TY - JOUR AU - Gantsetseg, Garmaa AU - Bunduc, Stefania AU - Kói, Tamás AU - Hegyi, Péter AU - Csupor, Dezső AU - Dariimaa, Ganbat AU - Dembrovszky, Fanni AU - Meznerics, Fanni Adél AU - Ailar, Nasirzadeh AU - Cristina, Barbagallo AU - Kökény, Gábor TI - A Systematic Review and Meta-Analysis of microRNA Profiling Studies in Chronic Kidney Diseases JF - NON-CODING RNA J2 - NON-CODING RNA VL - 10 PY - 2024 IS - 3 PG - 26 SN - 2311-553X DO - 10.3390/ncrna10030030 UR - https://m2.mtmt.hu/api/publication/34833996 ID - 34833996 LA - English DB - MTMT ER - TY - JOUR AU - Kocsmár, Éva AU - Kocsmár, Ildikó AU - Elamin, Flóra AU - Pápai, Laura AU - Jakab, Ákos AU - Várkonyi, Tibor AU - Glasz, Tibor AU - Rácz, Gergely AU - Pesti, Adrián István AU - Danics, Krisztina AU - Kiss, András AU - Röst, Gergely AU - Belicza, Éva AU - Schaff, Zsuzsa AU - Lotz, Gábor TI - Autopsy findings in cancer patients infected with SARS-CoV-2 show a milder presentation of COVID-19 compared to non-cancer patients. JF - GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE) J2 - GEROSCIENCE VL - In press PY - 2024 IS - In press SP - In press SN - 2509-2715 DO - 10.1007/s11357-024-01163-7 UR - https://m2.mtmt.hu/api/publication/34833220 ID - 34833220 N1 - Online Published: 30 April 2024 AB - COVID-19, caused by SARS-CoV-2, manifests with differing severity across distinct patient subgroups, with outcomes influenced by underlying comorbidities such as cancer, which may cause functional and compositional alterations of the immune system during tumor progression. We aimed to investigate the association of SARS-CoV-2 infection and its complications with cancer in a large autopsy series and the role of COVID-19 in the fatal sequence leading to death. A total of 2641 adult autopsies were investigated, 539 of these were positive for SARS-CoV-2. Among the total number of patients analyzed, 829 had active cancer. Overall, the cohort included 100 patients who simultaneously had cancer and SARS-CoV-2 infection. The course of COVID-19 was less severe in cancer patients, including a significantly lower incidence of viral and bacterial pneumonia, occurring more frequently as a contributory disease or coexisting morbidity, or as SARS-CoV-2 positivity without viral disease. SARS-CoV-2 positivity was more frequent among non-metastatic than metastatic cancer cases, and in specific tumor types including hematologic malignancies. COVID-19 was more frequently found to be directly involved in the fatal sequence in patients undergoing active anticancer therapy, but less frequently in perioperative status, suggesting that the underlying malignancy and consequent surgery are more important factors leading to death perioperatively than viral disease. The course of COVID-19 in cancer patients was milder and balanced during the pandemic. This may be due to relative immunosuppressed status, and the fact that even early/mild viral infections can easily upset their condition, leading to death from their underlying cancer or its complications. LA - English DB - MTMT ER - TY - JOUR AU - Jones, S. AU - Juhász, Alexandra Csilla AU - Makaula, P. AU - Cunningham, L. J. AU - Archer, J. AU - Nkolokosa, C. AU - Namacha, G. AU - Kambewa, E. AU - Lally, D. AU - Kapira, D. R. AU - Chammudzi, P. AU - Kayuni, S. A. AU - Musaya, J. AU - Stothard, J. Russell TI - A first report of Pseudosuccinea columella (Say, 1817), an alien intermediate host for liver fluke, in Malawi JF - PARASITES AND VECTORS J2 - PARASITE VECT VL - 17 PY - 2024 IS - 1 PG - 5 SN - 1756-3305 DO - 10.1186/s13071-024-06241-5 UR - https://m2.mtmt.hu/api/publication/34833210 ID - 34833210 AB - Starting in October 2021, quarterly malacological surveys have been undertaken in Malawi, with the sampling of 12 specified freshwater habitats throughout a calendar year. Each survey monitors the presence of aquatic intermediate snail hosts of medical and veterinary importance. In March 2023, the alien lymnaeid species Pseudosuccinea columella was encountered for the first time in the surveys, in Nsanje District. This species identity was later confirmed upon DNA analysis of mitochondrial ribosomal 16S sequences. In July 2023, P. columella was also noted at single sites within Mangochi and Chikwawa Districts, and again in Nsanje District, with an additional location observed. Of particular importance, our sampled location in Mangochi District was directly connected to Lake Malawi, which expands the species list of invasive molluscs in this lake. While P. columella is a well-known intermediate snail host for human and animal fascioliasis, screening collected snails for trematode cercariae, alongside molecular xenomonitoring, did not yield equivocal evidence of active fluke infection. However, the newly recognized presence of this alien intermediate snail host within Lake Malawi, and along the Shire River Valley, flags a new concern in altered local transmission potential for human and animal fascioliasis. LA - English DB - MTMT ER - TY - JOUR AU - Kovacs, Arpad AU - Zhazykbayeva, Saltanat AU - Herwig, Melissa AU - Fueloep, Gabor a. AU - Csipo, Tamas AU - Olah, Nikolett AU - Hassoun, Roua AU - Budde, Heidi AU - Osman, Hersh AU - Kacmaz, Mustafa AU - Jaquet, Kornelia AU - Priksz, Daniel AU - Juhasz, Bela AU - Akin, Ibrahim AU - Papp, Zoltan AU - Schmidt, Wolfgang E. AU - Muegge, Andreas AU - El-Battrawy, Ibrahim AU - Toth, Attila AU - Hamdani, Nazha TI - Sex-specific cardiovascular remodeling leads to a divergent sex-dependent development of heart failure in aged hypertensive rats JF - GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE) J2 - GEROSCIENCE VL - In press PY - 2024 PG - 19 SN - 2509-2715 DO - 10.1007/s11357-024-01160-w UR - https://m2.mtmt.hu/api/publication/34831833 ID - 34831833 AB - Introduction The prevalence of heart failure with preserved ejection fraction (HFpEF) is continuously rising and predominantly affects older women often hypertensive and/or obese or diabetic. Indeed, there is evidence on sex differences in the development of HF. Hence, we studied cardiovascular performance dependent on sex and age as well as pathomechanisms on a cellular and molecular level.Methods We studied 15-week- and 1-year-old female and male hypertensive transgenic rats carrying the mouse Ren-2 renin gene (TG) and compared them to wild-type (WT) controls at the same age. We tracked blood pressure and cardiac function via echocardiography. After sacrificing the 1-year survivors we studied vascular smooth muscle and endothelial function. Isolated single skinned cardiomyocytes were used to determine passive stiffness and Ca2+-dependent force. In addition, Western blots were applied to analyse the phosphorylation status of sarcomeric regulatory proteins, titin and of protein kinases AMPK, PKG, CaMKII as well as their expression. Protein kinase activity assays were used to measure activities of CaMKII, PKG and angiotensin-converting enzyme (ACE).Results TG male rats showed significantly higher mortality at 1 year than females or WT male rats. Left ventricular (LV) ejection fraction was specifically reduced in male, but not in female TG rats, while LV diastolic dysfunction was evident in both TG sexes, but LV hypertrophy, increased LV ACE activity, and reduced AMPK activity as evident from AMPK hypophosphorylation were specific to male rats. Sex differences were also observed in vascular and cardiomyocyte function showing different response to acetylcholine and Ca2+-sensitivity of force production, respectively cardiomyocyte functional changes were associated with altered phosphorylation states of cardiac myosin binding protein C and cardiac troponin I phosphorylation in TG males only. Cardiomyocyte passive stiffness was increased in TG animals. On a molecular level titin phosphorylation pattern was altered, though alterations were sex-specific. Thus, also the reduction of PKG expression and activity was more pronounced in TG females. However, cardiomyocyte passive stiffness was restored by PKG and CaMKII treatments in both TG sexes.Conclusion Here we demonstrated divergent sex-specific cardiovascular adaptation to the over-activation of the renin-angiotensin system in the rat. Higher mortality of male TG rats in contrast to female TG rats was observed as well as reduced LV systolic function, whereas females mainly developed HFpEF. Though both sexes developed increased myocardial stiffness to which an impaired titin function contributes to a sex-specific molecular mechanism. The functional derangements of titin are due to a sex-specific divergent regulation of PKG and CaMKII systems. LA - English DB - MTMT ER - TY - JOUR AU - Győrffy, Balázs TI - Integrated analysis of public datasets for the discovery and validation of survival-associated genes in solid tumors JF - INNOVATION(UNITED STATES) J2 - INNOVATION(UNITED STATES) VL - 5 PY - 2024 IS - 3 PG - 9 SN - 2666-6758 DO - 10.1016/j.xinn.2024.100625 UR - https://m2.mtmt.hu/api/publication/34831592 ID - 34831592 N1 - Department of Biophysics, Medical School, University of Pecs, Pecs, 7624, Hungary Department of Bioinformatics, Semmelweis University, Budapest, 1094, Hungary Cancer Biomarker Research Group, Institute of Molecular Life Sciences, HUN-REN Research Centre for Natural Sciences, Budapest, 1117, Hungary Export Date: 3 May 2024 Correspondence Address: Győrffy, B.; Department of Biophysics, Hungary; email: gyorffy.balazs@yahoo.com LA - English DB - MTMT ER - TY - JOUR AU - Benkő, Beáta Mária AU - Tóth, Gergő AU - Moldvai, Dorottya AU - Kádár, Szabina AU - Szabó, Edina AU - Szabó, Zoltán-István AU - Mazákné Kraszni, Márta AU - Szente, Lajos AU - Fiser, Béla AU - Sebestyén, Anna AU - Zelkó, Romána AU - Sebe, István TI - Cyclodextrin encapsulation enabling the anticancer repositioning of disulfiram: Preparation, analytical and in vitro biological characterization of the inclusion complexes JF - INTERNATIONAL JOURNAL OF PHARMACEUTICS J2 - INT J PHARM VL - In press PY - 2024 SN - 0378-5173 DO - 10.1016/j.ijpharm.2024.124187 UR - https://m2.mtmt.hu/api/publication/34830527 ID - 34830527 LA - English DB - MTMT ER - TY - JOUR AU - Cseprekál, Orsolya AU - Rosivall, László TI - Budapest nephrology school - 30 years of history - from modest start to an international success: systematic summary of the 27th BNS held between 28th August and 2nd of September 2023 JF - RENAL FAILURE J2 - RENAL FAILURE VL - 46 PY - 2024 IS - 1 PG - 5 SN - 0886-022X DO - 10.1080/0886022X.2023.2282709 UR - https://m2.mtmt.hu/api/publication/34830464 ID - 34830464 AB - Budapest Nephrology School (BNS) could have celebrated its 30th event if it had not been interrupted by COVID pandemic for a few years. Yet, the organization of 27th BNS in August 2023 resumed its successful and traditional activities at Semmelweis University, in the beautiful central European city of Budapest. In over two decades, BNS has faithfully adapted to the changes and developments of medical science and clinical nephrology, the fact which has kept it unique and attractive for nephrologists from across the globe. With such a long history and representing the top international professors of nephrology, BNS has proved to be a successful one-week, in-person refreshing course which has attracted over 1600 medical doctors from more than 60 countries. It has well served as an academic meeting point suitable for networking and exchange of up-to-date knowledge presented by the best international experts in nephrology. The dedication and focus of these experts on education, research and patient care represent the very concept of translational medicine. The invaluable experience of the past 27 years has set the standards for BNS to contribute to the evolution of translational nephrology in Europe in the next decade. LA - English DB - MTMT ER - TY - JOUR AU - Smith, K. AU - Beach, D. AU - Silva, R. AU - Győrffy, Balázs AU - Salani, F. AU - Crea, F. TI - Comprehensive analysis of differentially expressed miRNAs in hepatocellular carcinoma: Prognostic, predictive significance and pathway insights JF - PLOS ONE J2 - PLOS ONE VL - 19 PY - 2024 PG - 13 SN - 1932-6203 DO - 10.1371/journal.pone.0296198 UR - https://m2.mtmt.hu/api/publication/34828997 ID - 34828997 N1 - Cancer Research Group-School of Life Health and Chemical Sciences, The Open University, Milton Keynes, United Kingdom School of Life Sciences, University of Sussex, Brighton, United Kingdom Department of Medicine, Cancer Research Program Research Institute, the McGill University Health Centre, McGill University, Montreal, Canada Department of Bioinformatics, Semmelweis University, Budapest, Hungary Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy Institute of Interdisciplinary Research “Health Science”, Scuola Superiore Sant’Anna, Pisa, Italy Research Centre for Natural Sciences, Institute of Molecular Life Sciences, Budapest, Hungary Export Date: 3 May 2024 CODEN: POLNC Correspondence Address: Salani, F.; Cancer Research Group-School of Life Health and Chemical Sciences, United Kingdom; email: f.salani1@gmail.com Chemicals/CAS: MicroRNAs LA - English DB - MTMT ER - TY - JOUR AU - Puska, Gina AU - Szendi, Vivien AU - Dobolyi, Árpád TI - Lateral septum as a possible regulatory center of maternal behaviors JF - NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS J2 - NEUROSCI BIOBEHAV R VL - 161 PY - 2024 PG - 11 SN - 0149-7634 DO - 10.1016/j.neubiorev.2024.105683 UR - https://m2.mtmt.hu/api/publication/34828140 ID - 34828140 LA - English DB - MTMT ER - TY - JOUR AU - Kerpel-Fronius, Sándor AU - Gottwald, M. AU - Arányi, P. AU - Renczes, G. AU - Görbe, Anikó AU - Papp, Renáta Emese AU - Ferdinandy, Péter TI - Past and future of an IMI-PharmaTrain (IMI-PhT)-initiated multinational pharmaceutical medicine course at the Semmelweis University in Hungary JF - FRONTIERS IN PHARMACOLOGY J2 - FRONT PHARMACOL VL - 15 PY - 2024 PG - 8 SN - 1663-9812 DO - 10.3389/fphar.2024.1394987 UR - https://m2.mtmt.hu/api/publication/34827426 ID - 34827426 AB - The pharmaceutical medicine course at the Semmelweis University of Budapest, Hungary, was initiated as part of the Innovative Medicines Initiative (IMI is the main program, IMI-PharmaTrain is one of the IMI projects) Pharmaceutical Medicine Training Programs (16 IMI Call 2008/1/16). The aim was to extend training in the development of pharmaceutical medicine to those EU member states where no such education was present. The final program envisaged the development of a cooperative education supported by universities located in Central and Eastern Europe. It was considered to be the economically and scientifically most viable approach to combine the expertise from these countries to form a united teaching staff and provide education jointly for young professionals of the region. Semmelweis University was selected to manage this coordinated program. In this report, we describe the organization and functioning of this international university-based pharmaceutical medicine education project called the Cooperative European Medicines Development Course (CEMDC) and evaluate its successes and shortcomings. During the pandemic, the educational course was interrupted. The follow-on program is reorganized as a postgraduate MSc course named “Semmelweis Pharma MBA” and will be started in 2025. It will continue the established PharmaTrain educational tradition. However, it will deal in more detail with the transition from basic pharmacological to industrial research, as well as biopharmaceutical formulation and manufacturing and marketing aspects of medicines development. LA - English DB - MTMT ER -