@CONFERENCE{MTMT:35314817,
	title = {Development and characterization of a Nanofibrous Ophthalmic Insert for the Treatment of Age-related Macular Degeneration},
	url = {https://m2.mtmt.hu/api/publication/35314817},
	author = {Nochta-Kazsoki, Adrienn Katalin and Abboud, Houssam and Niczinger, Noémi and Nándor, Nagy and Zelkó, Romána},
	booktitle = {PhD Scientific Days 2024},
	unique-id = {35314817},
	year = {2024},
	orcid-numbers = {Nochta-Kazsoki, Adrienn Katalin/0000-0002-0611-3124; Abboud, Houssam/0009-0001-5833-6506; Niczinger, Noémi/0000-0002-2076-0643; Zelkó, Romána/0000-0002-5419-9137}
}

@article{MTMT:35181230,
	title = {Formulation and Development of Nanofiber-Based Ophthalmic Insert for the Treatment of Bacterial Conjunctivitis},
	url = {https://m2.mtmt.hu/api/publication/35181230},
	author = {Farkas, Eszter and Abboud, Houssam and Nagy, Nándor and Hofmeister, Bálint and Ostorházi, Eszter and Tóth, Bence and Pinke, Balázs and Mészáros, László and Zelkó, Romána and Nochta-Kazsoki, Adrienn Katalin},
	doi = {10.3390/ijms25179228},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {25},
	unique-id = {35181230},
	issn = {1661-6596},
	year = {2024},
	eissn = {1422-0067},
	orcid-numbers = {Abboud, Houssam/0009-0001-5833-6506; Nagy, Nándor/0000-0002-6223-5214; Ostorházi, Eszter/0000-0002-9459-7316; Mészáros, László/0000-0001-5979-7403; Zelkó, Romána/0000-0002-5419-9137; Nochta-Kazsoki, Adrienn Katalin/0000-0002-0611-3124}
}

@article{MTMT:35149948,
	title = {Microfluidic Rheology: An Innovative Method for Viscosity Measurement of Gels and Various Pharmaceuticals},
	url = {https://m2.mtmt.hu/api/publication/35149948},
	author = {Vilimi, Zsófia and Pápay, Zsófia Edit and Basa, Bálint and Orekhova, Xeniya and Kállai-Szabó, Nikolett and Antal, István},
	doi = {10.3390/gels10070464},
	journal-iso = {GELS-BASEL},
	journal = {GELS (BASEL)},
	volume = {10},
	unique-id = {35149948},
	abstract = {Measuring the viscosity of pharmaceutical dosage forms is a crucial process. Viscosity provides information about the stability of the composition, the release rate of the drug, bioavailability, and, in the case of injectable drug formulations, even the force required for injection. However, measuring viscosity is a complex task with numerous challenges, especially for non-Newtonian materials, which include most pharmaceutical formulations, such as gels. Selecting the appropriate shear rate is critical. Since viscosity in many systems is highly temperature-dependent, stable temperature control is necessary during the measurement. Using microfluidics technology, it is now possible to perform rheological characterization and conduct fast and accurate measurements. Small sample volumes (even below 500 µL) are required, and viscosity determination can be carried out over a wide range of shear rates. Nevertheless, the pharmaceutical application of viscometers operating on the principle of microfluidics is not yet widespread. In our work, we compare the results of measurements taken with a microfluidic chip-based viscometer on different pharmaceutical forms (gels, solution) with those obtained using a traditional rotational viscometer, evaluating the relative advantages and disadvantages of the different methods. The microfluidics-based method enables time- and sample-efficient viscosity analysis of the examined pharmaceutical forms.},
	year = {2024},
	eissn = {2310-2861},
	orcid-numbers = {Vilimi, Zsófia/0000-0002-9241-5267; Pápay, Zsófia Edit/0000-0002-7653-1065; Basa, Bálint/0000-0003-4546-1727; Kállai-Szabó, Nikolett/0000-0002-8164-3993; Antal, István/0000-0002-5434-201X}
}

@article{MTMT:35062202,
	title = {Fluid Dynamics Optimization of Microfluidic Diffusion Systems for Assessment of Transdermal Drug Delivery: An Experimental and Simulation Study},
	url = {https://m2.mtmt.hu/api/publication/35062202},
	author = {Kocsis, Dorottya and Dhinakaran, Shanmugam and Pandey, Divyam and Laki, András József and Laki, Mária and Sztankovics, Dániel and Lengyel, Miléna and Vrábel, Judit and Naszlady, Márton Bese and Sebestyén, Anna and Ponmozhi, Jeyaraj and Antal, István and Erdő, Franciska},
	doi = {10.3390/scipharm92020035},
	journal-iso = {SCI PHARM},
	journal = {SCIENTIA PHARMACEUTICA},
	volume = {92},
	unique-id = {35062202},
	issn = {0036-8709},
	abstract = {Organ-on-a-chip technologies show exponential growth driven by the need to reduce the number of experimental animals and develop physiologically relevant human models for testing drugs. In vitro, microfluidic devices should be carefully designed and fabricated to provide reliable tools for modeling physiological or pathological conditions and assessing, for example, drug delivery through biological barriers. The aim of the current study was to optimize the utilization of three existing skin-on-a-chip microfluidic diffusion chambers with various designs. For this, different perfusion flow rates were compared using cellulose acetate membrane, polyester membrane, excised rat skin, and acellular alginate scaffold in the chips. These diffusion platforms were integrated into a single-channel microfluidic diffusion chamber, a multi-channel chamber, and the LiveBox2 system. The experimental results revealed that the 40 µL/min flow rate resulted in the highest diffusion of the hydrophilic model formulation (2% caffeine cream) in each system. The single-channel setup was used for further analysis by computational fluid dynamics simulation. The visualization of shear stress and fluid velocity within the microchannel and the presentation of caffeine progression with the perfusion fluid were consistent with the measured data. These findings contribute to the development and effective application of microfluidic systems for penetration testing.},
	year = {2024},
	eissn = {2218-0532},
	orcid-numbers = {Kocsis, Dorottya/0000-0001-7908-3248; Dhinakaran, Shanmugam/0000-0002-7785-4130; Sztankovics, Dániel/0009-0007-3168-1151; Lengyel, Miléna/0000-0001-8865-054X; Naszlady, Márton Bese/0000-0001-8114-1750; Sebestyén, Anna/0000-0001-8814-4794; Ponmozhi, Jeyaraj/0000-0002-8215-6476; Antal, István/0000-0002-5434-201X; Erdő, Franciska/0000-0001-6265-3777}
}

@article{MTMT:34871984,
	title = {Long-Term Implicit Epigenetic Stress Information in the Enteric Nervous System and its Contribution to Developing and Perpetuating IBS},
	url = {https://m2.mtmt.hu/api/publication/34871984},
	author = {Császár-Nagy, Noémi and Bob, Petr and Bókkon, István},
	doi = {10.2174/1570159X22666240507095700},
	journal-iso = {CURR NEUROPHARMACOL},
	journal = {CURRENT NEUROPHARMACOLOGY},
	volume = {22},
	unique-id = {34871984},
	issn = {1570-159X},
	abstract = {Psychiatric and mood disorders may play an important role in the development and persistence of irritable bowel syndrome (IBS). Previously, we hypothesized that stress-induced implicit memories may persist throughout life via epigenetic processes in the enteric nervous system (ENS), independent of the central nervous system (CNS). These epigenetic memories in the ENS may contribute to developing and perpetuating IBS. Here, we further elaborate on our earlier hypothesis. That is, during pregnancy, maternal prenatal stresses perturb the HPA axis and increase circulating cortisol levels, which can affect the maternal gut microbiota. Maternal cortisol can cross the placental barrier and increase cortisol-circulating levels in the fetus. This leads to dysregulation of the HPA axis, affecting the gut microbiota, microbial metabolites, and intestinal permeability in the fetus. Microbial metabolites, such as short-chain fatty acids (which also regulate the development of fetal ENS), can modulate a range of diseases by inducing epigenetic changes. These mentioned processes suggest that stress-related, implicit, long-term epigenetic memories may be programmed into the fetal ENS during pregnancy. Subsequently, this implicit epigenetic stress information from the fetal ENS could be conveyed to the CNS through the bidirectional microbiota-gut-brain axis (MGBA), leading to perturbed functional connectivity among various brain networks and the dysregulation of affective and pain processes.},
	keywords = {Short-chain fatty acids; IBS; Microbiota-gut-brain-axis; stress; Implicit epigenetic long-term memory},
	year = {2024},
	eissn = {1875-6190},
	pages = {2100-2112},
	orcid-numbers = {Császár-Nagy, Noémi/0000-0001-9972-8189}
}

@article{MTMT:34821651,
	title = {A Mass Spectrometry Strategy for Protein Quantification Based on the Differential Alkylation of Cysteines Using Iodoacetamide and Acrylamide},
	url = {https://m2.mtmt.hu/api/publication/34821651},
	author = {Virág, Dávid and Schlosser, Gitta (Vácziné) and Borbély, Adina Noémi and Gellén, Gabriella and Papp, Dávid and Kaleta, Zoltán and Dalmadiné Kiss, Borbála and Antal, István and Ludányi, Krisztina},
	doi = {10.3390/ijms25094656},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {25},
	unique-id = {34821651},
	issn = {1661-6596},
	abstract = {Mass spectrometry has become the most prominent yet evolving technology in quantitative proteomics. Today, a number of label-free and label-based approaches are available for the relative and absolute quantification of proteins and peptides. However, the label-based methods rely solely on the employment of stable isotopes, which are expensive and often limited in availability. Here we propose a label-based quantification strategy, where the mass difference is identified by the differential alkylation of cysteines using iodoacetamide and acrylamide. The alkylation reactions were performed under identical experimental conditions; therefore, the method can be easily integrated into standard proteomic workflows. Using high-resolution mass spectrometry, the feasibility of this approach was assessed with a set of tryptic peptides of human serum albumin. Several critical questions, such as the efficiency of labeling and the effect of the differential alkylation on the peptide retention and fragmentation, were addressed. The concentration of the quality control samples calculated against the calibration curves were within the ±20% acceptance range. It was also demonstrated that heavy labeled peptides exhibit a similar extraction recovery and matrix effect to light ones. Consequently, the approach presented here may be a viable and cost-effective alternative of stable isotope labeling strategies for the quantification of cysteine-containing proteins.},
	year = {2024},
	eissn = {1422-0067},
	orcid-numbers = {Virág, Dávid/0000-0001-8411-0773; Schlosser, Gitta (Vácziné)/0000-0002-7637-7133; Borbély, Adina Noémi/0000-0002-5506-6555; Papp, Dávid/0000-0002-2006-7777; Kaleta, Zoltán/0000-0003-2350-5100; Dalmadiné Kiss, Borbála/0000-0002-5774-7880; Antal, István/0000-0002-5434-201X; Ludányi, Krisztina/0000-0002-2380-9529}
}

@article{MTMT:34813473,
	title = {Mathematical modeling of transdermal delivery of topical drug formulations in a dynamic microfluidic diffusion chamber in health and disease},
	url = {https://m2.mtmt.hu/api/publication/34813473},
	author = {Szederkényi, Gábor and Kocsis, Dorottya and Vághy, Mihály András and Czárán, Domonkos Tamás and Sasvári, Péter and Lengyel, Miléna and Naszlady, Márton Bese and Kreis, F and Antal, István and Csépányi-Kömi, Roland and Erdő, Franciska},
	doi = {10.1371/journal.pone.0299501},
	journal-iso = {PLOS ONE},
	journal = {PLOS ONE},
	volume = {19},
	unique-id = {34813473},
	issn = {1932-6203},
	abstract = {Mathematical models of epidermal and dermal transport are essential for optimization and development of products for percutaneous delivery both for local and systemic indication and for evaluation of dermal exposure to chemicals for assessing their toxicity. These models often help directly by providing information on the rate of drug penetration through the skin and thus on the dermal or systemic concentration of drugs which is the base of their pharmacological effect. The simulations are also helpful in analyzing experimental data, reducing the number of experiments and translating the in vitro investigations to an in-vivo setting. In this study skin penetration of topically administered caffeine cream was investigated in a skin-on-a-chip microfluidic diffusion chamber at room temperature and at 32̊C. Also the transdermal penetration of caffeine in healthy and diseased conditions was compared in mouse skins from intact, psoriatic and allergic animals. In the last experimental setup dexamethasone, indomethacin, piroxicam and diclofenac were examined as a cream formulation for absorption across the dermal barrier. All the measured data were used for making mathematical simulation in a three-compartmental model. The calculated and measured results showed a good match, which findings indicate that our mathematical model might be applied for prediction of drug delivery through the skin under different circumstances and for various drugs in the novel, miniaturized diffusion chamber. © 2024 Szederkényi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License,},
	keywords = {ABSORPTION; DEXAMETHASONE; ARTICLE; MOUSE; PREDICTION; nonhuman; in vitro study; simulation; drug formulation; drug delivery system; indometacin; room temperature; CAFFEINE; diclofenac; mathematical model; piroxicam; drug penetration; cream; Product development; diffusion chamber; psoriasis; Epidermis; compartment model; skin penetration; dermis; skin on a chip},
	year = {2024},
	eissn = {1932-6203},
	orcid-numbers = {Szederkényi, Gábor/0000-0003-4199-6089; Lengyel, Miléna/0000-0001-8865-054X; Antal, István/0000-0002-5434-201X; Csépányi-Kömi, Roland/0000-0001-6825-7142}
}

@article{MTMT:34796435,
	title = {External quality assurance program for diagnostic complement laboratories: evaluation of the results of the past seven years},
	url = {https://m2.mtmt.hu/api/publication/34796435},
	author = {Kirschfink, M. and Frazer-Abel, A. and Bertalanné Balogh, Emese and Goseberg, S. and Weiss, N. and Prohászka, Zoltán},
	doi = {10.3389/fimmu.2024.1368399},
	journal-iso = {FRONT IMMUNOL},
	journal = {FRONTIERS IN IMMUNOLOGY},
	volume = {15},
	unique-id = {34796435},
	issn = {1664-3224},
	year = {2024},
	eissn = {1664-3224},
	orcid-numbers = {Bertalanné Balogh, Emese/0000-0002-1127-3923; Prohászka, Zoltán/0000-0003-1761-7982}
}

@article{MTMT:34631071,
	title = {Microparticles and multi-unit systems for advanced drug delivery},
	url = {https://m2.mtmt.hu/api/publication/34631071},
	author = {Kállai-Szabó, Nikolett and Farkas, Dóra and Lengyel, Miléna and Basa, Bálint and Fleck, C. and Antal, István},
	doi = {10.1016/j.ejps.2024.106704},
	journal-iso = {EUR J PHARM SCI},
	journal = {EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES},
	volume = {194},
	unique-id = {34631071},
	issn = {0928-0987},
	year = {2024},
	eissn = {1879-0720},
	orcid-numbers = {Kállai-Szabó, Nikolett/0000-0002-8164-3993; Farkas, Dóra/0000-0003-4737-2108; Lengyel, Miléna/0000-0001-8865-054X; Basa, Bálint/0000-0003-4546-1727; Antal, István/0000-0002-5434-201X}
}

@article{MTMT:34506340,
	title = {Long-term shelf-life liposomes for delivery of prednisolone and budesonide},
	url = {https://m2.mtmt.hu/api/publication/34506340},
	author = {Budavári, Bálint Péter and Karancsi, Áron and Pinke, Balázs Gábor and Pállinger, Éva and Juriga-Tóth, Krisztina and Király, Márton and Szász, Adrienn Zsófia and Voszka, István and Molnár, Kolos and Kőhidai, László and Jedlovszky-Hajdú, Angéla and S. Nagy, Krisztina},
	doi = {10.1016/j.molliq.2023.123756},
	journal-iso = {J MOL LIQ},
	journal = {JOURNAL OF MOLECULAR LIQUIDS},
	volume = {394},
	unique-id = {34506340},
	issn = {0167-7322},
	year = {2024},
	eissn = {1873-3166},
	orcid-numbers = {Budavári, Bálint Péter/0000-0002-9846-4609; Pállinger, Éva/0000-0002-5789-0951; Juriga-Tóth, Krisztina/0000-0002-7939-5492; Király, Márton/0000-0002-9792-663X; Voszka, István/0000-0002-4555-853X; Molnár, Kolos/0000-0002-9331-4652; Kőhidai, László/0000-0002-9002-0296; Jedlovszky-Hajdú, Angéla/0000-0003-2720-783X; S. Nagy, Krisztina/0000-0002-4942-2947}
}