TY - JOUR AU - Bányai, Bálint Péter AU - Répás, C. AU - Miklós, Zsuzsanna AU - Johnsen, J. AU - Horvath, Eszter Mária AU - Benkő, Rita TI - Delta 9-tetrahydrocannabinol conserves cardiovascular functions in a rat model of endotoxemia: Involvement of endothelial molecular mechanisms and oxidativenitrative stress JF - PLOS ONE J2 - PLOS ONE VL - 18 PY - 2023 IS - 6 PG - 16 SN - 1932-6203 DO - 10.1371/journal.pone.0287168 UR - https://m2.mtmt.hu/api/publication/34066780 ID - 34066780 N1 - Export Date: 04 December 2025; Cited By: 3; Correspondence Address: E.M. Horváth; Department of Physiology, Semmelweis University, Budapest, Hungary; email: horvath.eszter@med.semmelweis-univ.hu; CODEN: POLNC LA - English DB - MTMT ER - TY - CHAP AU - Szász, Attila Marcell AU - Árkosy, Péter AU - Arrojo, EE AU - Bakacs, T AU - Balogh, A AU - Barich, J AU - Borbényi, Erika AU - Chi, KH AU - Csoszi, T AU - Daniilidis, L AU - Douwes, F AU - Eller, YG AU - Fiorentini, G AU - Forika, Gertrud AU - Herzog, A AU - Kleef, R AU - Krenács, Tibor AU - Lee, SY AU - Minnaar, CA AU - Ou, J AU - Pang, CLK AU - Papastravrou, A AU - Parmar, G AU - Szentmártoni, Gyöngyvér AU - Szigeti, Gyula Péter AU - Van, Gool S AU - Wust, P AU - Dank, Magdolna ED - Szász, András TI - Guidelines for Local Hyperthermia Treatment in Oncology T2 - Challenges and Solutions of Oncological Hyperthermia PB - Cambridge Scholars Publishing CY - Newcastle upon Tyne SN - 1527548171 PY - 2020 SP - 32 EP - 71 PG - 30 UR - https://m2.mtmt.hu/api/publication/31359099 ID - 31359099 LA - English DB - MTMT ER - TY - JOUR AU - Jósvai, Attila AU - Török, Marianna AU - Mátrai, Máté AU - Hetthéssy, Judit AU - Monori-Kiss, Anna AU - Makk, Jennifer AU - Székács, Béla AU - Nádasy, György László AU - Várbíró, Szabolcs TI - Effects of Testosterone Deficiency and Angiotensin II-Induced Hypertension on the Biomechanics of Intramural Coronary Arteries JF - JOURNAL OF SEXUAL MEDICINE J2 - J SEX MED VL - 17 PY - 2020 IS - 12 SP - 2322 EP - 2330 PG - 9 SN - 1743-6095 DO - 10.1016/j.jsxm.2020.09.003 UR - https://m2.mtmt.hu/api/publication/31637466 ID - 31637466 N1 - These authors contributed equally to this work: Béla Székács, György L. Nádasy, and Szabolcs Várbíró Ellenőrizve teljes szöveg alapján GT AB - Andropause and hypertension also increase the risk of coronary artery damage.To investigate the effect of testosterone deficiency and hypertension on intramural coronary vessels.4 groups of 8-week-old Sprague-Dawley rats were studied: control male (Co, n=10), orchidectomized male (OCT, n=13), angiotensin (AII) hypertensive male (AII, n=10), and AII hypertensive and OCT (AII + OCT, n=8). Surgical orchidectomy was performed, and an osmotic minipump was inserted for chronic angiotensin II infusion (100 ng/min/kg). After 4 weeks, spontaneous tone and biomechanical properties of the intramural coronary resistance artery were investigated in vitro, by pressure microarteriography.Morphology and biomechanics of the intramural coronaries were evaluated: the outer diameter, wall thickness-to-lumen diameter ratio, and tangential wall stress in the contracted and relaxed states.The outer diameter was reduced in OCT and AII + OCT groups (on 50 mmHg 315 ± 20 Co; 237 ± 21 OCT; 291 ± 16 AII, and 166 ± 12 μm AII + OCT). The increased wall thickness-to-lumen diameter ratio resulted in lower tangential wall stress in AII + OCT rats (on 50 mmHg 19 ± 2 Co; 24 ± OCT; 26 ± 5 AII, and 9 ± 1 kPa AII + OCT). Spontaneous tone was increased in the hypertensive rats (AII and AII + OCT groups) (on 50 mmHg 7.7 ± 1.8 Co; 6.1 ± 1.4 OCT; 14.5 ± 3.0 AII, and 17.4 ± 4.1 % AII + OCT).Andropause alone can be considered as a cardiovascular risk factor that will further exacerbate vascular damage in hypertension.A limitation of our study is that it was performed on relatively young rats, and the conclusions might not apply to coronary remodelling in older animals with slower adaptation processes.Testosterone deficiency and hypertension damage the mechanical adaptation of the vessel wall additively: double noxa caused inward eutrophic remodeling and increased tone. Jósvai A, Török M, Mátrai M, et al. Effects of Testosterone Deficiency and Angiotensin II-Induced Hypertension on the Biomechanics of Intramural Coronary Arteries. J Sex Med 2020;XX:XXX-XXX. LA - English DB - MTMT ER - TY - JOUR AU - Szász, Olivér AU - Szigeti, Gyula Péter AU - Vancsik, Tamás AU - Szász, András TI - Hyperthermia dosing and depth of effect JF - OPEN JOURNAL OF BIOPHYSICS J2 - OPEN J BIOPHYS VL - 8 PY - 2018 IS - 1 SP - 31 EP - 48 PG - 18 SN - 2164-5396 DO - 10.4236/ojbiphy.2018.81004 UR - https://m2.mtmt.hu/api/publication/3328964 ID - 3328964 LA - English DB - MTMT ER - TY - JOUR AU - Németh, Tamás AU - Ruisanchez, Éva AU - Hricisák, László AU - Fülöp, Ágnes AU - Iring, András AU - Káldi, Krisztina AU - Várnai, Péter AU - Smrcka, Alan V AU - Merkely, Béla Péter AU - Offermanns, Stefan AU - Benyó, Zoltán TI - Foszfolipáz C epszilon szerepe a nitrogén-monoxid hiányhoz kapcsolódó hipertóniában [The role of phospholipase C epsilon in nitric oxide deficiency associated hypertension] JF - CARDIOLOGIA HUNGARICA J2 - CARDIOL HUNG VL - 48 PY - 2018 IS - Suppl. C SP - C35 EP - C36 PG - 2 SN - 0133-5596 UR - https://m2.mtmt.hu/api/publication/3380109 ID - 3380109 LA - English DB - MTMT ER - TY - JOUR AU - Szigeti, Gyula Péter AU - Szasz, O AU - Hegyi, Gabriella TI - Connections between Warburg's and Szentgyorgyi's Approach about the Causes of Cancer JF - JOURNAL OF NEOPLASM J2 - JOURNAL OF NEOPLASM VL - 1 PY - 2017 IS - 2 PG - 13 SN - 2576-3903 UR - https://m2.mtmt.hu/api/publication/3200408 ID - 3200408 LA - English DB - MTMT ER - TY - JOUR AU - Szasz, Oliver AU - Szigeti, Gyula Péter AU - Szász, Attila Marcell TI - Electrokinetics of Temperature for Development and Treatment of Effusions JF - ADVANCES IN BIOSCIENCE AND BIOTECHNOLOGY J2 - ADV BIOS BIO VL - 8 PY - 2017 IS - 11 SP - 434 EP - 449 PG - 16 SN - 2156-8456 DO - 10.4236/abb.2017.811032 UR - https://m2.mtmt.hu/api/publication/30345075 ID - 30345075 LA - English DB - MTMT ER - TY - JOUR AU - Mátrai, Máté AU - Hetthéssy, Judit AU - Nádasy, György László AU - Székács, Béla AU - Mericli, M AU - Ács, Nándor AU - Monos, Emil AU - Arbib, N AU - Várbíró, Szabolcs TI - Estrogen therapy may counterbalance eutrophic remodeling of coronary arteries and increase bradykinin relaxation in a rat model of menopausal hypertension. JF - MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY J2 - MENOPAUSE VL - 23 PY - 2016 IS - 7 SP - 778 EP - 783 PG - 6 SN - 1072-3714 DO - 10.1097/GME.0000000000000654 UR - https://m2.mtmt.hu/api/publication/3073859 ID - 3073859 N1 - M.M. and J.R.H. contributed equally to this work. AB - OBJECTIVE: Hypertension causes adverse remodeling and vasomotor alterations in coronaries. Hormones such as estrogen may help counterbalance some of these effects. The aim of this study was to analyze the effects of ovariectomy and estrogen therapy in a rat model of menopausal hypertension induced by angiotensin II (AII). METHODS: We investigated diameter, tone, and mechanics of intramural coronaries taken from ovariectomized female rats (n = 11) that received chronic AII treatment to induce hypertension, and compared the results with those found in female rats that were also given estrogen therapy (n = 11). The "hypertensive control" group (n = 11) underwent an abdominal sham operation, and received AII. After 4 weeks of AII treatment, side branches of left anterior descendent coronary (approximately 200 mum in diameter) were isolated, cannulated with plastic microcannulas at both ends, and studied in vitro in a vessel chamber. The inner and outer diameter of the arteries were measured by microangiometry, and spontenuous tone, wall thickness, wall cross-sectional area, tangential stress, incremental distensibility, circumferential incremental elastic modulus, thromboxane agonist-induced tone, and bradykinin-induced dilation were calculated. RESULTS: In hypertension, intramural small coronaries show inward eutrophic remodeling after ovariectomy comparing with hypertensive controls. Estrogen therapy had an opposite effect on vessel diameter. Hormone therapy led to an increase in spontaneous tone, allowing for greater dilatative capacity. CONCLUSIONS: Estrogen may therefore be considered to counterbalance some of the adverse changes seen in the wall of intramural coronaries in the early stages of chronic hypertension.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/4.0. LA - English DB - MTMT ER - TY - GEN AU - Monori-Kiss, Anna AU - Lónyi, F AU - Nádasy, György László TI - KÉT HÓNAPOS QUERCETIN SZUPPLEMENTÁCIÓ MÉRSÉKELI A KORONÁRIA ARTERIOLÁK HÁLÓZATI TULAJDONSÁGAINAK HIPERTÓNIA INDUKÁLTA KÓROS ÁTÉPÜLÉSÉT PY - 2016 SP - 148 EP - 148 PG - 1 UR - https://m2.mtmt.hu/api/publication/3085400 ID - 3085400 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Szász, Olivér AU - Szigeti, Gyula Péter AU - Szász, András TI - Connections between the Specific Absorption Rate and the local Temperature JF - OPEN JOURNAL OF BIOPHYSICS J2 - OPEN J BIOPHYS VL - 6 PY - 2016 SP - 53 EP - 74 PG - 22 SN - 2164-5396 UR - https://m2.mtmt.hu/api/publication/3090568 ID - 3090568 LA - English DB - MTMT ER -