@article{MTMT:33610921,
	title = {MEK Is a Potential Indirect Target in Subtypes of Head and Neck Cancers},
	url = {https://m2.mtmt.hu/api/publication/33610921},
	author = {Gurbi, Bianka and Brauswetter, Diána and Pénzes, Kinga and Varga, Attila and Krenács, Tibor and Dános, Kornél and Birtalan, Ede and Tamás, László and Csala, Miklós},
	doi = {10.3390/ijms24032782},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {24},
	unique-id = {33610921},
	issn = {1661-6596},
	abstract = {The poor prognosis of head-and-neck squamous cell carcinoma (HNSCC) is partly due to the lack of reliable prognostic and predictive markers. The Ras/Raf/MEK/ERK signaling pathway is often activated by overexpressed epidermal growth factor receptor (EGFR) and stimulates the progression of HNSCCs. Our research was performed on three human papillomavirus (HPV)-negative HNSCC-cell lines: Detroit 562, FaDu and SCC25. Changes in cell viability upon EGFR and/or MEK inhibitors were measured by the MTT method. The protein-expression and phosphorylation profiles of the EGFR-initiated signaling pathways were assessed using Western-blot analysis. The EGFR expression and pY1068-EGFR levels were also studied in the patient-derived HNSCC samples. We found significant differences between the sensitivity of the tumor-cell lines used. The SCC25 line was found to be the most sensitive to the MEK inhibitors, possibly due to the lack of feedback Akt activation through EGFR. By contrast, this feedback activation had an important role in the FaDu cells. The observed insensitivity of the Detroit 562 cells to the MEK inhibitors might have been caused by their PIK3CA mutation. Among HNSCC cell lines, EGFR-initiated signaling pathways are particularly versatile. An ERK/EGFR feedback loop can lead to Akt-pathway activation upon MEK inhibition, and it is related not only to increased amounts of EGFR but also to the elevation of pY1068-EGFR levels. The presence of this mechanism may justify the combined application of EGFR and MEK inhibitors.},
	year = {2023},
	eissn = {1422-0067},
	orcid-numbers = {Gurbi, Bianka/0000-0002-5635-6255; Krenács, Tibor/0000-0001-9164-065X; Dános, Kornél/0000-0002-3829-8266; Birtalan, Ede/0000-0002-5699-3545; Tamás, László/0000-0003-3723-9149; Csala, Miklós/0000-0002-3829-4361}
}

@article{MTMT:33541689,
	title = {Protein Kinase D3 (PKD3) Requires Hsp90 for Stability and Promotion of Prostate Cancer Cell Migration},
	url = {https://m2.mtmt.hu/api/publication/33541689},
	author = {Varga, Attila and Nguyen, Minh Tu and Pénzes, Kinga and Bátai, Bence and Gyulavári, Pál and Gurbi, Bianka and Murányi, József and Csermely, Péter and Csala, Miklós and Vántus, Tibor and Sőti, Csaba},
	doi = {10.3390/cells12020212},
	journal-iso = {CELLS-BASEL},
	journal = {CELLS},
	volume = {12},
	unique-id = {33541689},
	abstract = {Prostate cancer metastasis is a significant cause of mortality in men. PKD3 facilitates tumor growth and metastasis, however, its regulation is largely unclear. The Hsp90 chaperone stabilizes an array of signaling client proteins, thus is an enabler of the malignant phenotype. Here, using different prostate cancer cell lines, we report that Hsp90 ensures PKD3 conformational stability and function to promote cancer cell migration. We found that pharmacological inhibition of either PKDs or Hsp90 dose-dependently abrogated the migration of DU145 and PC3 metastatic prostate cancer cells. Hsp90 inhibition by ganetespib caused a dose-dependent depletion of PKD2, PKD3, and Akt, which are all involved in metastasis formation. Proximity ligation assay and immunoprecipitation experiments demonstrated a physical interaction between Hsp90 and PKD3. Inhibition of the chaperone–client interaction induced misfolding and proteasomal degradation of PKD3. PKD3 siRNA combined with ganetespib treatment demonstrated a specific involvement of PKD3 in DU145 and PC3 cell migration, which was entirely dependent on Hsp90. Finally, ectopic expression of PKD3 enhanced migration of non-metastatic LNCaP cells in an Hsp90-dependent manner. Altogether, our findings identify PKD3 as an Hsp90 client and uncover a potential mechanism of Hsp90 in prostate cancer metastasis. The molecular interaction revealed here may regulate other biological and pathological functions.},
	year = {2023},
	eissn = {2073-4409},
	orcid-numbers = {Nguyen, Minh Tu/0000-0003-1653-8377; Gyulavári, Pál/0000-0002-5850-0441; Gurbi, Bianka/0000-0002-5635-6255; Csermely, Péter/0000-0001-9234-0659; Csala, Miklós/0000-0002-3829-4361; Vántus, Tibor/0000-0002-7894-017X; Sőti, Csaba/0000-0002-4057-7678}
}

@article{MTMT:33538163,
	title = {Cell-Penetrating Dabcyl-Containing Tetraarginines with Backbone Aromatics as Uptake Enhancers},
	url = {https://m2.mtmt.hu/api/publication/33538163},
	author = {Yousef, M. and Szabó, Ildikó and Murányi, József and Illien, Françoise and Soltész, Dóra and Bató, Csaba and Tóth, Gabriella and Batta, Gyula Gábor (Ifj.) and Nagy, Péter and Sagan, Sandrine and Bánóczi, Zoltán},
	doi = {10.3390/pharmaceutics15010141},
	journal-iso = {PHARMACEUTICS},
	journal = {PHARMACEUTICS},
	volume = {15},
	unique-id = {33538163},
	issn = {1999-4923},
	abstract = {Cell-penetrating peptides represent an emerging class of carriers capable of effective cellular delivery. This work demonstrates the preparation and investigation of efficient CPPs. We have already shown that the presence of 4-((4-(dimethylamino)phenyl)azo)benzoic acid (Dabcyl) and Trp greatly increase the uptake of oligoarginines. This work is a further step in that direction. We have explored the possibility of employing unnatural, aromatic amino acids, to mimic Trp properties and effects. The added residues allow the introduction of aromaticity, not as a side-chain group, but rather as a part of the sequence. The constructs presented exceptional internalization on various cell lines, with an evident structure–activity relationship. The CPPs were investigated for their entry mechanisms, and our peptides exploit favorable pathways, yet one of the peptides relies highly on direct penetration. Confocal microscopy studies have shown selectivity towards the cell lines, by showing diffuse uptake in FADU cells, while vesicular uptake takes place in SCC-25 cell line. These highly active CPPs have proved their applicability in cargo delivery by successfully delivering antitumor drugs into MCF-7 and MDA-MB-231 cells. The modifications in the sequences allow the preparation of short yet highly effective constructs able to rival the penetration of well-known CPPs such as octaarginine (Arg8).},
	year = {2023},
	eissn = {1999-4923},
	orcid-numbers = {Szabó, Ildikó/0000-0002-9844-7841; Murányi, József/0000-0001-5672-6482; Batta, Gyula Gábor (Ifj.)/0000-0001-8735-6920; Nagy, Péter/0000-0002-7466-805X; Bánóczi, Zoltán/0000-0003-1880-4042}
}

@article{MTMT:32782717,
	title = {Synthesis and Antiproliferative Activity of Novel Imipridone–Ferrocene Hybrids with Triazole and Alkyne Linkers},
	url = {https://m2.mtmt.hu/api/publication/32782717},
	author = {Czuczi, Tamás and Murányi, József and Bárány, Péter Tibor and Móra , István András and Borbély, Adina Noémi and Csala, Miklós and Csámpai, Antal},
	doi = {10.3390/ph15040468},
	journal-iso = {PHARMACEUTICALS-BASE},
	journal = {PHARMACEUTICALS},
	volume = {15},
	unique-id = {32782717},
	year = {2022},
	eissn = {1424-8247},
	orcid-numbers = {Borbély, Adina Noémi/0000-0002-5506-6555; Csala, Miklós/0000-0002-3829-4361; Csámpai, Antal/0000-0003-2107-7309}
}

@{MTMT:32683354,
	title = {Synthesis of novel imipridone derivatives and their evaluation for their anticancer activity.. WO2022029459A1},
	url = {https://m2.mtmt.hu/api/publication/32683354},
	author = {Csámpai, Antal and Bárány, Péter Tibor and Czuczi, Tamas and Kovacs, Imre and Adamis, Balint and Nemeth, Zsofia and Murányi, József and Olahne, Szabo Rita and Bosze, Szilvia and Mezo, Gabor and Kőhidai, László and Lajkó, Eszter and Takács, Angéla and Láng, Orsolya and Mezo, Diana},
	unique-id = {32683354},
	abstract = {The present invention relates to compds. of formula (I) (I) or pharmaceutically acceptable salts, and stereoisomers thereof, including enantiomers, racemic mixts., mixts. of enantiomers, or combinations thereof, which are applicable for use in treating cancer diseases. The present invention further relates to a pharmaceutical compn. comprising the above compds. [on SciFinder(R)]},
	year = {2022},
	pages = {91pp.},
	orcid-numbers = {Csámpai, Antal/0000-0003-2107-7309; Kőhidai, László/0000-0002-9002-0296; Lajkó, Eszter/0000-0002-4796-4646; Takács, Angéla/0000-0002-8912-8216; Láng, Orsolya/0000-0002-2787-2154}
}

@article{MTMT:32574856,
	title = {Production of NOS2 and inflammatory cytokines is reduced by selected protein kinase inhibitors with partial repolarization of HL-60 derived and human blood macrophages},
	url = {https://m2.mtmt.hu/api/publication/32574856},
	author = {Bőgel, Gábor and Murányi, József and Szokol, Bálint and Kukor, Zoltán and Móra , István András and Kardon Tamás, Zoltán and Őrfi, László and Hrabák, András},
	doi = {10.1016/j.heliyon.2021.e08670},
	journal-iso = {HELIYON},
	journal = {HELIYON},
	volume = {8},
	unique-id = {32574856},
	year = {2022},
	eissn = {2405-8440},
	orcid-numbers = {Bőgel, Gábor/0000-0002-7677-6855; Kukor, Zoltán/0000-0002-7250-2160; Őrfi, László/0000-0001-6149-2385; Hrabák, András/0000-0002-7818-6509}
}

@article{MTMT:32461679,
	title = {Combination of multifunctional ursolic acid with kinase inhibitors for anti-cancer drug carrier vesicles},
	url = {https://m2.mtmt.hu/api/publication/32461679},
	author = {Lőrincz, András and Mihály, Judith and Wacha, András Ferenc and Németh, Csaba and Besztercei, Balázs and Gyulavári, Pál and Varga, Zoltán and Peták, István and Bóta, Attila},
	doi = {10.1016/j.msec.2021.112481},
	journal-iso = {MAT SCI ENG C-MATER},
	journal = {MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS},
	volume = {131},
	unique-id = {32461679},
	issn = {0928-4931},
	year = {2021},
	eissn = {1873-0191},
	orcid-numbers = {Wacha, András Ferenc/0000-0002-9609-0893; Besztercei, Balázs/0000-0002-5636-284X; Gyulavári, Pál/0000-0002-5850-0441; Varga, Zoltán/0000-0002-5741-2669; Peták, István/0000-0003-0422-9286}
}

@{MTMT:31916954,
	title = {Optimation of homing peptide sequence selected by phage display for HT-29 colon cancer cells to improve the antitumor activity},
	url = {https://m2.mtmt.hu/api/publication/31916954},
	author = {Kiss, Krisztina and Biri-Kovács, Beáta and Szabó, Rita (Oláhné) and Enyedi, Kata Nóra and Murányi, József and Schlosser, Gitta (Vácziné) and Ranđelović, I. and Tóvári, J. and Mező, Gábor},
	booktitle = {Development of bioconjugates and their module constructs for targeted therapy of cancers with high mortality},
	unique-id = {31916954},
	year = {2020},
	pages = {5-9},
	orcid-numbers = {Enyedi, Kata Nóra/0000-0003-3724-5936; Schlosser, Gitta (Vácziné)/0000-0002-7637-7133; Mező, Gábor/0000-0002-7618-7954}
}

@article{MTMT:31643674,
	title = {Fine-tuning of AMPK–ULK1–mTORC1 regulatory triangle is crucial for autophagy oscillation},
	url = {https://m2.mtmt.hu/api/publication/31643674},
	author = {Holczer, Marianna and Hajdú, Bence and Lőrincz, T. and Szarka, András and Bánhegyi, Gábor and Kapuy, Orsolya},
	doi = {10.1038/s41598-020-75030-8},
	journal-iso = {SCI REP},
	journal = {SCIENTIFIC REPORTS},
	volume = {10},
	unique-id = {31643674},
	issn = {2045-2322},
	abstract = {Autophagy is an intracellular digestive process, which has a crucial role in maintaining cellular homeostasis by self-eating the unnecessary and/or damaged components of the cell at various stress events. ULK1, one of the key elements of autophagy activator complex, together with the two sensors of nutrient and energy conditions, called mTORC1 and AMPK kinases, guarantee the precise function of cell response mechanism. We claim that the feedback loops of AMPK–mTORC1–ULK1 regulatory triangle determine an accurate dynamical characteristic of autophagic process upon cellular stress. By using both molecular and theoretical biological techniques, here we reveal that a delayed negative feedback loop between active AMPK and ULK1 is essential to manage a proper cellular answer after prolonged starvation or rapamycin addition. AMPK kinase quickly gets induced followed by AMPK-P-dependent ULK1 activation, whereas active ULK1 has a rapid negative effect on AMPK-P resulting in a delayed inhibition of ULK1. The AMPK-P → ULK1 ˧ AMPK-P negative feedback loop results in a periodic repeat of their activation and inactivation and an oscillatory activation of autophagy, as well. We demonstrate that the periodic induction of self-cannibalism is necessary for the proper dynamical behaviour of the control network when mTORC1 is inhibited with respect to various stress events. By computational simulations we also suggest various scenario to introduce “delay” on AMPK-P-dependent ULK1 activation (i.e. extra regulatory element in the wiring diagram or multi-phosphorylation of ULK1). © 2020, The Author(s).},
	year = {2020},
	eissn = {2045-2322},
	orcid-numbers = {Holczer, Marianna/0000-0002-2509-8716; Hajdú, Bence/0000-0001-5443-4136; Szarka, András/0000-0001-6594-254X; Bánhegyi, Gábor/0000-0001-7559-0066; Kapuy, Orsolya/0000-0002-8484-4504}
}

@article{MTMT:31314893,
	title = {Genetic Polymorphism of GSTP-1 Affects Cyclophosphamide Treatment of Autoimmune Diseases},
	url = {https://m2.mtmt.hu/api/publication/31314893},
	author = {Hajdinák, Péter and Szabó, Melinda and Kiss, Emese and Veress, Lili and Wunderlich, Lívius and Szarka, András},
	doi = {10.3390/molecules25071542},
	journal-iso = {MOLECULES},
	journal = {MOLECULES},
	volume = {25},
	unique-id = {31314893},
	issn = {1420-3049},
	year = {2020},
	eissn = {1420-3049},
	orcid-numbers = {Hajdinák, Péter/0000-0002-7705-2074; Kiss, Emese/0000-0002-5399-2379; Szarka, András/0000-0001-6594-254X}
}