TY  - JOUR
AU  - Connolly, Stuart J.
AU  - Sharma, Mukul
AU  - Cohen, Alexander T.
AU  - Demchuk, Andrew M.
AU  - Członkowska, Anna
AU  - Lindgren, Arne G.
AU  - Molina, Carlos A.
AU  - Bereczki, Dániel
AU  - Toni, Danilo
AU  - Seiffge, David J.
AU  - Tanne, David
AU  - Sandset, Else Charlotte
AU  - Tsivgoulis, Georgios
AU  - Christensen, Hanne
AU  - Beyer-Westendorf, Jan
AU  - Coutinho, Jonathan M.
AU  - Crowther, Mark
AU  - Verhamme, Peter
AU  - Amarenco, Pierre
AU  - Roine, Risto O.
AU  - Mikulik, Robert
AU  - Lemmens, Robin
AU  - Veltkamp, Roland
AU  - Middeldorp, Saskia
AU  - Robinson, Thompson G.
AU  - Milling, Truman John
AU  - Tedim-Cruz, Vitor
AU  - Lang, Wilfried
AU  - Himmelmann, Anders
AU  - Ladenvall, Per
AU  - Knutsson, Mikael
AU  - Ekholm, Ella
AU  - Law, Andrew
AU  - Taylor, Amanda
AU  - Karyakina, Tetyana
AU  - Xu, Lizhen
AU  - Tsiplova, Kate
AU  - Poli, Sven
AU  - Kallmünzer, Bernd
AU  - Gumbinger, Christoph
AU  - Shoamanesh, Ashkan
TI  - Andexanet for Factor Xa Inhibitor–Associated Acute Intracerebral Hemorrhage
JF  - NEW ENGLAND JOURNAL OF MEDICINE
J2  - NEW ENGL J MED
VL  - 390
PY  - 2024
IS  - 19
SP  - 1745
EP  - 1755
PG  - 11
SN  - 0028-4793
DO  - 10.1056/NEJMoa2313040
UR  - https://m2.mtmt.hu/api/publication/34871953
ID  - 34871953
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Lengyel, Balázs Csaba
AU  - Stang, Rita
AU  - Pál, Hanga
AU  - Debreczeni, Róbert
AU  - Sándor, Ágnes Dóra
AU  - Székely, Andrea
AU  - Gyürki, Dániel László
AU  - Csippa, Benjamin
AU  - István, Lilla
AU  - Kovács, Illés
AU  - Sótonyi, Péter
AU  - Mihály, Zsuzsanna
TI  - Non-Invasive Tools in Perioperative Stroke Risk Assessment for Asymptomatic Carotid Artery Stenosis with a Focus on the Circle of Willis
JF  - JOURNAL OF CLINICAL MEDICINE
J2  - J CLIN MED
VL  - 13
PY  - 2024
IS  - 9
PG  - 21
SN  - 2077-0383
DO  - 10.3390/jcm13092487
UR  - https://m2.mtmt.hu/api/publication/34863880
ID  - 34863880
AB  - This review aims to explore advancements in perioperative ischemic stroke risk estimation for asymptomatic patients with significant carotid artery stenosis, focusing on Circle of Willis (CoW) morphology based on the CTA or MR diagnostic imaging in the current preoperative diagnostic algorithm. Functional transcranial Doppler (fTCD), near-infrared spectroscopy (NIRS), and optical coherence tomography angiography (OCTA) are discussed in the context of evaluating cerebrovascular reserve capacity and collateral vascular systems, particularly the CoW. These non-invasive diagnostic tools provide additional valuable insights into the cerebral perfusion status. They support biomedical modeling as the gold standard for the prediction of the potential impact of carotid artery stenosis on the hemodynamic changes of cerebral perfusion. Intraoperative risk assessment strategies, including selective shunting, are explored with a focus on CoW variations and their implications for perioperative ischemic stroke and cognitive function decline. By synthesizing these insights, this review underscores the potential of non-invasive diagnostic methods to support clinical decision making and improve asymptomatic patient outcomes by reducing the risk of perioperative ischemic neurological events and preventing further cognitive decline.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
ED  - Tegze, Nárcis / Interviewed person
AU  - Koller, Zsófia
TI  - Derékfájdalom neuropathiás komponenssel
JF  - MOZGÁSSZERVI TOVÁBBKÉPZŐ SZEMLE : INTERDISZCIPLINÁRIS SZAKMAI LAP
J2  - MOZGÁSSZERVI TOVÁBBKÉPZŐ SZEMLE
VL  - 7
PY  - 2024
IS  - 1
SP  - 37
EP  - 38
PG  - 2
SN  - 2630-8924
UR  - https://m2.mtmt.hu/api/publication/34847267
ID  - 34847267
LA  - Hungarian
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Cavallieri, Francesco
AU  - Sellner, Johann
AU  - Akhvlediani, Tamar
AU  - Bassetti, Claudio L.
AU  - Bereczki, Dániel
AU  - Fanciulli, Alessandra
AU  - Filipovic, Sasa R.
AU  - Guekht, Alla
AU  - Helbok, Raimund
AU  - Hochmeister, Sonja
AU  - Martinelli, Boneschi Filippo
AU  - von, Oertzen Tim J.
AU  - Oezturk, Serefnur
AU  - Priori, Alberto
AU  - Ramankulov, Dauren
AU  - Willekens, Barbara
AU  - Rakusa, Martin
AU  - Moro, Elena
TI  - The European Academy of Neurology NeuroCOVID-19 Task Force: A lesson for the future
JF  - EUROPEAN JOURNAL OF NEUROLOGY
J2  - EUR J NEUROL
PY  - 2024
PG  - 8
SN  - 1351-5101
DO  - 10.1111/ene.16321
UR  - https://m2.mtmt.hu/api/publication/34847128
ID  - 34847128
AB  - Background: The COVID-19 pandemic has made its mark on world history forever causing millions of deaths, and straining health systems, economies, and societies worldwide. The European Academy of Neurology (EAN) reacted promptly. A special NeuroCOVID-19 Task Force was set up at the beginning of the pandemic to promote knowledge, research, international collaborations, and raise awareness about the prevention and treatment of COVID-19-related neurological issues. Methods: Activities carried out during and after the pandemic by the EAN NeuroCOVID-19 Task Force are described. The main aim was to review all these initiatives in detail as an overarching lesson from the past to improve the present and be better prepared in case of future pandemics. Results: During the pandemic, the Task Force was engaged in several initiatives: the creation of the EAN NEuro-covid ReGistrY (ENERGY); the launch of several surveys (neurological manifestations of COVID-19 infection; the pandemic's impact on patients with chronic neurological diseases; the pandemic's impact of restrictions for clinical practice, curricular training, and health economics); the publication of position papers regarding the management of patients with neurological diseases during the pandemic, and vaccination hesitancy among people with chronic neurological disorders; and the creation of a dedicated "COVID-19 Breaking News" section in EANpages. Conclusions: The EAN NeuroCOVID-19 Task Force was immediately engaged in various activities to participate in the fight against COVID-19. The Task Force's concerted strategy may serve as a foundation for upcoming global neurological emergencies.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Sisa-Vajda, Szilvia
AU  - Gunda, Bence
AU  - Knézy, Krisztina
AU  - Barsi, Péter
AU  - Varga, Csaba
AU  - Maurovich-Horvat, Pál
AU  - Bereczki, Dániel
AU  - Nagy, Zoltán Zsolt
TI  - Arteria centralis retinae elzáródás thrombolysiskezelése és multidiszciplináris ellátása a hagyományos szemészeti kezelési formákkal összehasonlítva
JF  - IDEGGYOGYASZATI SZEMLE / CLINICAL NEUROSCIENCE
J2  - IDEGGYOGY SZEMLE
VL  - 77
PY  - 2024
IS  - 3-4
SP  - 89
EP  - 96
PG  - 8
SN  - 0019-1442
DO  - 10.18071/isz.77.0089
UR  - https://m2.mtmt.hu/api/publication/34780867
ID  - 34780867
AB  - Háttér és cél – Az arteria centralis retinae okklúzió (ACRO) eddigi konzervatív terápiái limitált hatékonyságúak, szemészeti osztályokon történtek, ahogyan az egységes protokoll nélküli etiológiai vizsgálatok is. Pedig az ACRO a központi idegrendszeri ischaemiás stroke analógiájának tekinthető, így a szisztémás thrombolysis és a multidiszciplináris ellátás hasonlóan hatékony lehet. Emiatt 2022 májusa óta a Semmelweis Egyetemen klinikai vizsgálat keretében a 4,5 órán belül diagnosztizált ACRO thrombolysiskezelését és etiológiai vizsgálatait végezzük egységes protokoll alapján. Vizsgálatunk célja a szemészeti, nem protokoll szerinti, és a multidiszciplináris, protokoll szerinti ACRO-ellátás összehasonlítása. Módszerek – Áttekintettük a 2013 és 2022 között a Szemészeti Klinikán ACRO-val konzervatívan és 6 órán belül paracentesissel is kezelt betegek látásélesség-változását, fellelhető neurológiai és cardiovascularis vizsgálatainak eredményeit, valamint a thrombolysisprojekt keretében ellátott betegeket. Eredmények – A 78 nem protokoll szerinti ellátásban részesülő betegnél látásjavulást természetes lefolyás esetén 37%, konzervatív kezelés mellett 47%, paracentesissel 47%-nál láttunk. Szignifikáns carotisstenosis négy, carotisdissectio egy, cardialis emboliaforrás hat, óriássejtes arteritis egy esetben igazolódott; endarterectomián két beteg esett át. A protokoll szerinti klinikai vizsgálatba négy, időablakon belüli betegből három egyezett bele, náluk thrombolysis történt. Két betegnek javult a visusa, két betegnél szignifikáns carotisstenosis igazolódott, és endarterectomián estek át, egy betegnél novum pitvarfibrilláció miatt antikoagulálást kezdtünk. Következtetés – A terápiás időablakon belül jelentkező ACRO-betegek ritkák, a thrombolysis hatásosságának megítéléséhez nagyobb betegszám szükséges. Az egységes vizsgálati protokoll azonban egyértelműen elősegíti az etiológiai diagnózist, így a további, akár súlyosabb formában jelentkező thromboemboliás szövődmények megelőzését.
LA  - Hungarian
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Csukly, Gábor
AU  - Tombor, László
AU  - Hidasi, Zoltán
AU  - Csibri, Eva
AU  - Fullajtár, Máté
AU  - Huszár, Zsolt
AU  - Koszovácz, Vanda
AU  - Lányi, Orsolya
AU  - Vass, Edit
AU  - Koleszár, Boróka
AU  - Kóbor, István
AU  - Farkas, Katalin
AU  - Rosenfeld, Viktória
AU  - Berente, Dalida Borbála
AU  - Bolla, Gergő Levente
AU  - Kiss, Mate
AU  - Kamondi, Anita
AU  - Horváth, András Attila
TI  - Low Functional network integrity in cognitively unimpaired and MCI subjects with depressive symptoms. results from a multi-center fMRI study.
TS  - results from a multi-center fMRI study.
JF  - TRANSLATIONAL PSYCHIATRY
J2  - TRANSL PSYCHIAT
VL  - 14
PY  - 2024
IS  - 1
PG  - 11
SN  - 2158-3188
DO  - 10.1038/s41398-024-02891-2
UR  - https://m2.mtmt.hu/api/publication/34774958
ID  - 34774958
N1  - Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary            
            Neurocognitive Research Center, National Institute of Mental Health, Neurology, Neurosurgery, Budapest, Hungary            
            Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary            
            Medical Imaging Centre, Semmelweis University, Budapest, Hungary            
            Neurocognitive Research Center, National Institute of Mental Health, Neurology, Neurosurgery, Budapest, Hungary            
            Department of Measurement and Information Systems, University of Technology and Economics, Budapest, Hungary            
            Siemens Healthcare, Budapest, Hungary            
            Department of Neurology, Semmelweis University, Budapest, Hungary            
            Department of Anatomy Histology and Embryology, Semmelweis University, Budapest, Hungary            
            Export Date: 24 April 2024; Cited By: 0
AB  - Evidence suggests that depressive symptomatology is a consequence of network dysfunction rather than lesion pathology. We studied whole-brain functional connectivity using a Minimum Spanning Tree as a graph-theoretical approach. Furthermore, we examined functional connectivity in the Default Mode Network, the Frontolimbic Network (FLN), the Salience Network, and the Cognitive Control Network. All 183 elderly subjects underwent a comprehensive neuropsychological evaluation and a 3 Tesla brain MRI scan. To assess the potential presence of depressive symptoms, the 13-item version of the Beck Depression Inventory (BDI) or the Geriatric Depression Scale (GDS) was utilized. Participants were assigned into three groups based on their cognitive status: amnestic mild cognitive impairment (MCI), non-amnestic MCI, and healthy controls. Regarding affective symptoms, subjects were categorized into depressed and non-depressed groups. An increased mean eccentricity and network diameter were found in patients with depressive symptoms relative to non-depressed ones, and both measures showed correlations with depressive symptom severity. In patients with depressive symptoms, a functional hypoconnectivity was detected between the Anterior Cingulate Cortex (ACC) and the right amygdala in the FLN, which impairment correlated with depressive symptom severity. While no structural difference was found in subjects with depressive symptoms, the volume of the hippocampus and the thickness of the precuneus and the entorhinal cortex were decreased in subjects with MCI, especially in amnestic MCI. The increase in eccentricity and diameter indicates a more path-like functional network configuration that may lead to an impaired functional integration in depression, a possible cause of depressive symptomatology in the elderly.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Leone, M.A.
AU  - Helbok, R.
AU  - Bianchi, E.
AU  - Yasuda, C.L.
AU  - Konti, M.
AU  - Ramankulov, D.
AU  - Lolich, M.
AU  - Lovrencic-Huzjan, A.
AU  - Kovács, Tibor
AU  - Armon, C.
AU  - Cotelli, M.S.
AU  - Cavallieri, F.
AU  - Grosu, O.
AU  - Kiteva-Trenchevska, G.
AU  - Rodriguez-Leyva, I.
AU  - Boldingh, M.
AU  - Brola, W.
AU  - Maia, L.F.
AU  - de, Seabra M.M.L.
AU  - Davidescu, E.I.
AU  - Popescu, B.O.
AU  - Kopishinskaia, S.
AU  - Bassetti, C.L.A.
AU  - Moro, E.
ED  - Bereczki, Dániel / Collaborator
TI  - Outcome predictors of post-COVID conditions in the European Academy of Neurology COVID-19 registry
JF  - JOURNAL OF NEUROLOGY
J2  - J NEUROL
PY  - 2024
SN  - 0340-5354
DO  - 10.1007/s00415-024-12212-8
UR  - https://m2.mtmt.hu/api/publication/34772248
ID  - 34772248
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Frisoni, Giovanni B
AU  - Festari, Cristina
AU  - Massa, Federico
AU  - Cotta Ramusino, Matteo
AU  - Orini, Stefania
AU  - Aarsland, Dag
AU  - Agosta, Federica
AU  - Babiloni, Claudio
AU  - Borroni, Barbara
AU  - Cappa, Stefano F
AU  - Frederiksen, Kristian S
AU  - Froelich, Lutz
AU  - Garibotto, Valentina
AU  - Haliassos, Alexander
AU  - Jessen, Frank
AU  - Kamondi, Anita
AU  - Kessels, Roy Pc
AU  - Morbelli, Silvia D
AU  - O'Brien, John T
AU  - Otto, Markus
AU  - Perret-Liaudet, Armand
AU  - Pizzini, Francesca B
AU  - Vandenbulcke, Mathieu
AU  - Vanninen, Ritva
AU  - Verhey, Frans
AU  - Vernooij, Meike W
AU  - Yousry, Tarek
AU  - Boada Rovira, Mercè
AU  - Dubois, Bruno
AU  - Georges, Jean
AU  - Hansson, Oskar
AU  - Ritchie, Craig W
AU  - Scheltens, Philip
AU  - van der Flier, Wiesje M
AU  - Nobili, Flavio
TI  - European intersocietal recommendations for the biomarker-based diagnosis of neurocognitive disorders
JF  - LANCET NEUROLOGY
J2  - LANCET NEUROL
VL  - 23
PY  - 2024
IS  - 3
SP  - 302
EP  - 312
PG  - 11
SN  - 1474-4422
DO  - 10.1016/S1474-4422(23)00447-7
UR  - https://m2.mtmt.hu/api/publication/34627801
ID  - 34627801
N1  - Journal Article; Review
AB  - The recent commercialisation of the first disease-modifying drugs for Alzheimer's disease emphasises the need for consensus recommendations on the rational use of biomarkers to diagnose people with suspected neurocognitive disorders in memory clinics. Most available recommendations and guidelines are either disease-centred or biomarker-centred. A European multidisciplinary taskforce consisting of 22 experts from 11 European scientific societies set out to define the first patient-centred diagnostic workflow that aims to prioritise testing for available biomarkers in individuals attending memory clinics. After an extensive literature review, we used a Delphi consensus procedure to identify 11 clinical syndromes, based on clinical history and examination, neuropsychology, blood tests, structural imaging, and, in some cases, EEG. We recommend first-line and, if needed, second-line testing for biomarkers according to the patient's clinical profile and the results of previous biomarker findings. This diagnostic workflow will promote consistency in the diagnosis of neurocognitive disorders across European countries.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Kamondi, Anita
AU  - Grigg-Damberger, Madeleine
AU  - Löscher, Wolfgang
AU  - Tanila, Heikki
AU  - Horváth, András Attila
TI  - Epilepsy and epileptiform activity in late-onset Alzheimer disease. clinical and pathophysiological advances, gaps and conundrums
TS  - clinical and pathophysiological advances, gaps and conundrums
JF  - NATURE REVIEWS NEUROLOGY
J2  - NAT REV NEUROL
VL  - 20
PY  - 2024
IS  - 3
SP  - 162
EP  - 182
PG  - 21
SN  - 1759-4758
DO  - 10.1038/s41582-024-00932-4
UR  - https://m2.mtmt.hu/api/publication/34596897
ID  - 34596897
N1  - Journal Article; Review
AB  - A growing body of evidence has demonstrated a link between Alzheimer disease (AD) and epilepsy. Late-onset epilepsy and epileptiform activity can precede cognitive deterioration in AD by years, and its presence has been shown to predict a faster disease course. In animal models of AD, amyloid and tau pathology are linked to cortical network hyperexcitability that precedes the first signs of memory decline. Thus, detection of epileptiform activity in AD has substantial clinical importance as a potential novel modifiable risk factor for dementia. In this Review, we summarize the epidemiological evidence for the complex bidirectional relationship between AD and epilepsy, examine the effect of epileptiform activity and seizures on cognition in people with AD, and discuss the precision medicine treatment strategies based on the latest research in human and animal models. Finally, we outline some of the unresolved questions of the field that should be addressed by rigorous research, including whether particular clinicopathological subtypes of AD have a stronger association with epilepsy, and the sequence of events between epileptiform activity and amyloid and tau pathology.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Bankó, Éva Mária
AU  - Weiss, Béla
AU  - Hevesi, István
AU  - Manga, Annamária Eszter
AU  - Vakli, Pál
AU  - Havadi-Nagy, Menta
AU  - Kelemen, Rebeka
AU  - Somogyi, Eszter
AU  - Homolya, István
AU  - Bihari, Adél
AU  - Simon, Ádám
AU  - Nárai, Ádám
AU  - Tóth, Krisztina
AU  - Báthori, Noémi
AU  - Tomacsek, Vivien
AU  - Horváth, András Attila
AU  - Kamondi, Anita
AU  - Racsmány, Mihály
AU  - Dénes, Ádám
AU  - Simor, Péter
AU  - Kovács, Tibor
AU  - Hermann, Petra
AU  - Vidnyánszky, Zoltán
TI  - Study protocol of the Hungarian Longitudinal Study of Healthy Brain Aging (HuBA).
JF  - IDEGGYOGYASZATI SZEMLE / CLINICAL NEUROSCIENCE
J2  - IDEGGYOGY SZEMLE
VL  - 77
PY  - 2024
IS  - 1-2
SP  - 51
EP  - 59
PG  - 9
SN  - 0019-1442
DO  - 10.18071/isz.77.0051
UR  - https://m2.mtmt.hu/api/publication/34568140
ID  - 34568140
N1  - Funding Agency and Grant Number: Hungarian National Research, Development and Innovation Office [2019-2.1.7-ERANET-2020-00008]; European Union [RRF-2.3.1-21-202200015]; HUN-REN [0708-21 515 AT]; Ministry of Culture and Innovation of Hungary from the National-Research, Development, and Innovation Fund
            Funding text: This research was supported by the Hungarian National Research, Development and Innovation Office (grant number 2019-2.1.7-ERANET-2020-00008) and Project no. RRF-2.3.1-21-202200015, which has been implemented with the support provided by the European Union. This work was also supported by a grant from HUN-REN (0708-21 515 AT) to MR and ZV. NB was supported by the Ministry of Culture and Innovation of Hungary from the National-Research, Development, and Innovation Fund, financed under the TKP2021EGA funding scheme. We thank Szandra Pancsusak and Emilia Nagy for managing patient logistics and are very grateful to all participants for their time and participation in this study.
AB  - Neuro­cog­nitive aging and the associated brain diseases impose a major social and economic burden. Therefore, substantial efforts have been put into revealing the lifestyle, the neurobiological and the genetic underpinnings of healthy neurocognitive aging. However, these studies take place almost exclusively in a limited number of highly-developed countries. Thus, it is an important open question to what extent their findings may generalize to neurocognitive aging in other, not yet investigated regions. The purpose of the Hungarian Longitudinal Study of Healthy Brain Aging (HuBA) is to collect multi-modal longitudinal data on healthy neurocognitive aging to address the data gap in this field in Central and Eastern Europe..We adapted the Australian Ima­ging, Biomarkers and Lifestyle (AIBL) study of aging study protocol to local circumstances and collected demographic, lifestyle, men­tal and physical health, medication and medical history related information as well as re­cor­ded a series of magnetic resonance imaging (MRI) data. In addition, participants were al­so offered to participate in the collection of blood samples to assess circulating in­flam­matory biomarkers as well as a sleep study aimed at evaluating the general sleep quality based on multi-day collection of subjective sleep questionnaires and whole-night elec­troencephalographic (EEG) data..Baseline data collection has al­ready been accomplished for more than a hundred participants and data collection in the se­condsession is on the way. The collected data might reveal specific local trends or could also indicate the generalizability of previous findings. Moreover, as the HuBA protocol al­so offers a sleep study designed for tho­rough characterization of participants’ sleep quality and related factors, our extended multi-modal dataset might provide a base for incorporating these measures into healthy and clinical aging research. .Besides its straightforward na­tional benefits in terms of health ex­pen­di­ture, we hope that this Hungarian initiative could provide results valid for the whole Cent­ral and Eastern European region and could also promote aging and Alzheimer’s disease research in these countries..
LA  - English
DB  - MTMT
ER  -