@article{MTMT:34760823, title = {Editorial: Endocrine regulation of aging: impacts of humoral factors and circulating mediators}, url = {https://m2.mtmt.hu/api/publication/34760823}, author = {Petersen, B. and Negri, S. and Milan, M. and Reyff, Z. and Ballard, C. and Ihuoma, J. and Ungvári, Zoltán István and Tarantini, Stefano}, doi = {10.3389/fendo.2024.1387435}, journal-iso = {FRONT ENDOCRINOL}, journal = {FRONTIERS IN ENDOCRINOLOGY}, volume = {15}, unique-id = {34760823}, issn = {1664-2392}, year = {2024}, eissn = {1664-2392}, orcid-numbers = {Ungvári, Zoltán István/0000-0002-6035-6039; Tarantini, Stefano/0000-0001-5627-1430} } @article{MTMT:34760801, title = {Editorial: Effects of vascular function and aging on brain circulation and neurodegeneration}, url = {https://m2.mtmt.hu/api/publication/34760801}, author = {Petersen, B. and Negri, S. and Milan, M. and Shi, H. and Reyff, Z. and Ballard, C. and Ihuoma, J. and Di, Francesco A. and Tarantini, Stefano}, doi = {10.3389/fragi.2024.1385066}, journal-iso = {FRONT AGING}, journal = {FRONTIERS IN AGING}, volume = {5}, unique-id = {34760801}, year = {2024}, eissn = {2673-6217}, orcid-numbers = {Tarantini, Stefano/0000-0001-5627-1430} } @{MTMT:34760618, title = {Relationship between diet and cardiovascular health. a review}, url = {https://m2.mtmt.hu/api/publication/34760618}, author = {Fekete, Mónika and Lehoczki, Andrea Marianna and Alliquander, Anna and Varga, János Tamás}, booktitle = {Cukorova 12th International Scientific Researches Conference}, unique-id = {34760618}, year = {2024}, pages = {184-184}, orcid-numbers = {Fekete, Mónika/0000-0001-8632-2120; Alliquander, Anna/0000-0001-5731-8739; Varga, János Tamás/0000-0002-8552-1336} } @article{MTMT:34741829, title = {Expert Opinion on Current Trends in the Use of Insulin in the Management of People with Type 2 Diabetes from the South-Eastern European Region and Israel.}, url = {https://m2.mtmt.hu/api/publication/34741829}, author = {Tabák, Ádám and Kempler, Péter and Guja, Cristian and Eldor, Roy and Haluzik, Martin and Klupa, Tomasz and Papanas, Nikolaos and Stoian, Anca Pantea and Mankovsky, Boris}, doi = {10.1007/s13300-024-01556-z}, journal-iso = {DIABTHERAP}, journal = {DIABETES THERAPY}, volume = {In press}, unique-id = {34741829}, issn = {1869-6953}, abstract = {Despite the availability of various antihyperglycaemic therapies and comprehensive guidelines, glycaemic control in diabetes management has not improved significantly during the last decade in the real-world clinical setting. Treatment inertia arising from a complex interplay among patient-, clinician- and healthcare-system-related factors is the prime reason for this suboptimal glycaemic control. Also, the key factor leading to inadequate glycaemic levels remains limited communication between healthcare professionals (HCPs) and people with type 2 diabetes (PwT2D). Early insulin administration has several advantages including reduced glucotoxicity, high efficacy and preserved β-cell mass/function, leading to lowering the risk of diabetes complications. The current publication is based on consensus of experts from the South-Eastern European region and Israel who reviewed the existing evidence and guidelines for the treatment of PwT2D. Herein, the experts emphasised the timely use of insulin, preferably second-generation basal insulin (BI) analogues and intensification using basal-plus therapy, as the most-potent glucose-lowering treatment choice in the real-world clinical setting. Despite an increase in the use of glucagon-like peptide-1 receptor agonists (GLP-1 RAs), the experts urged timely insulin initiation for inadequate glycaemic control in PwT2D. Furthermore, the combination of BI and GLP-1 RA addressing both fasting plasma glucose and post-prandial excursions as a free- or fixed-ratio combination was identified to reduce treatment complexity and burden. To minimise discontinuation and improve adherence, the experts reiterated quality, regular interactions and discussions between HCPs and PwT2D/carers for their involvement in the diabetes management decision-making process. Clinicians and HCPs should consider the opinions of the experts in accordance with the most recent recommendations for diabetes management.}, keywords = {ISRAEL; clinical practice; Titration; Type 2 diabetes; INTENSIFICATION; Insulin initiation; South-Eastern European region}, year = {2024}, eissn = {1869-6961}, pages = {In press}, orcid-numbers = {Tabák, Ádám/0000-0002-6234-3936; Kempler, Péter/0000-0002-6072-8832} } @inproceedings{MTMT:34738079, title = {The role of diet in preventing and managing chronic diseases. Food as medicine}, url = {https://m2.mtmt.hu/api/publication/34738079}, author = {Fekete, Mónika and Pártos, Katalin and Lehoczki, Andrea Marianna and Varga, János Tamás}, booktitle = {III. International Cankaya Scientific Studies Congress}, unique-id = {34738079}, year = {2024}, pages = {685-694}, orcid-numbers = {Fekete, Mónika/0000-0001-8632-2120; Varga, János Tamás/0000-0002-8552-1336} } @article{MTMT:34735108, title = {A szív- és érrendszeri egészség gondozása. Az étrend hatásainak vizsgálata}, url = {https://m2.mtmt.hu/api/publication/34735108}, author = {Fekete, Mónika and Lehoczki, Andrea Marianna and Fehér, Ágnes and Varga, János Tamás}, journal-iso = {ÚJ DIÉTA (GYŐR) (2001)}, journal = {ÚJ DIÉTA: A MAGYAR DIETETIKUSOK LAPJA (2001-)}, volume = {32}, unique-id = {34735108}, issn = {1587-169X}, year = {2024}, pages = {38-44}, orcid-numbers = {Fekete, Mónika/0000-0001-8632-2120; Varga, János Tamás/0000-0002-8552-1336} } @article{MTMT:34735092, title = {Krónikus obstruktív tüdőbetegség és fizikai aktivitás. a légzőrendszeri egészség megőrzésének kulcsa}, url = {https://m2.mtmt.hu/api/publication/34735092}, author = {Varga, János Tamás and Fekete, Mónika}, journal-iso = {ORVOSTOVÁBBKÉPZŐ SZLE}, journal = {ORVOSTOVÁBBKÉPZŐ SZEMLE}, volume = {31}, unique-id = {34735092}, issn = {1218-2583}, year = {2024}, pages = {69-73}, orcid-numbers = {Varga, János Tamás/0000-0002-8552-1336; Fekete, Mónika/0000-0001-8632-2120} } @article{MTMT:34730261, title = {Exploring the Influence of Gut–Brain Axis Modulation on Cognitive Health: A Comprehensive Review of Prebiotics, Probiotics, and Symbiotics}, url = {https://m2.mtmt.hu/api/publication/34730261}, author = {Fekete, Mónika and Lehoczki, Andrea Marianna and Major, Dávid and Fazekas-Pongor, Vince and Csípő, Tamás and Tarantini, Stefano and Csizmadia, Zoltán and Varga, János Tamás}, doi = {10.3390/nu16060789}, journal-iso = {NUTRIENTS}, journal = {NUTRIENTS}, volume = {16}, unique-id = {34730261}, abstract = {Recent research exploring the relationship between the gut and the brain suggests that the condition of the gut microbiota can influence cognitive health. A well-balanced gut microbiota may help reduce inflammation, which is linked to neurodegenerative conditions. Prebiotics, probiotics, and symbiotics are nutritional supplements and functional food components associated with gastrointestinal well-being. The bidirectional communication of the gut–brain axis is essential for maintaining homeostasis, with pre-, pro-, and symbiotics potentially affecting various cognitive functions such as attention, perception, and memory. Numerous studies have consistently shown that incorporating pre-, pro-, and symbiotics into a healthy diet can lead to improvements in cognitive functions and mood. Maintaining a healthy gut microbiota can support optimal cognitive function, which is crucial for disease prevention in our fast-paced, Westernized society. Our results indicate cognitive benefits in healthy older individuals with probiotic supplementation but not in healthy older individuals who have good and adequate levels of physical activity. Additionally, it appears that there are cognitive benefits in patients with mild cognitive impairment and Alzheimer’s disease, while mixed results seem to arise in younger and healthier individuals. However, it is important to acknowledge that individual responses may vary, and the use of these dietary supplements should be tailored to each individual’s unique health circumstances and needs.}, year = {2024}, eissn = {2072-6643}, orcid-numbers = {Fekete, Mónika/0000-0001-8632-2120; Major, Dávid/0000-0002-6108-9745; Fazekas-Pongor, Vince/0000-0002-6405-4003; Tarantini, Stefano/0000-0001-5627-1430; Varga, János Tamás/0000-0002-8552-1336} } @article{MTMT:34724864, title = {Vascular smooth muscle cell-specific Igf1r deficiency exacerbates the development of hypertension-induced cerebral microhemorrhages and gait defects}, url = {https://m2.mtmt.hu/api/publication/34724864}, author = {Miller, L.R. and Bickel, M.A. and Vance, M.L. and Vaden, H. and Nagykaldi, D. and Nyúl-Tóth, Ádám and Bullen, E.C. and Gautam, T. and Tarantini, Stefano and Yabluchanskiy, A. and Kiss, Tamás and Ungvári, Zoltán István and Conley, S.M.}, doi = {10.1007/s11357-024-01090-7}, journal-iso = {GEROSCIENCE}, journal = {GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)}, unique-id = {34724864}, issn = {2509-2715}, year = {2024}, eissn = {2509-2723}, orcid-numbers = {Tarantini, Stefano/0000-0001-5627-1430; Kiss, Tamás/0000-0001-5339-5227; Ungvári, Zoltán István/0000-0002-6035-6039} } @article{MTMT:34684374, title = {Geroscience and pathology: a new frontier in understanding age-related diseases}, url = {https://m2.mtmt.hu/api/publication/34684374}, author = {Fekete, Mónika and Major, Dávid and Fehér, Ágnes and Fazekas-Pongor, Vince and Lehoczki, Andrea Marianna}, doi = {10.3389/pore.2024.1611623}, journal-iso = {PATHOL ONCOL RES}, journal = {PATHOLOGY AND ONCOLOGY RESEARCH}, volume = {30}, unique-id = {34684374}, issn = {1219-4956}, abstract = {Geroscience, a burgeoning discipline at the intersection of aging and disease, aims to unravel the intricate relationship between the aging process and pathogenesis of age-related diseases. This paper explores the pivotal role played by geroscience in reshaping our understanding of pathology, with a particular focus on age-related diseases. These diseases, spanning cardiovascular and cerebrovascular disorders, malignancies, and neurodegenerative conditions, significantly contribute to the morbidity and mortality of older individuals. We delve into the fundamental cellular and molecular mechanisms underpinning aging, including mitochondrial dysfunction and cellular senescence, and elucidate their profound implications for the pathogenesis of various age-related diseases. Emphasis is placed on the importance of assessing key biomarkers of aging and biological age within the realm of pathology. We also scrutinize the interplay between cellular senescence and cancer biology as a central area of focus, underscoring its paramount significance in contemporary pathological research. Moreover, we shed light on the integration of anti-aging interventions that target fundamental aging processes, such as senolytics, mitochondria-targeted treatments, and interventions that influence epigenetic regulation within the domain of pathology research. In conclusion, the integration of geroscience concepts into pathological research heralds a transformative paradigm shift in our understanding of disease pathogenesis and promises breakthroughs in disease prevention and treatment.}, year = {2024}, eissn = {1532-2807}, orcid-numbers = {Fekete, Mónika/0000-0001-8632-2120; Major, Dávid/0000-0002-6108-9745; Fazekas-Pongor, Vince/0000-0002-6405-4003} }