TY - JOUR AU - Eszlári, Nóra AU - Hullám, Gábor István AU - Gál, Zsófia AU - Török, Dóra AU - Nagy, Tamás AU - Millinghoffer, András Dániel AU - Baksa, Dániel AU - Gonda, Xénia AU - Antal, Péter AU - Bagdy, György AU - Juhász, Gabriella TI - Olfactory genes affect major depression in highly educated, emotionally stable, lean women: a bridge between animal models and precision medicine JF - TRANSLATIONAL PSYCHIATRY J2 - TRANSL PSYCHIAT VL - 14 PY - 2024 IS - 1 PG - 10 SN - 2158-3188 DO - 10.1038/s41398-024-02867-2 UR - https://m2.mtmt.hu/api/publication/34779723 ID - 34779723 N1 - Funding Agency and Grant Number: Hungarian National Research, Development, and Innovation Office [K 139330, K 143391, PD 146014, 2019-2.1.7-ERA-NET-2020-00005, ERAPERMED2019-108]; Hungarian Brain Research Program [2017-1.2.1-NKP-2017-00002]; Hungarian Brain Research Program 3.0 [NAP2022-I-4/2022, TKP2021-EGA-25]; Ministry of Innovation and Technology of Hungary National Research, Development and Innovation Fund [TKP2021-EGA-25]; National Research, Development, and Innovation Fund of Hungary [TKP2021-EGA-02]; European Union [RRF-2.3.1-21-2022-00004]; New National Excellence Program of the Ministry for Culture and Innovation National Research, Development and Innovation Fund [UNKP-23-4-II-SE-2]; Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences; Semmelweis University; [UNKP-22-4-II-SE-1] Funding text: This study was supported by the Hungarian National Research, Development, and Innovation Office, with grants K 139330, K 143391, and PD 146014, as well as 2019-2.1.7-ERA-NET-2020-00005 under the frame of ERA PerMed (ERAPERMED2019-108); by the Hungarian Brain Research Program (grant: 2017-1.2.1-NKP-2017-00002) and the Hungarian Brain Research Program 3.0 (NAP2022-I-4/2022); and by TKP2021-EGA-25, implemented with the support provided by the Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund, financed under the TKP2021-EGA funding scheme. It was also supported by the National Research, Development, and Innovation Fund of Hungary under Grant TKP2021-EGA-02 and the European Union project RRF-2.3.1-21-2022-00004 within the framework of the Artificial Intelligence National Laboratory. NE was supported by the UNKP-22-4-II-SE-1, and DB by the UNKP-23-4-II-SE-2 New National Excellence Program of the Ministry for Culture and Innovation from the source of the National Research, Development and Innovation Fund. NE is supported by the Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences. This work uses data provided by patients and collected by the NHS as part of their care and support. Copyright (c) (2019), NHS England. Re-used with the permission of the UK Biobank (Application Number 1602). All rights reserved.Open access funding provided by Semmelweis University. AB - Most current approaches to establish subgroups of depressed patients for precision medicine aim to rely on biomarkers that require highly specialized assessment. Our present aim was to stratify participants of the UK Biobank cohort based on three readily measurable common independent risk factors, and to investigate depression genomics in each group to discover common and separate biological etiology. Two-step cluster analysis was run separately in males ( n = 149,879) and females ( n = 174,572), with neuroticism (a tendency to experience negative emotions), body fat percentage, and years spent in education as input variables. Genome-wide association analyses were implemented within each of the resulting clusters, for the lifetime occurrence of either a depressive episode or recurrent depressive disorder as the outcome. Variant-based, gene-based, gene set-based, and tissue-specific gene expression test were applied. Phenotypically distinct clusters with high genetic intercorrelations in depression genomics were found. A two-cluster solution was the best model in each sex with some differences including the less important role of neuroticism in males. In females, in case of a protective pattern of low neuroticism, low body fat percentage, and high level of education, depression was associated with pathways related to olfactory function. While also in females but in a risk pattern of high neuroticism, high body fat percentage, and less years spent in education, depression showed association with complement system genes. Our results, on one hand, indicate that alteration of olfactory pathways, that can be paralleled to the well-known rodent depression models of olfactory bulbectomy, might be a novel target towards precision psychiatry in females with less other risk factors for depression. On the other hand, our results in multi-risk females may provide a special case of immunometabolic depression. LA - English DB - MTMT ER - TY - JOUR AU - Alpay, Pelin AU - Kocsel, Natália AU - Galambos, Attila AU - Kökönyei, Gyöngyi TI - The relationship between alexithymia, rumination and binge drinking among university students JF - PERSONALITY AND INDIVIDUAL DIFFERENCES J2 - PERS INDIV DIFFER VL - 223 PY - 2024 PG - 6 SN - 0191-8869 DO - 10.1016/j.paid.2024.112621 UR - https://m2.mtmt.hu/api/publication/34752694 ID - 34752694 N1 - Export Date: 16 April 2024 CODEN: PEIDD Correspondence Address: Kökönyei, G.; Institute of Psychology, Hungary; email: kokonyei.gyongyi@ppk.elte.hu LA - English DB - MTMT ER - TY - JOUR AU - Gonda, Xénia TI - Reconceptualising depression along the endogenuous-reactive spectrum: GWAS shows involvement of different genes in depression depending on presence vs absence of exposure to stress. SP40.02 TS - SP40.02 JF - EUROPEAN PSYCHIATRY J2 - EUR PSYCHIAT PY - 2024 SN - 0924-9338 UR - https://m2.mtmt.hu/api/publication/34740737 ID - 34740737 N1 - 32nd European Congress of Psychiatry, 2024. április 6-9, Budapest. Előadás SP40.02 LA - English DB - MTMT ER - TY - JOUR AU - Csikos, Mate AU - Krause, Sándor AU - Gal, Zsofia AU - Bagdy, Gyorgy AU - Juhasz, Gabriella. AU - Gonda, Xénia AU - Torok, Dora TI - Larks under pressure: The genetic background of the morning chronotype may contribute to depression in interaction with stress. EPV0407 TS - EPV0407 JF - EUROPEAN PSYCHIATRY J2 - EUR PSYCHIAT PY - 2024 SN - 0924-9338 UR - https://m2.mtmt.hu/api/publication/34740442 ID - 34740442 N1 - 32nd European Congress of Psychiatry, 2024. április 6-9, Budapest. EPV0407 LA - English DB - MTMT ER - TY - JOUR AU - Biliczki, Judit AU - Bognár, Judit AU - B. Pólya, Dorottya AU - Somogyi, Szilvia AU - Sutori, Sára AU - Gonda, Xénia AU - Hamvas, Szilárd AU - Réthelyi, János TI - Psychological understanding of Anorexia nervosa gained from combined clinical care. EPV0455 TS - EPV0455 JF - EUROPEAN PSYCHIATRY J2 - EUR PSYCHIAT PY - 2024 SN - 0924-9338 UR - https://m2.mtmt.hu/api/publication/34740426 ID - 34740426 N1 - 32nd European Congress of Psychiatry, 2024. április 6-9, Budapest. EPV0455 LA - English DB - MTMT ER - TY - JOUR AU - Pribula, Viktoria AU - Kiraly, Lilien AU - Biliczki, Judit AU - Pongracz, Fanni AU - Ruscsak, Peter AU - B. Vadon, Nikolett AU - Erdelyi- Hamza, Berta AU - A. Renko, Tamara AU - Szocs, Henrietta AU - Vizin, Gabriella AU - Gonda, Xénia TI - Multidimensional assessment of personality disorders using different theoretical models: a comparison of the Young Schema Questionnaire, the SCID-5-AMPD structured diagnostic interview, and the PDS-ICD-11 self-report questionnaire. EPP0024 TS - EPP0024 JF - EUROPEAN PSYCHIATRY J2 - EUR PSYCHIAT PY - 2024 SN - 0924-9338 UR - https://m2.mtmt.hu/api/publication/34740415 ID - 34740415 N1 - 32nd European Congress of Psychiatry. 2024. április 6-9. Poszter EPP0024 LA - English DB - MTMT ER - TY - JOUR AU - Gonda, Xénia AU - Krause, Sándor AU - Erdelyi-Hamza, Berta AU - Sutori, Sara AU - Gal, Zsofia AU - Eszlari, Nora AU - Bagdy, Gyorgy AU - Juhasz, Gabriella AU - Torok, Dora TI - GWAS in interaction with childhood traumas implicates novel variants and genes previously associated with suiciderelated factors in the background of suicidal ideation. EPP0586 TS - EPP0586 JF - EUROPEAN PSYCHIATRY J2 - EUR PSYCHIAT PY - 2024 SN - 0924-9338 UR - https://m2.mtmt.hu/api/publication/34740399 ID - 34740399 N1 - 32nd European Congress of Psychiatry. 2024. április 6-9, Budapest. Poszter EPP0586 LA - English DB - MTMT ER - TY - JOUR AU - Zábó, Virág AU - Erát, Dávid AU - Vargha, András AU - Harangozó, Judit AU - Iváncsics, Máté László AU - Vincze, Ágnes AU - Farkas, Judit AU - Balogh, Gábor AU - Cowden, Richard AU - Pongrácz, Fanni AU - Bognár, Judit AU - Nagy, Enikő AU - Purebl, György AU - Gonda, Xénia TI - Mental health competencies are stronger determinants of well-being than mental disorder symptoms even in psychiatric samples JF - EUROPEAN PSYCHIATRY J2 - EUR PSYCHIAT PY - 2024 SN - 0924-9338 UR - https://m2.mtmt.hu/api/publication/34740391 ID - 34740391 N1 - 32nd European Congress of Psychiatry. 2024. április 6-9 Budapest, Poszter. LA - English DB - MTMT ER - TY - JOUR AU - Zábó, Virág AU - Erát, Dávid AU - Gonda, Xénia AU - Harangozó, Judit AU - Iváncsics, Máté László AU - Vincze, Ágnes AU - Farkas, Judit AU - Balogh, Gábor AU - Cowden, Richard AU - Oláh, Attila AU - Kéri, Szabolcs AU - Purebl, György AU - Vargha, András TI - Psychological immunity: A new mental health test for psychiatric samples. EPP0053 TS - EPP0053 JF - EUROPEAN PSYCHIATRY J2 - EUR PSYCHIAT PY - 2024 SN - 0924-9338 UR - https://m2.mtmt.hu/api/publication/34740378 ID - 34740378 N1 - 32nd European Congress of Psychiatry. 2024. április 6-9. Poszter EPP0053 LA - English DB - MTMT ER - TY - JOUR AU - Szabó, Georgina Irén AU - Szigeti F., Judit AU - Sipos, Miklos AU - Varbiro, Szabolcs AU - Gonda, Xénia TI - Dominant depressive, anxious and cyclothymic affective temperaments lower the chance of infertility treatment success. EPV1127 TS - EPV1127 JF - EUROPEAN PSYCHIATRY J2 - EUR PSYCHIAT PY - 2024 SN - 0924-9338 UR - https://m2.mtmt.hu/api/publication/34740356 ID - 34740356 N1 - 32nd European Congress of Psychiatry. 2024. április 6-9 Budapest. EPV1127. Poszter, EPV1127 LA - English DB - MTMT ER -