TY - JOUR AU - Hu, Hao-Chun AU - Yu, Szu-Yin AU - Tsi, Yi-Hong AU - Hsieh, Pei-Wen AU - Wang, Hui-Chun AU - Chen, Yan-Ning AU - Chuang, Ya-Ting AU - Lee, Min-Yu AU - Chang, Hsueh-Wei AU - Hu, Hao-Chun AU - Wu, Yang-Chang AU - Chang, Fang-Rong AU - Szatmári, István AU - Fülöp, Ferenc TI - Synthesis of bioactive evodiamine and rutaecarpine analogues under a ball milling condition JF - ORGANIC & BIOMOLECULAR CHEMISTRY J2 - ORG BIOMOL CHEM VL - 22 PY - 2024 IS - 13 SP - 2620 EP - 2629 PG - 10 SN - 1477-0520 DO - 10.1039/D4OB00056K UR - https://m2.mtmt.hu/api/publication/34721105 ID - 34721105 AB - Mechanochemical reactions achieved by processes such as milling and grinding offer a promising alternative to traditional solution-based chemistry. This approach not only eliminates the need for large quantities of solvents,... LA - English DB - MTMT ER - TY - JOUR AU - Varga, Borisz AU - Fülöp, Ferenc AU - Toldi, G AU - Vécsei, László AU - Mándi, Yvette AU - Balog, Attila TI - Investigation of the effects of kynurenic acid analog in ankylosing spondylitis and psoriatic arthritis JF - ANNALS OF THE RHEUMATIC DISEASES J2 - ANN RHEUM DIS VL - 82 PY - 2023 IS - Suppl 1 SP - 1227 EP - 1227 PG - 1 SN - 0003-4967 DO - 10.1136/annrheumdis-2023-eular.5149 UR - https://m2.mtmt.hu/api/publication/33925574 ID - 33925574 N1 - Supplement: 1 LA - English DB - MTMT ER - TY - CHAP AU - Majláth, Zsófia AU - Szalárdy, Levente AU - Zádori, Dénes AU - Klivényi, Péter AU - Fülöp, Ferenc AU - Toldi, József AU - Vécsei, László ED - Kostrzewa, Richard M. TI - Neuroprotection by Kynurenine Metabolites T2 - Handbook of Neurotoxicity PB - Springer Nature Switzerland CY - Cham SN - 9783031150807 PY - 2023 SP - 1067 EP - 1080 PG - 14 DO - 10.1007/978-3-031-15080-7_165 UR - https://m2.mtmt.hu/api/publication/33665496 ID - 33665496 LA - English DB - MTMT ER - TY - JOUR AU - Forró, Enikő AU - Fülöp, Ferenc TI - Enzymatic Strategies for the Preparation of Pharmaceutically Important Amino Acids through Hydrolysis of Amino Carboxylic Esters and Lactams JF - CURRENT MEDICINAL CHEMISTRY J2 - CURR MED CHEM VL - 29 PY - 2022 IS - 41 SP - 6218 EP - 6227 PG - 10 SN - 0929-8673 DO - 10.2174/0929867329666220718123153 UR - https://m2.mtmt.hu/api/publication/33025006 ID - 33025006 N1 - Funding Agency and Grant Number: Hungarian Scientific Research Council (OTKA) [K129049]; Ministry of National Economy, National Research, Development and Innovation Office (GINOP) [2.3.2-15-2016-00014]; ITM NKFIA [TKP2021-EGA-32] Funding text: The authors thank the Hungarian Scientific Research Council (OTKA, K129049) and the Ministry of National Economy, National Research, Development and Innovation Office (GINOP, 2.3.2-15-2016-00014) and ITM NKFIA TKP2021-EGA-32 for financial support. LA - English DB - MTMT ER - TY - JOUR AU - Szabó, Melinda AU - Biróné Lajkó, Noémi AU - Dulka, Karolina AU - Szatmári, István AU - Fülöp, Ferenc AU - Mihály, András AU - Vécsei, László AU - Gulya, Károly TI - Kynurenic Acid and Its Analog SZR104 Exhibit Strong Antiinflammatory Effects and Alter the Intracellular Distribution and Methylation Patterns of H3 Histones in Immunochallenged Microglia-Enriched Cultures of Newborn Rat Brains JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 23 PY - 2022 IS - 3 PG - 23 SN - 1661-6596 DO - 10.3390/ijms23031079 UR - https://m2.mtmt.hu/api/publication/32677622 ID - 32677622 N1 - Department of Cell Biology and Molecular Medicine, University of Szeged, Szeged, 6720, Hungary ELKH–SZTE Stereochemistry Research Group, Institute of Pharmaceutical Chemistry, University of Szeged, Szeged, 6720, Hungary Interdisciplinary Excellence Center, Institute of Pharmaceutical Chemistry, University of Szeged, Szeged, 6720, Hungary Department of Anatomy, University of Szeged, Szeged, 6720, Hungary ELKH–SZTE Neuroscience Research Group, Department of Neurology, Interdisciplinary Excellence Center, University of Szeged, Szeged, 6720, Hungary Cited By :5 Export Date: 7 March 2024 Correspondence Address: Gulya, K.; Department of Cell Biology and Molecular Medicine, Hungary; email: gulyak@bio.u-szeged.hu Funding details: Ministry of Natural Resources, 2.3.2-15-2016-00034, GINOP 2.3.2-15-2016-00030 Funding text 1: This work was supported by a grant from the Ministry of National Resources (GINOP 2.3.2-15-2016-00030 and 2.3.2-15-2016-00034) through the European Union Cohesion Fund. At the time of the experiments, NL and KD were PhD students, partly supported by the Theoretical Medicine Doctoral School, Albert Szent-Györgyi School of Medicine, University of Szeged. The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. AB - Kynurenic acid (KYNA) is implicated in antiinflammatory processes in the brain through several cellular and molecular targets, among which microglia-related mechanisms are of paramount importance. In this study, we describe the effects of KYNA and one of its analogs, the brain-penetrable SZR104 (N-(2-(dimethylamino)ethyl)-3-(morpholinomethyl)-4-hydroxyquinoline-2-carboxamide), on the intracellular distribution and methylation patterns of histone H3 in immunochallenged microglia cultures. Microglia-enriched secondary cultures made from newborn rat forebrains were immunochallenged with lipopolysaccharide (LPS). The protein levels of selected inflammatory markers C-X-C motif chemokine ligand 10 (CXCL10) and C-C motif chemokine receptor 1 (CCR1), histone H3, and posttranslational modifications of histone H3 lys methylation sites (H3K9me3 and H3K36me2, marks typically associated with opposite effects on gene expression) were analyzed using quantitative fluorescent immunocytochemistry and western blots in control or LPS-treated cultures with or without KYNA or SZR104. KYNA and SZR104 reduced levels of the inflammatory marker proteins CXCL10 and CCR1 after LPS-treatment. Moreover, KYNA and SZR104 favorably affected histone methylation patterns as H3K9me3 and H3K36me2 immunoreactivities, and histone H3 protein levels returned toward control values after LPS treatment. The cytoplasmic translocation of H3K9me3 from the nucleus indicated inflammatory distress, a process that could be inhibited by KYNA and SZR104. Thus, KYNA signaling and metabolism, and especially brain-penetrable KYNA analogs such as SZR104, could be key targets in the pathway that connects chromatin structure and epigenetic mechanisms with functional consequences that affect neuroinflammation and perhaps neurodegeneration. LA - English DB - MTMT ER - TY - CHAP AU - Lázár, László AU - Fülöp, Ferenc ED - Black, David StC ED - Cossy, Janine ED - Stevens, Christian V TI - 1,3-Oxazines and Their Benzo Derivatives T2 - Comprehensive Heterocylic Chemistry IV PB - Elsevier Ltd. CY - Amsterdam SN - 9780128186565 PY - 2022 SP - 416 EP - 479 PG - 64 DO - 10.1016/B978-0-12-818655-8.00008-1 UR - https://m2.mtmt.hu/api/publication/32524104 ID - 32524104 N1 - Cited By :1 Export Date: 1 February 2023 LA - English DB - MTMT ER - TY - CONF AU - Tanaka, Masaru AU - Szabó, Ágnes AU - Lőrinczi, Bálint AU - Szatmári, István AU - Fülöp, Ferenc AU - Vécsei, László TI - Antidepressant-like Effects of Kynurenic Acid Analogues T2 - Proceedings of 1st International Electronic Conference on Biomedicine PY - 2021 PG - 8 DO - 10.3390/ECB2021-10301 UR - https://m2.mtmt.hu/api/publication/32837674 ID - 32837674 LA - English DB - MTMT ER - TY - JOUR AU - Balla, Zsolt AU - Kormányos, Eszter Sára AU - Kui, Balázs AU - Bálint, Emese Réka AU - Fűr, Gabriella AU - Orján, Erik Márk AU - Iványi, Béla AU - Vécsei, László AU - Fülöp, Ferenc AU - Varga, Gabriella AU - Harazin, András AU - Tubak, Vilmos AU - Deli, Mária Anna AU - Papp, Csaba Gergő AU - Gácser, Attila AU - Madácsy, Tamara AU - Venglovecz, Viktória AU - Maléth, József AU - Hegyi, Péter AU - Kiss, Lóránd AU - Rakonczay, Zoltán TI - Kynurenic acid and its analogue SZR-72 ameliorate the severity of experimental acute necrotizing pancreatitis JF - FRONTIERS IN IMMUNOLOGY J2 - FRONT IMMUNOL VL - 12 PY - 2021 PG - 15 SN - 1664-3224 DO - 10.3389/fimmu.2021.702764 UR - https://m2.mtmt.hu/api/publication/32258744 ID - 32258744 LA - English DB - MTMT ER - TY - JOUR AU - Szécsényi, Zsanett AU - Fülöp, Ferenc AU - Ötvös, Sándor Balázs TI - Bismuth Subnitrate-Catalyzed Markovnikov-Type Alkyne Hydrations under Batch and Continuous Flow Conditions JF - MOLECULES J2 - MOLECULES VL - 26 PY - 2021 IS - 10 PG - 12 SN - 1420-3049 DO - 10.3390/molecules26102864 UR - https://m2.mtmt.hu/api/publication/32242848 ID - 32242848 AB - Bismuth subnitrate is reported herein as a simple and efficient catalyst for the atom-economical synthesis of methyl ketones via Markovnikov-type alkyne hydration. Besides an effective batch process under reasonably mild conditions, a chemically intensified continuous flow protocol was also developed in a packed-bed system. The applicability of the methodologies was demonstrated through hydration of a diverse set of terminal acetylenes. By simply switching the reaction medium from methanol to methanol-d(4), valuable trideuteromethyl ketones were also prepared. Due to the ready availability and nontoxicity of the heterogeneous catalyst, which eliminated the need for any special additives and/or harmful reagents, the presented processes display significant advances in terms of practicality and sustainability. LA - English DB - MTMT ER - TY - JOUR AU - Poles, Marietta Zita AU - Nászai, Anna AU - Gulácsi, Levente AU - Czakó, Bálint L. AU - Gál, Krisztián G. AU - Glenz, Romy J. AU - Dookhun, Dishana AU - Rutai, Attila AU - Tallósy, Szabolcs Péter AU - Szabó, Andrea AU - Lőrinczi, Bálint AU - Szatmári, István AU - Fülöp, Ferenc AU - Vécsei, László AU - Boros, Mihály AU - Juhász, László AU - Kaszaki, József TI - Kynurenic Acid and Its Synthetic Derivatives Protect Against Sepsis-Associated Neutrophil Activation and Brain Mitochondrial Dysfunction in Rats JF - FRONTIERS IN IMMUNOLOGY J2 - FRONT IMMUNOL VL - 12 PY - 2021 PG - 13 SN - 1664-3224 DO - 10.3389/fimmu.2021.717157 UR - https://m2.mtmt.hu/api/publication/32163528 ID - 32163528 N1 - Institute of Surgical Research, Faculty of Medicine, University of Szeged, Szeged, Hungary Institute of Pharmaceutical Chemistry and Research Group for Stereochemistry, Hungarian Academy of Sciences, University of Szeged, Szeged, Hungary Department of Neurology, Interdisciplinary Excellence Centre, Faculty of Medicine, University of Szeged, Szeged, Hungary Neuroscience Research Group, Hungarian Academy of Sciences (MTA), University of Szeged (SZTE), Szeged, Hungary Cited By :14 Export Date: 7 March 2024 Correspondence Address: Kaszaki, J.; Institute of Surgical Research, Hungary Funding details: Szegedi Tudományegyetem, SZTE, 5312 Funding text 1: A link between BBB damage and intravascular/ intraparenchymal NET formation in the CNS has already been suggested (34), and reduced BBB damage as a consequence of neutrophil depletion has also been demonstrated (9). Since KYNA and KYNA analogues modulated NET components and inhibited neutrophil accumulation (and their potential-tissue damaging effects related to MPO and NADPH oxidase) in the brain, a causal relationship between ameliorated BBB function and attenuated NETosis is very likely. This assumption was supported by the strong correlation (Spearman coefficient; r=0.806; P<0.001) found between plasma CitH3 and plasma S100B levels in septic rats (Supplementary Figure S3). LA - English DB - MTMT ER -