TY - JOUR AU - Hangya, Balázs TI - Az agyi neuronhálózatok szerepe a dementiák kialakulásában: vizsgálati módszereink az optogenetikától a mesterséges intelligenciáig JF - LEGE ARTIS MEDICINAE J2 - LEGE ART MED VL - 33 PY - 2023 IS - 12 SP - 625 EP - 630 PG - 6 SN - 0866-4811 DO - 10.33616/lam.33.0625 UR - https://m2.mtmt.hu/api/publication/34498341 ID - 34498341 AB - A Kísérleti Orvostudományi Kutatóintézet Rendszer-Neurobiológia Ku­tatócsoportjában a fő célkitűzésünk a kognitív folyamatok agyi mechanizmusainak jobb megértése. A tanulás, memória, figyelem és döntéshozás idegrendszeri alapjait nemcsak normális körülmények között, hanem kóros állapotokban is vizsgáljuk, különös tekintettel a neurodegeneratív dementiákra, mint az Alzheimer- és a Par­kinson-kór. LA - Hungarian DB - MTMT ER - TY - JOUR AU - Király, Bálint AU - Domonkos, Andor AU - Jelitai, Márta AU - Lopes-dos-Santos, Vítor AU - Martínez-Bellver, Sergio AU - Kocsis, Barnabás AU - Schlingloff, Dániel AU - Joshi, Abhilasha AU - Salib, Minas AU - Fiáth, Richárd AU - Barthó, Péter AU - Ulbert, István AU - Freund, Tamás AU - Viney, Tim J. AU - Dupret, David AU - Varga, Viktor AU - Hangya, Balázs TI - Author Correction: The medial septum controls hippocampal supra-theta oscillations JF - NATURE COMMUNICATIONS J2 - NAT COMMUN VL - 14 PY - 2023 IS - 1 PG - 1 SN - 2041-1723 DO - 10.1038/s41467-023-43190-6 UR - https://m2.mtmt.hu/api/publication/34400320 ID - 34400320 LA - English DB - MTMT ER - TY - JOUR AU - Slézia, Andrea AU - Hegedüs, Panna AU - Rusina, Evgeniia AU - Lengyel, Katalin AU - Solari, Nicola AU - Kaszás, Attila AU - Balázsfi, Diána AU - Botzanowski, Boris AU - Acerbo, Emma AU - Missey, Florian AU - Williamson, Adam AU - Hangya, Balázs TI - Behavioral, neural and ultrastructural alterations in a graded-dose 6-OHDA mouse model of early-stage Parkinson's disease JF - SCIENTIFIC REPORTS J2 - SCI REP VL - 13 PY - 2023 IS - 1 PG - 17 SN - 2045-2322 DO - 10.1038/s41598-023-46576-0 UR - https://m2.mtmt.hu/api/publication/34341943 ID - 34341943 AB - Studying animal models furthers our understanding of Parkinson’s disease (PD) pathophysiology by providing tools to investigate detailed molecular, cellular and circuit functions. Different versions of the neurotoxin-based 6-hydroxydopamine (6-OHDA) model of PD have been widely used in rats. However, these models typically assess the result of extensive and definitive dopaminergic lesions that reflect a late stage of PD, leading to a paucity of studies and a consequential gap of knowledge regarding initial stages, in which early interventions would be possible. Additionally, the better availability of genetic tools increasingly shifts the focus of research from rats to mice, but few mouse PD models are available yet. To address these, we characterize here the behavioral, neuronal and ultrastructural features of a graded-dose unilateral, single-injection, striatal 6-OHDA model in mice, focusing on early-stage changes within the first two weeks of lesion induction. We observed early onset, dose-dependent impairments of overall locomotion without substantial deterioration of motor coordination. In accordance, histological evaluation demonstrated a partial, dose-dependent loss of dopaminergic neurons of substantia nigra pars compacta (SNc). Furthermore, electron microscopic analysis revealed degenerative ultrastructural changes in SNc dopaminergic neurons. Our results show that mild ultrastructural and cellular degradation of dopaminergic neurons of the SNc can lead to certain motor deficits shortly after unilateral striatal lesions, suggesting that a unilateral dose-dependent intrastriatal 6-OHDA lesion protocol can serve as a successful model of the early stages of Parkinson’s disease in mice. LA - English DB - MTMT ER - TY - JOUR AU - Balkányi, László AU - Hangya, Balázs TI - LAMMI: mesterséges intelligencia (MI) rovat a LAM-ban – beköszöntô JF - LEGE ARTIS MEDICINAE J2 - LEGE ART MED VL - 33 PY - 2023 IS - 8-9 SP - 459 EP - 466 PG - 8 SN - 0866-4811 UR - https://m2.mtmt.hu/api/publication/34191844 ID - 34191844 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Király, Bálint AU - Domonkos, Andor AU - Jelitai, Márta AU - Lopes-dos-Santos, Vítor AU - Martínez-Bellver, Sergio AU - Kocsis, Barnabás AU - Schlingloff, Dániel AU - Joshi, Abhilasha AU - Salib, Minas AU - Fiáth, Richárd AU - Barthó, Péter AU - Ulbert, István AU - Freund, Tamás AU - Viney, Tim J. AU - Dupret, David AU - Varga, Viktor AU - Hangya, Balázs TI - The medial septum controls hippocampal supra-theta oscillations JF - NATURE COMMUNICATIONS J2 - NAT COMMUN VL - 14 PY - 2023 IS - 1 PG - 25 SN - 2041-1723 DO - 10.1038/s41467-023-41746-0 UR - https://m2.mtmt.hu/api/publication/34188237 ID - 34188237 AB - Hippocampal theta oscillations orchestrate faster beta-to-gamma oscillations facilitating the segmentation of neural representations during navigation and episodic memory. Supra-theta rhythms of hippocampal CA1 are coordinated by local interactions as well as inputs from the entorhinal cortex (EC) and CA3 inputs. However, theta-nested gamma-band activity in the medial septum (MS) suggests that the MS may control supra-theta CA1 oscillations. To address this, we performed multi-electrode recordings of MS and CA1 activity in rodents and found that MS neuron firing showed strong phase-coupling to theta-nested supra-theta episodes and predicted changes in CA1 beta-to-gamma oscillations on a cycle-by-cycle basis. Unique coupling patterns of anatomically defined MS cell types suggested that indirect MS-to-CA1 pathways via the EC and CA3 mediate distinct CA1 gamma-band oscillations. Optogenetic activation of MS parvalbumin-expressing neurons elicited theta-nested beta-to-gamma oscillations in CA1. Thus, the MS orchestrates hippocampal network activity at multiple temporal scales to mediate memory encoding and retrieval. LA - English DB - MTMT ER - TY - GEN AU - Hegedüs, Panna AU - Victoria, Lyakhova AU - Velencei, Anna AU - Mayer, Márton István AU - Zelenak, Zsofia AU - Nyíri, Gábor AU - Hangya, Balázs TI - Parvalbumin-expressing basal forebrain neurons mediate learning from negative experience PY - 2023 PG - 51 UR - https://m2.mtmt.hu/api/publication/34096335 ID - 34096335 LA - English DB - MTMT ER - TY - JOUR AU - Schlingloff, Dániel AU - Hangya, Balázs AU - Pinto, Lucas TI - A cholinergic auditory pathway JF - NATURE NEUROSCIENCE J2 - NAT NEUROSCI VL - 26 PY - 2023 SP - 726 EP - 728 PG - 3 SN - 1097-6256 DO - 10.1038/s41593-023-01300-z UR - https://m2.mtmt.hu/api/publication/33756936 ID - 33756936 LA - English DB - MTMT ER - TY - JOUR AU - Hangya, Balázs AU - Varga, Viktor TI - Editorial: The medial septum as a smart clock: New aspects of its function beyond pacemaking. JF - FRONTIERS IN NEURAL CIRCUITS J2 - FRONT NEURAL CIRCUIT VL - 16 PY - 2023 PG - 3 SN - 1662-5110 DO - 10.3389/fncir.2022.1093711 UR - https://m2.mtmt.hu/api/publication/33624175 ID - 33624175 LA - English DB - MTMT ER - TY - JOUR AU - Hegedüs, Panna AU - Tóthné Sviatkó, Katalin AU - Király, Bálint AU - Martínez-Bellver, Sergio AU - Hangya, Balázs TI - Cholinergic activity reflects reward expectations and predicts behavioral responses JF - ISCIENCE J2 - ISCIENCE VL - 26 PY - 2023 IS - 1 PG - 22 SN - 2589-0042 DO - 10.1016/j.isci.2022.105814 UR - https://m2.mtmt.hu/api/publication/33548218 ID - 33548218 LA - English DB - MTMT ER - TY - JOUR AU - Várkonyi, Dorottya AU - Török, Bibiána AU - Bodóné Sipos, Eszter AU - Fazekas, Csilla Lea AU - Bánrévi, Krisztina AU - Correia, Pedro AU - Chaves, Tiago AU - Farkas, Szidónia AU - Szabó, Adrienn AU - Martínez-Bellver, Sergio AU - Hangya, Balázs AU - Zelena, Dóra TI - Investigation of Anxiety- and Depressive-like Symptoms in 4- and 8-Month-Old Male Triple Transgenic Mouse Models of Alzheimer’s Disease JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 23 PY - 2022 IS - 18 PG - 22 SN - 1661-6596 DO - 10.3390/ijms231810816 UR - https://m2.mtmt.hu/api/publication/33123196 ID - 33123196 N1 - * Megosztott szerzőség AB - Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most common form of dementia. Approximately 50% of AD patients show anxiety and depressive symptoms, which may contribute to cognitive decline. We aimed to investigate whether the triple-transgenic mouse (3xTg-AD) is a good preclinical model of this co-morbidity. The characteristic histological hallmarks are known to appear around 6-month; thus, 4- and 8-month-old male mice were compared with age-matched controls. A behavioral test battery was used to examine anxiety- (open field (OF), elevated plus maze, light-dark box, novelty suppressed feeding, and social interaction (SI) tests), and depression-like symptoms (forced swim test, tail suspension test, sucrose preference test, splash test, and learned helplessness) as well as the cognitive decline (Morris water maze (MWM) and social discrimination (SD) tests). Acetylcholinesterase histochemistry visualized cholinergic fibers in the cortex. Dexamethasone-test evaluated the glucocorticoid non-suppression. In the MWM, the 3xTg-AD mice found the platform later than controls in the 8-month-old cohort. The SD abilities of the 3xTg-AD mice were missing at both ages. In OF, both age groups of 3xTg-AD mice moved significantly less than the controls. During SI, 8-month-old 3xTg-AD animals spent less time with friendly social behavior than the controls. In the splash test, 3xTg-AD mice groomed themselves significantly less than controls of both ages. Cortical fiber density was lower in 8-month-old 3xTg-AD mice compared to the control. Dexamethasone non-suppression was detectable in the 4-month-old group. All in all, some anxiety- and depressive-like symptoms were present in 3xTg-AD mice. Although this strain was not generally more anxious or depressed, some aspects of comorbidity might be studied in selected tests, which may help to develop new possible treatments. LA - English DB - MTMT ER -