@article{MTMT:34836459, title = {Gyógyszerhulladék-monitorozás a környezettudatosság jegyében}, url = {https://m2.mtmt.hu/api/publication/34836459}, author = {Vajda, Péter and Botz, Lajos}, doi = {10.1556/650.2024.33023}, journal-iso = {ORV HETIL}, journal = {ORVOSI HETILAP}, volume = {165}, unique-id = {34836459}, issn = {0030-6002}, keywords = {pharmaceutical waste; green pharmacy; gyógyszerhulladék; gyógyszertudatosság; környezetbarát gyógyszerészet; medicine awareness}, year = {2024}, eissn = {1788-6120}, pages = {672-679} } @article{MTMT:34830527, title = {Cyclodextrin encapsulation enabling the anticancer repositioning of disulfiram: Preparation, analytical and in vitro biological characterization of the inclusion complexes}, url = {https://m2.mtmt.hu/api/publication/34830527}, author = {Benkő, Beáta Mária and Tóth, Gergő and Moldvai, Dorottya and Kádár, Szabina and Szabó, Edina and Szabó, Zoltán-István and Mazákné Kraszni, Márta and Szente, Lajos and Fiser, Béla and Sebestyén, Anna and Zelkó, Romána and Sebe, István}, doi = {10.1016/j.ijpharm.2024.124187}, journal-iso = {INT J PHARM}, journal = {INTERNATIONAL JOURNAL OF PHARMACEUTICS}, volume = {657}, unique-id = {34830527}, issn = {0378-5173}, year = {2024}, eissn = {1873-3476}, orcid-numbers = {Benkő, Beáta Mária/0000-0002-3608-6219; Tóth, Gergő/0000-0001-5341-319X; Szabó, Edina/0000-0001-9616-5122; Szabó, Zoltán-István/0000-0002-8740-0212; Mazákné Kraszni, Márta/0000-0003-4364-9486; Sebestyén, Anna/0000-0001-8814-4794; Zelkó, Romána/0000-0002-5419-9137; Sebe, István/0000-0003-0752-781X} } @article{MTMT:34776969, title = {Assessment of the practical impact of adjusting beta-lactam dosages based on therapeutic drug monitoring in critically ill adult patients: a systematic review and meta-analysis of randomized clinical trials and observational studies}, url = {https://m2.mtmt.hu/api/publication/34776969}, author = {Gulyás, Eszter and Horváth, István László and Engh, Marie Anne and Bunduc, Stefania and Dembrovszky, Fanni and Fehérvári, Péter and Bánvölgyi, András and Csupor, Dezső and Hegyi, Péter and Karvaly, Gellért Balázs}, doi = {10.1038/s41598-024-58200-w}, journal-iso = {SCI REP}, journal = {SCIENTIFIC REPORTS}, volume = {14}, unique-id = {34776969}, issn = {2045-2322}, keywords = {[Meta-analysis]}, year = {2024}, eissn = {2045-2322}, orcid-numbers = {Engh, Marie Anne/0000-0003-4269-5130; Dembrovszky, Fanni/0000-0001-6953-3591; Bánvölgyi, András/0000-0002-7071-1364; Csupor, Dezső/0000-0002-4088-3333; Hegyi, Péter/0000-0003-0399-7259; Karvaly, Gellért Balázs/0000-0003-2468-5633} } @article{MTMT:34768534, title = {A Clinical, Pharmacological, and Formulation Evaluation of Melatonin in the Treatment of Ocular Disorders—A Systematic Review}, url = {https://m2.mtmt.hu/api/publication/34768534}, author = {Romeo, Alessia and Nochta-Kazsoki, Adrienn Katalin and Musumeci, Teresa and Zelkó, Romána}, doi = {10.3390/ijms25073999}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {25}, unique-id = {34768534}, issn = {1661-6596}, abstract = {Melatonin’s cytoprotective properties may have therapeutic implications in treating ocular diseases like glaucoma and age-related macular degeneration. Literature data suggest that melatonin could potentially protect ocular tissues by decreasing the production of free radicals and pro-inflammatory mediators. This study aims to summarize the screened articles on melatonin’s clinical, pharmacological, and formulation evaluation in treating ocular disorders. The identification of relevant studies on the topic in focus was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA 2020) guidelines. The studies were searched in the following databases and web search engines: Pubmed, Scopus, Science Direct, Web of Science, Reaxys, Google Scholar, Google Patents, Espacenet, and Patentscope. The search time interval was 2013–2023, with the following keywords: melatonin AND ocular OR ophthalmic AND formulation OR insert AND disease. Our key conclusion was that using melatonin-loaded nano-delivery systems enabled the improved permeation of the molecule into intraocular tissues and assured controlled release profiles. Although preclinical studies have demonstrated the efficacy of developed formulations, a considerable gap has been observed in the clinical translation of the results. To overcome this failure, revising the preclinical experimental phase might be useful by selecting endpoints close to clinical ones.}, year = {2024}, eissn = {1422-0067}, orcid-numbers = {Nochta-Kazsoki, Adrienn Katalin/0000-0002-0611-3124; Musumeci, Teresa/0000-0003-2299-7780; Zelkó, Romána/0000-0002-5419-9137} } @article{MTMT:34538437, title = {A Comparative Pharmacokinetic Study for Cysteamine-Containing Eye Drops as an Orphan Topical Therapy in Cystinosis}, url = {https://m2.mtmt.hu/api/publication/34538437}, author = {Csorba, Anita and Katona, Gábor and Budai-Szűcs, Mária and Balogh Weiser, Diána and Molnár, P. and Maka, Erika and Nochta-Kazsoki, Adrienn Katalin and Vajna, Márton Antal and Zelkó, Romána and Nagy, Zoltán Zsolt and Balogh, György Tibor}, doi = {10.3390/ijms25031623}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {25}, unique-id = {34538437}, issn = {1661-6596}, year = {2024}, eissn = {1422-0067}, orcid-numbers = {Csorba, Anita/0000-0002-3256-9440; Katona, Gábor/0000-0003-1564-4813; Budai-Szűcs, Mária/0000-0001-5187-5702; Balogh Weiser, Diána/0000-0002-9957-1203; Maka, Erika/0000-0002-3631-3506; Nochta-Kazsoki, Adrienn Katalin/0000-0002-0611-3124; Vajna, Márton Antal/0000-0001-5280-7533; Zelkó, Romána/0000-0002-5419-9137; Nagy, Zoltán Zsolt/0000-0002-7330-0464; Balogh, György Tibor/0000-0003-3347-1880} } @article{MTMT:34521945, title = {Impact of regulatory tightening of the Hungarian tobacco retail market on availability, access and cigarette smoking prevalence of adolescents.}, url = {https://m2.mtmt.hu/api/publication/34521945}, author = {Joó, Tamás and Foley, Kristie and Brys, Zoltán and Rogers, Todd and Szócska, Miklós and Bodrogi, József and Gaál, Péter and Pénzes, Melinda}, doi = {10.1136/tc-2023-058232}, journal-iso = {TOB CONTROL}, journal = {TOBACCO CONTROL}, volume = {In press}, unique-id = {34521945}, issn = {0964-4563}, abstract = {Policies that reduce tobacco retail density to decrease tobacco use among the youth are critical for the tobacco endgame. This paper reviews a Hungarian tobacco regulatory measure, which, since 2013, has confined the sale of tobacco products exclusively to so-called National Tobacco Shops, summarises the changes in the national tobacco retail marketplace and reports on analyses of the impact of this intervention on illegal sales to minors and adolescent smoking behaviour.We reviewed the available national statistical data on the structure and dynamics of the tobacco retail market. Changes in lifetime and current (past 30 days) use of cigarettes among Hungarian adolescents aged 13-17 years were assessed using data from international youth surveys on health behaviours collected in 2010-2020.Since the start of policy implementation, the density of tobacco shops in Hungary decreased by 85%, from 4.1 to 0.6 per 1000 persons. The prevalence of lifetime and current cigarette smoking among adolescents declined by 13-24 percentage points (pp) and by 4.8-15 pp, respectively. The rate of illegal sales of tobacco products to minors decreased by 27.6 pp, although the prevalence of compensatory access strategies, especially asking others to buy cigarettes for minors, increased.After a significant decrease in the nationwide availability of licensed tobacco retailers, Hungary experienced short-term reductions in youth smoking prevalence. However, the sporadic implementation of complementary, evidence-based tobacco control strategies might limit further declines in youth smoking initiation and tobacco product use.}, keywords = {Public Policy; surveillance and monitoring; End game}, year = {2024}, eissn = {1468-3318}, orcid-numbers = {Joó, Tamás/0000-0002-3551-6125; Brys, Zoltán/0000-0002-3324-2255; Szócska, Miklós/0000-0003-0648-9778; Gaál, Péter/0000-0002-6815-9021; Pénzes, Melinda/0000-0001-7396-4028} } @article{MTMT:34498800, title = {Beyond the Gut: A Systematic Review and Meta-analysis of Advanced Therapies for Inflammatory Bowel Disease-associated Extraintestinal Manifestations}, url = {https://m2.mtmt.hu/api/publication/34498800}, author = {Tímár, Ágnes Eszter and Párniczky, Andrea and Budai, Kinga Anna and Hernádfői , Márk Viktor and Kasznár, Emese and Varga, Péter and Hegyi, Péter and Váncsa, Szilárd and Tóth, Réka and Veres, Dániel and Garami, Miklós and Müller, Katalin Eszter}, doi = {10.1093/ecco-jcc/jjae002}, journal-iso = {J CROHNS COLITIS}, journal = {JOURNAL OF CROHNS & COLITIS}, unique-id = {34498800}, issn = {1873-9946}, keywords = {[Meta-analysis]}, year = {2024}, eissn = {1876-4479}, orcid-numbers = {Hegyi, Péter/0000-0003-0399-7259; Váncsa, Szilárd/0000-0002-9347-8163; Veres, Dániel/0000-0002-9687-3556; Garami, Miklós/0000-0003-4298-2746; Müller, Katalin Eszter/0000-0001-5355-4224} } @article{MTMT:34413258, title = {Nafamostat Reduces the Incidence of post-ERCP Pancreatitis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials}, url = {https://m2.mtmt.hu/api/publication/34413258}, author = {Horváth, István László and Kleiner, Dénes and Nagy, Rita and Fehérvári, Péter and Hankó, Balázs and Hegyi, Péter and Csupor, Dezső}, doi = {10.1002/cpt.3118}, journal-iso = {CLIN PHARMACOL THER}, journal = {CLINICAL PHARMACOLOGY & THERAPEUTICS}, volume = {115}, unique-id = {34413258}, issn = {0009-9236}, abstract = {Pancreatitis is the most common complication of endoscopic retrograde cholangiopancreatography (ERCP). As the management of pancreatitis is limited, clinical approaches focus on the prevention of post-ERCP pancreatitis (PEP). In theory, the serine protease inhibitor nafamostat can reduce circulating inflammatory mediators in pancreatitis. We aimed to investigate the effect of nafamostat in the prevention of PEP in this systematic review and meta-analysis. The protocol for this review was registered in PROSPERO (CRD42022367988). We systematically searched five databases without any filters on 26th September 2022. The eligible population was adult patients undergoing ERCP. We compared the PEP preventive effect of nafamostat to placebo. The main outcome was the occurrence of PEP. We calculated the pooled odds ratios (OR), mean differences (MD), and corresponding 95% confidence intervals (95%CI) and multilevel model. The risk of bias was assessed using the Rob2 tool. Seven randomized controlled trials involving 2,962 patients were eligible for inclusion. Nafamostat reduced the overall incidence rate of PEP [20 mg OR 0.50; 95%CI 0.30-0.82 and 50 mg 0.48; 95%CI 0.24-0.96]. However, the occurrence of mild PEP was significantly reduced only in the subgroup receiving 20 mg nafamostat [OR 0.49; 95%CI 0.31-0.77]. Overall, nafamostat therapy reduced moderate PEP in high-risk patients [OR 0.18; 95%CI 0.0.4-0.84] and mild PEP in low-risk patients [OR 0.32; 95%CI 0.17-0.61]. Nafamostat is an effective therapy in the prevention of mild post-ERCP pancreatitis. Further research is required to determine the cost-effectiveness of this therapy.}, keywords = {[Meta-analysis]}, year = {2024}, eissn = {1532-6535}, pages = {206-212}, orcid-numbers = {Kleiner, Dénes/0000-0002-4715-8695; Nagy, Rita/0000-0002-2663-4912; Hankó, Balázs/0000-0002-1953-2838; Hegyi, Péter/0000-0003-0399-7259; Csupor, Dezső/0000-0002-4088-3333} } @article{MTMT:34434109, title = {Innovatív gyógyszerformák és összetett hatóanyag-leadó rendszerek}, url = {https://m2.mtmt.hu/api/publication/34434109}, author = {Zelkó, Romána}, journal-iso = {ORVOSKÉPZÉS}, journal = {ORVOSKÉPZÉS}, volume = {98}, unique-id = {34434109}, issn = {0030-6037}, year = {2023}, pages = {740-743}, orcid-numbers = {Zelkó, Romána/0000-0002-5419-9137} } @article{MTMT:34421579, title = {Managing Antibiotic Shortages in Inpatient Care - A Review of Recent Years in Comparison with the Hungarian Status}, url = {https://m2.mtmt.hu/api/publication/34421579}, author = {Lőrinczy, Lilla and Turbucz, Béla and Hankó, Balázs and Zelkó, Romána}, doi = {10.3390/antibiotics12121704}, journal-iso = {ANTIBIOTICS-BASEL}, journal = {ANTIBIOTICS}, volume = {12}, unique-id = {34421579}, year = {2023}, eissn = {2079-6382}, orcid-numbers = {Turbucz, Béla/0000-0003-0321-2810; Hankó, Balázs/0000-0002-1953-2838; Zelkó, Romána/0000-0002-5419-9137} }