@article{MTMT:34804161,
	title = {Atherosclerotic burden and cerebral small vessel disease : exploring the link through microvascular aging and cerebral microhemorrhages},
	url = {https://m2.mtmt.hu/api/publication/34804161},
	author = {Csiszar, Anna and Ungvari, Anna and Patai, Roland and Gulej, Rafal and Yabluchanskiy, Andriy and Benyo, Zoltan and Kovacs, Illes and Sotonyi, Peter and Kirkpartrick, Angelia C and Prodan, Calin I and Liotta, Eric M and Zhang, Xin A and Tóth, Péter József and Tarantini, Stefano and Sorond, Farzaneh A and Ungvari, Zoltan},
	doi = {10.1007/s11357-024-01139-7},
	journal-iso = {GEROSCIENCE},
	journal = {GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)},
	unique-id = {34804161},
	issn = {2509-2715},
	abstract = {Cerebral microhemorrhages (CMHs, also known as cerebral microbleeds) are a critical but frequently underestimated aspect of cerebral small vessel disease (CSVD), bearing substantial clinical consequences. Detectable through sensitive neuroimaging techniques, CMHs reveal an extensive pathological landscape. They are prevalent in the aging population, with multiple CMHs often being observed in a given individual. CMHs are closely associated with accelerated cognitive decline and are increasingly recognized as key contributors to the pathogenesis of vascular cognitive impairment and dementia (VCID) and Alzheimer's disease (AD). This review paper delves into the hypothesis that atherosclerosis, a prevalent age-related large vessel disease, extends its pathological influence into the cerebral microcirculation, thereby contributing to the development and progression of CSVD, with a specific focus on CMHs. We explore the concept of vascular aging as a continuum, bridging macrovascular pathologies like atherosclerosis with microvascular abnormalities characteristic of CSVD. We posit that the same risk factors precipitating accelerated aging in large vessels (i.e., atherogenesis), primarily through oxidative stress and inflammatory pathways, similarly instigate accelerated microvascular aging. Accelerated microvascular aging leads to increased microvascular fragility, which in turn predisposes to the formation of CMHs. The presence of hypertension and amyloid pathology further intensifies this process. We comprehensively overview the current body of evidence supporting this interconnected vascular hypothesis. Our review includes an examination of epidemiological data, which provides insights into the prevalence and impact of CMHs in the context of atherosclerosis and CSVD. Furthermore, we explore the shared mechanisms between large vessel aging, atherogenesis, microvascular aging, and CSVD, particularly focusing on how these intertwined processes contribute to the genesis of CMHs. By highlighting the role of vascular aging in the pathophysiology of CMHs, this review seeks to enhance the understanding of CSVD and its links to systemic vascular disorders. Our aim is to provide insights that could inform future therapeutic approaches and research directions in the realm of neurovascular health.},
	keywords = {ATHEROSCLEROSIS; Aging; Blood-Brain Barrier; Arteriosclerosis; stroke; Leukoaraiosis; Peripheral artery disease; VASCULAR DEMENTIA; Microbleed; White matter hyperintensities; white matter injury},
	year = {2024},
	eissn = {2509-2723}
}

@misc{MTMT:34794821,
	title = {Neural correlates of valence and arousal ratings responding to socio-emotional stimuli.},
	url = {https://m2.mtmt.hu/api/publication/34794821},
	author = {Rendes, Réka and Orsi, Gergely and Perlaki, Gábor and Bereczkei, Tamás and Deák, Anita},
	unique-id = {34794821},
	year = {2024},
	orcid-numbers = {Bereczkei, Tamás/0000-0002-4665-3475; Deák, Anita/0000-0001-6862-4993}
}

@{MTMT:34774903,
	title = {Additive manufacturing in limb prosthetics and orthotics: the past, present and future of 3D printing orthopedic assistive devices},
	url = {https://m2.mtmt.hu/api/publication/34774903},
	author = {Maróti, Péter and Schlégl, Ádám Tibor and Nagy, Bálint and Tóth, Luca and Bogár, Péter Zoltán and Józsa, Gergő and Rendeki, Szilárd and Mallakpour, Shadpour and Hussain, Chaudhery Mustansar},
	booktitle = {Medical Additive Manufacturing},
	doi = {10.1016/B978-0-323-95383-2.00028-7},
	unique-id = {34774903},
	year = {2024},
	pages = {179-207},
	orcid-numbers = {Maróti, Péter/0000-0001-7538-0675}
}

@article{MTMT:34521154,
	title = {Early management of adult traumatic spinal cord injury in patients with polytrauma: a consensus and clinical recommendations jointly developed by the World Society of Emergency Surgery (WSES) & the European Association of Neurosurgical Societies (EANS)},
	url = {https://m2.mtmt.hu/api/publication/34521154},
	author = {Picetti, Edoardo and Demetriades, Andreas K. and Catena, Fausto and Aarabi, Bizhan and Abu-Zidan, Fikri M. and Alves, Oscar L. and Ansaloni, Luca and Armonda, Rocco A. and Badenes, Rafael and Bala, Miklosh and Balogh, Zsolt J. and Barbanera, Andrea and Bertuccio, Alessandro and Biffl, Walter L. and Bouzat, Pierre and Buki, Andras and Castano-Leon, Ana Maria and Cerasti, Davide and Citerio, Giuseppe and Coccolini, Federico and Coimbra, Raul and Coniglio, Carlo and Costa, Francesco and De Iure, Federico and Depreitere, Bart and Fainardi, Enrico and Fehlings, Michael J. and Gabrovsky, Nikolay and Godoy, Daniel Agustin and Gruen, Peter and Gupta, Deepak and Hawryluk, Gregory W. J. and Helbok, Raimund and Hossain, Iftakher and Hutchinson, Peter J. and Iaccarino, Corrado and Inaba, Kenji and Ivanov, Marcel and Kaprovoy, Stanislav and Kirkpatrick, Andrew W. and Klein, Sam and Kolias, Angelos and Konovalov, Nikolay A. and Lagares, Alfonso and Lippa, Laura and Loza-Gomez, Angelica and Luoto, Teemu M. and Maas, Andrew I. R. and Maciejczak, Andrzej and Maier, Ronald V. and Marklund, Niklas and Martin, Matthew J. and Melloni, Ilaria and Mendoza-Lattes, Sergio and Meyfroidt, Geert and Munari, Marina and Napolitano, Lena M. and Okonkwo, David O. and Otomo, Yasuhiro and Papadopoulos, Marios C. and Petr, Ondra and Peul, Wilco C. and Pudkrong, Aichholz K. and Qasim, Zaffer and Rasulo, Frank and Reizinho, Carla and Ringel, Florian and Rizoli, Sandro and Rostami, Elham and Rubiano, Andres M. and Russo, Emanuele and Sarwal, Aarti and Schwab, Jan M. and Servadei, Franco and Sharma, Deepak and Sharif, Salman and Shiban, Ehab and Shutter, Lori and Stahel, Philip F. and Taccone, Fabio S. and Terpolilli, Nicole A. and Thomé, Claudius and Tóth, Péter József and Tsitsopoulos, Parmenion P. and Udy, Andrew and Vaccaro, Alexander R. and Varon, Albert J. and Vavilala, Monica S. and Younsi, Alexander and Zackova, Monika and Zoerle, Tommaso and Robba, Chiara},
	doi = {10.1186/s13017-023-00525-4},
	journal-iso = {WJES},
	journal = {WORLD JOURNAL OF EMERGENCY SURGERY},
	volume = {19},
	unique-id = {34521154},
	issn = {1749-7922},
	abstract = {Background: The early management of polytrauma patients with traumatic spinal cord injury (tSCI) is a major challenge. Sparse data is available to provide optimal care in this scenario and worldwide variability in clinical practice has been documented in recent studies. Methods: A multidisciplinary consensus panel of physicians selected for their established clinical and scientific expertise in the acute management of tSCI polytrauma patients with different specializations was established. The World Society of Emergency Surgery (WSES) and the European Association of Neurosurgical Societies (EANS) endorsed the consensus, and a modified Delphi approach was adopted. Results: A total of 17 statements were proposed and discussed. A consensus was reached generating 17 recommendations (16 strong and 1 weak). Conclusions: This consensus provides practical recommendations to support a clinician’s decision making in the management of tSCI polytrauma patients. © 2024, The Author(s).},
	keywords = {Adult; Humans; human; MANAGEMENT; Consensus; Complication},
	year = {2024},
	eissn = {1749-7922}
}

@article{MTMT:34493390,
	title = {Gravity sedimentation reveals functionally and morphologically different platelets in human blood},
	url = {https://m2.mtmt.hu/api/publication/34493390},
	author = {Ezer, Erzsébet and Schrick, Diana Zsuzsanna and Tőkés-Füzesi, Margit and Papp, István and Réger, Barbara and Molnár, Abigél and Ábrahám, Hajnalka and Koller, Ákos and Hársfalvi, Jolán and Kellermayer, Miklós and Molnár, Tihamér},
	doi = {10.1080/09537104.2023.2298341},
	journal-iso = {PLATELETS},
	journal = {PLATELETS},
	volume = {35},
	unique-id = {34493390},
	issn = {0953-7104},
	year = {2024},
	eissn = {1369-1635},
	orcid-numbers = {Koller, Ákos/0000-0003-3256-8701; Hársfalvi, Jolán/0000-0001-9940-4846; Kellermayer, Miklós/0000-0002-5553-6553}
}

@article{MTMT:34477406,
	title = {Volumetric alteration of brainstem in female migraineurs with and without aura},
	url = {https://m2.mtmt.hu/api/publication/34477406},
	author = {He, Mingchen and Kis-Jakab, Gréta and Komáromy, Hedvig and Perlaki, Gábor and Orsi, Gergely and Bosnyák, Edit and Rozgonyi, Renáta and John, Flóra and Trauninger, Anita and Eklicsné Lepenye, Katalin and Pfund, Zoltán},
	doi = {10.1016/j.clineuro.2023.108089},
	journal-iso = {CLIN NEUROL NEUROSUR},
	journal = {CLINICAL NEUROLOGY AND NEUROSURGERY},
	volume = {236},
	unique-id = {34477406},
	issn = {0303-8467},
	abstract = {Brainstem descending modulatory circuits have been postulated to be involved in migraine. Differences in brainstem volume between migraineurs and healthy controls have been demonstrated in previous research, nevertheless, the effect of migraine aura on brainstem volume is still uncertain. The aim of this study was to investigate the brainstem volume in migraineurs and examine the effect of migraine aura on brainstem volume.Our study included 90 female migraine patients without white matter lesions. (29 migraine patients with aura (MwA) and 61 migraine patients without aura (MwoA) and 32 age-matched female healthy controls (HC). Using the FreeSurfer image analysis suite, the volumes of the entire brainstem and its subfields (medulla, pons, and midbrain) were measured and compared between migraine subgroups (MwA vs. MwoA) and the healthy control group. The possible effects of migraine characteristics (i.e., disease duration and migraine attack frequency) on brainstem volume were also investigated.Migraineurs had greater medulla volume (MwoA 3552 ± 459 mm3, MwA 3424 ± 448 mm3) than healthy controls (3236 ± 411 mm3). Statistically, MwA vs. HC p = 0.040, MwoA vs. HC p = 0.002, MwA vs. MwoA p = 0.555. A significant positive correlation was found between disease duration and the volume of medulla in the whole migraine group (r = 0.334, p = 0.001). Neither the whole brainstem nor its subfields were significantly different in volume between migraine subgroups.Brainstem volume changes in migraine are mainly localized to the medulla and not specific to the presence of aura.},
	keywords = {morphometry; Magnetic Resonance Imaging; AURA; EPISODIC MIGRAINE; Brainstem volume},
	year = {2024},
	eissn = {1872-6968}
}

@article{MTMT:34477401,
	title = {Impaired Neurovascular Coupling and Increased Functional Connectivity in the Frontal Cortex Predict Age-Related Cognitive Dysfunction},
	url = {https://m2.mtmt.hu/api/publication/34477401},
	author = {Mukli, Péter and Pinto, Camila B and Owens, Cameron D and Csípő, Tamás and Lipécz, Ágnes and Szarvas, Zsófia and Péterfi, Anna and Langley, Ana Clara da Costa Pinaffi and Hoffmeister, Jordan and Rácz, Frigyes Sámuel and Perry, Jonathan W and Tarantini, Stefano and Nyúl-Tóth, Ádám and Sorond, Farzaneh A and Yang, Yuan and James, Judith A and Kirkpatrick, Angelia C and Prodan, Calin I and Tóth, Péter József and Galindo, Juliette and Gardner, Andrew W and Sonntag, William E and Csiszar, Anna and Ungvári, Zoltán István and Yabluchanskiy, Andriy},
	doi = {10.1002/advs.202303516},
	journal-iso = {ADV SCI},
	journal = {ADVANCED SCIENCE},
	volume = {11},
	unique-id = {34477401},
	abstract = {Impaired cerebrovascular function contributes to the genesis of age-related cognitive decline. In this study, the hypothesis is tested that impairments in neurovascular coupling (NVC) responses and brain network function predict cognitive dysfunction in older adults. Cerebromicrovascular and working memory function of healthy young (n = 21, 33.2±7.0 years) and aged (n = 30, 75.9±6.9 years) participants are assessed. To determine NVC responses and functional connectivity (FC) during a working memory (n-back) paradigm, oxy- and deoxyhemoglobin concentration changes from the frontal cortex using functional near-infrared spectroscopy are recorded. NVC responses are significantly impaired during the 2-back task in aged participants, while the frontal networks are characterized by higher local and global connection strength, and dynamic FC (p < 0.05). Both impaired NVC and increased FC correlate with age-related decline in accuracy during the 2-back task. These findings suggest that task-related brain states in older adults require stronger functional connections to compensate for the attenuated NVC responses associated with working memory load.},
	keywords = {Aging; cognitive decline; functional connectivity; Neurovascular coupling; functional near-infrared spectroscopy},
	year = {2024},
	eissn = {2198-3844},
	orcid-numbers = {Mukli, Péter/0000-0003-4355-8103; Szarvas, Zsófia/0000-0002-0022-5053; Rácz, Frigyes Sámuel/0000-0001-9077-498X; Tarantini, Stefano/0000-0001-5627-1430; Ungvári, Zoltán István/0000-0002-6035-6039}
}

@article{MTMT:34477399,
	title = {Screening Performance of S100B, GFAP and UCH-L1 For Intracranial Injury Within 6 hours of Injury and beyond},
	url = {https://m2.mtmt.hu/api/publication/34477399},
	author = {Trivedi, Dhanisha Trivedi and Forssten, Maximilian Peter and Cao, Yang and Mohammad Ismail, Ahmad and Czeiter, Endre and Amrein, Krisztina and Kobeissy, Firas and Wang, Kevin K W and DeSoucy, Erik and Büki, András and Mohseni, Shahin},
	doi = {10.1089/neu.2023.0322},
	journal-iso = {J NEUROTRAUM},
	journal = {JOURNAL OF NEUROTRAUMA},
	volume = {41},
	unique-id = {34477399},
	issn = {0897-7151},
	abstract = {The Scandinavian NeuroTrauma Committee (SNC) guidelines recommend S100B as a screening tool for early detection of Traumatic brain injury (TBI) in patients presenting with an initial Glasgow coma scale (GCS) of 14-15. The objective of the current study was to compare S100B's diagnostic performance within the recommended 6-hour window after injury, compared to GFAP and UCH-L1. The secondary outcome of interest was the ability of these biomarkers in detecting traumatic intracranial pathology beyond the 6-hour mark.The Center-TBI core database (2014-2017) was queried for data pertaining to all TBI patients with an initial GCS of 14-15 who had a blood sample taken within 6 hours of injury in which the levels of S100B, GFAP, and UCH-L1 were measured. As a subgroup analysis, data involving patients with blood samples taken within 6-9 hours, and 9-12 hours were analyzed separately for diagnostic ability. The diagnostic ability of these biomarkers for detecting any intracranial injury was evaluated based on the area under the receiver operating characteristic curve (AUC). Each biomarker's sensitivity, specificity, and accuracy were also reported at the cutoff that maximized Youden's index.A total of 531 TBI patients with GCS 14-15 on admission had a blood sample taken within 6 hours, of whom 24.9% (N = 132) had radiologically confirmed intracranial injury. The AUCs of GFAP (0.86, 95% confidence interval (CI): 0.82-0.90) and UCH-L1 (0.81, 95% CI: 0.76-0.85) were statistically significantly higher than that of S100B (0.74, 95% CI: 0.69-0.79) during this time. There was no statistically significant difference in the predictive ability of S100B when sampled within 6 hours, 6-9 hours, and 9-12 hours of injury, as the p-values were >0.05 when comparing the AUCs. Overlapping AUC 95% CI suggests no benefit of a combined GFAP and UCH-L1 screening tool over GFAP during the time periods studied [ 0.87 (0.83-0.90) vs 0.86 (0.82-0.90) when sampled within 6 hours of injury, 0.83 (0.78-0.88) vs 0.83 (0.78-0.89) within 6-to-9 hours and 0.81 (0.73-0.88) vs 0.79 (0.72-0.87) within 9-12 hours].Targeted analysis of the CENTER-TBI core database, with focus on the patient category for which biomarker testing is recommended by the SNC guidelines, revealed that GFAP and UCH-L1 perform superior to S100B in predicting CT-positive intracranial lesions within 6 hours of injury. GFAP continued to exhibit superior predictive ability to S100B during the time periods studied. S100B displayed relatively unaltered screening performance beyond the diagnostic timeline provided by SNC guidelines. These findings suggest the need for a re-evaluation of the current SNC TBI guidelines.},
	keywords = {Biomarkers; traumatic brain injury; Head trauma; adult brain injury},
	year = {2024},
	eissn = {1557-9042},
	pages = {349-358},
	orcid-numbers = {Czeiter, Endre/0000-0002-9578-6944}
}

@article{MTMT:34474356,
	title = {Blood biomarkers for traumatic brain injury: A narrative review of current evidence},
	url = {https://m2.mtmt.hu/api/publication/34474356},
	author = {Hossain, I. and Marklund, N. and Czeiter, Endre and Hutchinson, P. and Büki, András},
	doi = {10.1016/j.bas.2023.102735},
	journal-iso = {BRAIN SPINE},
	journal = {BRAIN AND SPINE},
	volume = {4},
	unique-id = {34474356},
	issn = {2772-5294},
	year = {2024},
	orcid-numbers = {Czeiter, Endre/0000-0002-9578-6944}
}

@article{MTMT:34420912,
	title = {Altered functional brain networks in problematic smartphone and social media use: resting-state fMRI study},
	url = {https://m2.mtmt.hu/api/publication/34420912},
	author = {Áfra, Eszter and Janszky, József Vladimír and Perlaki, Gábor and Orsi, Gergely and Nagy, Szilvia Anett and Arató, Ákos and Szente, Anna Tímea and Alhour, Husamalddin Ali Mohammad and Kis-Jakab, Gréta and Darnai, Gergely},
	doi = {10.1007/s11682-023-00825-y},
	journal-iso = {BRAIN IMAGING BEHAV},
	journal = {BRAIN IMAGING AND BEHAVIOR},
	unique-id = {34420912},
	issn = {1931-7557},
	abstract = {Nowadays, the limitless availability to the World Wide Web can lead to general Internet misuse and dependence. Currently, smartphone and social media use belong to the most prevalent Internet-related behavioral addiction forms. However, the neurobiological background of these Internet-related behavioral addictions is not sufficiently explored. In this study, these addiction forms were assessed with self-reported questionnaires. Resting-state functional magnetic resonance imaging was acquired for all participants ( n  = 59, 29 males) to examine functional brain networks. The resting-state networks that were discovered using independent component analysis were analyzed to estimate within network differences. Significant negative associations with social media addiction and smartphone addiction were found in the language network, the lateral visual networks, the auditory network, the sensorimotor network, the executive network and the frontoparietal network. These results suggest that problematic smartphone and social media use are associated with sensory processing and higher cognitive functioning .},
	year = {2024},
	eissn = {1931-7565},
	orcid-numbers = {Janszky, József Vladimír/0000-0001-6100-832X; Nagy, Szilvia Anett/0000-0001-6483-9209; Alhour, Husamalddin Ali Mohammad/0000-0001-5841-1652}
}