TY - CHAP AU - Penke, Botond AU - Datki, Zsolt László AU - Soós, Katalin AU - Zarándi, Márta ED - Slaninová, J TI - Mechanism of Neurodegeneration and Neuroprotection T2 - Biologically Active Peptides : XIIth Conference, Collection Symposium Series PB - Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic CY - Prague SN - 9788086241449 T3 - Collection symposium series, ISSN 2464-8183 ; vol. 13. PY - 2011 SP - 81 EP - 85 PG - 5 UR - https://m2.mtmt.hu/api/publication/247717 ID - 247717 LA - English DB - MTMT ER - TY - JOUR AU - Zádori, Dénes AU - Datki, Zsolt László AU - Penke, Botond TI - A krónikus agyi hipoperfúzió szerepe az Alzheimer-kór kialakulásában--tények és hipotézisek [The role of chronic brain hypoperfusion in the pathogenesis of Alzheimer's disease--facts and hypotheses] JF - IDEGGYOGYASZATI SZEMLE / CLINICAL NEUROSCIENCE J2 - IDEGGYOGY SZEMLE VL - 60 PY - 2007 IS - 11-12 SP - 428 EP - 437 PG - 10 SN - 0019-1442 UR - https://m2.mtmt.hu/api/publication/246981 ID - 246981 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Pádár, Petra AU - Bokros, Attila AU - Paragi, Gábor AU - Forgó, Péter AU - Kele, Zoltán AU - Howarth, Nicola M AU - Kovács, Lajos TI - Single Diastereomers of Polyhydroxylated 9-Oxa-1-azabicyclo[4.2.1]nonanes from Intramolecular 1,3-Dipolar Cycloaddition of ω-Unsaturated Nitrones JF - JOURNAL OF ORGANIC CHEMISTRY J2 - J ORG CHEM VL - 71 PY - 2006 IS - 22 SP - 8669 EP - 8672 PG - 4 SN - 0022-3263 DO - 10.1021/jo061503b UR - https://m2.mtmt.hu/api/publication/1329879 ID - 1329879 LA - English DB - MTMT ER - TY - JOUR AU - Fülöp, Lívia AU - Zarándi, Márta AU - Soós, Katalin AU - Penke, Botond TI - Self-assembly of Alzheimer's disease-related amyloid peptides into highly ordered nanostructures JF - NANOPAGES J2 - NANOPAGES VL - 1 PY - 2006 IS - 1 SP - 69 EP - 83 PG - 15 SN - 1787-4033 DO - 10.1556/NANO.1.2006.1.3 UR - https://m2.mtmt.hu/api/publication/1070570 ID - 1070570 LA - English DB - MTMT ER - TY - JOUR AU - Hetényi, Csaba AU - Paragi, Gábor AU - Maran, U AU - Timár, Zoltán AU - Karelson, M AU - Penke, Botond TI - Combination of a modified scoring function with two-dimensional descriptors for calculation of binding affinities of bulky, flexible ligands to proteins JF - JOURNAL OF THE AMERICAN CHEMICAL SOCIETY J2 - J AM CHEM SOC VL - 128 PY - 2006 IS - 4 SP - 1233 EP - 1239 PG - 7 SN - 0002-7863 DO - 10.1021/ja055804z UR - https://m2.mtmt.hu/api/publication/1008544 ID - 1008544 LA - English DB - MTMT ER - TY - JOUR AU - Oksman, M AU - Livonen, H AU - Hogyes, E AU - Amtul, Z AU - Penke, Botond AU - Leenders, I AU - Broersen, L AU - Lutjohann, D AU - Hartmann, T AU - Tanila, H TI - Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP/PS1 transgenic mice JF - NEUROBIOLOGY OF DISEASE J2 - NEUROBIOL DIS VL - 23 PY - 2006 IS - 3 SP - 563 EP - 572 PG - 10 SN - 0969-9961 DO - 10.1016/j.nbd.2006.04.013 UR - https://m2.mtmt.hu/api/publication/247670 ID - 247670 LA - English DB - MTMT ER - TY - JOUR AU - Law, JMS AU - Szőri, Milán AU - Izsak, R AU - Penke, Botond AU - Csizmadia, Imre Gyula AU - Viskolcz, Béla TI - Folded and unfolded conformations of the omega-3 polyunsaturated fatty acid family: CH3CH2[CH=CHCH2](B)[CH2](M)COOH. First principles study JF - JOURNAL OF PHYSICAL CHEMISTRY A J2 - J PHYS CHEM A VL - 110 PY - 2006 IS - 18 SP - 6100 EP - 6111 PG - 12 SN - 1089-5639 DO - 10.1021/jp058215o UR - https://m2.mtmt.hu/api/publication/247668 ID - 247668 LA - English DB - MTMT ER - TY - JOUR AU - Bartha, Ferenc AU - Howard, IA AU - Geerlings, P AU - Van, Alsenoy C AU - Vanderzande, D AU - Cleij, TJ AU - Bogár, Ferenc TI - Density functional crystal orbital study of cyano-substituted poly(para-phenylene-vinylene) and poly(quinoxaline-vinylene) JF - INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY J2 - INT J QUANTUM CHEM VL - 106 PY - 2006 IS - 8 SP - 1912 EP - 1923 PG - 12 SN - 0020-7608 DO - 10.1002/qua.20937 UR - https://m2.mtmt.hu/api/publication/247664 ID - 247664 LA - English DB - MTMT ER - TY - JOUR AU - Verdier, Y AU - Penke, Botond TI - Polypeptide and protein aggregates with neurotoxic properties in neurodegenerative disorders: Emphasis on beta-amyloid-induced dysfunction of receptor-mediated signal transduction pathways JF - CURRENT SIGNAL TRANSDUCTION THERAPY J2 - CURR SIGNAL TRANSDUCT THER VL - 1 PY - 2006 IS - 1 SP - 97 EP - 112 PG - 16 SN - 1574-3624 DO - 10.2174/157436206775269208 UR - https://m2.mtmt.hu/api/publication/246979 ID - 246979 AB - Polypeptides and proteins may undergo misfolding processes resulting in aggregates: oligomers and fibrils possessing toxic properties. In most cases a beta-structure will be formed with high tendency to form suprachemical structures, assemblies. The aggregation grade might play crucial role in the biological activities of protein assemblies. Protein aggregates bind to receptors or receptor complexes of neuronal and glial cells and activate signal transduction pathways. Beta amyloid may interact with Writ receptors as well as increases the intracellular Ca-ion level in neurons. GSK-3beta activation causes tau-hyperphosphorylation and collaps of the microtubular system. beta-amyloid triggers also a CD36 dependent signaling cascade and activates microglia. Other misfolded protein assemblies of alpha-synuclein, huntingtin and prion proteins similarly interact with receptor complexes and disturb signal transduction. Rational drug design may start after understanding these signalisation disturbances. Novel drugs will prevent receptor interaction with misfolded protein aggregates. LA - English DB - MTMT ER - TY - JOUR AU - Beleznay, Ferenc AU - Szekeres, Z AU - Bogár, Ferenc AU - Ladik, J TI - The effect of breathing vibration on the charge carrier mobility of a guanine-cytosine base pair stack JF - CHEMICAL PHYSICS LETTERS J2 - CHEM PHYS LETT VL - 424 PY - 2006 IS - 4-6 SP - 399 EP - 402 PG - 4 SN - 0009-2614 DO - 10.1016/j.cplett.2006.04.019 UR - https://m2.mtmt.hu/api/publication/140526 ID - 140526 LA - English DB - MTMT ER -