@article{MTMT:34813473,
	title = {Mathematical modeling of transdermal delivery of topical drug formulations in a dynamic microfluidic diffusion chamber in health and disease},
	url = {https://m2.mtmt.hu/api/publication/34813473},
	author = {Szederkényi, G. and Kocsis, D. and Vághy, M.A. and Czárán, Domonkos Tamás and Sasvári, Péter and Lengyel, Miléna and Naszlady, M.B. and Kreis, F. and Antal, István and Csépányi-Kömi, Roland and Erdő, F.},
	doi = {10.1371/journal.pone.0299501},
	journal-iso = {PLOS ONE},
	journal = {PLOS ONE},
	volume = {19},
	unique-id = {34813473},
	issn = {1932-6203},
	abstract = {Mathematical models of epidermal and dermal transport are essential for optimization and development of products for percutaneous delivery both for local and systemic indication and for evaluation of dermal exposure to chemicals for assessing their toxicity. These models often help directly by providing information on the rate of drug penetration through the skin and thus on the dermal or systemic concentration of drugs which is the base of their pharmacological effect. The simulations are also helpful in analyzing experimental data, reducing the number of experiments and translating the in vitro investigations to an in-vivo setting. In this study skin penetration of topically administered caffeine cream was investigated in a skin-on-a-chip microfluidic diffusion chamber at room temperature and at 32̊C. Also the transdermal penetration of caffeine in healthy and diseased conditions was compared in mouse skins from intact, psoriatic and allergic animals. In the last experimental setup dexamethasone, indomethacin, piroxicam and diclofenac were examined as a cream formulation for absorption across the dermal barrier. All the measured data were used for making mathematical simulation in a three-compartmental model. The calculated and measured results showed a good match, which findings indicate that our mathematical model might be applied for prediction of drug delivery through the skin under different circumstances and for various drugs in the novel, miniaturized diffusion chamber. © 2024 Szederkényi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License,},
	keywords = {ABSORPTION; DEXAMETHASONE; ARTICLE; MOUSE; PREDICTION; nonhuman; in vitro study; simulation; drug formulation; drug delivery system; indometacin; room temperature; CAFFEINE; diclofenac; mathematical model; piroxicam; drug penetration; cream; Product development; diffusion chamber; psoriasis; Epidermis; compartment model; skin penetration; dermis; skin on a chip},
	year = {2024},
	eissn = {1932-6203},
	orcid-numbers = {Lengyel, Miléna/0000-0001-8865-054X; Antal, István/0000-0002-5434-201X; Csépányi-Kömi, Roland/0000-0001-6825-7142}
}

@article{MTMT:34792167,
	title = {Characterization of Atherosclerotic Mice Reveals a Sex-Dependent Susceptibility to Plaque Calcification but No Major Changes in the Lymphatics in the Arterial Wall},
	url = {https://m2.mtmt.hu/api/publication/34792167},
	author = {Christ, Carolin and Ocskay, Zsombor and Kovács, Gábor and Jakus, Zoltán},
	doi = {10.3390/ijms25074046},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {25},
	unique-id = {34792167},
	issn = {1661-6596},
	abstract = {Lymphatics participate in reverse cholesterol transport, and their presence in the arterial wall of the great vessels and prior experimental results suggest their possible role in the development of atherosclerosis. The aim of this study was to characterize the lymphatic vasculature of the arterial wall in atherosclerosis. Tissue sections and tissue-cleared aortas of wild-type mice unveiled significant differences in the density of the arterial lymphatic network throughout the arterial tree. Male and female Ldlr−/− and ApoE−/− mice on a Western diet showed sex-dependent differences in plaque formation and calcification. Female mice on a Western diet developed more calcification of atherosclerotic plaques than males. The lymphatic vessels within the aortic wall of these mice showed no major changes regarding the number of lymphatic junctions and end points or the lymphatic area. However, female mice on a Western diet showed moderate dilation of lymphatic vessels in the abdominal aorta and exhibited indications of increased peripheral lymphatic function, findings that require further studies to understand the role of lymphatics in the arterial wall during the development of atherosclerosis.},
	year = {2024},
	eissn = {1422-0067},
	orcid-numbers = {Jakus, Zoltán/0000-0002-6304-2369}
}

@article{MTMT:34786398,
	title = {Neutrophil IL-26 fuels autoinflammation},
	url = {https://m2.mtmt.hu/api/publication/34786398},
	author = {Futosi, Krisztina and Mócsai, Attila},
	doi = {10.1084/jem.20240229},
	journal-iso = {J EXP MED},
	journal = {JOURNAL OF EXPERIMENTAL MEDICINE},
	volume = {221},
	unique-id = {34786398},
	issn = {0022-1007},
	abstract = {Pustular psoriasis is an inflammatory skin disease with features of neutrophil-mediated sterile autoinflammation. In this issue of JEM, Baldo et al. show that this autoinflammation is driven by a vicious cycle through neutrophil-derived IL-26. Pustular psoriasis is an inflammatory skin disease with features of neutrophil-mediated sterile autoinflammation. In this issue of JEM, Baldo et al. (https://doi.org/10.1084/jem.20231464) show that this autoinflammation is driven by a vicious cycle through neutrophil-derived IL-26.},
	keywords = {immunology},
	year = {2024},
	eissn = {1540-9538},
	orcid-numbers = {Futosi, Krisztina/0000-0002-1661-4635; Mócsai, Attila/0000-0002-0512-1157}
}

@article{MTMT:34779359,
	title = {Correction to: The First Quarter Century of the Dense Alignment Surface Transmembrane Prediction Method (International Journal of Molecular Sciences, (2023), 24, 18, (14016), 10.3390/ijms241814016)},
	url = {https://m2.mtmt.hu/api/publication/34779359},
	author = {Cserző, Miklós and Eisenhaber, B. and Eisenhaber, F. and Magyar, C. and Simon, I.},
	doi = {10.3390/ijms25063422},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {25},
	unique-id = {34779359},
	issn = {1661-6596},
	year = {2024},
	eissn = {1422-0067},
	orcid-numbers = {Cserző, Miklós/0000-0002-9425-4487}
}

@article{MTMT:34775042,
	title = {Novel and potential future therapeutic options in systemic autoimmune diseases},
	url = {https://m2.mtmt.hu/api/publication/34775042},
	author = {Balogh, Lili and Olah, Katalin and Santa, Soma and Majerhoffer, Nora and Németh, Tamás},
	doi = {10.3389/fimmu.2024.1249500},
	journal-iso = {FRONT IMMUNOL},
	journal = {FRONTIERS IN IMMUNOLOGY},
	volume = {15},
	unique-id = {34775042},
	issn = {1664-3224},
	abstract = {Autoimmune inflammation is caused by the loss of tolerance to specific self-antigens and can result in organ-specific or systemic disorders. Systemic autoimmune diseases affect a significant portion of the population with an increasing rate of incidence, which means that is essential to have effective therapies to control these chronic disorders. Unfortunately, several patients with systemic autoimmune diseases do not respond at all or just partially respond to available conventional synthetic disease-modifying antirheumatic drugs and targeted therapies. However, during the past few years, some new medications have been approved and can be used in real-life clinical settings. Meanwhile, several new candidates appeared and can offer promising novel treatment options in the future. Here, we summarize the newly available medications and the most encouraging drug candidates in the treatment of systemic lupus erythematosus, rheumatoid arthritis, Sjogren's disease, systemic sclerosis, systemic vasculitis, and autoimmune myositis.},
	keywords = {INHIBITOR; SAFETY; RHEUMATOID-ARTHRITIS; ANTIBODY; EFFICACY; placebo; autoimmune disease; DOUBLE-BLIND; treatment; PRIMARY SJOGRENS-SYNDROME; Pathomechanism; LUPUS-ERYTHEMATOSUS; PHASE-2 TRIAL; EOSINOPHILIC GRANULOMATOSIS},
	year = {2024},
	eissn = {1664-3224},
	orcid-numbers = {Németh, Tamás/0000-0001-6854-4301}
}

@article{MTMT:34771485,
	title = {Combining detrended cross-correlation analysis with Riemannian geometry-based classification for improved brain-computer interface performance},
	url = {https://m2.mtmt.hu/api/publication/34771485},
	author = {Rácz, Frigyes Sámuel and Kumar, S. and Káposzta, Zalán and Alawieh, H. and Liu, D.H. and Liu, R. and Czoch, Ákos and Mukli, Péter and Millán, J.D.R.},
	doi = {10.3389/fnins.2024.1271831},
	journal-iso = {FRONT NEUROSCI-SWITZ},
	journal = {FRONTIERS IN NEUROSCIENCE},
	volume = {18},
	unique-id = {34771485},
	issn = {1662-4548},
	abstract = {Riemannian geometry-based classification (RGBC) gained popularity in the field of brain-computer interfaces (BCIs) lately, due to its ability to deal with non-stationarities arising in electroencephalography (EEG) data. Domain adaptation, however, is most often performed on sample covariance matrices (SCMs) obtained from EEG data, and thus might not fully account for components affecting covariance estimation itself, such as regional trends. Detrended cross-correlation analysis (DCCA) can be utilized to estimate the covariance structure of such signals, yet it is computationally expensive in its original form. A recently proposed online implementation of DCCA, however, allows for its fast computation and thus makes it possible to employ DCCA in real-time applications. In this study we propose to replace the SCM with the DCCA matrix as input to RGBC and assess its effect on offline and online BCI performance. First we evaluated the proposed decoding pipeline offline on previously recorded EEG data from 18 individuals performing left and right hand motor imagery (MI), and benchmarked it against vanilla RGBC and popular MI-detection approaches. Subsequently, we recruited eight participants (with previous BCI experience) who operated an MI-based BCI (MI-BCI) online using the DCCA-enhanced Riemannian decoder. Finally, we tested the proposed method on a public, multi-class MI-BCI dataset. During offline evaluations the DCCA-based decoder consistently and significantly outperformed the other approaches. Online evaluation confirmed that the DCCA matrix could be computed in real-time even for 22-channel EEG, as well as subjects could control the MI-BCI with high command delivery (normalized Cohen's κ: 0.7409 ± 0.1515) and sample-wise MI detection (normalized Cohen's κ: 0.5200 ± 0.1610). Post-hoc analysis indicated characteristic connectivity patterns under both MI conditions, with stronger connectivity in the hemisphere contralateral to the MI task. Additionally, fractal scaling exponent of neural activity was found increased in the contralateral compared to the ipsilateral motor cortices (C4 and C3 for left and right MI, respectively) in both classes. Combining DCCA with Riemannian geometry-based decoding yields a robust and effective decoder, that not only improves upon the SCM-based approach but can also provide relevant information on the neurophysiological processes behind MI. Copyright © 2024 Racz, Kumar, Kaposzta, Alawieh, Liu, Liu, Czoch, Mukli and Millán.},
	keywords = {DETRENDED FLUCTUATION ANALYSIS; ONLINE; Brain-computer Interface; Detrended Cross-Correlation Analysis; motor imagery; Fractal connectivity; Reimannian geometry},
	year = {2024},
	eissn = {1662-453X},
	orcid-numbers = {Rácz, Frigyes Sámuel/0000-0001-9077-498X; Mukli, Péter/0000-0003-4355-8103}
}

@misc{MTMT:34758494,
	title = {Identifying Ferroptosis Inducers, HDAC,and RTK Inhibitor Sensitivity in Melanoma Subtypes through Unbiased Drug Target Prediction},
	url = {https://m2.mtmt.hu/api/publication/34758494},
	author = {Indira, Pla and Botond, L. Szabolcs and Petra, Nikolett Péter and Zsuzsanna, Ujfaludi and Yonghyo, Kim and Peter, Horvatovich and Aniel Sanchez, Krzysztof Pawlowski and Elisabet, Wieslander and Jéssica, Guedes and Pál, Dorottya and Anna A. Ascsillán, Lazaro Hiram Betancourt and István, Balázs Németh and Jeovanis, Gil and Natália, Pinto de Almeida, Beáta Szeitz, Leticia Szadai and Viktória, Doma and Nicole, Woldmar and Áron, Bartha and Zoltan, Pahi and Tibor, Pankotai and Balázs, Győrffy and A., Marcell Szasz and Gilberto, Domont and Fábio, Nogueira and Ho, Jeong Kwon and Roger, Appelqvist and Sarolta, Kárpáti and David, Fenyö and Johan, Malm and György, Marko-Varga and Kemény, Lajos Vince},
	unique-id = {34758494},
	year = {2024},
	orcid-numbers = {Pál, Dorottya/0000-0002-9426-487X; Kemény, Lajos Vince/0000-0002-8233-1844}
}

@article{MTMT:34757704,
	title = {Lymphatics-dependent modulation of the sensitization and elicitation phases of contact hypersensitivity},
	url = {https://m2.mtmt.hu/api/publication/34757704},
	author = {Aradi, Petra and Kovács, Gábor and Kemecsei, Éva and Molnár, Kornél and Sági, Stella Márta and Horváth, Zalán and Mehrara, Babak J. and Kataru, Raghu P. and Jakus, Zoltán},
	doi = {10.1016/j.jid.2024.03.021},
	journal-iso = {J INVEST DERMATOL},
	journal = {JOURNAL OF INVESTIGATIVE DERMATOLOGY},
	unique-id = {34757704},
	issn = {0022-202X},
	year = {2024},
	eissn = {1523-1747},
	orcid-numbers = {Kemecsei, Éva/0000-0002-3602-7112; Molnár, Kornél/0009-0000-4944-1980; Sági, Stella Márta/0009-0003-3228-2655; Mehrara, Babak J./0000-0001-5717-697X; Kataru, Raghu P./0000-0003-1315-7982; Jakus, Zoltán/0000-0002-6304-2369}
}

@article{MTMT:34756276,
	title = {Neurovascular coupling impairment as a mechanism for cognitive deficits in COVID-19},
	url = {https://m2.mtmt.hu/api/publication/34756276},
	author = {Owens, Cameron D and Bonin Pinto, Camila and Detwiler, Sam and Olay, Lauren and Pinaffi-Langley, Ana Clara da C and Mukli, Péter and Péterfi, Anna and Szarvas, Zsófia and James, Judith A and Galvan, Veronica and Tarantini, Stefano and Csiszar, Anna and Ungvári, Zoltán István and Kirkpatrick, Angelia C and Prodan, Calin I and Yabluchanskiy, Andriy},
	doi = {10.1093/braincomms/fcae080},
	journal-iso = {BRAIN COMMUN},
	journal = {BRAIN COMMUNICATIONS},
	volume = {6},
	unique-id = {34756276},
	abstract = {Components that comprise our brain parenchymal and cerebrovascular structures provide a homeostatic environment for proper neuronal function to ensure normal cognition. Cerebral insults (e.g. ischaemia, microbleeds and infection) alter cellular structures and physiologic processes within the neurovascular unit and contribute to cognitive dysfunction. COVID-19 has posed significant complications during acute and convalescent stages in multiple organ systems, including the brain. Cognitive impairment is a prevalent complication in COVID-19 patients, irrespective of severity of acute SARS-CoV-2 infection. Moreover, overwhelming evidence from in vitro, preclinical and clinical studies has reported SARS-CoV-2-induced pathologies in components of the neurovascular unit that are associated with cognitive impairment. Neurovascular unit disruption alters the neurovascular coupling response, a critical mechanism that regulates cerebromicrovascular blood flow to meet the energetic demands of locally active neurons. Normal cognitive processing is achieved through the neurovascular coupling response and involves the coordinated action of brain parenchymal cells (i.e. neurons and glia) and cerebrovascular cell types (i.e. endothelia, smooth muscle cells and pericytes). However, current work on COVID-19-induced cognitive impairment has yet to investigate disruption of neurovascular coupling as a causal factor. Hence, in this review, we aim to describe SARS-CoV-2's effects on the neurovascular unit and how they can impact neurovascular coupling and contribute to cognitive decline in acute and convalescent stages of the disease. Additionally, we explore potential therapeutic interventions to mitigate COVID-19-induced cognitive impairment. Given the great impact of cognitive impairment associated with COVID-19 on both individuals and public health, the necessity for a coordinated effort from fundamental scientific research to clinical application becomes imperative. This integrated endeavour is crucial for mitigating the cognitive deficits induced by COVID-19 and its subsequent burden in this especially vulnerable population.},
	year = {2024},
	eissn = {2632-1297},
	orcid-numbers = {Owens, Cameron D/0000-0002-5020-2810; Mukli, Péter/0000-0003-4355-8103; Szarvas, Zsófia/0000-0002-0022-5053; Tarantini, Stefano/0000-0001-5627-1430; Ungvári, Zoltán István/0000-0002-6035-6039; Yabluchanskiy, Andriy/0000-0002-9648-7161}
}

@article{MTMT:34746956,
	title = {De novo steroidogenesis in tumor cells drives bone metastasis and osteoclastogenesis},
	url = {https://m2.mtmt.hu/api/publication/34746956},
	author = {Sándor, Luca Fatime and Huh, Joon B. and Benkő, Péter and Hiraga, Toru and Poliska, Szilard and Dobó-Nagy, Csaba and Simpson, Joanna P. and Homer, Natalie Z.M. and Mahata, Bidesh and Győri, Dávid Sándor},
	doi = {10.1016/j.celrep.2024.113936},
	journal-iso = {CELL REP},
	journal = {CELL REPORTS},
	volume = {43},
	unique-id = {34746956},
	issn = {2211-1247},
	year = {2024},
	eissn = {2211-1247},
	orcid-numbers = {Dobó-Nagy, Csaba/0000-0001-9530-7926; Győri, Dávid Sándor/0000-0002-2048-6752}
}