TY  - JOUR
AU  - Horváth, Ádám
AU  - Steib, Anita
AU  - Nehr-Majoros, Andrea Kinga
AU  - Kántás, Boglárka
AU  - Király, Ágnes
AU  - Racskó, Márk
AU  - Tóth, Balázs István
AU  - Szánti-Pintér, Eszter
AU  - Kudová, Eva
AU  - Skodáné Földes, Rita
AU  - Helyes, Zsuzsanna
AU  - Szőke, Éva
TI  - Anti-Nociceptive Effects of Sphingomyelinase and Methyl-Beta-Cyclodextrin in the Icilin-Induced Mouse Pain Model
JF  - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
J2  - INT J MOL SCI
VL  - 25
PY  - 2024
IS  - 9
PG  - 13
SN  - 1661-6596
DO  - 10.3390/ijms25094637
UR  - https://m2.mtmt.hu/api/publication/34824919
ID  - 34824919
AB  - The thermo- and pain-sensitive Transient Receptor Potential Melastatin 3 and 8 (TRPM3 and TRPM8) ion channels are functionally associated in the lipid rafts of the plasma membrane. We have already described that cholesterol and sphingomyelin depletion, or inhibition of sphingolipid biosynthesis decreased the TRPM8 but not the TRPM3 channel opening on cultured sensory neurons. We aimed to test the effects of lipid raft disruptors on channel activation on TRPM3- and TRPM8-expressing HEK293T cells in vitro, as well as their potential analgesic actions in TRPM3 and TRPM8 channel activation involving acute pain models in mice. CHO cell viability was examined after lipid raft disruptor treatments and their effects on channel activation on channel expressing HEK293T cells by measurement of cytoplasmic Ca2+ concentration were monitored. The effects of treatments were investigated in Pregnenolone-Sulphate-CIM-0216-evoked and icilin-induced acute nocifensive pain models in mice. Cholesterol depletion decreased CHO cell viability. Sphingomyelinase and methyl-beta-cyclodextrin reduced the duration of icilin-evoked nocifensive behavior, while lipid raft disruptors did not inhibit the activity of recombinant TRPM3 and TRPM8. We conclude that depletion of sphingomyelin or cholesterol from rafts can modulate the function of native TRPM8 receptors. Furthermore, sphingolipid cleavage provided superiority over cholesterol depletion, and this method can open novel possibilities in the management of different pain conditions.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Nörenberg, Jasper Maximilian
AU  - Vida, P.
AU  - Bösmeier, I.
AU  - Forró, B.
AU  - Nörenberg, A.
AU  - Buda, Á.
AU  - Simon, Diána
AU  - Erdő-Bonyár, Szabina
AU  - Jáksó, Pál
AU  - Kovács, Kálmán András
AU  - Mikó, Éva
AU  - Berki, Tímea
AU  - Mezősi, Emese
AU  - Barakonyi, Alíz
TI  - Decidual γδT cells of early human pregnancy produce angiogenic and immunomodulatory proteins while also possessing cytotoxic potential
JF  - FRONTIERS IN IMMUNOLOGY
J2  - FRONT IMMUNOL
VL  - 15
PY  - 2024
PG  - 12
SN  - 1664-3224
DO  - 10.3389/fimmu.2024.1382424
UR  - https://m2.mtmt.hu/api/publication/34796888
ID  - 34796888
N1  - Journal Article; Research Support, Non-U.S. Gov't
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Abrán, Hunor
AU  - Kovács, Kálmán András
AU  - Horvát, Zalán
AU  - Erőss, Edina
AU  - Hollins Martin, Caroline J
AU  - Martin, Colin R
TI  - Translation and validation of the Hungarian version of the Birth Satisfaction Scale-Revised (BSS-R).
JF  - MIDWIFERY
J2  - MIDWIFERY
VL  - 132
PY  - 2024
PG  - 7
SN  - 0266-6138
DO  - 10.1016/j.midw.2024.103983
UR  - https://m2.mtmt.hu/api/publication/34786848
ID  - 34786848
N1  - Export Date: 18 April 2024            
            CODEN: MIDWE
AB  - Evidence relating maternal birth experience to a range of maternal and neonatal outcomes is increasingly compelling. Consequently valid and reliable self-report of birth experience from the mothers perspective is critical.The current study sought to translate and validate a Hungarian-language version of the Birth Satisfaction Scale-Revised (BSS-R).Following forward and backwards translation into Hungarian, the Hungarian BSS-R (HU-BSS-R) was administered to women in a major Transylvanian hospital maternity unit within 72 h postpartum. Key psychometric characteristics were then examined in relation to factor structure, divergent and convergent validity, internal consistency, and known-groups discriminant validity.Two-hundred and thirty-two women completed the HU-BSS-R. Confirmatory factor analysis revealed the HU-BSS-R to offer an excellent fit to data for the established tri-dimensional measurement model. The HU-BSS-R was also found to offer excellent convergent and divergent validity and known-groups discriminant validity. No significant differences were observed between internal consistency observations between the current study and the original UK validation study.The HU-BSS-R is a valid and reliable translation of the original BSS-R, it has proved itself to have excellent psychometric properties and is suitable for use in the Hungarian maternity context.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Vesztergom, Dóra
AU  - Téglás, Gyöngyvér
AU  - Bahrehmand, Kiarash
AU  - Török, Attila
AU  - Balla, Levente
AU  - Forgács, Vince
AU  - Konc, János
AU  - Tándor, Zoltán
AU  - Várnagy, Ákos
AU  - Boga, Péter
AU  - Zádori, János
AU  - Sipos, Miklós
AU  - Mánfai, Zoltán
AU  - Novák, Zoltán
TI  - Reducing radicality in fertility-sparing surgery is associated with improved in vitro fertilization outcome in early-stage cervical cancer: A national retrospective study
JF  - GYNECOLOGIC ONCOLOGY
J2  - GYNECOL ONCOL
VL  - 186
PY  - 2024
SP  - 35
EP  - 41
PG  - 7
SN  - 0090-8258
DO  - 10.1016/j.ygyno.2024.03.024
UR  - https://m2.mtmt.hu/api/publication/34769257
ID  - 34769257
N1  - Export Date: 18 April 2024            
            CODEN: GYNOA
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Gödöny, Krisztina
AU  - Herczeg, Róbert
AU  - Gyenesei, Attila
AU  - Várnagy, Ákos
AU  - Bognár, Zoltán
AU  - Kovács, L. Gábor
AU  - Szekeres, Júlia
AU  - Mauchart, Péter
AU  - Nagy, Bernadett
AU  - Erostyák, János
AU  - Kovács, Kálmán András
AU  - Bódis, József
TI  - Clinical Benefits of Decreased Photo-Oxidative Stress on Human Embryo Development
JF  - MEDICAL PRINCIPLES AND PRACTICE
J2  - MED PRIN PRACT
PY  - 2024
SN  - 1011-7571
DO  - 10.1159/000536358
UR  - https://m2.mtmt.hu/api/publication/34763514
ID  - 34763514
N1  - Funding Agency and Grant Number: Recovery and Resilience Facility of the European Union within the framework of Programme Szechenyi Plan Plus [RRF-2.3.1-21-2022-00012]; HUN-REN Hungarian Research Network; ELIXIR Hungary; National Research, Development, and Innovation Fund of Hungary [TKP2021-EGA-17];  [GINOP-2.3.4-15-2020-00010];  [GINOP-2.3.1-20-2020-00001];  [ERASMUS+-2019-0-HU01-KA203-061251]
            Funding text: Project No. RRF-2.3.1-21-2022-00012, titled National Laboratoryon Human Reproduction, has been implemented with the support provided by the Recovery and Resilience Facility of the European Union within the framework of Programme Szechenyi Plan Plus, andthis project has received funding from the HUN-REN HungarianResearch Network. The research was performed in collaboration withthe Genomics and Bioinformatics Core Facility at the SzentagothaiResearch Centre of the University of Pecs. R.H and A.G. weresupported by the grants GINOP-2.3.4-15-2020-00010, GINOP-2.3.1-20-2020-00001, and ERASMUS+-2019-0-HU01-KA203-061251.Bioinformatics infrastructurewas supported by ELIXIR Hungary(http://elixir-hungary.org). J.E. was supported by TKP2021-EGA-17provided by the National Research, Development, and Innovation Fund of Hungary,financed under the EGA 17 funding scheme.
AB  - <b><i>Objective:</i></b> Early embryonic development is characterized by rapid cell division and gene activation, making the embryo extremely sensitive to environmental influences. Light exposure can affect embryonic development through a direct toxic effect on the embryo via the generation of reactive oxygen species. In a previous study, we demonstrated the positive effect of improved light-protected embryo culture conditions implemented in our laboratory. This study aimed to investigate the changes in human embryo development under light protection during the conventional in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). <b><i>Materials and Methods:</i></b> We tested the potential beneficial effect of light filters to reduce the risk of toxic effects of light. IVF outcomes were compared between two experimental conditions, light protection with red light filters versus no light protection as a control. <b><i>Results:</i></b> Blastocyst development rate in IVF was significantly higher in the light-protected group than in the group treated under conventional conditions (46.6 vs. 26.7%). In the case of ICSI, we obtained a similar result (44.5 vs. 31.6%). The rate of cryopreservation with at least one embryo was higher in the light-protected phase (32.8%) than in the conventionally manipulated phase (26.8%). The abortion rate was also significantly lower during the light-protected period in IVF, resulting in a higher live birth rate. <b><i>Conclusions:</i></b> The implementation of light protection to reduce the embryotoxic wavelengths of light in IVF centers may improve the blastocyst development rate and embryo quality while maintaining embryo safety.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Bokor, Szilvia
AU  - Csölle, Ildikó
AU  - Heidinger-Felső, Regina
AU  - Vass, Réka Anna
AU  - Funke Kiss, Simone
AU  - Ertl, Tibor
AU  - Molnár, Dénes
TI  - Dietary nutrients during gestation cause obesity and related metabolic changes by altering DNA methylation in the offspring
JF  - FRONTIERS IN ENDOCRINOLOGY
J2  - FRONT ENDOCRINOL
VL  - 15
PY  - 2024
PG  - 17
SN  - 1664-2392
DO  - 10.3389/fendo.2024.1287255
UR  - https://m2.mtmt.hu/api/publication/34729560
ID  - 34729560
N1  - Department of Paediatrics, Medical School, University of Pécs, Pécs, Hungary            
            National Laboratory on Human Reproduction, University of Pécs, Pécs, Hungary            
            Doctoral School of Health Sciences, Faculty of Health Sciences, University of Pécs, Pécs, Hungary            
            Department of Obstetrics and Gynaecology, Medical School, University of Pécs, Pécs, Hungary            
            Obstetrics and Gynecology, Magyar Imre Hospital Ajka, Ajka, Hungary            
            Export Date: 18 March 2024            
            Correspondence Address: Bokor, S.; Department of Paediatrics, Hungary; email: bokor.szilvia@pte.hu
AB  - Growing evidence shows that maternal nutrition from preconception until lactation has an important effect on the development of non-communicable diseases in the offspring. Biological responses to environmental stress during pregnancy, including undernutrition or overnutrition of various nutrients, are transmitted in part by DNA methylation. The aim of the present narrative review is to summarize literature data on altered DNA methylation patterns caused by maternal macronutrient or vitamin intake and its association with offspring's phenotype (obesity and related metabolic changes). With our literature search, we found evidence for the association between alterations in DNA methylation pattern of different genes caused by maternal under- or overnutrition of several nutrients (protein, fructose, fat, vitamin D, methyl-group donor nutrients) during 3 critical periods of programming (preconception, pregnancy, lactation) and the development of obesity or related metabolic changes (glucose, insulin, lipid, leptin, adiponectin levels, blood pressure, non-alcoholic fatty liver disease) in offspring. The review highlights that maternal consumption of several nutrients could individually affect the development of offspring's obesity and related metabolic changes via alterations in DNA methylation.
LA  - English
DB  - MTMT
ER  - 

TY  - CHAP
AU  - Ertl, Tibor
ED  - Tulassay, Tivadar
TI  - Necrotizáló enterocolitis és rövidbél-szindróma
T2  - Klinikai gyermekgyógyászat
PB  - Medicina Könyvkiadó
CY  - Budapest
SN  - 9789632286673
PY  - 2024
SP  - 210
EP  - 212
PG  - 3
UR  - https://m2.mtmt.hu/api/publication/34688851
ID  - 34688851
LA  - Hungarian
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Rashidiani, Shima
AU  - Mamo, Gizaw
AU  - Farkas, Benjámin
AU  - Szabadi, András
AU  - Farkas, Bálint
AU  - Uszkai, Veronika
AU  - Császár, András
AU  - Brandt, Barbara
AU  - Kovács, Kálmán András
AU  - Pap, Marianna
AU  - Rauch, Tibor
TI  - Integrative Epigenetic and Molecular Analysis Reveals a Novel Promoter for a New Isoform of the Transcription Factor TEAD4
JF  - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
J2  - INT J MOL SCI
VL  - 25
PY  - 2024
IS  - 4
PG  - 15
SN  - 1661-6596
DO  - 10.3390/ijms25042223
UR  - https://m2.mtmt.hu/api/publication/34684525
ID  - 34684525
N1  - * Megosztott szerzőség
AB  - TEAD4 is a transcription factor that plays a crucial role in the Hippo pathway by regulating the expression of genes related to proliferation and apoptosis. It is also involved in the maintenance and differentiation of the trophectoderm during pre- and post-implantation embryonic development. An alternative promoter for the TEAD4 gene was identified through epigenetic profile analysis, and a new transcript from the intronic region of TEAD4 was discovered using the 5'RACE method. The transcript of the novel promoter encodes a TEAD4 isoform (TEAD4-ΔN) that lacks the DNA-binding domain but retains the C-terminal protein-protein interaction domain. Gene expression studies, including end-point PCR and Western blotting, showed that full-length TEAD4 was present in all investigated tissues. However, TEAD4-ΔN was only detectable in certain cell types. The TEAD4-ΔN promoter is conserved throughout evolution and demonstrates transcriptional activity in transient-expression experiments. Our study reveals that TEAD4 interacts with the alternative promoter and increases the expression of the truncated isoform. DNA methylation plays a crucial function in the restricted expression of the TEAD4-ΔN isoform in specific tissues, including the umbilical cord and the placenta. The data presented indicate that the DNA-methylation status of the TEAD4-ΔN promoter plays a critical role in regulating organ size, cancer development, and placenta differentiation.
LA  - English
DB  - MTMT
ER  - 

TY  - CONF
AU  - Pónusz-Kovács, Dalma
AU  - Csákvári, Tímea
AU  - Kajos, Luca Fanni
AU  - Elmer, Diána
AU  - Pónusz, Róbert
AU  - Bódis, József
AU  - Boncz, Imre
ED  - Figler, Mária
ED  - Karamánné Pakai, Annamária
ED  - Tigyi, Zoltánné
ED  - Kajos, Luca Fanni
ED  - Trixler, Bettina
TI  - Magyarországi területi egyenlőtlenségek elemzése a női infertilitás diagnózis esetében
T2  - Jubileumi Szakkollégiumi Konferencia: Absztrakt kötet
PB  - Pécsi Tudományegyetem Egészségtudományi Kar (PTE ETK)
C1  - Pécs
SN  - 9789636262402
PY  - 2024
SP  - 20
EP  - 20
PG  - 1
UR  - https://m2.mtmt.hu/api/publication/34667323
ID  - 34667323
LA  - Hungarian
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Nemeth, Zoltan
AU  - Schmidt, Roxana
AU  - Farkas, Bálint
TI  - Single-incision vaginal mesh insertion for recurrent vaginal vault prolapse after radical cystectomy and radical hysterectomy with irradiation: A case report
JF  - Continence Reports
J2  - Continence Reports
VL  - 9
PY  - 2024
PG  - 3
SN  - 2772-9745
DO  - 10.1016/j.contre.2024.100047
UR  - https://m2.mtmt.hu/api/publication/34641519
ID  - 34641519
N1  - Case report
LA  - English
DB  - MTMT
ER  -