TY - CONF AU - Leiva, Genre Andres AU - Nasi, Luis AU - Kiss, Mátyás AU - Tibai, Zoltán AU - Almási, Gábor AU - Hebling, János AU - Turnár, Szabolcs ED - Kovács, Bettina ED - Glázer-Kniesz, Adrienn ED - Tislér, Ádám TI - Multi-cycle THz pulse generation and Start-to-End simulation of THz-driven dielectric laser accelerator T2 - Absztraktkötet: XII. Interdiszciplináris Doktorandusz Konferencia = Book of Abstract: XII. Interdisciplinary Doctoral Conference PB - Pécsi Tudományegyetem Doktorandusz Önkormányzat C1 - Pécs SN - 9789636262457 PY - 2024 SP - 124 EP - 124 PG - 1 UR - https://m2.mtmt.hu/api/publication/34828067 ID - 34828067 LA - English DB - MTMT ER - TY - JOUR AU - Gödöny, Krisztina AU - Herczeg, Róbert AU - Gyenesei, Attila AU - Várnagy, Ákos AU - Bognár, Zoltán AU - Kovács, L. Gábor AU - Szekeres, Júlia AU - Mauchart, Péter AU - Nagy, Bernadett AU - Erostyák, János AU - Kovács, Kálmán András AU - Bódis, József TI - Clinical Benefits of Decreased Photo-Oxidative Stress on Human Embryo Development JF - MEDICAL PRINCIPLES AND PRACTICE J2 - MED PRIN PRACT PY - 2024 SN - 1011-7571 DO - 10.1159/000536358 UR - https://m2.mtmt.hu/api/publication/34763514 ID - 34763514 N1 - National Laboratory on Human Reproduction, University of Pecs, Pecs, Hungary Department of Obstetrics and Gynecology, Medical School, University of Pecs, Pecs, Hungary HUN-REN-PTE Human Reproduction Research Group, University of Pecs, Pecs, Hungary Szentagothai Research Center, University of Pecs, Pecs, Hungary Department of Medical Biology and Central Electron Microscope Laboratory, Medical School, University of Pecs, Pecs, Hungary Department of Laboratory Medicine, Medical School, University of Pecs, Pecs, Hungary Institute of Physics, University of Pecs, Pecs, Hungary Export Date: 6 May 2024 CODEN: MPPRE Correspondence Address: Mauchart, P.; National Laboratory on Human Reproduction, Hungary; email: mauchart.peter@pte.hu AB - Objective: Early embryonic development is characterized by rapid cell division and gene activation, making the embryo extremely sensitive to environmental influences. Light exposure can affect embryonic development through a direct toxic effect on the embryo via the generation of reactive oxygen species. In a previous study, we demonstrated the positive effect of improved light-protected embryo culture conditions implemented in our laboratory. This study aimed to investigate the changes in human embryo development under light protection during the conventional in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). Materials and Methods: We tested the potential beneficial effect of light filters to reduce the risk of toxic effects of light. IVF outcomes were compared between two experimental conditions, light protection with red light filters versus no light protection as a control. Results: Blastocyst development rate in IVF was significantly higher in the light-protected group than in the group treated under conventional conditions (46.6 vs. 26.7%). In the case of ICSI, we obtained a similar result (44.5 vs. 31.6%). The rate of cryopreservation with at least one embryo was higher in the light-protected phase (32.8%) than in the conventionally manipulated phase (26.8%). The abortion rate was also significantly lower during the light-protected period in IVF, resulting in a higher live birth rate. Conclusions: The implementation of light protection to reduce the embryotoxic wavelengths of light in IVF centers may improve the blastocyst development rate and embryo quality while maintaining embryo safety. LA - English DB - MTMT ER - TY - JOUR AU - Fekete, Balázs AU - Kiss, Mátyás AU - Shapolov, A. A. AU - Szatmari, S. AU - Kuhlevszkij, Szergej TI - Short rise- and decay-time Z-pinch currents for soft x-ray laser excitation JF - AIP ADVANCES J2 - AIP ADV VL - 14 PY - 2024 IS - 2 SN - 2158-3226 DO - 10.1063/5.0191533 UR - https://m2.mtmt.hu/api/publication/34751080 ID - 34751080 AB - The article addresses how to create inductance-free plasma and use it to excite soft x-ray lasers. The method employs a bifilar phenomenon in which one part of the pulsed current flows via the plasma column while the other part runs in the opposite direction via the closely placed external conductor. The electromagnetic fields formed by the plasma and return conductor are adjusted by lowering the distance between them to neutralize the magnetic field of the bifilar. Because the net transient magnetic field is drastically reduced, the plasma-conductor mutual inductance is near zero during current rise and decay. The inductance-free (L ∼ 2 nH) 35 cm-long Z pinches in a 3.1 mm-diameter argon-filled alumina capillary with current rise and decay times of 15 ns, dI/dt > 1012 A/s, and amplitudes up to 17 kA were predicted, realized, and verified to be suitable for pumping soft x-ray Ar+8 lasers. Without the bifilar phenomenon, the 35 cm Z pinches obey a 200 nH inductance that restricts the rise and decay durations of currents to 150 ns. The 35 cm Z pinches with 2 nH inductance generated 46.9 nm laser pulses with up to 4 μJ of energy and a beam divergence of 2 mrad at a low operating voltage of 35–45 kV, compared to 0.1–0.8 MV for similar lasers. The bifilar method could find applications in many research and technological fields, where the rise and decay times of discharge currents play a key role. LA - English DB - MTMT ER - TY - JOUR AU - Ádám, Péter AU - Mechler, Mátyás Illés TI - Single-photon sources based on incomplete binary-tree multiplexers with optimized inputs JF - PHYSICS LETTERS A J2 - PHYS LETT A VL - 503 PY - 2024 PG - 9 SN - 0375-9601 DO - 10.1016/j.physleta.2024.129416 UR - https://m2.mtmt.hu/api/publication/34742369 ID - 34742369 LA - English DB - MTMT ER - TY - JOUR AU - Mechler, Mátyás Illés AU - Man’ko, M.A. AU - Man’ko, V.I. AU - Ádám, Péter TI - Probability Representation of Nonclassical States of the Inverted Oscillator JF - JOURNAL OF RUSSIAN LASER RESEARCH J2 - J RUSS LASER RES VL - 45 PY - 2024 IS - 1 SP - 1 EP - 13 PG - 13 SN - 1071-2836 DO - 10.1007/s10946-024-10182-w UR - https://m2.mtmt.hu/api/publication/34738042 ID - 34738042 LA - English DB - MTMT ER - TY - CHAP AU - Polónyi, Gyula AU - Hebling, János ED - Park, Gun-Sik ED - Tani, Masahiko ED - Rieh, Jae-Sung ED - Park, Sang Yoon TI - Optical Rectification–Based Sources T2 - Advances in Terahertz Source Technologies PB - Jenny Stanford Publishing CY - New York, New York SN - 9781003459675 PY - 2024 SP - 47 EP - 82 PG - 36 UR - https://m2.mtmt.hu/api/publication/34727105 ID - 34727105 LA - English DB - MTMT ER - TY - JOUR AU - Isken, Tobias AU - Guo, Xiao-Yu AU - Heo, Yonggoo AU - Korpa, Csaba AU - Lutz, Matthias F. M. TI - Triangle and box diagrams in coupled-channel systems from the chiral Lagrangian JF - PHYSICAL REVIEW D J2 - PHYS REV D VL - 109 PY - 2024 IS - 3 PG - 37 SN - 2470-0010 DO - 10.1103/PhysRevD.109.034032 UR - https://m2.mtmt.hu/api/publication/34726860 ID - 34726860 LA - English DB - MTMT ER - TY - JOUR AU - Nehr-Majoros, Andrea Kinga AU - Erostyák, János AU - Fenyvesi, Éva AU - Szabó-Meleg, Edina AU - Szőcs, Levente AU - Sétáló, György (ifj.) AU - Helyes, Zsuzsanna AU - Szőke, Éva TI - Cyclodextrin derivatives decrease Transient Receptor Potential vanilloid 1 and Ankyrin 1 ion channel activation via altering the surrounding membrane microenvironment by cholesterol depletion JF - FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY J2 - FRONT CELL DEV BIOL VL - 12 PY - 2024 PG - 13 SN - 2296-634X DO - 10.3389/fcell.2024.1334130 UR - https://m2.mtmt.hu/api/publication/34689825 ID - 34689825 AB - Transient Receptor Potential Vanilloid 1 (TRPV1) and Ankyrin 1 (TRPA1) are nonselective cation channels expressed in primary sensory neurons and several other non-neuronal structures such as immune cells, keratinocytes, and vascular smooth muscle cells. They play important roles in nociception, pain processing and their chanellopathies are associated with the development of several pathological conditions. They are located in cholesterol- and sphingolipid-rich membrane lipid raft regions serving as platforms to modulate their activations. We demonstrated earlier that disruption of these lipid rafts leads to decreased TRP channel activation and exerts analgesic effects. Cyclodextrins are macrocyclic molecules able to form host-guest complexes with cholesterol and deplete it from the membrane lipid rafts. The aim of this study was to investigate 8 structurally different (methylated and non-methylated) CD derivatives on cell viability, mitochondrial membrane potential, membrane composition and activation abilities of the TRPV1 and TRPA1 channels. We showed that non-methylated derivatives have preferable safety profiles compared to methylated ones. Furthermore, methylated derivatives reduced mitochondrial membrane potential. However, all investigated derivatives influence the ordered cell membrane structure depleting membrane cholesterol and inhibit the TRPV1 agonist capsaicin- and the TRPA1 agonist allyl isothiocyanate-induced Ca 2+− influx. This mechanism of action might provide novel perspectives for the development of peripherally acting analgesics via indirectly decreasing the generation and transmission of nociceptive signals. LA - English DB - MTMT ER - TY - JOUR AU - Benabdelghani, Imene AU - Tóth, György AU - Krizsán, Gergő AU - Bazsó, Gábor AU - Szaller, Zsuzsanna AU - Mbithi, Nelson AU - Rácz, Péter AU - Dombi, Péter AU - Polónyi, Gyula AU - Hebling, János TI - Three-photon and four-photon absorption in lithium niobate measured by the Z-scan technique JF - OPTICS EXPRESS J2 - OPT EXPRESS VL - 32 PY - 2024 IS - 5 SP - 7030 EP - 7043 PG - 14 SN - 1094-4087 DO - 10.1364/OE.505995 UR - https://m2.mtmt.hu/api/publication/34596731 ID - 34596731 N1 - Szentágothai Research Centre, Ifjúság street 20, Pécs, 7624, Hungary University of Pécs, Ifjúság Street 6, Pécs, 7624, Hungary HUN-REN – PTE High Intensity Terahertz Research Group, Ifjúság Street 6, Pécs, 7624, Hungary Wigner Research Center for Physics, Institute for Solid State Physics and Optics, Budapest, H-1121, Hungary Garissa University, Garissa, Kenya Export Date: 29 April 2024 Correspondence Address: Hebling, J.; Szentágothai Research Centre, Ifjúság street 20, Hungary; email: hebling@fizika.ttk.pte.hu AB - Open-aperture Z-scan measurements have been carried out to investigate the three-photon (3 PA) and four-photon absorption (4 PA) coefficients at 800 nm and 1030 nm wavelengths, respectively in congruent and stoichiometric lithium niobate (cLN, sLN) with different concentrations of Mg doping. The laser pulse duration at the two wavelengths were 40 and 190 fs. The peak intensity inside the crystals varied between approximately 110 and 550 GW/cm 2 . The 3 PA and 4 PA coefficients were evaluated using a theoretical model and the results suggest that their minima are at or around the Mg doping level corresponding to the threshold for suppressing photo-refraction for both cLN and sLN. This result can be attributed to the contribution of crystal defects to the 3 PA and 4 PA processes. Furthermore, the 4 PA at 1030 nm exhibited greater nonlinear absorption than the 3 PA at 800 nm under the same intensity level. Possible reasons for this unexpected behavior are discussed. Overall, comparing the 3 PA and 4 PA values of these crystals will enable for selection of the optimum composition of LN crystal for efficient THz generation and for other nonlinear optical processes requiring high pump intensities. LA - English DB - MTMT ER - TY - JOUR AU - Pálfalvi, László TI - Hé, elektron, most röpül a kismadár!. A 2023-as fizikai Nobel-díj kapcsán TS - A 2023-as fizikai Nobel-díj kapcsán JF - MAGYAR KÉMIKUSOK LAPJA J2 - MAGY KEM LAP VL - 79 PY - 2024 IS - 2 SP - 40 EP - 42 PG - 3 SN - 0025-0163 UR - https://m2.mtmt.hu/api/publication/34563178 ID - 34563178 LA - Hungarian DB - MTMT ER -