TY - JOUR AU - Ahmadi, Yasin AU - Ahmadi, Hamid AU - Aghebati-Maleki, Leili TI - Increase in the specificity of immunoassay methods by direct targeting different epitopes; sequential chain reactions. JF - Human antibodies J2 - Hum Antibodies PY - 2024 SN - 1875-869X DO - 10.3233/HAB-240019 UR - https://m2.mtmt.hu/api/publication/35320044 ID - 35320044 AB - Immunoassay methods typically involve the use of antibodies, which are either labeled with an enzyme to generate a detectable product or directly tagged with a radioactive or fluorescent substrate.One approach to enhance the specificity of immuno-detection methods is by employing a combination of different antibodies, such as primary and secondary.However, relying solely on one antibody targeting another may not offer the highest level of precision for improving immunoassay specificity; A novel strategy for enhancing the specificity of immunoassay techniques involves directly targeting different epitopes of an antigen.This approach entails utilizing sequential chain reactions facilitated by distinct enzymes bound to various antibodies, each directed at specific epitopes on the antigen. Such an innovative method holds promise for advancing the specificity of immunoassay methods. LA - English DB - MTMT ER - TY - JOUR AU - Szabó-Meleg, Edina TI - Intercellular Highways in Transport Processes. JF - RESULTS AND PROBLEMS IN CELL DIFFERENTIATION J2 - RES PROB CELL DIFF VL - 73 PY - 2024 SP - 173 EP - 201 PG - 29 SN - 0080-1844 DO - 10.1007/978-3-031-62036-2_9 UR - https://m2.mtmt.hu/api/publication/35320041 ID - 35320041 N1 - Journal Article; Review AB - Communication among cells is vital in multicellular organisms. Various structures and mechanisms have evolved over time to achieve the intricate flow of material and information during this process. One such way of communication is through tunnelling membrane nanotubes (TNTs), which were initially described in 2004. These TNTs are membrane-bounded actin-rich cellular extensions, facilitating direct communication between distant cells. They exhibit remarkable diversity in terms of structure, morphology, and function, in which cytoskeletal proteins play an essential role. Biologically, TNTs play a crucial role in transporting membrane components, cell organelles, and nucleic acids, and they also present opportunities for the efficient transmission of bacteria and viruses, furthermore, may contribute to the dissemination of misfolded proteins in certain neurodegenerative diseases. Convincing results of studies conducted both in vitro and in vivo indicate that TNTs play roles in various biomedical processes, including cell differentiation, tissue regeneration, neurodegenerative diseases, immune response and function, as well as tumorigenesis. LA - English DB - MTMT ER - TY - JOUR AU - Barozzi, I. AU - Slaven, N. AU - Canale, E. AU - Lopes, R. AU - Amorim, Monteiro Barbosa I. AU - Bleu, M. AU - Ivanoiu, D. AU - Pacini, C. AU - Mensa', E. AU - Chambers, A. AU - Bravaccini, S. AU - Ravaioli, S. AU - Győrffy, Balázs AU - Dieci, M.V. AU - Pruneri, G. AU - Galli, G.G. AU - Magnani, L. TI - A Functional Survey of the Regulatory Landscape of Estrogen Receptor-Positive Breast Cancer Evolution JF - CANCER DISCOVERY J2 - CANCER DISCOV VL - 14 PY - 2024 IS - 9 SP - 1612 EP - 1630 PG - 19 SN - 2159-8274 DO - 10.1158/2159-8290.CD-23-1157 UR - https://m2.mtmt.hu/api/publication/35309371 ID - 35309371 LA - English DB - MTMT ER - TY - JOUR AU - Sipos, Dávid AU - Debreczeni-Máté, Zsanett AU - Ritter, Zsombor AU - Freihat, Omar AU - Mihály, Simon AU - Kovács, Árpád TI - Complex Diagnostic Challenges in Glioblastoma. The Role of 18F-FDOPA PET Imaging TS - The Role of 18F-FDOPA PET Imaging JF - PHARMACEUTICALS J2 - PHARMACEUTICALS-BASE VL - 17 PY - 2024 IS - 9 SP - 1215 PG - 16 SN - 1424-8247 DO - 10.3390/ph17091215 UR - https://m2.mtmt.hu/api/publication/35306447 ID - 35306447 LA - English DB - MTMT ER - TY - JOUR AU - Osváth, Anikó Éva AU - Hankó, C AU - Csáki, M AU - Molnár, E AU - Pahocsa, J AU - Kocsor, S AU - Tóth, K AU - Fertői, D AU - Sándor-Bajusz, Kinga Amália AU - Dergez, Tímea AU - Tényiné Csábi, Györgyi TI - Risk factors and personality characteristics of nunsuicidal self-injurious behavior in clinical sample of female adolescents JF - EUROPEAN PSYCHIATRY J2 - EUR PSYCHIAT VL - 67 PY - 2024 SP - S446 EP - S447 SN - 0924-9338 UR - https://m2.mtmt.hu/api/publication/35298246 ID - 35298246 LA - English DB - MTMT ER - TY - JOUR AU - Medrano, Mireia AU - Allaoui, Wissal AU - Haddad, Ra’fat Ehab Salim AU - Makrini-Maleville, Leila AU - Valjent, Emmanuel AU - Smolders, Ilse AU - Kormos, Viktória AU - Gaszner, Balázs AU - De Bundel, Dimitri TI - Neuromedin U Neurons in the Edinger–Westphal Nucleus Respond to Alcohol Without Interfering with the Urocortin 1 Response JF - NEUROCHEMICAL RESEARCH J2 - NEUROCHEM RES PY - 2024 SN - 0364-3190 DO - 10.1007/s11064-024-04238-1 UR - https://m2.mtmt.hu/api/publication/35297704 ID - 35297704 N1 - * Megosztott szerzőség AB - The Edinger–Westphal nucleus (EW) is a midbrain nucleus composed of a preganglionic, cholinergic subpopulation and a densely clustered peptidergic subpopulation (EWcp). The EWcp is one of the few brain regions that show consistent induction of FOS following voluntary alcohol intake. Previous results in rodents point to urocortin 1 (UCN1) as one of the peptides most involved in the control of ethanol intake and preference. Notably, the functions described for UCN1, such as reward processing, stress coping or the regulation of feeding behavior are similar to those described for the neuropeptide neuromedin U (NMU). Interestingly, NMU has been recently associated with the modulation of alcohol-related behaviors. However, little is known about the expression and functionality of NMU neurons in alcohol-responsive areas. In this study, we used the recently developed Nmu-Cre knock-in mouse model to examine the expression of NMU in the subaqueductal paramedian zone comprising the EWcp. We delved into the characterization and co-expression of NMU with other markers already described in the EWcp. Moreover, using FOS as a marker of neuronal activity, we tested whether NMU neurons were sensitive to acute alcohol administration. Overall, we provided novel insights on NMU expression and functionality in the EW region. We showed the presence of NMU within a subpopulation of UCN1 neurons in the EWcp and demonstrated that this partial co-expression does not interfere with the responsivity of UCN1-containing cells to alcohol. Moreover, we proposed that the UCN1 content in these neurons may be influenced by sex. LA - English DB - MTMT ER - TY - JOUR AU - Csulak, Timea AU - Herold, Róbert AU - Berke, Gergő AU - Sipos, Zoltán AU - Borbásné Farkas, Kornélia AU - Hegyi, Péter AU - Tényi, Tamás AU - Hajnal, András Sándor TI - Spontaneous mentalizing in patients with schizophrenia – a meta-analysis JF - EUROPEAN PSYCHIATRY J2 - EUR PSYCHIAT VL - 67 PY - 2024 SP - S746 EP - S746 SN - 0924-9338 UR - https://m2.mtmt.hu/api/publication/35297643 ID - 35297643 LA - English DB - MTMT ER - TY - JOUR AU - Vörös, Viktor AU - Sághy, Éva AU - Molnár, Cs AU - Kovács, Márton Áron AU - Pethő, Borbála AU - Kovács, Sándor AU - Zemplényi, Antal Tamás AU - Fekete, Sándor AU - Tényi, Tamás AU - Osváth, Péter TI - Certain immune parameters may have a significant impact on suicidal behavior – a naturalistic study among psychiatric in-patients JF - EUROPEAN PSYCHIATRY J2 - EUR PSYCHIAT VL - 67 PY - 2024 SP - S349 EP - S350 SN - 0924-9338 UR - https://m2.mtmt.hu/api/publication/35297642 ID - 35297642 LA - English DB - MTMT ER - TY - JOUR AU - Pethő, Borbála AU - Tényi, Tamás AU - Herold, Róbert AU - Osváth, Péter AU - Vörös, Viktor AU - Simon, Diána AU - Molnar, Cs AU - Kovács, Márton Áron TI - Investigation of peripheral inflammatory biomarkers in association with suicide risk in major depression JF - EUROPEAN PSYCHIATRY J2 - EUR PSYCHIAT VL - 67 PY - 2024 SP - S792 EP - S793 SN - 0924-9338 UR - https://m2.mtmt.hu/api/publication/35297641 ID - 35297641 LA - English DB - MTMT ER - TY - JOUR AU - Karakas-Török, D AU - Fábi, E AU - Szennai, M AU - Csuta, C AU - Kelemen, O AU - Tényi, Tamás AU - Czéh, Boldizsár AU - Simon, Mária TI - Mentalizing abilities in major depressive disorder and borderline personality disorder : measuring hypermentalization and implicit mentalization with the Hungarian versionof the MASC JF - EUROPEAN PSYCHIATRY J2 - EUR PSYCHIAT VL - 67 PY - 2024 SP - S527 EP - S528 SN - 0924-9338 UR - https://m2.mtmt.hu/api/publication/35297638 ID - 35297638 LA - English DB - MTMT ER -