@article{MTMT:2330891, title = {Thermodynamics of formation of b-cyclodextrin inclusion complexes with four series of surfactant homologs}, url = {https://m2.mtmt.hu/api/publication/2330891}, author = {Benkő, Mária and Réka, Tabajdi and Király, Zoltán}, doi = {10.1007/s10973-012-2603-0}, journal-iso = {J THERM ANAL CALORIM}, journal = {JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY}, volume = {112}, unique-id = {2330891}, issn = {1388-6150}, year = {2013}, eissn = {1572-8943}, pages = {969-976} } @article{MTMT:2330885, title = {Application of mass spectrometry for study of the adsorption of multicomponent surfactant mixtures at the solid/solution interface}, url = {https://m2.mtmt.hu/api/publication/2330885}, author = {Benkő, Mária and Sándor, Puskás and Király, Zoltán}, doi = {10.1007/s10450-012-9419-x}, journal-iso = {ADSORPTION}, journal = {ADSORPTION-JOURNAL OF THE INTERNATIONAL ADSORPTION SOCIETY}, volume = {19}, unique-id = {2330885}, issn = {0929-5607}, year = {2013}, eissn = {1572-8757}, pages = {71-76} } @article{MTMT:2064032, title = {Thermodynamics of inclusion complex formation of beta-cyclodextrin with a variety of surfactants differing in the nature of headgroup}, url = {https://m2.mtmt.hu/api/publication/2064032}, author = {Benkő, Mária and Király, Zoltán}, doi = {10.1016/j.jct.2012.03.033}, journal-iso = {J CHEM THERMODYN}, journal = {JOURNAL OF CHEMICAL THERMODYNAMICS}, volume = {54}, unique-id = {2064032}, issn = {0021-9614}, year = {2012}, eissn = {1096-3626}, pages = {211-216} } @article{MTMT:2034805, title = {A Foldamer-Dendrimer Conjugate Neutralizes Synaptotoxic Beta-Amyloid Oligomers}, url = {https://m2.mtmt.hu/api/publication/2034805}, author = {Fülöp, Lívia and Mándity, István and Juhász, Gábor and Szegedi, Viktor and Hetényi, Anasztázia and Wéber, Edit and Bozsó, Zsolt and Simon, Dóra and Benkő, Mária and Király, Zoltán and Martinek, Tamás}, doi = {10.1371/journal.pone.0039485}, journal-iso = {PLOS ONE}, journal = {PLOS ONE}, volume = {7}, unique-id = {2034805}, issn = {1932-6203}, abstract = {Background and Aims

Unnatural self-organizing biomimetic polymers (foldamers) emerged as promising materials for biomolecule recognition and inhibition. Our goal was to construct multivalent foldamer-dendrimer conjugates which wrap the synaptotoxic β-amyloid (Aβ) oligomers with high affinity through their helical foldamer tentacles. Oligomeric Aβ species play pivotal role in Alzheimer's disease, therefore recognition and direct inhibition of this undruggable target is a great current challenge.

Methods and Results

Short helical β-peptide foldamers with designed secondary structures and side chain chemistry patterns were applied as potential recognition segments and their binding to the target was tested with NMR methods (saturation transfer difference and transferred-nuclear Overhauser effect). Helices exhibiting binding in the µM region were coupled to a tetravalent G0-PAMAM dendrimer. In vitro biophysical (isothermal titration calorimetry, dynamic light scattering, transmission electron microscopy and size-exclusion chromatography) and biochemical tests (ELISA and dot blot) indicated the tight binding between the foldamer conjugates and the Aβ oligomers. Moreover, a selective low nM interaction with the low molecular weight fraction of the Aβ oligomers was found. Ex vivo electrophysiological experiments revealed that the new material rescues the long-term potentiation from the toxic Aβ oligomers in mouse hippocampal slices at submicromolar concentration.

Conclusions

The combination of the foldamer methodology, the fragment-based approach and the multivalent design offers a pathway to unnatural protein mimetics that are capable of specific molecular recognition, and has already resulted in an inhibitor for an extremely difficult target.

}, keywords = {Neurotoxicity; hippocampus; ARTICLE; MOUSE; controlled study; nonhuman; animal tissue; Protein Binding; in vitro study; POLYMER; unclassified drug; binding affinity; chemical structure; Biophysics; BIOCHEMISTRY; ex vivo study; Oligomer; Nuclear magnetic resonance spectroscopy; protein interaction; amyloid beta protein; chemical binding; long term potentiation; dendrimer; foldamer}, year = {2012}, eissn = {1932-6203}, orcid-numbers = {Fülöp, Lívia/0000-0002-8010-0129; Mándity, István/0000-0003-2865-6143; Szegedi, Viktor/0000-0003-4191-379X; Hetényi, Anasztázia/0000-0001-8080-6992; Wéber, Edit/0000-0002-5904-0619; Bozsó, Zsolt/0000-0002-5713-3096; Martinek, Tamás/0000-0003-3168-8066} } @article{MTMT:1828531, title = {Synthesis and catalytic investigation of organophilic Pd/graphite oxide nanocomposites}, url = {https://m2.mtmt.hu/api/publication/1828531}, author = {Mastalir, Ágnes and Szabó, Tamás and Király, Zoltán and Dékány, Imre}, doi = {10.1016/j.catcom.2011.10.028}, journal-iso = {CATAL COMMUN}, journal = {CATALYSIS COMMUNICATIONS}, volume = {17}, unique-id = {1828531}, issn = {1566-7367}, year = {2012}, eissn = {1873-3905}, pages = {104-107}, orcid-numbers = {Mastalir, Ágnes/0000-0002-8038-4635; Szabó, Tamás/0000-0001-8182-640X; Dékány, Imre/0000-0001-5472-5355} } @article{MTMT:1881941, title = {Mass spectrometric characterization of the non-ionic gemini surfactant Surfynol 465 and a microcalorimetric study of its micelle formation in water}, url = {https://m2.mtmt.hu/api/publication/1881941}, author = {Pahi, AB and Király, Zoltán and Puskas, S}, doi = {10.1016/j.colsurfa.2009.05.009}, journal-iso = {COLLOID SURFACE A}, journal = {COLLOIDS AND SURFACES A : PHYSICOCHEMICAL AND ENGINEERING ASPECTS}, volume = {345}, unique-id = {1881941}, issn = {0927-7757}, abstract = {Electrospray ionization mass spectrometry was applied to determine the molecular weight distribution and the number average molecular weight of the commercially available gemini surfactant alpha,alpha'-[2,4,7,9-tetramethyl-5-decyne-4,7-diyl]bis[omega-hydroxylpo ly(oxyethylene)], Surfynol 465 (S465), with NaCl and KCl as the cationization agents. The enthalpies of S465 micelle formation in aqueous solution were measured over a range of temperature by thermometric titration with a MicroCal VP-ITC microcalorimeter. The critical micelle concentration (cmc) of S465 decreased as the temperature was increased from 298 K to 348 K. The variation of the calorimetric enthalpy of micelle formation with temperature was markedly linear in this range of temperature, which allowed extrapolation to slightly higher temperatures. The van't Hoff enthalpies calculated from the temperature dependence of the cmc, were in excellent agreement with the directly measured calorimetric enthalpies. It could be established that S465 micellization changed from endothermic to exothermic as the cmc passed through a minimum at 357 K. The thermodynamic analysis indicated that micelle formation is favoured by entropy and opposed by enthalpy up to this temperature, after which the aggregation is favoured by both entropy and enthalpy. The enthalpy-entropy compensation resulted in a slight decrease in Gibbs free energy with increase in temperature. (C) 2009 Elsevier B.V. All rights reserved.}, keywords = {BEHAVIOR; STATE; SIZE; MICELLIZATION; HYDRATION; THERMODYNAMICS; ESI-MS; Micelle formation; microcalorimetry; ENTHALPIES; D2O; TITRATION CALORIMETRY; ACETYLENIC DIOL SURFACTANTS; Surfynol 465; Gemini surfactant}, year = {2009}, eissn = {1873-4359}, pages = {13-17} } @article{MTMT:1365987, title = {Determination of the dispersion of supported Pt particles by gas-phase and liquid-phase measurements}, url = {https://m2.mtmt.hu/api/publication/1365987}, author = {H, Kivrak and Mastalir, Ágnes and Király, Zoltán and D, Üner}, doi = {10.1016/j.catcom.2008.12.049}, journal-iso = {CATAL COMMUN}, journal = {CATALYSIS COMMUNICATIONS}, volume = {10}, unique-id = {1365987}, issn = {1566-7367}, year = {2009}, eissn = {1873-3905}, pages = {1002-1005}, orcid-numbers = {Mastalir, Ágnes/0000-0002-8038-4635} } @article{MTMT:1712120, title = {IASON – Intelligent Activated Sludge Operated by Nanotechnology – Hydrogel Microcarriers in Wastewater Treatment}, url = {https://m2.mtmt.hu/api/publication/1712120}, author = {Fleit, Ernő and Melicz, Zoltán György and Sándor, Dániel and Zrínyi, Miklós and Filipcsei, Genovéva and Nagyné László, Krisztina and Dékány, Imre and Király, Zoltán}, doi = {10.1007/2882_2008_092}, journal-iso = {PROG COLL POL SCI}, journal = {PROGRESS IN COLLOID AND POLYMER SCIENCE}, volume = {135}, unique-id = {1712120}, issn = {0340-255X}, year = {2008}, pages = {209-217}, orcid-numbers = {Zrínyi, Miklós/0000-0002-9362-3199; Nagyné László, Krisztina/0000-0003-4499-3983; Dékány, Imre/0000-0001-5472-5355} } @article{MTMT:1365983, title = {Thermodynamics of the micelle formation of the counterion coupled gemini surfactant bis(4-(2-dodecyl)benzenesulfonate)-jeffamine salt and its dynamic adsorption on sandstone}, url = {https://m2.mtmt.hu/api/publication/1365983}, author = {A B, Páhi and Király, Zoltán and Mastalir, Ágnes and Dudás, József and S, Puskás and Á, Vágó}, doi = {10.1021/jp806522h}, journal-iso = {J PHYS CHEM B}, journal = {JOURNAL OF PHYSICAL CHEMISTRY B}, volume = {112}, unique-id = {1365983}, issn = {1520-6106}, year = {2008}, eissn = {1520-5207}, pages = {15320-15326}, orcid-numbers = {Mastalir, Ágnes/0000-0002-8038-4635} } @article{MTMT:1365980, title = {Thermodynamics of micelle formation of the ephedrine-based chiral cationic surfactant DMEB in water, and the intercalation of DMEB in montmorillonite}, url = {https://m2.mtmt.hu/api/publication/1365980}, author = {A B, Páhi and D, Varga and Király, Zoltán and Mastalir, Ágnes}, doi = {10.1016/j.colsurfa.2007.06.056}, journal-iso = {COLLOID SURFACE A}, journal = {COLLOIDS AND SURFACES A : PHYSICOCHEMICAL AND ENGINEERING ASPECTS}, volume = {319}, unique-id = {1365980}, issn = {0927-7757}, year = {2008}, eissn = {1873-4359}, pages = {77-83}, orcid-numbers = {Mastalir, Ágnes/0000-0002-8038-4635} }