipients, shear wave elastography, fibrosis, and kidney dysfunction. Meta-analytical calculations for pooled Pearson and Spearman correlation coefficients (r) were interpreted with 95% confidence intervals (CIs). Heterogeneity was tested with Cochran's Q test. I2 statistic and 95% CI were reported as a measurement of between-study heterogeneity. Study quality was assessed with the QUADAS2 tool.In total, 16 studies were included in our meta-analysis. Results showed a moderate correlation between kidney stiffness and interstitial fibrosis and tubular atrophy, graded according to BANFF classification, on biopsy findings for pooled Pearson (r = 0.48; CI: 0.20, 0.69; I2 = 84%) and Spearman correlations (r = 0.57; CI: 0.35, 0.72; I2 = 74%). When compared to kidney dysfunction parameters, we found a moderate correlation between shear wave elastography and resistive index (r = 0.34 CI: 0.13, 0.51; I2 = 67%) and between shear wave elastography and estimated Glomerular Filtration Rate (eGFR) (r = -0.65; CI: - 0.81, - 0.40; I2 = 73%). All our outcomes had marked heterogeneity.Our results showed a moderate correlation between kidney stiffness measured by shear wave elastography and biopsy results. While noninvasive assessment of kidney fibrosis after transplantation is an important clinical goal, there is insufficient evidence to support the use of elastography over the performance of a kidney biopsy.},
keywords = {Biopsy; Renal transplantation; shear wave elastography; Sonoelastography},
year = {2024},
eissn = {1724-6059},
orcid-numbers = {Teutsch, Brigitta/0000-0002-9530-7886; Váradi, Alex/0000-0001-8229-6340; Hegyi, Péter/0000-0003-0399-7259; Szarvas, Tibor/0000-0002-6321-0799; Ács, Nándor/0000-0002-1919-1869; Nyirády, Péter/0000-0002-7037-4919}
}
@article{MTMT:34719089,
title = {The 2-aminoethyl diphenylborinate-based fluorescent method identifies quercetin and luteolin metabolites as substrates of Organic anion transporting polypeptides, OATP1B1 and OATP2B1},
url = {https://m2.mtmt.hu/api/publication/34719089},
author = {Kaci, Hana and Bakos, Éva and Needs, Paul W. and Kroon, Paul A. and Valentová, Kateřina and Poór, Miklós and Laczka, Csilla},
doi = {10.1016/j.ejps.2024.106740},
journal-iso = {EUR J PHARM SCI},
journal = {EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES},
unique-id = {34719089},
issn = {0928-0987},
abstract = {Organic anion transporting polypeptides (OATPs), OATP1B1 and OATP2B1 are membrane proteins mediating the cellular uptake of chemically diverse organic compounds. OATP1B1 is exclusively expressed in hepatocytes and plays a key role in hepatic detoxification. The ubiquitously expressed OATP2B1 promotes the intestinal absorption of orally administered drugs. Flavonoids are widely found in foods and beverages, and many of them can inhibit OATP function, resulting in food-drug interactions. In our previous work, we have shown that not only luteolin (LUT) and quercetin (Q), but also some of their metabolites can inhibit OATP1B1 and OATP2B1 activity. However, data about the potential direct transport of these flavonoids by OATPs have been incomplete. Hence, in the current study, we developed a simple, fluorescence-based method for the measurement of intracellular flavonoid levels. The method applies a cell-permeable small molecule (2-aminoethyl diphenylborinate, 2-APB), that, upon forming a complex with flavonoids, results in their fluorescence enhancement. This way the direct uptake of LUT and Q, and also their metabolites could be investigated both by confocal microscopy and in a fluorescence plate reader in living cells. With this approach we identified quercetin-3'-O-sulfate, luteolin-3'-O-glucuronide, luteolin-7-O-glucuronide and luteolin-3'-O-sulfate as substrates of both OATP1B1 and OATP2B1. Our results highlight that OATP1B1 and OATP2B1 can be key participants in the transmembrane movement of cell-permeable LUT and Q conjugates with otherwise low cell permeability. In addition, the novel method developed in this study can be a good completion to existing fluorescence-based assays to investigate OATP function.},
year = {2024},
eissn = {1879-0720}
}
@techreport{MTMT:34684358,
title = {Örökletes betegségek genomikai diagnosztikája a Markusovszky Egyetemi Oktatókórház és az iBioScience együttműködésében. Előadás a Ritka Betegség Világnap alkalmából 2024.02.24. Sopron.},
url = {https://m2.mtmt.hu/api/publication/34684358},
author = {Kálmán, Bernadette},
unique-id = {34684358},
year = {2024}
}
@article{MTMT:34575448,
title = {Interaction of mycotoxins zearalenone, α-zearalenol, and β-zearalenol with cytochrome P450 (CYP1A2, 2C9, 2C19, 2D6, and 3A4) enzymes and organic anion transporting polypeptides (OATP1A2, OATP1B1, OATP1B3, and OATP2B1)},
url = {https://m2.mtmt.hu/api/publication/34575448},
author = {Kaci, Hana and Dombi, Ágnes and Gömbös, Patrik and Szabó, András and Bakos, Éva and Laczka, Csilla and Poór, Miklós},
doi = {10.1016/j.tiv.2024.105789},
journal-iso = {TOXICOL IN VITRO},
journal = {TOXICOLOGY IN VITRO},
volume = {96},
unique-id = {34575448},
issn = {0887-2333},
keywords = {ZEARALENONE; Cytochrome P450 enzymes; organic anion transporting polypeptides; α-zearalenol; β-zearalenol},
year = {2024},
eissn = {1879-3177},
orcid-numbers = {Szabó, András/0000-0002-5315-0024}
}
@article{MTMT:34574202,
title = {Glioblastoma epigenomics discloses a complex biology and potential therapeutic targets},
url = {https://m2.mtmt.hu/api/publication/34574202},
author = {Krabóth, Zoltán and Tompa, Márton and Urbán, Péter and Gálik, Bence and Kajtár, Béla and Gyenesei, Attila and Kálmán, Bernadette},
doi = {10.18071/isz.77.0027},
journal-iso = {IDEGGYOGY SZEMLE},
journal = {IDEGGYOGYASZATI SZEMLE / CLINICAL NEUROSCIENCE},
volume = {77},
unique-id = {34574202},
issn = {0019-1442},
abstract = {Glioblastoma (GBM), a highly aggressive form of brain tumors, has been extensively studied using OMICS methods, and the most characteristic molecular determinants have been incorporated into the histopathological diagnosis. Research data, nevertheless, only partially have been adopted in clinical practice. Here we aimed to present results of our epigenomic GBM profiling to better understand early and late determinants of these tumors, and to share main elements of our findings with practicing professionals..GBM specimens were surgically obtained after first diagnosis (GBM1) and at recurrence (GBM2). DNA was extracted from 24 sequential pairs of formalin-fixed, paraffin-embedded tumor tissues. The Reduced Representation Bisulfite Sequencing kit was used for library preparation. Pooled libraries were sequenced on an Illumina NextSeq 550 instrument. Methylation controls (MC) were obtained from a publicly available database. Bioinformatic analyses were performed to identify differentially methylated pathways and their elements in cohorts of MC, GBM1 and GBM2..Several differentially methylated pathways involved in basic intracellular and brain tissue developmental processes were identified in the GBM1 vs. MC and GBM2 vs. MC comparisons. Among differentially methylated pathways, those involved in immune regulation, neurotransmitter (particularly dopaminergic, noradrenergic and glutaminergic) responses and regulation of stem cell differentiation and proliferation stood out in the GBM2 vs. GBM1 comparisons..Our study revealed biological complexity of early and late gliomagenesis encompassing mechanisms from basic intracellular through distorted neurodevelopmental processes to more specific immune and highjacked neurotransmitter pathways in the tumor microenvironment. These findings may offer considerations for therapeutic approaches..},
keywords = {glioblastoma; Therapeutic targets; DNA CpG methylation; pathways of gliomagenesis},
year = {2024},
eissn = {2498-6208},
pages = {27-37},
orcid-numbers = {Tompa, Márton/0000-0002-4045-6219; Kajtár, Béla/0000-0001-5551-3709}
}
@misc{MTMT:34548155,
title = {Kardiomiopátiás család genetikai elemzése.. Előadás a Szívelégtelenség konferencián, 2024.01.25. Keszthely},
url = {https://m2.mtmt.hu/api/publication/34548155},
author = {Kálmán, Orsolya and Kálmán, Bernadette and Nagy, Lajos},
unique-id = {34548155},
year = {2024}
}
@article{MTMT:34506124,
title = {Staphylococcus aureus mutants resistant to the feed-additive monensin show increased virulence and altered purine metabolism},
url = {https://m2.mtmt.hu/api/publication/34506124},
author = {Warsi, Omar M and Upterworth, Lina M and Breidenstein, Annika and Lustig, Ulrika and Mikkelsen, Kasper and Nagy, Tamás and Szatmári, Dávid Zoltán and Ingmer, Hanne and Andersson, Dan I},
doi = {10.1128/mbio.03155-23},
journal-iso = {MBIO},
journal = {MBIO},
volume = {15},
unique-id = {34506124},
issn = {2161-2129},
abstract = {This study demonstrates a novel link between ionophore resistance, purine metabolism, and virulence/fitness in the key human and animal pathogen Staphylococcus aureus. The results show that mutants with reduced susceptibility to the commonly used ionophore monensin can be readily selected and that the reduced susceptibility observed is associated with an increased expression of the de novo purine synthesis pathway. This study increases our understanding of the impact of the use of animal feed additives on both human and veterinary medicine.},
keywords = {IONOPHORE; fitness; CROSS-RESISTANCE; PURINE METABOLISM; drug resistance evolution; drug resistance mechanisms; mouse experiment},
year = {2024},
eissn = {2150-7511},
orcid-numbers = {Nagy, Tamás/0000-0001-5437-1411}
}
@article{MTMT:34505937,
title = {An overlooked phenomenon: complex interactions of potential error sources on the quality of bacterial de novo genome assemblies},
url = {https://m2.mtmt.hu/api/publication/34505937},
author = {Rádai, Z. and Váradi, Alex and Takács, P. and Nagy, N.A. and Schmitt, N. and Prépost, E. and Kardos, G. and Laczkó, Levente},
doi = {10.1186/s12864-023-09910-4},
journal-iso = {BMC GENOMICS},
journal = {BMC GENOMICS},
volume = {25},
unique-id = {34505937},
issn = {1471-2164},
year = {2024},
eissn = {1471-2164},
orcid-numbers = {Váradi, Alex/0000-0001-8229-6340}
}