TY - JOUR AU - Ryvlin, Philippe AU - Barba, Carmen AU - Bartolomei, Fabrice AU - Baumgartner, Christoph AU - Brazdil, Milan AU - Fabó, Dániel AU - Fahoum, Firas AU - Frauscher, Birgit AU - Ikeda, Akio AU - Lhatoo, Samden AU - Mani, Jayanti AU - McGonigal, Aileen AU - Metsahonkala, Eeva-Liisa AU - Mindruta, Ioana AU - Nguyen, Dang Khoa AU - Rheims, Sylvain AU - Rocamora, Rodrigo AU - Rydenhag, Bertil AU - Schuele, Stephan AU - Schulze-Bonhage, Andreas AU - Surges, Rainer AU - Vulliemoz, Serge AU - Beniczky, Sandor TI - Grading system for assessing the confidence in the epileptogenic zone reported in published studies. A Delphi consensus study. TS - A Delphi consensus study. JF - EPILEPSIA J2 - EPILEPSIA VL - In press PY - 2024 SN - 0013-9580 DO - 10.1111/epi.17928 UR - https://m2.mtmt.hu/api/publication/34714085 ID - 34714085 AB - This study was undertaken to develop a standardized grading system based on expert consensus for evaluating the level of confidence in the localization of the epileptogenic zone (EZ) as reported in published studies, to harmonize and facilitate systematic reviews in the field of epilepsy surgery.We conducted a Delphi study involving 22 experts from 18 countries, who were asked to rate their level of confidence in the localization of the EZ for various theoretical clinical scenarios, using different scales. Information provided in these scenarios included one or several of the following data: magnetic resonance imaging (MRI) findings, invasive electroencephalography summary, and postoperative seizure outcome.The first explorative phase showed an overall interrater agreement of .347, pointing to large heterogeneity among experts' assessments, with only 17% of the 42 proposed scenarios associated with a substantial level of agreement. A majority showed preferences for the simpler scale and single-item scenarios. The successive Delphi voting phases resulted in a majority consensus across experts, with more than two thirds of respondents agreeing on the rating of each of the tested single-item scenarios. High or very high levels of confidence were ascribed to patients with either an Engel class I or class IA postoperative seizure outcome, a well-delineated EZ according to all available invasive EEG (iEEG) data, or a well-delineated focal epileptogenic lesion on MRI. MRI signs of hippocampal sclerosis or atrophy were associated with a moderate level of confidence, whereas a low level was ascribed to other MRI findings, a poorly delineated EZ according to iEEG data, or an Engel class II-IV postoperative seizure outcome.The proposed grading system, based on an expert consensus, provides a simple framework to rate the level of confidence in the EZ reported in published studies in a structured and harmonized way, offering an opportunity to facilitate and increase the quality of systematic reviews and guidelines in the field of epilepsy surgery. LA - English DB - MTMT ER - TY - JOUR AU - Szalárdy, Orsolya AU - Simor, Péter Dániel AU - Ujma, Przemyslaw Péter AU - Jordán, Zsófia AU - Halász, László AU - Erőss, Loránd AU - Fabó, Dániel AU - Bódizs, Róbert TI - Temporal association between sleep spindles and ripples in the human anterior and mediodorsal thalamus JF - EUROPEAN JOURNAL OF NEUROSCIENCE J2 - EUR J NEUROSCI VL - 59 PY - 2024 IS - 4 SP - 641 EP - 661 PG - 21 SN - 0953-816X DO - 10.1111/ejn.16240 UR - https://m2.mtmt.hu/api/publication/34505166 ID - 34505166 AB - Sleep spindles are major oscillatory components of Non-Rapid Eye Movement (NREM) sleep, reflecting hyperpolarization-rebound sequences of thalamocortical neurons. Reports suggest a link between sleep spindles and several forms of high-frequency oscillations which are considered as expressions of pathological off-line neural plasticity in the central nervous system. Here we investigated the relationship between thalamic sleep spindles and ripples in the anterior and mediodorsal nuclei (ANT and MD) of epilepsy patients. Whole-night LFP from the ANT and MD were co-registered with scalp EEG/polysomnography by using externalized leads in 15 epilepsy patients undergoing a Deep Brain Stimulation protocol. Slow (~12 Hz) and fast (~14 Hz) sleep spindles were present in the human ANT and MD and roughly, 20% of them were associated with ripples. Ripple-associated thalamic sleep spindles were characterized by longer duration and exceeded pure spindles in terms of spindle power as indicated by time-frequency analysis. Furthermore, ripple amplitude was modulated by the phase of sleep spindles within both thalamic nuclei. No signs of pathological processes were correlated with measures of ripple and spindle association, furthermore, the density of ripple-associated sleep spindles in the ANT showed a positive correlation with verbal comprehension. Our findings indicate the involvement of the human thalamus in coalescent spindle-ripple oscillations of NREM sleep. LA - English DB - MTMT ER - TY - JOUR AU - Hadady, Levente AU - Sperling, Michael R AU - Alcala-Zermeno, Juan Luis AU - French, Jacqueline A AU - Dugan, Patricia AU - Jehi, Lara AU - Fabó, Dániel AU - Klivényi, Péter AU - Rubboli, Guido AU - Beniczky, Sándor TI - Prediction tools and risk stratification in epilepsy surgery. JF - EPILEPSIA J2 - EPILEPSIA VL - 65 PY - 2024 IS - 2 SP - 414 EP - 421 PG - 8 SN - 0013-9580 DO - 10.1111/epi.17851 UR - https://m2.mtmt.hu/api/publication/34426398 ID - 34426398 AB - To conduct external validation of previously published epilepsy surgery prediction tools using a large independent multicenter dataset and to assess whether these tools can stratify patients for being operated and for becoming free of disabling seizures (ILAE 1 and 2).We analyzed a dataset of 1,562 patients, not used for tool development. We applied two scales: Epilepsy Surgery Grading Scale (ESGS) and Seizure Freedom Score (SFS), and two versions of Epilepsy Surgery Nomograms (ESNs): the original version and the modified version which included EEG data. For the ESNs we used calibration curves and concordance indexes. We stratified the patients into three tiers, for assessing the chances of attaining freedom of disabling seizures after surgery: high (ESGS 1, SFS 3-4, ESNs>70%), moderate (ESGS 2, SFS 2, ESNs 40-70%) and low (ESGS 2, SFS 0-1, ESNs<40%). We compared the three tiers as stratified by these tools, concerning the proportion of patients who were operated, and for the proportion of patients who became free of disabling seizures.The concordance indexes for the various versions of the nomograms were between 0.56 and 0.69. Both scales (ESGS, SFS) and nomograms accurately stratified the patients for becoming free of disabling seizures, with significant differences among the three tiers (p<0.05). In addition, ESGS and the modified ESN accurately stratified the patients for having been offered surgery, with significant difference among the three tiers (p<0.05).ESGS and the modified ESN (at thresholds of 40% and 70%) stratify patients undergoing presurgical evaluation into three tiers, with high, moderate and low chance for favorable outcome, with significant differences between the groups concerning having surgery and becoming free of disabling seizures. Stratifying patients for epilepsy surgery has the potential to help select the optimal candidates in underprivileged areas and better allocation of resources in developed countries. LA - English DB - MTMT ER - TY - GEN AU - Rydenhag, B. AU - Cukiert, A. AU - Fabó, Dániel TI - Callosotomy and VNS surgical aspects, palliative procedures - neurosurgical view PY - 2024 UR - https://m2.mtmt.hu/api/publication/34145291 ID - 34145291 LA - English DB - MTMT ER - TY - GEN AU - Fabó, Dániel TI - Broadening spectrum of surgically treatable epilepsies PY - 2024 UR - https://m2.mtmt.hu/api/publication/34145289 ID - 34145289 LA - English DB - MTMT ER - TY - JOUR AU - Brandt, C. AU - Fabó, Dániel AU - Milovanovic, M. AU - Alvarez-Baron, E. AU - Thangavelu, K. AU - Milanov, I. TI - Number of seizure-free days with adjunctive cenobamate: post-hoc analysis of an open-label extension study JF - EUROPEAN JOURNAL OF NEUROLOGY J2 - EUR J NEUROL VL - 30 PY - 2023 SP - 171 EP - 171 PG - 1 SN - 1351-5101 UR - https://m2.mtmt.hu/api/publication/34429139 ID - 34429139 LA - English DB - MTMT ER - TY - JOUR AU - Sákovics, Anna AU - Csukly, Gábor AU - Virág, Márta AU - Borbély, Csaba AU - Kelemen, Anna AU - Erőss, Loránd AU - Fabó, Dániel TI - Prolongation of cortical sleep spindles during hippocampal interictal epileptiform discharges in epilepsy patients JF - EUROPEAN JOURNAL OF NEUROLOGY J2 - EUR J NEUROL VL - 30 PY - 2023 SP - 624 EP - 625 PG - 2 SN - 1351-5101 UR - https://m2.mtmt.hu/api/publication/34428820 ID - 34428820 LA - English DB - MTMT ER - TY - GEN AU - Jordán, Zsófia AU - Pető, Nóra AU - Sákovics, Anna AU - Hajnal, Boglárka Zsófia AU - Szabó, Johanna Petra AU - Ujvári, Ákos AU - Kelemen, Anna AU - Fabó, Dániel TI - Long-term results with the novel anti-seizure medication, cenobamate, in a single center in Hungary PY - 2023 UR - https://m2.mtmt.hu/api/publication/34428213 ID - 34428213 LA - English DB - MTMT ER - TY - JOUR AU - Stippinger, Marcell AU - Varga, Bálint AU - Benkő, Zsigmond AU - Fabó, Dániel AU - Erőss, Loránd AU - Somogyvári, Zoltán AU - Telcs, András TI - CCDH: Complexity based Causal Discovery of Hidden common cause in time series JF - CHAOS SOLITONS & FRACTALS J2 - CHAOS SOLITON FRACT VL - 176 PY - 2023 PG - 9 SN - 0960-0779 DO - 10.1016/j.chaos.2023.114054 UR - https://m2.mtmt.hu/api/publication/34167230 ID - 34167230 LA - English DB - MTMT ER - TY - JOUR AU - Jordán, Zsófia AU - Szabó, J. AU - Sákovics, Anna AU - Kelemen, Anna AU - Halász, László AU - Erőss, Loránd AU - Fabó, Dániel TI - Epileptiform discharges in the anterior thalamus of epilepsy patients JF - EUROPEAN JOURNAL OF NEUROLOGY J2 - EUR J NEUROL VL - 30 PY - 2023 IS - Suppl. 1 SP - 772 SN - 1351-5101 UR - https://m2.mtmt.hu/api/publication/34124897 ID - 34124897 LA - English DB - MTMT ER -