TY - GEN AU - Rendes, Réka AU - Orsi, Gergely AU - Perlaki, Gábor AU - Bereczkei, Tamás AU - Deák, Anita TI - Neural correlates of valence and arousal ratings responding to socio-emotional stimuli. PY - 2024 UR - https://m2.mtmt.hu/api/publication/34794821 ID - 34794821 N1 - Z3-Poster 3-9002 LA - English DB - MTMT ER - TY - CHAP AU - Maróti, Péter AU - Schlégl, Ádám Tibor AU - Nagy, Bálint AU - Tóth, Luca AU - Bogár, Péter Zoltán AU - Józsa, Gergő AU - Rendeki, Szilárd AU - Mallakpour, Shadpour AU - Hussain, Chaudhery Mustansar TI - Additive manufacturing in limb prosthetics and orthotics: the past, present and future of 3D printing orthopedic assistive devices T2 - Medical Additive Manufacturing PB - Elsevier SN - 9780323953832 PY - 2024 SP - 179 EP - 207 PG - 29 DO - 10.1016/B978-0-323-95383-2.00028-7 UR - https://m2.mtmt.hu/api/publication/34774903 ID - 34774903 LA - English DB - MTMT ER - TY - JOUR AU - Picetti, Edoardo AU - Demetriades, Andreas K. AU - Catena, Fausto AU - Aarabi, Bizhan AU - Abu-Zidan, Fikri M. AU - Alves, Oscar L. AU - Ansaloni, Luca AU - Armonda, Rocco A. AU - Badenes, Rafael AU - Bala, Miklosh AU - Balogh, Zsolt J. AU - Barbanera, Andrea AU - Bertuccio, Alessandro AU - Biffl, Walter L. AU - Bouzat, Pierre AU - Buki, Andras AU - Castano-Leon, Ana Maria AU - Cerasti, Davide AU - Citerio, Giuseppe AU - Coccolini, Federico AU - Coimbra, Raul AU - Coniglio, Carlo AU - Costa, Francesco AU - De Iure, Federico AU - Depreitere, Bart AU - Fainardi, Enrico AU - Fehlings, Michael J. AU - Gabrovsky, Nikolay AU - Godoy, Daniel Agustin AU - Gruen, Peter AU - Gupta, Deepak AU - Hawryluk, Gregory W. J. AU - Helbok, Raimund AU - Hossain, Iftakher AU - Hutchinson, Peter J. AU - Iaccarino, Corrado AU - Inaba, Kenji AU - Ivanov, Marcel AU - Kaprovoy, Stanislav AU - Kirkpatrick, Andrew W. AU - Klein, Sam AU - Kolias, Angelos AU - Konovalov, Nikolay A. AU - Lagares, Alfonso AU - Lippa, Laura AU - Loza-Gomez, Angelica AU - Luoto, Teemu M. AU - Maas, Andrew I. R. AU - Maciejczak, Andrzej AU - Maier, Ronald V. AU - Marklund, Niklas AU - Martin, Matthew J. AU - Melloni, Ilaria AU - Mendoza-Lattes, Sergio AU - Meyfroidt, Geert AU - Munari, Marina AU - Napolitano, Lena M. AU - Okonkwo, David O. AU - Otomo, Yasuhiro AU - Papadopoulos, Marios C. AU - Petr, Ondra AU - Peul, Wilco C. AU - Pudkrong, Aichholz K. AU - Qasim, Zaffer AU - Rasulo, Frank AU - Reizinho, Carla AU - Ringel, Florian AU - Rizoli, Sandro AU - Rostami, Elham AU - Rubiano, Andres M. AU - Russo, Emanuele AU - Sarwal, Aarti AU - Schwab, Jan M. AU - Servadei, Franco AU - Sharma, Deepak AU - Sharif, Salman AU - Shiban, Ehab AU - Shutter, Lori AU - Stahel, Philip F. AU - Taccone, Fabio S. AU - Terpolilli, Nicole A. AU - Thomé, Claudius AU - Tóth, Péter József AU - Tsitsopoulos, Parmenion P. AU - Udy, Andrew AU - Vaccaro, Alexander R. AU - Varon, Albert J. AU - Vavilala, Monica S. AU - Younsi, Alexander AU - Zackova, Monika AU - Zoerle, Tommaso AU - Robba, Chiara TI - Early management of adult traumatic spinal cord injury in patients with polytrauma: a consensus and clinical recommendations jointly developed by the World Society of Emergency Surgery (WSES) & the European Association of Neurosurgical Societies (EANS) JF - WORLD JOURNAL OF EMERGENCY SURGERY J2 - WJES VL - 19 PY - 2024 IS - 1 PG - 10 SN - 1749-7922 DO - 10.1186/s13017-023-00525-4 UR - https://m2.mtmt.hu/api/publication/34521154 ID - 34521154 AB - Background: The early management of polytrauma patients with traumatic spinal cord injury (tSCI) is a major challenge. Sparse data is available to provide optimal care in this scenario and worldwide variability in clinical practice has been documented in recent studies. Methods: A multidisciplinary consensus panel of physicians selected for their established clinical and scientific expertise in the acute management of tSCI polytrauma patients with different specializations was established. The World Society of Emergency Surgery (WSES) and the European Association of Neurosurgical Societies (EANS) endorsed the consensus, and a modified Delphi approach was adopted. Results: A total of 17 statements were proposed and discussed. A consensus was reached generating 17 recommendations (16 strong and 1 weak). Conclusions: This consensus provides practical recommendations to support a clinician’s decision making in the management of tSCI polytrauma patients. © 2024, The Author(s). LA - English DB - MTMT ER - TY - JOUR AU - Ezer, Erzsébet AU - Schrick, Diana Zsuzsanna AU - Tőkés-Füzesi, Margit AU - Papp, István AU - Réger, Barbara AU - Molnár, Abigél AU - Ábrahám, Hajnalka AU - Koller, Ákos AU - Hársfalvi, Jolán AU - Kellermayer, Miklós AU - Molnár, Tihamér TI - Gravity sedimentation reveals functionally and morphologically different platelets in human blood JF - PLATELETS J2 - PLATELETS VL - 35 PY - 2024 IS - 1 PG - 10 SN - 0953-7104 DO - 10.1080/09537104.2023.2298341 UR - https://m2.mtmt.hu/api/publication/34493390 ID - 34493390 LA - English DB - MTMT ER - TY - JOUR AU - He, Mingchen AU - Kis-Jakab, Gréta AU - Komáromy, Hedvig AU - Perlaki, Gábor AU - Orsi, Gergely AU - Bosnyák, Edit AU - Rozgonyi, Renáta AU - John, Flóra AU - Trauninger, Anita AU - Eklicsné Lepenye, Katalin AU - Pfund, Zoltán TI - Volumetric alteration of brainstem in female migraineurs with and without aura JF - CLINICAL NEUROLOGY AND NEUROSURGERY J2 - CLIN NEUROL NEUROSUR VL - 236 PY - 2024 PG - 6 SN - 0303-8467 DO - 10.1016/j.clineuro.2023.108089 UR - https://m2.mtmt.hu/api/publication/34477406 ID - 34477406 N1 - Pécs Diagnostic Center, Pécs, Hungary HUN-REN-PTE Clinical Neuroscience MR Research Group, Pécs, Hungary Department of Neurosurgery, Medical School, University of Pécs, Pécs, Hungary Department of Neurology, Medical School, University of Pécs, Pécs, Hungary Department of Languages for Biomedical Purposes and Communication, University of Pécs, Pécs, Hungary Export Date: 29 January 2024 CODEN: CNNSB Correspondence Address: Pfund, Z.; Department of Neurology, Rét u. 2, Hungary; email: pfund.zoltan@pte.hu AB - Brainstem descending modulatory circuits have been postulated to be involved in migraine. Differences in brainstem volume between migraineurs and healthy controls have been demonstrated in previous research, nevertheless, the effect of migraine aura on brainstem volume is still uncertain. The aim of this study was to investigate the brainstem volume in migraineurs and examine the effect of migraine aura on brainstem volume.Our study included 90 female migraine patients without white matter lesions. (29 migraine patients with aura (MwA) and 61 migraine patients without aura (MwoA) and 32 age-matched female healthy controls (HC). Using the FreeSurfer image analysis suite, the volumes of the entire brainstem and its subfields (medulla, pons, and midbrain) were measured and compared between migraine subgroups (MwA vs. MwoA) and the healthy control group. The possible effects of migraine characteristics (i.e., disease duration and migraine attack frequency) on brainstem volume were also investigated.Migraineurs had greater medulla volume (MwoA 3552 ± 459 mm3, MwA 3424 ± 448 mm3) than healthy controls (3236 ± 411 mm3). Statistically, MwA vs. HC p = 0.040, MwoA vs. HC p = 0.002, MwA vs. MwoA p = 0.555. A significant positive correlation was found between disease duration and the volume of medulla in the whole migraine group (r = 0.334, p = 0.001). Neither the whole brainstem nor its subfields were significantly different in volume between migraine subgroups.Brainstem volume changes in migraine are mainly localized to the medulla and not specific to the presence of aura. LA - English DB - MTMT ER - TY - JOUR AU - Mukli, Péter AU - Pinto, Camila B AU - Owens, Cameron D AU - Csípő, Tamás AU - Lipécz, Ágnes AU - Szarvas, Zsófia AU - Péterfi, Anna AU - Langley, Ana Clara da Costa Pinaffi AU - Hoffmeister, Jordan AU - Rácz, Frigyes Sámuel AU - Perry, Jonathan W AU - Tarantini, Stefano AU - Nyúl-Tóth, Ádám AU - Sorond, Farzaneh A AU - Yang, Yuan AU - James, Judith A AU - Kirkpatrick, Angelia C AU - Prodan, Calin I AU - Tóth, Péter József AU - Galindo, Juliette AU - Gardner, Andrew W AU - Sonntag, William E AU - Csiszar, Anna AU - Ungvári, Zoltán István AU - Yabluchanskiy, Andriy TI - Impaired Neurovascular Coupling and Increased Functional Connectivity in the Frontal Cortex Predict Age-Related Cognitive Dysfunction JF - ADVANCED SCIENCE J2 - ADV SCI VL - 11 PY - 2024 IS - 10 PG - 18 SN - 2198-3844 DO - 10.1002/advs.202303516 UR - https://m2.mtmt.hu/api/publication/34477401 ID - 34477401 AB - Impaired cerebrovascular function contributes to the genesis of age-related cognitive decline. In this study, the hypothesis is tested that impairments in neurovascular coupling (NVC) responses and brain network function predict cognitive dysfunction in older adults. Cerebromicrovascular and working memory function of healthy young (n = 21, 33.2±7.0 years) and aged (n = 30, 75.9±6.9 years) participants are assessed. To determine NVC responses and functional connectivity (FC) during a working memory (n-back) paradigm, oxy- and deoxyhemoglobin concentration changes from the frontal cortex using functional near-infrared spectroscopy are recorded. NVC responses are significantly impaired during the 2-back task in aged participants, while the frontal networks are characterized by higher local and global connection strength, and dynamic FC (p < 0.05). Both impaired NVC and increased FC correlate with age-related decline in accuracy during the 2-back task. These findings suggest that task-related brain states in older adults require stronger functional connections to compensate for the attenuated NVC responses associated with working memory load. LA - English DB - MTMT ER - TY - JOUR AU - Trivedi, Dhanisha Trivedi AU - Forssten, Maximilian Peter AU - Cao, Yang AU - Mohammad Ismail, Ahmad AU - Czeiter, Endre AU - Amrein, Krisztina AU - Kobeissy, Firas AU - Wang, Kevin K W AU - DeSoucy, Erik AU - Büki, András AU - Mohseni, Shahin TI - Screening Performance of S100B, GFAP and UCH-L1 For Intracranial Injury Within 6 hours of Injury and beyond JF - JOURNAL OF NEUROTRAUMA J2 - J NEUROTRAUM VL - 41 PY - 2024 IS - 3-4 SP - 349 EP - 358 PG - 10 SN - 0897-7151 DO - 10.1089/neu.2023.0322 UR - https://m2.mtmt.hu/api/publication/34477399 ID - 34477399 N1 - * Megosztott szerzőség AB - The Scandinavian NeuroTrauma Committee (SNC) guidelines recommend S100B as a screening tool for early detection of Traumatic brain injury (TBI) in patients presenting with an initial Glasgow coma scale (GCS) of 14-15. The objective of the current study was to compare S100B's diagnostic performance within the recommended 6-hour window after injury, compared to GFAP and UCH-L1. The secondary outcome of interest was the ability of these biomarkers in detecting traumatic intracranial pathology beyond the 6-hour mark.The Center-TBI core database (2014-2017) was queried for data pertaining to all TBI patients with an initial GCS of 14-15 who had a blood sample taken within 6 hours of injury in which the levels of S100B, GFAP, and UCH-L1 were measured. As a subgroup analysis, data involving patients with blood samples taken within 6-9 hours, and 9-12 hours were analyzed separately for diagnostic ability. The diagnostic ability of these biomarkers for detecting any intracranial injury was evaluated based on the area under the receiver operating characteristic curve (AUC). Each biomarker's sensitivity, specificity, and accuracy were also reported at the cutoff that maximized Youden's index.A total of 531 TBI patients with GCS 14-15 on admission had a blood sample taken within 6 hours, of whom 24.9% (N = 132) had radiologically confirmed intracranial injury. The AUCs of GFAP (0.86, 95% confidence interval (CI): 0.82-0.90) and UCH-L1 (0.81, 95% CI: 0.76-0.85) were statistically significantly higher than that of S100B (0.74, 95% CI: 0.69-0.79) during this time. There was no statistically significant difference in the predictive ability of S100B when sampled within 6 hours, 6-9 hours, and 9-12 hours of injury, as the p-values were >0.05 when comparing the AUCs. Overlapping AUC 95% CI suggests no benefit of a combined GFAP and UCH-L1 screening tool over GFAP during the time periods studied [ 0.87 (0.83-0.90) vs 0.86 (0.82-0.90) when sampled within 6 hours of injury, 0.83 (0.78-0.88) vs 0.83 (0.78-0.89) within 6-to-9 hours and 0.81 (0.73-0.88) vs 0.79 (0.72-0.87) within 9-12 hours].Targeted analysis of the CENTER-TBI core database, with focus on the patient category for which biomarker testing is recommended by the SNC guidelines, revealed that GFAP and UCH-L1 perform superior to S100B in predicting CT-positive intracranial lesions within 6 hours of injury. GFAP continued to exhibit superior predictive ability to S100B during the time periods studied. S100B displayed relatively unaltered screening performance beyond the diagnostic timeline provided by SNC guidelines. These findings suggest the need for a re-evaluation of the current SNC TBI guidelines. LA - English DB - MTMT ER - TY - JOUR AU - Hossain, I. AU - Marklund, N. AU - Czeiter, Endre AU - Hutchinson, P. AU - Büki, András TI - Blood biomarkers for traumatic brain injury: A narrative review of current evidence JF - BRAIN AND SPINE J2 - BRAIN SPINE VL - 4 PY - 2024 PG - 9 SN - 2772-5294 DO - 10.1016/j.bas.2023.102735 UR - https://m2.mtmt.hu/api/publication/34474356 ID - 34474356 N1 - * Megosztott szerzőség LA - English DB - MTMT ER - TY - JOUR AU - Áfra, Eszter AU - Janszky, József Vladimír AU - Perlaki, Gábor AU - Orsi, Gergely AU - Nagy, Szilvia Anett AU - Arató, Ákos AU - Szente, Anna Tímea AU - Alhour, Husamalddin Ali Mohammad AU - Kis-Jakab, Gréta AU - Darnai, Gergely TI - Altered functional brain networks in problematic smartphone and social media use: resting-state fMRI study JF - BRAIN IMAGING AND BEHAVIOR J2 - BRAIN IMAGING BEHAV PY - 2024 PG - 10 SN - 1931-7557 DO - 10.1007/s11682-023-00825-y UR - https://m2.mtmt.hu/api/publication/34420912 ID - 34420912 N1 - Funding Agency and Grant Number: University of Pecs from the National Research, Development and Innovation Fund of Hungary under the TKP2021-EGA funding scheme [TKP2021-EGA-16]; Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences; National Laboratory of Translational Neuroscience (NLTN) [RRF-2.3.1-21-2022-00011] Funding text: Open access funding provided by University of Pecs. Project no. TKP2021-EGA-16 has been implemented with the support provided from the National Research, Development and Innovation Fund of Hungary, financed under the TKP2021-EGA funding scheme. SAN was supported by the Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences. Project no. RRF-2.3.1-21-2022-00011 were supported from the National Laboratory of Translational Neuroscience (NLTN). AB - Nowadays, the limitless availability to the World Wide Web can lead to general Internet misuse and dependence. Currently, smartphone and social media use belong to the most prevalent Internet-related behavioral addiction forms. However, the neurobiological background of these Internet-related behavioral addictions is not sufficiently explored. In this study, these addiction forms were assessed with self-reported questionnaires. Resting-state functional magnetic resonance imaging was acquired for all participants ( n = 59, 29 males) to examine functional brain networks. The resting-state networks that were discovered using independent component analysis were analyzed to estimate within network differences. Significant negative associations with social media addiction and smartphone addiction were found in the language network, the lateral visual networks, the auditory network, the sensorimotor network, the executive network and the frontoparietal network. These results suggest that problematic smartphone and social media use are associated with sensory processing and higher cognitive functioning . LA - English DB - MTMT ER - TY - JOUR AU - Faakye, Janet AU - Nyúl-Tóth, Ádám AU - Murányi, Mihály AU - Gulej, Rafal AU - Csik, Boglarka AU - Shanmugarama, Santny AU - Tarantini, Stefano AU - Negri, Sharon AU - Prodan, Calin AU - Mukli, Peter AU - Yabluchanskiy, Andriy AU - Conley, Shannon AU - Tóth, Péter József AU - Csiszar, Anna AU - Ungvári, Zoltán István TI - Preventing spontaneous cerebral microhemorrhages in aging mice : a novel approach targeting cellular senescence with ABT263/navitoclax JF - GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE) J2 - GEROSCIENCE VL - 46 PY - 2024 SP - 21 EP - 37 PG - 17 SN - 2509-2715 DO - 10.1007/s11357-023-01024-9 UR - https://m2.mtmt.hu/api/publication/34415989 ID - 34415989 AB - Emerging evidence from both clinical and preclinical studies underscores the role of aging in potentiating the detrimental effects of hypertension on cerebral microhemorrhages (CMHs, or cerebral microbleeds). CMHs progressively impair neuronal function and contribute to the development of vascular cognitive impairment and dementia. There is growing evidence showing accumulation of senescent cells within the cerebral microvasculature during aging, which detrimentally affects cerebromicrovascular function and overall brain health. We postulated that this build-up of senescent cells renders the aged cerebral microvasculature more vulnerable, and consequently, more susceptible to CMHs. To investigate the role of cellular senescence in CMHs' pathogenesis, we subjected aged mice, both with and without pre-treatment with the senolytic agent ABT263/Navitoclax, and young control mice to hypertension via angiotensin-II and L-NAME administration. The aged cohort exhibited a markedly earlier onset, heightened incidence, and exacerbated neurological consequences of CMHs compared to their younger counterparts. This was evidenced through neurological examinations, gait analysis, and histological assessments of CMHs in brain sections. Notably, the senolytic pre-treatment wielded considerable cerebromicrovascular protection, effectively delaying the onset, mitigating the incidence, and diminishing the severity of CMHs. These findings hint at the potential of senolytic interventions as a viable therapeutic avenue to preempt or alleviate the consequences of CMHs linked to aging, by counteracting the deleterious effects of senescence on brain microvasculature. LA - English DB - MTMT ER -