TY - JOUR AU - Saleh, H.A. AU - Mitwasi, N. AU - R., Loureiro L. AU - Kegler, A. AU - Soto, K.E.G. AU - Hoffmann, L. AU - Crespo, E. AU - Arndt, C. AU - Bergmann, Ralf Konrad AU - Bachmann, M. AU - Feldmann, A. TI - RevCAR-expressing immune effector cells for targeting of Fn14-positive glioblastoma JF - CANCER GENE THERAPY J2 - CANCER GENE THER PY - 2024 SN - 0929-1903 DO - 10.1038/s41417-024-00766-8 UR - https://m2.mtmt.hu/api/publication/34797745 ID - 34797745 LA - English DB - MTMT ER - TY - JOUR AU - Mészáros, Balázs AU - Veres, Dániel AU - Nagyistók, Luca AU - Kovács, Bence Géza AU - Kukor, Zoltán AU - Valent, Sándor TI - A meta-analysis on first-trimester blood count parameters—is the neutrophil-to-lymphocyte ratio a potentially novel method for first-trimester preeclampsia screening? JF - FRONTIERS IN MEDICINE J2 - FRONT MED VL - 11 PY - 2024 PG - 11 SN - 2296-858X DO - 10.3389/fmed.2024.1336764 UR - https://m2.mtmt.hu/api/publication/34794477 ID - 34794477 LA - English DB - MTMT ER - TY - JOUR AU - Varga, Viktória Dóra AU - Smeller, László AU - Várdai, Róbert AU - Kocsis, Bence AU - Zsoldos, Ibolya AU - Cruciani, Sara AU - Pala, Renzo AU - Hornyák, István TI - Water-Insoluble, Thermostable, Crosslinked Gelatin Matrix for Soft Tissue Implant Development JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 25 PY - 2024 IS - 8 PG - 15 SN - 1661-6596 DO - 10.3390/ijms25084336 UR - https://m2.mtmt.hu/api/publication/34789637 ID - 34789637 N1 - ISSN:1422-0067 AB - In this present study, the material science background of crosslinked gelatin (GEL) was investigated. The aim was to assess the optimal reaction parameters for the production of a water-insoluble crosslinked gelatin matrix suitable for heat sterilization. Matrices were subjected to enzymatic degradation assessments, and their ability to withstand heat sterilization was evaluated. The impact of different crosslinkers on matrix properties was analyzed. It was found that matrices crosslinked with butanediol diglycidyl ether (BDDE) and poly(ethylene glycol) diglycidyl ether (PEGDE) were resistant to enzymatic degradation and heat sterilization. Additionally, at 1 v/v % crosslinker concentration, the crosslinked weight was lower than the starting weight, suggesting simultaneous degradation and crosslinking. The crosslinked weight and swelling ratio were optimal in the case of the matrices that were crosslinked with 3% and 5% v/v BDDE and PEGDE. FTIR analysis confirmed crosslinking, and the reduction of free primary amino groups indicated effective crosslinking even at a 1% v/v crosslinker concentration. Moreover, stress–strain and compression characteristics of the 5% v/v BDDE crosslinked matrix were comparable to native gelatin. Based on material science measurements, the crosslinked matrices may be promising candidates for scaffold development, including properties such as resistance to enzymatic degradation and heat sterilization. LA - English DB - MTMT ER - TY - JOUR AU - Weninger, Viktor AU - Agócs, Gergely AU - Kovács, Norbert AU - Váncsa, Szilárd AU - Hergár, Luca AU - Baek, Chan Ju AU - Hegyi, Péter AU - Holnapy, Gergely AU - Skaliczki, Gábor TI - Hyaluronate acid plus platelet-rich plasma is superior to steroids for pain relief less than 6 months using injection therapy of partial rotator cuff tears : A systematic review and network meta-analysis JF - ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY J2 - ARTHROSCOPY PY - 2024 SN - 0749-8063 DO - 10.1016/j.arthro.2024.03.035 UR - https://m2.mtmt.hu/api/publication/34788583 ID - 34788583 AB - We conducted our network meta-analysis to compare the efficacy of the steroid injections to other injectable therapies in partial-thickness rotator cuff tears (PTRCTs).A systematic literature search was performed until October 25, 2021 in three databases (CENTRAL, Embase, MEDLINE). Eligible studies compared the efficacy of steroid, hyaluronic acid (HA), platelet-rich plasma (PRP), the combination of HA and PRP (HA+PRP), and adipose-derived regenerative cells (ADRC) in RC tears. The primary outcomes were the Visual Analogue Scale (VAS), Constant Murley Score (CMS), and American Shoulder and Elbow Surgeons Standardized Shoulder Assessment Form. Using paired and network meta-analysis, we calculated pooled mean differences (MDs) with 95% confidence intervals (CIs).We included a total of seven articles in the quantitative synthesis. In shorter periods, the HA+PRP combination was superior to the other substances we investigated (HA+PRP: VAS (0-4 weeks): MD: -0.99 [CI = -1.62, -0.36]; CMS (0-3 months): 20.56 [CI = 16.18, 24.94]. This combination was followed by the use of HA or PRP alone, depending on the duration of follow-up and the outcome being studied. In our study, short-term results suggest that saline is superior to steroids for partial tears, but this trend is reversed at six-month follow-up.Our results suggest the combination of HA and PRP to be a more effective therapeutic option for partial RC ruptures for short terms, but there is no significant difference after 6 months.II, Included of Level of Evidence studies I-II. LA - English DB - MTMT ER - TY - JOUR AU - de Jonge, Robert AU - Máté, Miklós AU - Kovács, Norbert AU - Imrei, Marcell AU - Pap, Károly AU - Agócs, Gergely AU - Váncsa, Szilárd AU - Hegyi, Péter AU - Pánics, Gergely TI - Nonoperative Treatment as an Option for Isolated Anterior Cruciate Ligament Injury : A Systematic Review and Meta-analysis JF - ORTHOPAEDIC JOURNAL OF SPORTS MEDICINE J2 - ORTHOP J SPORTS MED VL - 12 PY - 2024 IS - 4 PG - 9 SN - 2325-9671 DO - 10.1177/23259671241239665 UR - https://m2.mtmt.hu/api/publication/34788581 ID - 34788581 AB - An anterior cruciate ligament (ACL) tear is a risk factor for early osteoarthritis (OA) onset. Generally, ACL reconstruction (ACLR) is associated with better outcomes. However, there is a lack of evidence regarding the effect of operative versus nonoperative treatment for preventing premature knee OA in isolated ACL tears while achieving good functional outcomes.The purpose of the study was to compare the outcomes of ACLR to primarily nonoperative management of isolated ACL tears. It was hypothesized that the outcomes between treatment types would be similar.Systematic review; Level of evidence, 3.This systematic review was registered on the International Prospective Register of Systematic Reviews (PROSPERO) (registration No. CRD42021285901) and was conducted according to the Cochrane Handbook guidelines. We systematically searched for randomized and nonrandomized studies that compared ACLR with nonoperative treatments in isolated ACL tears in 3 databases until October 25, 2021. The risk of bias and quality of evidence of the included studies was assessed in accordance with the Cochrane guidelines. The primary outcome was radiologic signs of OA, and the secondary outcomes were functional parameters. Using the common effects model, we calculated pooled mean differences (MDs) and odds ratios (ORs) with 95% CIs.Five studies-2 randomized controlled trials (RCTs) and 3 retrospective non-RCTs-were included. There was a moderate risk of bias in 2 studies and a serious risk of bias in 1 study. The quality of evidence was rated low because of the higher risk of bias and inconsistency. Nonoperatively treated knees showed a trend toward lower odds of developing radiological signs of OA (OR, 1.84 [95% CI, 0.90 to 3.75]); however, surgically reconstructed knees had significantly better stability (MD, -2.44 [95% CI, -3.21 to -1.66 ]) and a trend toward better but clinically not meaningful Lysholm scores (MD, 2.88 [95% CI, -1.09 to 6.85]). The qualitative synthesis showed that surgical reconstruction was protective against subsequent injuries but not superior when returning to previous activity levels or various functional tests.Findings indicated that there is no certain evidence that ACLR for an isolated ACL tear is superior to nonoperative treatment. Clinicians should consider nonoperative treatments with a well-designed rehabilitative program as a primary option. However, these findings must be interpreted with caution because of low study quality and high risk of bias. LA - English DB - MTMT ER - TY - JOUR AU - Tari, Edina AU - Gagyi , Endre AU - Rancz, Anett AU - Veres, Dániel AU - Váncsa, Szilárd AU - Hegyi, Péter Jenő AU - Hagymási, Krisztina AU - Hegyi, Péter AU - Erőss, Bálint Mihály TI - Morphology of the papilla can predict procedural safety and efficacy of ERCP-a systematic review and meta-analysis. JF - SCIENTIFIC REPORTS J2 - SCI REP VL - 14 PY - 2024 IS - 1 PG - 12 SN - 2045-2322 DO - 10.1038/s41598-024-57758-9 UR - https://m2.mtmt.hu/api/publication/34763940 ID - 34763940 N1 - Centre for Translational Medicine, Semmelweis University, Budapest, Hungary Institute of Pancreatic Diseases, Semmelweis University, Budapest, Hungary Selye János Doctoral College for Advanced Studies, Semmelweis University, Budapest, Hungary Department of Biophysics and Radiation Biology, Semmelweis University, Budapest, Hungary Institute for Translational Medicine, Medical School, University of Pécs, Pecs, Hungary Department of Surgery, Transplantation, and Gastroenterology, Semmelweis University, Budapest, Hungary Export Date: 12 April 2024 Correspondence Address: Erőss, B.; Centre for Translational Medicine, Hungary; email: dr.eross.balint@gmail.com AB - Endoscopic Retrograde Cholangiopancreatography (ERCP) is the primary therapeutic procedure for pancreaticobiliary disorders, and studies highlighted the impact of papilla anatomy on its efficacy and safety. Our objective was to quantify the influence of papilla morphology on ERCP outcomes. We systematically searched three medical databases in September 2022, focusing on studies detailing the cannulation process or the rate of adverse events in the context of papilla morphology. The Haraldsson classification served as the primary system for papilla morphology, and a pooled event rate with a 95% confidence interval was calculated as the effect size measure. Out of 17 eligible studies, 14 were included in the quantitative synthesis. In studies using the Haraldsson classification, the rate of difficult cannulation was the lowest in type I papilla (26%), while the highest one was observed in the case of type IV papilla (41%). For post-ERCP pancreatitis, the event rate was the highest in type II papilla (11%) and the lowest in type I and III papilla (6-6%). No significant difference was observed in the cannulation failure and post-ERCP bleeding event rates between the papilla types. In conclusion, certain papilla morphologies are associated with a higher rate of difficult cannulation and post-ERCP pancreatitis. LA - English DB - MTMT ER - TY - JOUR AU - Laczkó-Dobos, Hajnalka AU - Bhattacharjee, Arindam AU - Maddali, Asha Kiran AU - Kincses, András AU - Abuammar, Hussein AU - Sebőkné Nagy, Krisztina AU - Páli, Tibor AU - Dér, András AU - Hegedűs, Tamás AU - Csordás, Gábor AU - Juhász, Gábor TI - PtdIns4p is required for the autophagosomal recruitment of STX17 (syntaxin 17) to promote lysosomal fusion JF - AUTOPHAGY J2 - AUTOPHAGY VL - AiP PY - 2024 PG - 12 SN - 1554-8627 DO - 10.1080/15548627.2024.2322493 UR - https://m2.mtmt.hu/api/publication/34724664 ID - 34724664 N1 - Institute of Genetics, HUN-REN Biological Research Centre Szeged, Szeged, Hungary Doctoral School of Biology, University of Szeged, Szeged, Hungary Institute of Biophysics, HUN-REN Biological Research Centre Szeged, Szeged, Hungary Department of Biophysics and Radiation Biology, Semmelweis University, Budapest, Hungary HUN-REN Biophysical Virology Research Group, Budapest, Hungary Department of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, Budapest, Hungary Export Date: 27 March 2024 Correspondence Address: Juhász, G.; HUN-REN Biological Research Centre Szeged, Temesvari krt. 62, Hungary; email: juhasz.gabor@brc.hu LA - English DB - MTMT ER - TY - JOUR AU - Skaliczki, Gábor AU - Kovács, Krisztián AU - Antal, Imre AU - Sallai, Imre AU - Kovács, B. AU - Nyőgér, Z. AU - Géresi, Á. AU - Kiss, Balázs AU - Várnagy, Anna TI - Arthroscopic capsular release is more effective in pain relief than conservative treatment in patients with frozen shoulder JF - BMC MUSCULOSKELETAL DISORDERS J2 - BMC MUSCULOSKEL DIS VL - 25 PY - 2024 IS - 1 PG - 7 SN - 1471-2474 DO - 10.1186/s12891-024-07275-7 UR - https://m2.mtmt.hu/api/publication/34687462 ID - 34687462 LA - English DB - MTMT ER - TY - JOUR AU - Borbély, Ruben Zsolt AU - Szalai, Eszter AU - Philip, Bryan Mangalath AU - Dobszai, Dalma AU - Teutsch, Brigitta AU - Zolcsák, Ádám AU - Veres, Dániel AU - Erőss, Bálint Mihály AU - Gellért, Bálint AU - Hegyi, Péter Jenő AU - Hegyi, Péter AU - Faluhelyi, Nándor TI - The risk of developing splanchnic vein thrombosis in acute pancreatitis increases 3 days after symptom onset: A systematic review and meta-analysis JF - UNITED EUROPEAN GASTROENTEROLOGY JOURNAL J2 - UEG JOURNAL PY - 2024 SN - 2050-6406 DO - 10.1002/ueg2.12550 UR - https://m2.mtmt.hu/api/publication/34682498 ID - 34682498 AB - Abstract Background Splanchnic vein thrombosis is a complication of acute pancreatitis (AP) and is likely often underdiagnosed. Objectives We aimed to understand the time course and risk factors of splanchnic vein thrombosis in the early phase of AP. Methods A systematic search was conducted using the PRISMA guidelines (PROSPERO registration CRD42022367578). Inclusion criteria were appropriate imaging techniques in adult AP patients, studies that reported splanchnic vein thrombosis data from the early phase, and reliable information on the timing of imaging in relation to the onset of pancreatitis symptoms or hospital admission. The proportion of patients with thrombosis with 95% confidence intervals (CI) was calculated using random-effects meta-analyses, and multiple subgroup analyses were performed. Results Data from 1951 patients from 14 studies were analyzed. The proportion of patients with splanchnic vein thrombosis within 12 days after symptom onset was 0.13 (CI 0.07?0.23). The occurrence was lowest at 0.06 (CI 0.03?0.1) between 0 and 3 days after symptom onset, and increased fourfold to 0.23 (CI 0.16?0.31) between 3 and 11 days. On hospital admission, the proportion of patients affected was 0.12 (CI 0.02?0.49); it was 0.17 (CI 0.03?0.58) 1?5 days after admission. The prevalence in mild, moderate, and severe AP was 0.15 (CI 0.05?0.36), 0.26 (CI 0.15?0.43), and 0.27 (CI 0.17?0.4), respectively. Alcoholic etiology (0.31, CI 0.13?0.58) and pancreatic necrosis (0.55, CI 0.29?0.78, necrosis above 30%) correlated with increased SVT prevalence. Conclusion The risk of developing splanchnic vein thrombosis is significant in the early stages of AP and may affect up to a quarter of patients. Alcoholic etiology, pancreatic necrosis, and severity may increase the prevalence of splanchnic vein thrombosis. LA - English DB - MTMT ER - TY - JOUR AU - Peschke, J. C. AU - Bergmann, Ralf Konrad AU - Mehnert, M. AU - Soto, K. E. Gonzalez AU - Loureiro, L. R. AU - Mitwasi, N. AU - Kegler, A. AU - Altmann, H. AU - Wobus, M. AU - Neuber, C. AU - Máthé, Domokos AU - Szigeti, Krisztián AU - Feldmann, A. AU - Bornhaeuser, M. AU - Bachmann, M. AU - Fasslrinner, F. AU - Arndt, C. TI - FLT3-directed UniCAR T-cell therapy of acute myeloid leukaemia (vol 202, pg 1137, 2023) JF - BRITISH JOURNAL OF HAEMATOLOGY J2 - BRIT J HAEMATOL PY - 2024 PG - 1 SN - 0007-1048 DO - 10.1111/bjh.19328 UR - https://m2.mtmt.hu/api/publication/34675150 ID - 34675150 LA - English DB - MTMT ER -