@article{MTMT:34774521,
	title = {High sensitivity of host Helios + /Neuropilin‐1 + Treg to pretransplant conditioning hampers development of OX40 bright /integrin‐β7 + regulatory cells in acute gastrointestinal GvHD},
	url = {https://m2.mtmt.hu/api/publication/34774521},
	author = {Lupsa, Nikolett and Molnár-Érsek, Barbara and Böröczky, Csenge and Kis, Dávid and Szarka, Eszter and Lumniczky, Katalin and Sáfrány, Géza and Zádori, Zoltán Sándor and Szöőr, Árpád and Buzás, Edit Irén and Pós, Zoltán},
	doi = {10.1002/eji.202350619},
	journal-iso = {EUR J IMMUNOL},
	journal = {EUROPEAN JOURNAL OF IMMUNOLOGY},
	volume = {In press},
	unique-id = {34774521},
	issn = {0014-2980},
	abstract = {This study sought to compare the behavior of Treg subsets displaying different coexpression patterns of Neuropilin‐1 (Nrp1) and Helios, under the influence of gut stress unrelated to hematopoietic stem cell transplantation, pretransplantation conditioning, and posttransplant gastrointestinal acute graft versus host disease (GI‐aGvHD). Host CD4 + /CD25 hi /Foxp3 + Treg cells, identified by flow cytometry, were isolated from various tissues of mice affected by these stressors. Expression of CD25, CTLA‐4, CD39, OX40, integrin‐β7, LAG3, TGFβ/LAP, granzyme‐A, ‐B, and interleukin‐10 was compared in four Treg subsets displaying Helios or Nrp1 only, both or none. Fluorescence‐activated cell sorter–sorted Treg subsets, displaying markers affected in a conditioning‐ and GI‐aGVHD‐restricted manner, were further investigated by transcriptome profiling and T‐cell suppression assays. We found that conditioning by irradiation greatly diminished the relative frequency of Helios + /Nrp1 + Treg, shifting the balance toward Helios − /Nrp1 − Treg in the host. Upregulation of integrin‐β7 and OX40 occurred in GI‐aGvHD‐dependent manner in Helios + /Nrp1 + cells but not in Helios − /Nrp1 − Treg. Sorted Treg subsets, confirmed to overexpress Nrp1, Helios, OX40, or integrin‐β7, displayed superior immunosuppressive activity and enrichment in activation‐related messenger RNA transcripts. Our data suggest that conditioning‐induced shrinkage of the Nrp1 + /Helios + Treg subset may contribute to the development of GI‐GvHD by impairing gut homing and decreasing the efficiency of Treg‐mediated immunosuppression.},
	year = {2024},
	eissn = {1521-4141},
	orcid-numbers = {Lupsa, Nikolett/0000-0003-1968-0619; Molnár-Érsek, Barbara/0000-0001-8627-9601; Zádori, Zoltán Sándor/0000-0001-7312-618X; Buzás, Edit Irén/0000-0002-3744-206X; Pós, Zoltán/0000-0002-2574-7616}
}

@article{MTMT:34768413,
	title = {Growth and differentiation factor-15: A link between inflammaging and cardiovascular disease},
	url = {https://m2.mtmt.hu/api/publication/34768413},
	author = {Nyárády, Balázs Bence  and Kiss, Loretta Zsuzsa and Bagyura, Zsolt and Merkely, Béla Péter and Dósa, Edit and Láng, Orsolya and Kőhidai, László and Pállinger, Éva},
	doi = {10.1016/j.biopha.2024.116475},
	journal-iso = {BIOMED PHARMACOTHER},
	journal = {BIOMEDICINE & PHARMACOTHERAPY},
	volume = {174},
	unique-id = {34768413},
	issn = {0753-3322},
	year = {2024},
	eissn = {1950-6007},
	orcid-numbers = {Bagyura, Zsolt/0000-0001-8120-2322; Merkely, Béla Péter/0000-0001-6514-0723; Dósa, Edit/0000-0003-2984-2642; Láng, Orsolya/0000-0002-2787-2154; Kőhidai, László/0000-0002-9002-0296; Pállinger, Éva/0000-0002-5789-0951}
}

@article{MTMT:34766204,
	title = {Extracellular Vesicles of Patients on Peritoneal Dialysis Inhibit the TGF-β- and PDGF-B-Mediated Fibrotic Processes},
	url = {https://m2.mtmt.hu/api/publication/34766204},
	author = {Szebeni, Beáta and Veres-Székely, Apor and Pap, Domonkos and Bokrossy, Péter and Varga, Zoltán and Gaál, Anikó and Mihály, Judith and Pállinger, Éva and Takács, István Márton and Pajtók, Csenge and Bernáth, Mária and Reusz, György and Szabó, Attila and Vannay, Ádám},
	doi = {10.3390/cells13070605},
	journal-iso = {CELLS-BASEL},
	journal = {CELLS},
	volume = {13},
	unique-id = {34766204},
	abstract = {Among patients on peritoneal dialysis (PD), 50–80% will develop peritoneal fibrosis, and 0.5–4.4% will develop life-threatening encapsulating peritoneal sclerosis (EPS). Here, we investigated the role of extracellular vesicles (EVs) on the TGF-β- and PDGF-B-driven processes of peritoneal fibrosis. EVs were isolated from the peritoneal dialysis effluent (PDE) of children receiving continuous ambulatory PD. The impact of PDE-EVs on the epithelial–mesenchymal transition (EMT) and collagen production of the peritoneal mesothelial cells and fibroblasts were investigated in vitro and in vivo in the chlorhexidine digluconate (CG)-induced mice model of peritoneal fibrosis. PDE-EVs showed spherical morphology in the 100 nm size range, and their spectral features, CD63, and annexin positivity were characteristic of EVs. PDE-EVs penetrated into the peritoneal mesothelial cells and fibroblasts and reduced their PDE- or PDGF-B-induced proliferation. Furthermore, PDE-EVs inhibited the PDE- or TGF-β-induced EMT and collagen production of the investigated cell types. PDE-EVs contributed to the mesothelial layer integrity and decreased the submesothelial thickening of CG-treated mice. We demonstrated that PDE-EVs significantly inhibit the PDGF-B- or TGF-β-induced fibrotic processes in vitro and in vivo, suggesting that EVs may contribute to new therapeutic strategies to treat peritoneal fibrosis and other fibroproliferative diseases.},
	year = {2024},
	eissn = {2073-4409},
	orcid-numbers = {Szebeni, Beáta/0000-0001-7577-9803; Veres-Székely, Apor/0000-0002-6830-8779; Pap, Domonkos/0000-0002-1718-1210; Varga, Zoltán/0000-0002-5741-2669; Pállinger, Éva/0000-0002-5789-0951; Reusz, György/0000-0003-0396-043X; Szabó, Attila/0000-0001-7321-9861; Vannay, Ádám/0000-0001-7412-4733}
}

@article{MTMT:34741367,
	title = {Small extracellular vesicles from surviving cancer cells as multiparametric monitoring tools of measurable residual disease and therapeutic efficiency},
	url = {https://m2.mtmt.hu/api/publication/34741367},
	author = {Valcz, Gábor and Buzás, Edit Irén and Gatenby, Robert A. and Újvári, Beáta and Molnár, Béla},
	doi = {10.1016/j.bbcan.2024.189088},
	journal-iso = {BBA-REV CANCER},
	journal = {BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER},
	volume = {1879},
	unique-id = {34741367},
	issn = {0304-419X},
	year = {2024},
	eissn = {1879-2561},
	orcid-numbers = {Valcz, Gábor/0000-0002-7109-3529; Buzás, Edit Irén/0000-0002-3744-206X; Molnár, Béla/0000-0001-6655-7942}
}

@article{MTMT:34720976,
	title = {Characterisation of the cell and molecular biological effect of peptide-based daunorubicin conjugates developed for targeting pancreatic adenocarcinoma (PANC-1) cell line},
	url = {https://m2.mtmt.hu/api/publication/34720976},
	author = {Szász, Adrienn Zsófia and Enyedi, Kata Nóra and Takács, Angéla and Fekete, Nóra and Mező, Gábor and Kőhidai, László and Lajkó, Eszter},
	doi = {10.1016/j.biopha.2024.116293},
	journal-iso = {BIOMED PHARMACOTHER},
	journal = {BIOMEDICINE & PHARMACOTHERAPY},
	volume = {173},
	unique-id = {34720976},
	issn = {0753-3322},
	year = {2024},
	eissn = {1950-6007},
	orcid-numbers = {Szász, Adrienn Zsófia/0009-0000-3110-0379; Enyedi, Kata Nóra/0000-0003-3724-5936; Takács, Angéla/0000-0002-8912-8216; Mező, Gábor/0000-0002-7618-7954; Kőhidai, László/0000-0002-9002-0296; Lajkó, Eszter/0000-0002-4796-4646}
}

@misc{MTMT:34718713,
	title = {INVESTIGATING THE BIOMARKER ROLE OF CELL-FREE LONG NON-CODING RNAS IN PEDIATRIC PRECURSOR B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA},
	url = {https://m2.mtmt.hu/api/publication/34718713},
	author = {Almási, Laura and Horváth, Ágoston and Péterffy, Borbála and Novák, Nikolett and Oláh-Szabó, Rita and Pálóczi, Krisztina and Kutszegi, Nóra and Hegyesi, Hargita and Erdélyi, Dániel},
	unique-id = {34718713},
	year = {2024},
	orcid-numbers = {Almási, Laura/0000-0001-5615-8948; Kutszegi, Nóra/0000-0001-5957-3215; Hegyesi, Hargita/0000-0002-8800-5169; Erdélyi, Dániel/0000-0001-5544-9209}
}

@article{MTMT:34689879,
	title = {Peer education program to improve fluid consumption in primary schools—lessons learned from an innovative pilot study},
	url = {https://m2.mtmt.hu/api/publication/34689879},
	author = {Soósné Kiss, Zsuzsanna and Vitrai, József and Takács, Johanna and Lukács, Ágnes and Falus, András and Feith, Helga Judit},
	doi = {10.1016/j.heliyon.2024.e26769},
	journal-iso = {HELIYON},
	journal = {HELIYON},
	volume = {10},
	unique-id = {34689879},
	year = {2024},
	eissn = {2405-8440},
	orcid-numbers = {Soósné Kiss, Zsuzsanna/0000-0002-2080-807X; Vitrai, József/0000-0001-9267-806X; Takács, Johanna/0000-0002-8709-8826; Falus, András/0000-0002-6843-6789; Feith, Helga Judit/0000-0001-8855-5059}
}

@article{MTMT:34640829,
	title = {Recipient Pericardial Apolipoprotein Levels Might Be an Indicator of Worse Outcomes after Orthotopic Heart Transplantation},
	url = {https://m2.mtmt.hu/api/publication/34640829},
	author = {Székely, Andrea and Pállinger, Éva and Töreki, E. and Ifju, M. and Barta, Bálint András and Szécsi, Balázs and Losoncz, Eszter and Dohy, Zsófia and Barabás, János Imre and Kosztin, Annamária and Buzás, Edit Irén and Radovits, Tamás and Merkely, Béla Péter},
	doi = {10.3390/ijms25031752},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {25},
	unique-id = {34640829},
	issn = {1661-6596},
	year = {2024},
	eissn = {1422-0067},
	orcid-numbers = {Székely, Andrea/0000-0002-1382-7897; Pállinger, Éva/0000-0002-5789-0951; Szécsi, Balázs/0000-0003-2341-7389; Losoncz, Eszter/0000-0001-6426-8821; Dohy, Zsófia/0000-0002-0706-5179; Barabás, János Imre/0000-0002-4404-8730; Kosztin, Annamária/0000-0001-6647-2623; Buzás, Edit Irén/0000-0002-3744-206X; Merkely, Béla Péter/0000-0001-6514-0723}
}

@article{MTMT:34574311,
	title = {Oxime-Linked Peptide-Daunomycin Conjugates as Good Tools for Selection of Suitable Homing Devices in Targeted Tumor Therapy. An Overview.},
	url = {https://m2.mtmt.hu/api/publication/34574311},
	author = {Mező, Gábor and Gomena, Jacopo and Randelovic, Ivan and Dókus, Endre Levente and Kiss, Krisztina and Pethő, Lilla and Schuster, Sabine and Vári, Balázs and Mező, Diána and Lajkó, Eszter and Polgár, Lívia and Kőhidai, László and Tóvári, József and Szabó, Ildikó},
	doi = {10.3390/ijms25031864},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {25},
	unique-id = {34574311},
	issn = {1661-6596},
	abstract = {Chemotherapy is still one of the main therapeutic approaches in cancer therapy. Nevertheless, its poor selectivity causes severe toxic side effects that, together with the development of drug resistance in tumor cells, results in a limitation for its application. Tumor-targeted drug delivery is a possible choice to overcome these drawbacks. As well as monoclonal antibodies, peptides are promising targeting moieties for drug delivery. However, the development of peptide-drug conjugates (PDCs) is still a big challenge. The main reason is that the conjugates have to be stable in circulation, but the drug or its active metabolite should be released efficiently in the tumor cells. For this purpose, suitable linker systems are needed that connect the drug molecule with the homing peptide. The applied linker systems are commonly categorized as cleavable and non-cleavable linkers. Both the groups possess advantages and disadvantages that are summarized briefly in this manuscript. Moreover, in this review paper, we highlight the benefit of oxime-linked anthracycline-peptide conjugates in the development of PDCs. For instance, straightforward synthesis as well as a conjugation reaction proceed in excellent yields, and the autofluorescence of anthracyclines provides a good tool to select the appropriate homing peptides. Furthermore, we demonstrate that these conjugates can be used properly in in vivo studies. The results indicate that the oxime-linked PDCs are potential candidates for targeted tumor therapy.},
	keywords = {daunomycin; oxime linkage; peptide-drug conjugates; In vivo tumor growth inhibition; Targeted tumor therapy; homing peptides},
	year = {2024},
	eissn = {1422-0067},
	orcid-numbers = {Mező, Gábor/0000-0002-7618-7954; Randelovic, Ivan/0000-0003-0161-0022; Dókus, Endre Levente/0000-0002-3472-9911; Pethő, Lilla/0000-0002-0298-3341; Schuster, Sabine/0000-0001-9888-4446; Vári, Balázs/0000-0001-9919-1502; Lajkó, Eszter/0000-0002-4796-4646; Kőhidai, László/0000-0002-9002-0296; Tóvári, József/0000-0002-5543-3204; Szabó, Ildikó/0000-0002-9844-7841}
}

@article{MTMT:34567532,
	title = {Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches},
	url = {https://m2.mtmt.hu/api/publication/34567532},
	author = {Welsh, Joshua A. and Goberdhan, Deborah C. I. and O'Driscoll, Lorraine and Buzás, Edit Irén and Blenkiron, Cherie and Bussolati, Benedetta and Cai, Houjian and Di Vizio, Dolores and Driedonks, Tom A. P. and Erdbrügger, Uta and Falcon‐Perez, Juan M. and Fu, Qing‐Ling and Hill, Andrew F. and Lenassi, Metka and Lim, Sai Kiang and Mahoney, Mỹ G. and Mohanty, Sujata and Möller, Andreas and Nieuwland, Rienk and Ochiya, Takahiro and Sahoo, Susmita and Torrecilhas, Ana C. and Zheng, Lei and Zijlstra, Andries and Abuelreich, Sarah and Bagabas, Reem and Bergese, Paolo and Bridges, Esther M. and Brucale, Marco and Burger, Dylan and Carney, Randy P. and Cocucci, Emanuele and Colombo, Federico and Crescitelli, Rossella and Hanser, Edveena and Harris, Adrian L. and Haughey, Norman J. and Hendrix, An and Ivanov, Alexander R. and Jovanovic‐Talisman, Tijana and Kruh‐Garcia, Nicole A. and Ku'ulei‐Lyn Faustino, Vroniqa and Kyburz, Diego and Lässer, Cecilia and Lennon, Kathleen M. and Lötvall, Jan and Maddox, Adam L. and Martens‐Uzunova, Elena S. and Mizenko, Rachel R. and Newman, Lauren A. and Ridolfi, Andrea and Rohde, Eva and Rojalin, Tatu and Rowland, Andrew and Saftics, Andras and Sandau, Ursula S. and Saugstad, Julie A. and Shekari, Faezeh and Swift, Simon and Ter‐Ovanesyan, Dmitry and Tosar, Juan P. and Useckaite, Zivile and Valle, Francesco and Varga, Zoltán and van der Pol, Edwin and van Herwijnen, Martijn J. C. and Wauben, Marca H. M. and Wehman, Ann M. and Williams, Sarah and Zendrini, Andrea and Zimmerman, Alan J. and Théry, Clotilde and Witwer, Kenneth W. and Haseeb, Zubair},
	doi = {10.1002/jev2.12404},
	journal-iso = {J EXTRACELLULAR VESICL},
	journal = {JOURNAL OF EXTRACELLULAR VESICLES},
	volume = {13},
	unique-id = {34567532},
	abstract = {Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year‐on‐year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non‐vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its ‘Minimal Information for Studies of Extracellular Vesicles’, which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly.},
	year = {2024},
	eissn = {2001-3078},
	orcid-numbers = {Welsh, Joshua A./0000-0002-1097-9756; Goberdhan, Deborah C. I./0000-0003-0645-6714; Buzás, Edit Irén/0000-0002-3744-206X; Bussolati, Benedetta/0000-0002-3663-5134; Cai, Houjian/0000-0003-4887-2652; Falcon‐Perez, Juan M./0000-0003-3133-0670; Hill, Andrew F./0000-0001-5581-2354; Lenassi, Metka/0000-0002-9488-6855; Mohanty, Sujata/0000-0002-0047-4914; Nieuwland, Rienk/0000-0002-5671-3400; Ochiya, Takahiro/0000-0002-0776-9918; Sahoo, Susmita/0000-0002-7279-1564; Torrecilhas, Ana C./0000-0001-5724-2199; Zheng, Lei/0000-0003-2576-8780; Zijlstra, Andries/0000-0001-8460-8803; Brucale, Marco/0000-0001-7244-4389; Carney, Randy P./0000-0001-8193-1664; Crescitelli, Rossella/0000-0002-1714-3169; Haughey, Norman J./0000-0001-5194-4122; Martens‐Uzunova, Elena S./0000-0002-5363-2525; Newman, Lauren A./0000-0003-3303-1666; Rohde, Eva/0000-0001-8692-886X; Sandau, Ursula S./0000-0002-3646-7089; Saugstad, Julie A./0000-0002-2996-9611; Shekari, Faezeh/0000-0001-6026-5412; Tosar, Juan P./0000-0002-2021-2479; Varga, Zoltán/0000-0002-5741-2669; Wauben, Marca H. M./0000-0003-0360-0311; Wehman, Ann M./0000-0001-9826-4132; Zimmerman, Alan J./0000-0001-6280-4790; Théry, Clotilde/0000-0001-8294-6884; Witwer, Kenneth W./0000-0003-1664-4233; Bodnár, Bernadett Réka/0000-0003-3347-9225; Bukva, Mátyás/0000-0002-5225-0285; Buzás, Edit Irén/0000-0002-3744-206X; Buzás, Krisztina/0000-0001-8933-2033; Dobra, Gabriella/0000-0002-2814-7720; Försönits, András/0000-0002-9298-8890; Gyukity-Sebestyén, Edina/0000-0003-1383-6301; Koncz, Anna/0000-0003-2511-2394; Lőrincz, Márton Ákos/0000-0002-2819-5116; Németh, Krisztina/0000-0002-3825-2137; Oláh, Attila/0000-0003-4122-5639; Osteikoetxea, Xabier/0000-0003-3628-0174; Pálóczi, Krisztina/0000-0001-7065-3582; Stepanova, Ganna/0000-0002-8285-2762; Visnovitz, Tamás/0000-0002-7962-5083; Wiener, Zoltán/0000-0001-7056-4926; Harmati, Mária/0000-0002-4875-5723; Hegyesi, Hargita/0000-0002-8800-5169}
}