TY - JOUR AU - Pikó, Péter AU - Al Ashkar, Habib AU - Kovács, Nóra AU - Veres-Balajti, Ilona AU - Ádány, Róza TI - Genetic Background of Acute Heart Rate Response to Exercise JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 25 PY - 2024 IS - 6 PG - 12 SN - 1661-6596 DO - 10.3390/ijms25063238 UR - https://m2.mtmt.hu/api/publication/34749447 ID - 34749447 AB - The acute heart rate response (AHRR) to physical activity, which refers to the change in heart rate during and after exercise, has been associated with cardiovascular and all-cause mortality. Previous studies have shown that AHRR is significantly determined by genetics in addition to environmental and lifestyle factors. The aim of this study was to investigate the genetic background of AHRR by analysing ten single nucleotide polymorphisms (SNPs) associated with leisure-time physical activity (LTPA) in 620 samples from the Hungarian population. The AHRR can be characterised as the difference between post-exercise and resting heart rate, i.e., the delta heart rate (ΔHR) defined by the YMCA 3 min step test, with a lower value indicating better cardiovascular fitness. The association of SNPs with ΔHR was analysed both separately and in combination using an optimised polygenic score (oPGS). The results showed that five SNPs (rs10252228, rs459465, rs6022999, rs8097348, and rs12405556) had at least nominally significant (p < 0.05) individual associations with ΔHR. After optimizing the PGS, a cumulative effect was observed for eight SNPs (rs6022999, rs12405556, rs459465, rs10252228, rs8097348, rs10887741, rs12612420, and rs7023003) that had a strong and statistically significant association with ΔHR (B = −2.51, 95% CI: −3.46–−1.76; p = 2.99 × 10−9). Of the four main domains of physical activity, the oPGS showed a significant positive association only with LTPA (B = 84.60; 95%CI: 25.23–143.98; p = 0.005). In conclusion, our results suggest that the SNPs we investigated influence individual leisure-time physical activity, mediated by their effects on the acute heart rate response. LA - English DB - MTMT ER - TY - JOUR AU - Kasabji, Feras AU - Vincze, Ferenc AU - Lakatos, Kinga AU - Poráczkiné Pálinkás, Anita AU - Kőrösi, László AU - Ulicska, László AU - Kósa, Karolina AU - Ádány, Róza AU - Sándor, János TI - Cross-sectional comparison of health care delivery and reimbursement between segregated and nonsegregated communities in Hungary JF - FRONTIERS IN PUBLIC HEALTH J2 - FRONT PUBLIC HEALTH VL - 12 PY - 2024 PG - 9 SN - 2296-2565 DO - 10.3389/fpubh.2024.1152555 UR - https://m2.mtmt.hu/api/publication/34533032 ID - 34533032 LA - English DB - MTMT ER - TY - JOUR AU - Ungvári, Zoltán István AU - Tabák, Ádám AU - Ádány, Róza AU - Purebl, György AU - Kaposvári, Csilla AU - Fazekas-Pongor, Vince AU - Csípő, Tamás AU - Szarvas, Zsófia AU - Horváth, Krisztián AU - Mukli, Péter AU - Balog, Piroska AU - Bódizs, Róbert AU - Ujma, Przemyslaw Péter AU - Stauder, Adrienne AU - Belsky, Daniel W. AU - Kovács, Illés AU - Yabluchanskiy, Andriy AU - Maier, Andrea B. AU - Moizs, Mariann AU - Östlin, Piroska AU - Yon, Yongjie AU - Varga, Péter AU - Vokó, Zoltán AU - Papp, Magor Csongor AU - Takács, István AU - Vásárhelyi, Barna AU - Torzsa, Péter AU - Ferdinandy, Péter AU - Csiszar, Anna AU - Benyó, Zoltán AU - Szabó, Attila AU - Bednárikné Dörnyei, Gabriella AU - Kivimäki, Mika AU - Kellermayer, Miklós AU - Merkely, Béla Péter TI - The Semmelweis Study: a longitudinal occupational cohort study within the framework of the Semmelweis Caring University Model Program for supporting healthy aging JF - GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE) J2 - GEROSCIENCE VL - 46 PY - 2024 IS - 1 SP - 191 EP - 218 PG - 28 SN - 2509-2715 DO - 10.1007/s11357-023-01018-7 UR - https://m2.mtmt.hu/api/publication/34425939 ID - 34425939 N1 - International Training Program in Geroscience/Healthy Aging Program, Doctoral School of Basic and Translational Medicine/Department of Public Health, Semmelweis University, Budapest, Hungary Vascular Cognitive Impairment, Neurodegeneration and Healthy Brain Aging Program, Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States Department of Health Promotion Sciences, The Hudson College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States Department of Public Health, Faculty of Medicine, Semmelweis University, Budapest, Hungary UCL Brain Sciences, University College London, London, United Kingdom Department of Internal Medicine and Oncology, Semmelweis University, Faculty of Medicine, Budapest, Hungary HUN-REN-UD Public Health Research Group, Department of Public Health and Epidemiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary Institute of Behavioral Sciences, Faculty of Medicine, Semmelweis University, Budapest, Hungary Robert N. Butler Columbia Aging Center, Columbia University, New York, NY, United States Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY, United States Department of Ophthalmology, Faculty of Medicine, Semmelweis University, Budapest, Hungary Department of Ophthalmology, Weill Cornell Medical College, New York City, NY, United States Department of Clinical Ophthalmology, Faculty of Health Sciences, Semmelweis University, Budapest, Hungary Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore Centre for Healthy Longevity, National University Health System, Singapore, Singapore Department of Human Movement Sciences, @AgeAmsterdam, Vrije Universiteit, Amsterdam Movement Sciences, Amsterdam, Netherlands Ministry of Interior of Hungary, Budapest, Hungary WHO Regional Office for Europe, Copenhagen, Denmark Clinical Center, Semmelweis University, Budapest, Hungary Center for Health Technology Assessment, Semmelweis University, Budapest, Hungary Department of Laboratory Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary Department of Family Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, Semmelweis University, Budapest, Hungary Department of Translational Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary HUN-REN-SU Cerebrovascular and Neurocognitive Diseases Research Group, Budapest, Hungary First Department of Pediatrics, Faculty of Medicine, Semmelweis University, Budapest, Hungary HUN-REN-SU Pediatrics and Nephrology Research Group, Semmelweis University, Budapest, Hungary Department of Morphology and Physiology, Faculty of Health Sciences, Semmelweis University, Budapest, Hungary Department of Biophysics and Radiation Biology, Faculty of Medicine, Semmelweis University, Budapest, Hungary Heart and Vascular Center, Semmelweis University, Budapest, Hungary Cited By :1 Export Date: 29 February 2024 Correspondence Address: Ungvari, Z.; International Training Program in Geroscience/Healthy Aging Program, Hungary; email: Zoltan-Ungvari@ouhsc.edu Correspondence Address: Adany, R.; International Training Program in Geroscience/Healthy Aging Program, Hungary AB - The Semmelweis Study is a prospective occupational cohort study that seeks to enroll all employees of Semmelweis University (Budapest, Hungary) aged 25 years and older, with a population of 8866 people, 70.5% of whom are women. The study builds on the successful experiences of the Whitehall II study and aims to investigate the complex relationships between lifestyle, environmental, and occupational risk factors, and the development and progression of chronic age-associated diseases. An important goal of the Semmelweis Study is to identify groups of people who are aging unsuccessfully and therefore have an increased risk of developing age-associated diseases. To achieve this, the study takes a multidisciplinary approach, collecting economic, social, psychological, cognitive, health, and biological data. The Semmelweis Study comprises a baseline data collection with open healthcare data linkage, followed by repeated data collection waves every 5 years. Data are collected through computer-assisted self-completed questionnaires, followed by a physical health examination, physiological measurements, and the assessment of biomarkers. This article provides a comprehensive overview of the Semmelweis Study, including its origin, context, objectives, design, relevance, and expected contributions. LA - English DB - MTMT ER - TY - JOUR AU - Kovács, Nóra AU - Pikó, Péter AU - Juhász, Attila AU - Nagy, Csilla AU - Oroszi, Beatrix AU - Ungvári, Zoltán István AU - Ádány, Róza TI - Comparative analysis of health status and health service utilization patterns among rural and urban elderly populations in Hungary: a study on the challenges of unhealthy aging JF - GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE) J2 - GEROSCIENCE VL - 46 PY - 2024 SP - 2017 EP - 2031 PG - 15 SN - 2509-2715 DO - 10.1007/s11357-023-00926-y UR - https://m2.mtmt.hu/api/publication/34217068 ID - 34217068 N1 - Department of Public Health and Epidemiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary ELKH-DE Public Health Research Group, Department of Public Health and Epidemiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary Center for Epidemiology and Surveillance, National Laboratory for Health Security, Semmelweis University, Budapest, Hungary Vascular Cognitive Impairment and Neurodegeneration Program, Oklahoma Center for Geroscience and Healthy Brain Aging, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States Department of Health Promotion Sciences, College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States International Training Program in Geroscience, Doctoral School of Basic and Translational Medicine, Departments of Public Health and Translational Medicine, Semmelweis University, Budapest, Hungary The Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States Department of Public Health, Semmelweis University, Budapest, Hungary Export Date: 6 April 2024 Correspondence Address: Adany, R.; Department of Public Health, Hungary; email: adany.roza@semmelweis.hu Chemicals/CAS: cholesterol, 57-88-5 Tradenames: Stata version 13.0 software, StataCorp, United States Manufacturers: StataCorp, United States Funding details: RRF-2.3.1-21-2022-00006 Funding details: TKP2021-NKTA-47, ÚNKP-22–4-II-DE-268 Funding details: Semmelweis Egyetem Funding details: Magyar Tudományos Akadémia, MTA, 135784, TK2016-78, TKCS-2021/32 Funding details: European Regional Development Fund, ERDF, GINOP-2.3.2–15-2016–00005 Funding details: Nemzeti Kutatási, Fejlesztési és Innovaciós Alap, NKFIA Funding text 1: Open access funding provided by Semmelweis University. This project was co-funded by the European Regional Development Fund (GINOP-2.3.2–15-2016–00005), the Hungarian Academy of Sciences (TK2016-78) and the Eötvös Loránd Research Network (TKCS-2021/32). Project No. 135784 has also been implemented with the support of the National Research, Development, and Innovation Fund of Hungary, financed under the K_20 programme. Authors, including P.P. and R.A. also work as team members of the National Laboratory for Health Security Hungary (RRF-2.3.1–21-2022–00006) and the National Cardiovascular Laboratory Program (RRF-2.3.1–21-2022–00003) supported by the National Research, Development and Innovation Office (NKFIH). P.P. is a fellow of the New National Excellence Programme of the Ministry of Innovation and Technology, funded by the National Research, Development, and Innovation Fund of Hungary (ÚNKP-22–4-II-DE-268). Project no. TKP2021-NKTA-47 has been implemented with the support provided by the Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund, financed under the TKP2021-NKTA funding scheme. Funding text 2: The authors gratefully acknowledge all participants who volunteered for this study and the general practitioners who participated in data collection (Magdolna Baglé, Viktor Borbás, Renáta Cseke, Csilla Dobai, István Gadóczi, Ottó Gáti, Erzsébet Gulya, Mónika Herceg, Péter Komoróczy, Eszter Kovács, Eszter Kusicza, Krisztina Lovas, János Perneczky, András Péter, Sándor Sáska, Zsuzsanna Scheibli, János Tamás, Attila Valcsák, Attila Veress). National Laboratory for Health Security (RRF-2.3.1-21-2022-00006), Center for Epidemiology and Surveillance, Semmelweis University, Budapest, Hungary: Attila Juhász, Csilla Nagy, Beatrix Oroszi, Róza Ádány. AB - The demographic transition poses a significant challenge for health systems, especially in Central and Eastern European (CEE) countries, where the healthcare needs of aging populations are on the rise. This study aimed to describe and compare the health status and utilization of health services among the elderly residing in urban and rural areas of the most deprived region in Hungary. A comprehensive health survey was conducted in 2022, involving a randomly selected sample of 443 older adults (>= 65 years) in Northeast Hungary. Multivariable logistic regression models adjusting for age, sex, education, financial status, chronic diseases, and activity limitations were used to investigate the association between type of residence and health service use. Among the study participants, 62.3% were female, 38.3% attained primary education, 12.5% reported a bad or very bad financial situation and 52.6% lived in urban areas. Overall, 24% of the elderly rated their health as very good or good (27.8% in urban and 19.7% in rural areas), while 57.8% (52.6% and 63.5% in urban and rural areas) reported limitations in daily activities. Compared to urban residents, rural residents reported lower rates of dentist visits (p = 0.006), specialist visits (p = 0.028), faecal occult blood testing (p < 0.001), colorectal cancer screening with colonoscopy (p = 0.014), and breast cancer screening (p = 0.035), and a higher rate of blood pressure measurement (p = 0.042). Multivariable models indicated that urban residence was positively associated with faecal occult blood testing (OR = 2.32, p = 0.014), but negatively associated with blood pressure (OR = 0.42, p = 0.017) and blood glucose measurements (OR = 0.48, p = 0.009). These findings highlight the influence of residence on health service utilization among older adults in Hungary. Further comprehensive studies are needed to better understand the health needs of the elderly population and to develop policies aimed at promoting healthy aging in CEE countries. LA - English DB - MTMT ER - TY - JOUR AU - Bria, E. AU - Lococo, F. AU - Boldrini, L. AU - Evangelista, J. AU - Flamini, S. AU - Minucci, A. AU - Troost, E.G.C. AU - Ádány, Róza AU - Farré, N. AU - Öztürk, E. AU - Urbani, A. AU - Trisolini, R. AU - Giordano, A. AU - Rindi, G. AU - Sala, E. AU - Valentini, V. AU - Boccia, S. AU - Margaritora, S. AU - Scambia, G. AU - Tortora, G. TI - 1289TiP LANTERN study: A multi-omics digital human avatar for integrating precision medicine into clinical practice for lung cancer patients JF - ANNALS OF ONCOLOGY J2 - ANN ONCOL VL - 34 PY - 2023 IS - S2 SP - S743 EP - S744 SN - 0923-7534 DO - 10.1016/j.annonc.2023.09.3083 UR - https://m2.mtmt.hu/api/publication/34768299 ID - 34768299 LA - English DB - MTMT ER - TY - JOUR AU - Szűcs, Sándor AU - Muhollari, Teuta AU - Baranyai, Edina AU - Nagy, Attila Csaba AU - Ádány, Róza AU - Sándor, J. AU - McKee, M. AU - Pál, László TI - Heavy metals in recorded and unrecorded spirits JF - TOXICOLOGY LETTERS J2 - TOXICOL LETT VL - 384 PY - 2023 IS - S1 SP - S285 EP - S285 SN - 0378-4274 UR - https://m2.mtmt.hu/api/publication/34764897 ID - 34764897 LA - English DB - MTMT ER - TY - CHAP AU - Ádány, Róza AU - Ungvári, Zoltán István ED - Ádány, Róza ED - Kiss, István ED - Paulik, Edit ED - Sándor, János ED - Ungvári, Zoltán István TI - Az ENSZ és a WHO szerepvállalása a népegészségügy területén, alapvető dokumentumok - Agenda 2030, kapcsolódó WHO dokumentumok T2 - Megelőző orvostan és népegészségtan PB - Medicina Könyvkiadó CY - Budapest SN - 9789632269078 PY - 2023 SP - 17 EP - 20 PG - 4 UR - https://m2.mtmt.hu/api/publication/34721579 ID - 34721579 LA - Hungarian DB - MTMT ER - TY - CHAP AU - Ádány, Róza AU - Ungvári, Zoltán István ED - Ádány, Róza ED - Kiss, István ED - Paulik, Edit ED - Sándor, János ED - Ungvári, Zoltán István TI - A prevenció és szintjei T2 - Megelőző orvostan és népegészségtan PB - Medicina Könyvkiadó CY - Budapest SN - 9789632269078 PY - 2023 SP - 15 EP - 16 PG - 2 UR - https://m2.mtmt.hu/api/publication/34721420 ID - 34721420 LA - Hungarian DB - MTMT ER - TY - CHAP AU - Ádány, Róza AU - Ungvári, Zoltán István ED - Ádány, Róza ED - Kiss, István ED - Paulik, Edit ED - Sándor, János ED - Ungvári, Zoltán István TI - A népegészségügy története, fejlődése T2 - Megelőző orvostan és népegészségtan PB - Medicina Könyvkiadó CY - Budapest SN - 9789632269078 PY - 2023 SP - 4 EP - 9 PG - 6 UR - https://m2.mtmt.hu/api/publication/34721334 ID - 34721334 LA - Hungarian DB - MTMT ER - TY - CHAP AU - Ádány, Róza AU - Ungvári, Zoltán István ED - Ádány, Róza ED - Kiss, István ED - Paulik, Edit ED - Sándor, János ED - Ungvári, Zoltán István TI - A népegészségügy fő funkciói T2 - Megelőző orvostan és népegészségtan PB - Medicina Könyvkiadó CY - Budapest SN - 9789632269078 PY - 2023 SP - 1 EP - 1 PG - 1 UR - https://m2.mtmt.hu/api/publication/34721313 ID - 34721313 LA - Hungarian DB - MTMT ER -