@article{MTMT:34833996,
	title = {A Systematic Review and Meta-Analysis of microRNA Profiling Studies in Chronic Kidney Diseases},
	url = {https://m2.mtmt.hu/api/publication/34833996},
	author = {Gantsetseg, Garmaa and Bunduc, Stefania and Kói, Tamás and Hegyi, Péter and Csupor, Dezső and Dariimaa, Ganbat and Dembrovszky, Fanni and Meznerics, Fanni Adél and Ailar, Nasirzadeh and Cristina, Barbagallo and Kökény, Gábor},
	doi = {10.3390/ncrna10030030},
	journal-iso = {NON-CODING RNA},
	journal = {NON-CODING RNA},
	volume = {10},
	unique-id = {34833996},
	year = {2024},
	eissn = {2311-553X},
	orcid-numbers = {Gantsetseg, Garmaa/0000-0001-9631-8635; Hegyi, Péter/0000-0003-0399-7259; Csupor, Dezső/0000-0002-4088-3333; Dembrovszky, Fanni/0000-0001-6953-3591; Kökény, Gábor/0000-0002-0345-6914}
}

@article{MTMT:34833220,
	title = {Autopsy findings in cancer patients infected with SARS-CoV-2 show a milder presentation of COVID-19 compared to non-cancer patients.},
	url = {https://m2.mtmt.hu/api/publication/34833220},
	author = {Kocsmár, Éva and Kocsmár, Ildikó and Elamin, Flóra and Pápai, Laura and Jakab, Ákos and Várkonyi, Tibor and Glasz, Tibor and Rácz, Gergely and Pesti, Adrián István and Danics, Krisztina and Kiss, András and Röst, Gergely and Belicza, Éva and Schaff, Zsuzsa and Lotz, Gábor},
	doi = {10.1007/s11357-024-01163-7},
	journal-iso = {GEROSCIENCE},
	journal = {GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)},
	volume = {In press},
	unique-id = {34833220},
	issn = {2509-2715},
	abstract = {COVID-19, caused by SARS-CoV-2, manifests with differing severity across distinct patient subgroups, with outcomes influenced by underlying comorbidities such as cancer, which may cause functional and compositional alterations of the immune system during tumor progression. We aimed to investigate the association of SARS-CoV-2 infection and its complications with cancer in a large autopsy series and the role of COVID-19 in the fatal sequence leading to death. A total of 2641 adult autopsies were investigated, 539 of these were positive for SARS-CoV-2. Among the total number of patients analyzed, 829 had active cancer. Overall, the cohort included 100 patients who simultaneously had cancer and SARS-CoV-2 infection. The course of COVID-19 was less severe in cancer patients, including a significantly lower incidence of viral and bacterial pneumonia, occurring more frequently as a contributory disease or coexisting morbidity, or as SARS-CoV-2 positivity without viral disease. SARS-CoV-2 positivity was more frequent among non-metastatic than metastatic cancer cases, and in specific tumor types including hematologic malignancies. COVID-19 was more frequently found to be directly involved in the fatal sequence in patients undergoing active anticancer therapy, but less frequently in perioperative status, suggesting that the underlying malignancy and consequent surgery are more important factors leading to death perioperatively than viral disease. The course of COVID-19 in cancer patients was milder and balanced during the pandemic. This may be due to relative immunosuppressed status, and the fact that even early/mild viral infections can easily upset their condition, leading to death from their underlying cancer or its complications.},
	keywords = {CANCER; pathology; Autopsy; pneumonia; COVID-19; SARS-CoV-2},
	year = {2024},
	eissn = {2509-2723},
	pages = {In press},
	orcid-numbers = {Várkonyi, Tibor/0000-0002-8126-3982; Glasz, Tibor/0000-0003-2947-2733; Pesti, Adrián István/0000-0001-6706-6221; Danics, Krisztina/0000-0002-3694-5706; Kiss, András/0000-0002-7453-3163; Röst, Gergely/0000-0001-9476-3284; Belicza, Éva/0000-0002-2472-1318; Schaff, Zsuzsa/0000-0002-6429-8059; Lotz, Gábor/0000-0002-6921-8978}
}

@article{MTMT:34833210,
	title = {A first report of Pseudosuccinea columella (Say, 1817), an alien intermediate host for liver fluke, in Malawi},
	url = {https://m2.mtmt.hu/api/publication/34833210},
	author = {Jones, S. and Juhász, Alexandra Csilla and Makaula, P. and Cunningham, L. J. and Archer, J. and Nkolokosa, C. and Namacha, G. and Kambewa, E. and Lally, D. and Kapira, D. R. and Chammudzi, P. and Kayuni, S. A. and Musaya, J. and Stothard, J. Russell},
	doi = {10.1186/s13071-024-06241-5},
	journal-iso = {PARASITE VECT},
	journal = {PARASITES AND VECTORS},
	volume = {17},
	unique-id = {34833210},
	issn = {1756-3305},
	abstract = {Starting in October 2021, quarterly malacological surveys have been undertaken in Malawi, with the sampling of 12 specified freshwater habitats throughout a calendar year. Each survey monitors the presence of aquatic intermediate snail hosts of medical and veterinary importance. In March 2023, the alien lymnaeid species Pseudosuccinea columella was encountered for the first time in the surveys, in Nsanje District. This species identity was later confirmed upon DNA analysis of mitochondrial ribosomal 16S sequences. In July 2023, P. columella was also noted at single sites within Mangochi and Chikwawa Districts, and again in Nsanje District, with an additional location observed. Of particular importance, our sampled location in Mangochi District was directly connected to Lake Malawi, which expands the species list of invasive molluscs in this lake. While P. columella is a well-known intermediate snail host for human and animal fascioliasis, screening collected snails for trematode cercariae, alongside molecular xenomonitoring, did not yield equivocal evidence of active fluke infection. However, the newly recognized presence of this alien intermediate snail host within Lake Malawi, and along the Shire River Valley, flags a new concern in altered local transmission potential for human and animal fascioliasis.},
	keywords = {real-time PCR; parasitology; fascioliasis; Fasciola; Lake Malawi; Lymnaeids; Molecular xenomonitoring},
	year = {2024},
	eissn = {1756-3305}
}

@article{MTMT:34831833,
	title = {Sex-specific cardiovascular remodeling leads to a divergent sex-dependent development of heart failure in aged hypertensive rats},
	url = {https://m2.mtmt.hu/api/publication/34831833},
	author = {Kovacs, Arpad and Zhazykbayeva, Saltanat and Herwig, Melissa and Fueloep, Gabor a. and Csipo, Tamas and Olah, Nikolett and Hassoun, Roua and Budde, Heidi and Osman, Hersh and Kacmaz, Mustafa and Jaquet, Kornelia and Priksz, Daniel and Juhasz, Bela and Akin, Ibrahim and Papp, Zoltan and Schmidt, Wolfgang E. and Muegge, Andreas and El-Battrawy, Ibrahim and Toth, Attila and Hamdani, Nazha},
	doi = {10.1007/s11357-024-01160-w},
	journal-iso = {GEROSCIENCE},
	journal = {GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)},
	volume = {In press},
	unique-id = {34831833},
	issn = {2509-2715},
	abstract = {Introduction The prevalence of heart failure with preserved ejection fraction (HFpEF) is continuously rising and predominantly affects older women often hypertensive and/or obese or diabetic. Indeed, there is evidence on sex differences in the development of HF. Hence, we studied cardiovascular performance dependent on sex and age as well as pathomechanisms on a cellular and molecular level.Methods We studied 15-week- and 1-year-old female and male hypertensive transgenic rats carrying the mouse Ren-2 renin gene (TG) and compared them to wild-type (WT) controls at the same age. We tracked blood pressure and cardiac function via echocardiography. After sacrificing the 1-year survivors we studied vascular smooth muscle and endothelial function. Isolated single skinned cardiomyocytes were used to determine passive stiffness and Ca2+-dependent force. In addition, Western blots were applied to analyse the phosphorylation status of sarcomeric regulatory proteins, titin and of protein kinases AMPK, PKG, CaMKII as well as their expression. Protein kinase activity assays were used to measure activities of CaMKII, PKG and angiotensin-converting enzyme (ACE).Results TG male rats showed significantly higher mortality at 1 year than females or WT male rats. Left ventricular (LV) ejection fraction was specifically reduced in male, but not in female TG rats, while LV diastolic dysfunction was evident in both TG sexes, but LV hypertrophy, increased LV ACE activity, and reduced AMPK activity as evident from AMPK hypophosphorylation were specific to male rats. Sex differences were also observed in vascular and cardiomyocyte function showing different response to acetylcholine and Ca2+-sensitivity of force production, respectively cardiomyocyte functional changes were associated with altered phosphorylation states of cardiac myosin binding protein C and cardiac troponin I phosphorylation in TG males only. Cardiomyocyte passive stiffness was increased in TG animals. On a molecular level titin phosphorylation pattern was altered, though alterations were sex-specific. Thus, also the reduction of PKG expression and activity was more pronounced in TG females. However, cardiomyocyte passive stiffness was restored by PKG and CaMKII treatments in both TG sexes.Conclusion Here we demonstrated divergent sex-specific cardiovascular adaptation to the over-activation of the renin-angiotensin system in the rat. Higher mortality of male TG rats in contrast to female TG rats was observed as well as reduced LV systolic function, whereas females mainly developed HFpEF. Though both sexes developed increased myocardial stiffness to which an impaired titin function contributes to a sex-specific molecular mechanism. The functional derangements of titin are due to a sex-specific divergent regulation of PKG and CaMKII systems.},
	keywords = {PHOSPHORYLATION; DYSFUNCTION; SEX; PATHWAY; STRESS; Health; ACTIVATED PROTEIN-KINASE; CamKII; CamKII; STIFFNESS; PRESERVED EJECTION FRACTION; Heart failure with preserved ejection fraction; PKG},
	year = {2024},
	eissn = {2509-2723},
	orcid-numbers = {Hamdani, Nazha/0000-0002-3053-0008}
}

@article{MTMT:34831592,
	title = {Integrated analysis of public datasets for the discovery and validation of survival-associated genes in solid tumors},
	url = {https://m2.mtmt.hu/api/publication/34831592},
	author = {Győrffy, Balázs},
	doi = {10.1016/j.xinn.2024.100625},
	journal-iso = {INNOVATION(UNITED STATES)},
	journal = {INNOVATION(UNITED STATES)},
	volume = {5},
	unique-id = {34831592},
	year = {2024},
	eissn = {2666-6758},
	orcid-numbers = {Győrffy, Balázs/0000-0002-5772-3766}
}

@article{MTMT:34830527,
	title = {Cyclodextrin encapsulation enabling the anticancer repositioning of disulfiram: Preparation, analytical and in vitro biological characterization of the inclusion complexes},
	url = {https://m2.mtmt.hu/api/publication/34830527},
	author = {Benkő, Beáta Mária and Tóth, Gergő and Moldvai, Dorottya and Kádár, Szabina and Szabó, Edina and Szabó, Zoltán-István and Mazákné Kraszni, Márta and Szente, Lajos and Fiser, Béla and Sebestyén, Anna and Zelkó, Romána and Sebe, István},
	doi = {10.1016/j.ijpharm.2024.124187},
	journal-iso = {INT J PHARM},
	journal = {INTERNATIONAL JOURNAL OF PHARMACEUTICS},
	volume = {In press},
	unique-id = {34830527},
	issn = {0378-5173},
	year = {2024},
	eissn = {1873-3476},
	orcid-numbers = {Benkő, Beáta Mária/0000-0002-3608-6219; Tóth, Gergő/0000-0001-5341-319X; Szabó, Edina/0000-0001-9616-5122; Szabó, Zoltán-István/0000-0002-8740-0212; Mazákné Kraszni, Márta/0000-0003-4364-9486; Sebestyén, Anna/0000-0001-8814-4794; Zelkó, Romána/0000-0002-5419-9137; Sebe, István/0000-0003-0752-781X}
}

@article{MTMT:34830464,
	title = {Budapest nephrology school - 30 years of history - from modest start to an international success: systematic summary of the 27th BNS held between 28th August and 2nd of September 2023},
	url = {https://m2.mtmt.hu/api/publication/34830464},
	author = {Cseprekál, Orsolya and Rosivall, László},
	doi = {10.1080/0886022X.2023.2282709},
	journal-iso = {RENAL FAILURE},
	journal = {RENAL FAILURE},
	volume = {46},
	unique-id = {34830464},
	issn = {0886-022X},
	abstract = {Budapest Nephrology School (BNS) could have celebrated its 30th event if it had not been interrupted by COVID pandemic for a few years. Yet, the organization of 27th BNS in August 2023 resumed its successful and traditional activities at Semmelweis University, in the beautiful central European city of Budapest. In over two decades, BNS has faithfully adapted to the changes and developments of medical science and clinical nephrology, the fact which has kept it unique and attractive for nephrologists from across the globe. With such a long history and representing the top international professors of nephrology, BNS has proved to be a successful one-week, in-person refreshing course which has attracted over 1600 medical doctors from more than 60 countries. It has well served as an academic meeting point suitable for networking and exchange of up-to-date knowledge presented by the best international experts in nephrology. The dedication and focus of these experts on education, research and patient care represent the very concept of translational medicine. The invaluable experience of the past 27 years has set the standards for BNS to contribute to the evolution of translational nephrology in Europe in the next decade.},
	keywords = {education; Budapest; nephrology; Translational medicine},
	year = {2024},
	eissn = {1525-6049},
	orcid-numbers = {Cseprekál, Orsolya/0000-0003-2867-3875; Rosivall, László/0000-0002-9809-3879}
}

@article{MTMT:34828997,
	title = {Comprehensive analysis of differentially expressed miRNAs in hepatocellular carcinoma: Prognostic, predictive significance and pathway insights},
	url = {https://m2.mtmt.hu/api/publication/34828997},
	author = {Smith, K. and Beach, D. and Silva, R. and Győrffy, Balázs and Salani, F. and Crea, F.},
	doi = {10.1371/journal.pone.0296198},
	journal-iso = {PLOS ONE},
	journal = {PLOS ONE},
	volume = {19},
	unique-id = {34828997},
	issn = {1932-6203},
	year = {2024},
	eissn = {1932-6203},
	orcid-numbers = {Győrffy, Balázs/0000-0002-5772-3766}
}

@article{MTMT:34828140,
	title = {Lateral septum as a possible regulatory center of maternal behaviors},
	url = {https://m2.mtmt.hu/api/publication/34828140},
	author = {Puska, Gina and Szendi, Vivien and Dobolyi, Árpád},
	doi = {10.1016/j.neubiorev.2024.105683},
	journal-iso = {NEUROSCI BIOBEHAV R},
	journal = {NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS},
	volume = {161},
	unique-id = {34828140},
	issn = {0149-7634},
	year = {2024},
	eissn = {1873-7528},
	orcid-numbers = {Dobolyi, Árpád/0000-0003-0397-2991}
}

@article{MTMT:34827426,
	title = {Past and future of an IMI-PharmaTrain (IMI-PhT)-initiated multinational pharmaceutical medicine course at the Semmelweis University in Hungary},
	url = {https://m2.mtmt.hu/api/publication/34827426},
	author = {Kerpel-Fronius, Sándor and Gottwald, M. and Arányi, P. and Renczes, G. and Görbe, Anikó and Papp, Renáta Emese and Ferdinandy, Péter},
	doi = {10.3389/fphar.2024.1394987},
	journal-iso = {FRONT PHARMACOL},
	journal = {FRONTIERS IN PHARMACOLOGY},
	volume = {15},
	unique-id = {34827426},
	abstract = {The pharmaceutical medicine course at the Semmelweis University of Budapest, Hungary, was initiated as part of the Innovative Medicines Initiative (<xref ref-type="bibr" rid="B6">IMI</xref> is the main program, IMI-PharmaTrain is one of the IMI projects) Pharmaceutical Medicine Training Programs (16 IMI Call 2008/1/16). The aim was to extend training in the development of pharmaceutical medicine to those EU member states where no such education was present. The final program envisaged the development of a cooperative education supported by universities located in Central and Eastern Europe. It was considered to be the economically and scientifically most viable approach to combine the expertise from these countries to form a united teaching staff and provide education jointly for young professionals of the region. Semmelweis University was selected to manage this coordinated program. In this report, we describe the organization and functioning of this international university-based pharmaceutical medicine education project called the Cooperative European Medicines Development Course (CEMDC) and evaluate its successes and shortcomings. During the pandemic, the educational course was interrupted. The follow-on program is reorganized as a postgraduate MSc course named “Semmelweis Pharma MBA” and will be started in 2025. It will continue the established PharmaTrain educational tradition. However, it will deal in more detail with the transition from basic pharmacological to industrial research, as well as biopharmaceutical formulation and manufacturing and marketing aspects of medicines development.},
	year = {2024},
	eissn = {1663-9812},
	orcid-numbers = {Kerpel-Fronius, Sándor/0000-0002-3245-7414; Görbe, Anikó/0000-0003-4908-1094; Ferdinandy, Péter/0000-0002-6424-6806}
}