@article{MTMT:31637466, title = {Effects of Testosterone Deficiency and Angiotensin II-Induced Hypertension on the Biomechanics of Intramural Coronary Arteries}, url = {https://m2.mtmt.hu/api/publication/31637466}, author = {Jósvai, Attila and Török, Marianna and Mátrai, Máté and Hetthéssy, Judit and Monori-Kiss, Anna and Makk, Jennifer and Székács, Béla and Nádasy, György László and Várbíró, Szabolcs}, doi = {10.1016/j.jsxm.2020.09.003}, journal-iso = {J SEX MED}, journal = {JOURNAL OF SEXUAL MEDICINE}, volume = {17}, unique-id = {31637466}, issn = {1743-6095}, abstract = {Andropause and hypertension also increase the risk of coronary artery damage.To investigate the effect of testosterone deficiency and hypertension on intramural coronary vessels.4 groups of 8-week-old Sprague-Dawley rats were studied: control male (Co, n=10), orchidectomized male (OCT, n=13), angiotensin (AII) hypertensive male (AII, n=10), and AII hypertensive and OCT (AII + OCT, n=8). Surgical orchidectomy was performed, and an osmotic minipump was inserted for chronic angiotensin II infusion (100 ng/min/kg). After 4 weeks, spontaneous tone and biomechanical properties of the intramural coronary resistance artery were investigated in vitro, by pressure microarteriography.Morphology and biomechanics of the intramural coronaries were evaluated: the outer diameter, wall thickness-to-lumen diameter ratio, and tangential wall stress in the contracted and relaxed states.The outer diameter was reduced in OCT and AII + OCT groups (on 50 mmHg 315 ± 20 Co; 237 ± 21 OCT; 291 ± 16 AII, and 166 ± 12 μm AII + OCT). The increased wall thickness-to-lumen diameter ratio resulted in lower tangential wall stress in AII + OCT rats (on 50 mmHg 19 ± 2 Co; 24 ± OCT; 26 ± 5 AII, and 9 ± 1 kPa AII + OCT). Spontaneous tone was increased in the hypertensive rats (AII and AII + OCT groups) (on 50 mmHg 7.7 ± 1.8 Co; 6.1 ± 1.4 OCT; 14.5 ± 3.0 AII, and 17.4 ± 4.1 % AII + OCT).Andropause alone can be considered as a cardiovascular risk factor that will further exacerbate vascular damage in hypertension.A limitation of our study is that it was performed on relatively young rats, and the conclusions might not apply to coronary remodelling in older animals with slower adaptation processes.Testosterone deficiency and hypertension damage the mechanical adaptation of the vessel wall additively: double noxa caused inward eutrophic remodeling and increased tone. Jósvai A, Török M, Mátrai M, et al. Effects of Testosterone Deficiency and Angiotensin II-Induced Hypertension on the Biomechanics of Intramural Coronary Arteries. J Sex Med 2020;XX:XXX-XXX.}, keywords = {HYPERTENSION; testosterone; Biomechanics; Castration; Rat Andropause Model; Resistance Coronary Artery}, year = {2020}, eissn = {1743-6109}, pages = {2322-2330}, orcid-numbers = {Jósvai, Attila/0000-0002-2793-9152; Török, Marianna/0000-0002-2832-0626; Hetthéssy, Judit/0000-0001-8274-5257; Monori-Kiss, Anna/0000-0002-4315-8743; Székács, Béla/0000-0002-3007-8568; Nádasy, György László/0000-0003-2057-2391; Várbíró, Szabolcs/0000-0002-7109-6906} } @{MTMT:31359099, title = {Guidelines for Local Hyperthermia Treatment in Oncology}, url = {https://m2.mtmt.hu/api/publication/31359099}, author = {Szász, Attila Marcell and Árkosy, Péter and Arrojo, EE and Bakacs, T and Balogh, A and Barich, J and Borbényi, Erika and Chi, KH and Csoszi, T and Daniilidis, L and Douwes, F and Eller, YG and Fiorentini, G and Forika, Gertrud and Herzog, A and Kleef, R and Krenács, Tibor and Lee, SY and Minnaar, CA and Ou, J and Pang, CLK and Papastravrou, A and Parmar, G and Szentmártoni, Gyöngyvér and Szigeti, Gyula Péter and Van, Gool S and Wust, P and Dank, Magdolna}, booktitle = {Challenges and Solutions of Oncological Hyperthermia}, unique-id = {31359099}, year = {2020}, pages = {32-71}, orcid-numbers = {Szász, Attila Marcell/0000-0003-2739-4196; Borbényi, Erika/0000-0002-0425-5540; Forika, Gertrud/0000-0001-9622-1040; Krenács, Tibor/0000-0001-9164-065X; Szentmártoni, Gyöngyvér/0000-0003-1093-4619; Szigeti, Gyula Péter/0000-0003-0411-9992; Dank, Magdolna/0000-0002-4442-8733} } @article{MTMT:3380109, title = {Foszfolipáz C epszilon szerepe a nitrogén-monoxid hiányhoz kapcsolódó hipertóniában [The role of phospholipase C epsilon in nitric oxide deficiency associated hypertension]}, url = {https://m2.mtmt.hu/api/publication/3380109}, author = {Németh, Tamás and Ruisanchez, Éva and Hricisák, László and Fülöp, Ágnes and Iring, András and Káldi, Krisztina and Várnai, Péter and Smrcka, Alan V and Merkely, Béla Péter and Offermanns, Stefan and Benyó, Zoltán}, journal-iso = {CARDIOL HUNG}, journal = {CARDIOLOGIA HUNGARICA}, volume = {48}, unique-id = {3380109}, issn = {0133-5596}, year = {2018}, eissn = {1588-0230}, pages = {C35-C36}, orcid-numbers = {Ruisanchez, Éva/0000-0001-7779-226X; Hricisák, László/0000-0001-8320-2166; Iring, András/0000-0002-3087-4337; Várnai, Péter/0000-0002-7777-806X; Merkely, Béla Péter/0000-0001-6514-0723; Benyó, Zoltán/0000-0001-6015-0359} } @article{MTMT:3328964, title = {Hyperthermia dosing and depth of effect}, url = {https://m2.mtmt.hu/api/publication/3328964}, author = {Szász, Olivér and Szigeti, Gyula Péter and Vancsik, Tamás and Szász, András}, doi = {10.4236/ojbiphy.2018.81004}, journal-iso = {OPEN J BIOPHYS}, journal = {OPEN JOURNAL OF BIOPHYSICS}, volume = {8}, unique-id = {3328964}, issn = {2164-5396}, year = {2018}, pages = {31-48}, orcid-numbers = {Szigeti, Gyula Péter/0000-0003-0411-9992} } @article{MTMT:30345075, title = {Electrokinetics of Temperature for Development and Treatment of Effusions}, url = {https://m2.mtmt.hu/api/publication/30345075}, author = {Szasz, Oliver and Szigeti, Gyula Péter and Szász, Attila Marcell}, doi = {10.4236/abb.2017.811032}, journal-iso = {ADV BIOS BIO}, journal = {ADVANCES IN BIOSCIENCE AND BIOTECHNOLOGY}, volume = {8}, unique-id = {30345075}, issn = {2156-8456}, year = {2017}, eissn = {2156-8502}, pages = {434-449}, orcid-numbers = {Szigeti, Gyula Péter/0000-0003-0411-9992; Szász, Attila Marcell/0000-0003-2739-4196} } @article{MTMT:3200408, title = {Connections between Warburg's and Szentgyorgyi's Approach about the Causes of Cancer}, url = {https://m2.mtmt.hu/api/publication/3200408}, author = {Szigeti, Gyula Péter and Szasz, O and Hegyi, Gabriella}, journal-iso = {JOURNAL OF NEOPLASM}, journal = {JOURNAL OF NEOPLASM}, volume = {1}, unique-id = {3200408}, year = {2017}, eissn = {2576-3903}, orcid-numbers = {Szigeti, Gyula Péter/0000-0003-0411-9992} } @article{MTMT:32295028, title = {Reorganization of the cytoskeleton}, url = {https://m2.mtmt.hu/api/publication/32295028}, author = {Vincze, Gyula and Szász, András and Szigeti, Gyula Péter}, journal-iso = {JOURNAL OF ADVANCES IN BIOLOGY}, journal = {JOURNAL OF ADVANCES IN BIOLOGY}, volume = {9}, unique-id = {32295028}, issn = {2347-6893}, year = {2016}, pages = {1872-1882}, orcid-numbers = {Szigeti, Gyula Péter/0000-0003-0411-9992} } @article{MTMT:31837612, title = {Personalised Dosing of Hyperthermia}, url = {https://m2.mtmt.hu/api/publication/31837612}, author = {Szigeti, Gyula Péter and Szász, Olivér and Hegyi, Gabriella}, doi = {10.4172/2476-2253.1000107}, journal-iso = {JOURNAL OF CANCER DIAGNOSIS}, journal = {JOURNAL OF CANCER DIAGNOSIS}, volume = {1}, unique-id = {31837612}, year = {2016}, pages = {112-121}, orcid-numbers = {Szigeti, Gyula Péter/0000-0003-0411-9992} } @article{MTMT:3171758, title = {Mikroér-károsodás polycystás ovárium modellbetegségben}, url = {https://m2.mtmt.hu/api/publication/3171758}, author = {Nádasy, György László and Szekeres, Mária and Hadjadj, Leila and Monori-Kiss, Anna and Monos, Emil and Várbíró, Szabolcs}, journal-iso = {ÉRBETEGSÉGEK / HUNG J VASC DIS}, journal = {ÉRBETEGSÉGEK / HUNGARIAN JOURNAL OF VASCULAR DISEASES}, volume = {23}, unique-id = {3171758}, issn = {1218-3636}, year = {2016}, pages = {32-32}, orcid-numbers = {Nádasy, György László/0000-0003-2057-2391; Szekeres, Mária/0000-0002-6358-7270; Monori-Kiss, Anna/0000-0002-4315-8743; Monos, Emil/0000-0001-5423-3887; Várbíró, Szabolcs/0000-0002-7109-6906} } @article{MTMT:3090568, title = {Connections between the Specific Absorption Rate and the local Temperature}, url = {https://m2.mtmt.hu/api/publication/3090568}, author = {Szász, Olivér and Szigeti, Gyula Péter and Szász, András}, journal-iso = {OPEN J BIOPHYS}, journal = {OPEN JOURNAL OF BIOPHYSICS}, volume = {6}, unique-id = {3090568}, issn = {2164-5396}, year = {2016}, pages = {53-74}, orcid-numbers = {Szigeti, Gyula Péter/0000-0003-0411-9992} }