TY - JOUR AU - Marosvölgyi, Tamás AU - Mintál, Kitti AU - Borbásné Farkas, Kornélia AU - Sipos, Zoltán AU - Makszin, Lilla AU - Szabó, Éva AU - Tóth, Attila AU - Kocsis, Béla AU - Kovács, Krisztina AU - Hormay, Edina AU - Lénárd, László AU - Karádi, Zoltán György AU - Bufa, Anita TI - Antibiotics and probiotics-induced effects on the total fatty acid composition of feces in a rat model JF - SCIENTIFIC REPORTS J2 - SCI REP VL - 14 PY - 2024 IS - 1 PG - 12 SN - 2045-2322 DO - 10.1038/s41598-024-57046-6 UR - https://m2.mtmt.hu/api/publication/34745300 ID - 34745300 N1 - * Megosztott szerzőség AB - Fatty acids (FAs) play important roles as membrane components and signal transduction molecules. Changes in short chain FA (SCFA) composition are associated with gut microbiota modifications. However, the effect of bacteria-driven changes on the detailed FA spectrum has not been explored yet. We investigated the effect of antibiotics (ABx) and/or probiotics, in four treatment groups on rat stool FA composition. Principal component analysis indicated that the chromatogram profiles of the treatment groups differ, which was also observed at different time points. Linear mixed effects models showed that in the parameters compared (sampling times, treatments. and their interactions), both the weight percentage and the concentration of FAs were affected by ABx and probiotic administration. This study found that the gut microbiome defines trans and branched saturated FAs, most saturated FAs, and unsaturated FAs with less carbon atoms. These results are among the first ones to demonstrate the restoring effects of a probiotic mixture on a substantial part of the altered total FA spectrum, and also revealed a previously unknown relationship between gut bacteria and a larger group of FAs. These findings suggest that intestinal bacteria produce not only SCFAs but also other FAs that may affect the host’s physiological processes. LA - English DB - MTMT ER - TY - CONF AU - Hormay, Edina AU - Mintál, Kitti AU - László, Bettina Réka AU - Szabó, István AU - Tóth, Attila AU - László, Kristóf AU - Győrfi, Nina Rubina AU - Lénárd, László AU - Karádi, Zoltán György TI - Different aspects of the taste reactivity test to interpret gustatory responses elicited organismic changes. T2 - 7th Hungarian Neuroscience Doctoral Conference for Undergraduate Students, Graduate Students and Junior Post-Docs (HUNDOC) Booklet PY - 2024 SP - 48 UR - https://m2.mtmt.hu/api/publication/34735416 ID - 34735416 LA - English DB - MTMT ER - TY - CONF AU - Hormay, Edina AU - Mintál, Kitti AU - László, Bettina Réka AU - Szabó, István AU - Tóth, Attila AU - László, Kristóf AU - Győrfi, Nina Rubina AU - Lénárd, László AU - Karádi, Zoltán György TI - Long term saccharose consumption associated activity of limbic forebrain glucose-monitoring neurons: A pilot study in the rat. T2 - International Neuroscience Conference, Pécs 2024 PY - 2024 SP - 129 UR - https://m2.mtmt.hu/api/publication/34735333 ID - 34735333 LA - English DB - MTMT ER - TY - JOUR AU - Vörös, Dávid AU - Kiss, Orsolya AU - Taigiszer, Márton AU - László, Bettina Réka AU - Ollmann, Tamás AU - Péczely, László AU - Zagorácz, Olga AU - Kertes, Erika AU - Kállai, Veronika AU - Marosné Berta, Beáta AU - Kovács, Anita AU - Karádi, Zoltán György AU - Lénárd, László AU - László, Kristóf TI - The role of intraamygdaloid oxytocin in spatial learning and avoidance learning JF - PEPTIDES J2 - PEPTIDES VL - 175 PY - 2024 PG - 8 SN - 0196-9781 DO - 10.1016/j.peptides.2024.171169 UR - https://m2.mtmt.hu/api/publication/34642191 ID - 34642191 N1 - Medical School, Institute of Physiology, University of Pécs, Szigeti Str. 12, P.O. Box 99, Pécs, 7602, Hungary Neuropeptides, Cognition, Animal Models of Neuropsychiatric Disorders Research Group, Medical School, Institute of Physiology, University of Pécs, Pécs, 7602, Hungary Neuroscience Center, University of Pécs, Pécs, 7602, Hungary Learning in Biological and Artificial Systems Research Group, Medical School, Institute of Physiology, University of Pécs, Pécs, 7602, Hungary Cellular Bioimpedance Research Group, Szentágothai Research Center, University of Pécs, Pécs, 7602, Hungary Molecular Endocrinology and Neurophysiology Research Group, Szentágothai Center, University of Pécs, Pécs, 7602, Hungary Export Date: 26 February 2024 CODEN: PPTDD Correspondence Address: László, K.; Medical School, Szigeti Str. 12, P.O. Box 99, Hungary; email: kristof.laszlo@aok.pte.hu AB - The goal of the present study is to investigate the role of intraamygdaloid oxytocin in learning-related mechanisms. Oxytocin is a neuropeptide which is involved in social bonding, trust, emotional responses and various social behaviors. By conducting passive avoidance and Morris water maze tests on male Wistar rats, the role of intraamygdaloid oxytocin in memory performance and learning was investigated. Oxytocin doses of 10 ng and 100 ng were injected into the central nucleus of the amygdala. Our results showed that 10 ng oxytocin significantly reduced the time required to locate the platform during the Morris water maze test while significantly increasing the latency time in the passive avoidance test. However, the 100 ng oxytocin experiment failed to produce a significant effect in either of the tests. Wistar rats pretreated with 20 ng oxytocin receptor antagonist (L-2540) were administered 10 ng of oxytocin into the central nucleus of the amygdala and were also subjected to the aforementioned tests to highlight the role of oxytocin receptors in spatial- and avoidance learning. Results suggest that oxytocin supports memory processing during both the passive avoidance and the Morris water maze tests. Oxytocin antagonists can however block the effects of oxytocin in both tests. The results substantiate that oxytocin uses oxytocin receptors to enhance memory and learning performance. LA - English DB - MTMT ER - TY - CONF AU - Zagorácz, Olga AU - Ollmann, Tamás AU - Péczely, László AU - László, Kristóf AU - Kovács, Anita AU - Marosné Berta, Beáta AU - Kállai, Veronika AU - Kertes, Erika AU - Vörös, Dávid AU - Dusa, D AU - Szabó, Ádám AU - Lénárd, László TI - Neuropeptide QRFP enhances memory in passive avoidance paradigm. T2 - International Neuroscience Conference, Pécs 2024 PY - 2024 SP - 195 UR - https://m2.mtmt.hu/api/publication/34558057 ID - 34558057 LA - English DB - MTMT ER - TY - CONF AU - Zagorácz, Olga AU - Ollmann, Tamás AU - Péczely, László AU - László, Kristóf AU - Kovács, Anita AU - Marosné Berta, Beáta AU - Kállai, Veronika AU - Kertes, Erika AU - Lénárd, László TI - Unexpected effects of neuropeptide QRFP administration into the lateral hypothalamic area on feeding. T2 - 6th Hungarian Neuroscience Doctoral Conference for Undergraduate Students, Graduate Students and Junior Postdoc PY - 2023 SP - 107 UR - https://m2.mtmt.hu/api/publication/34558123 ID - 34558123 LA - English DB - MTMT ER - TY - CONF AU - Zagorácz, Olga AU - Ollmann, Tamás AU - Péczely, László AU - László, Kristóf AU - Kovács, Anita AU - Marosné Berta, Beáta AU - Kállai, Veronika AU - Kertes, Erika AU - Szabó, Ádám AU - Vörös, Dávid AU - Lénárd, László TI - Neuropeptide QRFP affects spatial memory in rats. T2 - FENS Regional Meeting 2023 (FRM2023) PY - 2023 UR - https://m2.mtmt.hu/api/publication/34558097 ID - 34558097 LA - English DB - MTMT ER - TY - JOUR AU - Győrfi, Nina Rubina AU - Gál, Adrián Róbert AU - Fincsur, András AU - Kalmar-Nagy, Karoly AU - Mintál, Kitti AU - Hormay, Edina AU - Miseta, Attila János AU - Tornóczky, Tamás AU - Nemeth, Anita K. AU - Bogner, Péter AU - Kiss, Tamas AU - Helyes, Zsuzsanna AU - Sári, Zoltán AU - Klincsik, Mihály AU - Tadity, Vladimir AU - Lénárd, László AU - Vereczkei, András AU - Karádi, Zoltán György AU - Vizvári, Zoltán Ákos AU - Tóth, Attila TI - Novel Noninvasive Paraclinical Study Method for Investigation of Liver Diseases JF - BIOMEDICINES J2 - BIOMEDICINES VL - 11 PY - 2023 IS - 9 PG - 21 SN - 2227-9059 DO - 10.3390/biomedicines11092449 UR - https://m2.mtmt.hu/api/publication/34124226 ID - 34124226 N1 - Communication AB - Based on a prior university patent, the authors developed a novel type of bioimpedance-based test method to noninvasively detect nonalcoholic fatty liver disease (NAFLD). The development of a new potential NAFLD diagnostic procedure may help to understand the underlying mechanisms between NAFLD and severe liver diseases with a painless and easy-to-use paraclinical examination method, including the additional function to detect even the earlier stages of liver disease. The aim of this study is to present new results and the experiences gathered in relation to NAFLD progress during animal model and human clinical trials. LA - English DB - MTMT ER - TY - JOUR AU - Vörös, Dávid AU - Kiss, Orsolya AU - Ollmann, Tamás AU - Mintál, Kitti AU - Péczely, László AU - Zagorácz, Olga AU - Kertes, Erika AU - Kállai, Veronika AU - László, Bettina Réka AU - Marosné Berta, Beáta AU - Tóth, Attila AU - Lénárd, László AU - László, Kristóf TI - Intraamygdaloid Oxytocin Increases Time Spent on Social Interaction in Valproate-Induced Autism Animal Model JF - BIOMEDICINES J2 - BIOMEDICINES VL - 11 PY - 2023 IS - 7 PG - 12 SN - 2227-9059 DO - 10.3390/biomedicines11071802 UR - https://m2.mtmt.hu/api/publication/34081444 ID - 34081444 AB - Autism spectrum disorder (ASD) is a pervasive neurodevelopmental disorder that affects about 1.5% of children worldwide. One of the core symptoms is impaired social interaction. Since proper treatment has not been found yet, an investigation of the exact pathophysiology of autism is essential. The valproate (VPA)-induced rat model can be an appropriate way to study autism. Oxytocin (OT) may amend some symptoms of ASD since it plays a key role in developing social relationships. In the present study, we investigated the effect of the intraamygdaloid OT on sham and intrauterine VPA-treated rats' social interaction using Crawley's social interaction test. Bilateral guide cannulae were implanted above the central nucleus of the amygdala (CeA), and intraamygdaloid microinjections were carried out before the test. Our results show that male Wistar rats prenatally exposed to VPA spent significantly less time on social interaction. Bilateral OT microinjection increased the time spent in the social zone; it also reached the level of sham-control animals. OT receptor antagonist blocked this effect of the OT but in itself did not significantly influence the behavior of the rats. Based on our results, we can establish that intraamygdaloid OT has significantly increased time spent on social interaction in the VPA-induced autism model, and its effect is receptor-specific. LA - English DB - MTMT ER - TY - CHAP AU - Mintál, Kitti AU - Tóth, Attila AU - Hormay, Edina AU - Kocsis, B AU - László, Kristóf AU - Vízvári, Z AU - Lénárd, László AU - Karádi, Zoltán György ED - Bali, C ED - Puskás, T ED - Kajos, Luca Fanni ED - Horváth-Polgár, P I ED - Kovács, E TI - Modifications of the gastrointestinal microbiome have crucial role in the control of social behavioural processes. T2 - MedPECS - Medical Conference for PhD Students and Experts of Clinical Science PB - University of Pécs, Doctoral Student Association CY - Pécs SN - 9789636261177 PY - 2023 SP - 46 UR - https://m2.mtmt.hu/api/publication/34001562 ID - 34001562 LA - English DB - MTMT ER -