@article{MTMT:34749447, title = {Genetic Background of Acute Heart Rate Response to Exercise}, url = {https://m2.mtmt.hu/api/publication/34749447}, author = {Pikó, Péter and Al Ashkar, Habib and Kovács, Nóra and Veres-Balajti, Ilona and Ádány, Róza}, doi = {10.3390/ijms25063238}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {25}, unique-id = {34749447}, issn = {1661-6596}, abstract = {The acute heart rate response (AHRR) to physical activity, which refers to the change in heart rate during and after exercise, has been associated with cardiovascular and all-cause mortality. Previous studies have shown that AHRR is significantly determined by genetics in addition to environmental and lifestyle factors. The aim of this study was to investigate the genetic background of AHRR by analysing ten single nucleotide polymorphisms (SNPs) associated with leisure-time physical activity (LTPA) in 620 samples from the Hungarian population. The AHRR can be characterised as the difference between post-exercise and resting heart rate, i.e., the delta heart rate (ΔHR) defined by the YMCA 3 min step test, with a lower value indicating better cardiovascular fitness. The association of SNPs with ΔHR was analysed both separately and in combination using an optimised polygenic score (oPGS). The results showed that five SNPs (rs10252228, rs459465, rs6022999, rs8097348, and rs12405556) had at least nominally significant (p < 0.05) individual associations with ΔHR. After optimizing the PGS, a cumulative effect was observed for eight SNPs (rs6022999, rs12405556, rs459465, rs10252228, rs8097348, rs10887741, rs12612420, and rs7023003) that had a strong and statistically significant association with ΔHR (B = −2.51, 95% CI: −3.46–−1.76; p = 2.99 × 10−9). Of the four main domains of physical activity, the oPGS showed a significant positive association only with LTPA (B = 84.60; 95%CI: 25.23–143.98; p = 0.005). In conclusion, our results suggest that the SNPs we investigated influence individual leisure-time physical activity, mediated by their effects on the acute heart rate response.}, year = {2024}, eissn = {1422-0067} } @article{MTMT:34533032, title = {Cross-sectional comparison of health care delivery and reimbursement between segregated and nonsegregated communities in Hungary}, url = {https://m2.mtmt.hu/api/publication/34533032}, author = {Kasabji, Feras and Vincze, Ferenc and Lakatos, Kinga and Poráczkiné Pálinkás, Anita and Kőrösi, László and Ulicska, László and Kósa, Karolina and Ádány, Róza and Sándor, János}, doi = {10.3389/fpubh.2024.1152555}, journal-iso = {FRONT PUBLIC HEALTH}, journal = {FRONTIERS IN PUBLIC HEALTH}, volume = {12}, unique-id = {34533032}, year = {2024}, eissn = {2296-2565} } @article{MTMT:34425939, title = {The Semmelweis Study: a longitudinal occupational cohort study within the framework of the Semmelweis Caring University Model Program for supporting healthy aging}, url = {https://m2.mtmt.hu/api/publication/34425939}, author = {Ungvári, Zoltán István and Tabák, Ádám and Ádány, Róza and Purebl, György and Kaposvári, Csilla and Fazekas-Pongor, Vince and Csípő, Tamás and Szarvas, Zsófia and Horváth, Krisztián and Mukli, Péter and Balog, Piroska and Bódizs, Róbert and Ujma, Przemyslaw Péter and Stauder, Adrienne and Belsky, Daniel W. and Kovács, Illés and Yabluchanskiy, Andriy and Maier, Andrea B. and Moizs, Mariann and Östlin, Piroska and Yon, Yongjie and Varga, Péter and Vokó, Zoltán and Papp, Magor Csongor and Takács, István and Vásárhelyi, Barna and Torzsa, Péter and Ferdinandy, Péter and Csiszar, Anna and Benyó, Zoltán and Szabó, Attila and Bednárikné Dörnyei, Gabriella and Kivimäki, Mika and Kellermayer, Miklós and Merkely, Béla Péter}, doi = {10.1007/s11357-023-01018-7}, journal-iso = {GEROSCIENCE}, journal = {GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)}, volume = {46}, unique-id = {34425939}, issn = {2509-2715}, abstract = {The Semmelweis Study is a prospective occupational cohort study that seeks to enroll all employees of Semmelweis University (Budapest, Hungary) aged 25 years and older, with a population of 8866 people, 70.5% of whom are women. The study builds on the successful experiences of the Whitehall II study and aims to investigate the complex relationships between lifestyle, environmental, and occupational risk factors, and the development and progression of chronic age-associated diseases. An important goal of the Semmelweis Study is to identify groups of people who are aging unsuccessfully and therefore have an increased risk of developing age-associated diseases. To achieve this, the study takes a multidisciplinary approach, collecting economic, social, psychological, cognitive, health, and biological data. The Semmelweis Study comprises a baseline data collection with open healthcare data linkage, followed by repeated data collection waves every 5 years. Data are collected through computer-assisted self-completed questionnaires, followed by a physical health examination, physiological measurements, and the assessment of biomarkers. This article provides a comprehensive overview of the Semmelweis Study, including its origin, context, objectives, design, relevance, and expected contributions.}, year = {2024}, eissn = {2509-2723}, pages = {191-218}, orcid-numbers = {Ungvári, Zoltán István/0000-0002-6035-6039; Tabák, Ádám/0000-0002-6234-3936; Purebl, György/0000-0002-9750-2001; Fazekas-Pongor, Vince/0000-0002-6405-4003; Szarvas, Zsófia/0000-0002-0022-5053; Mukli, Péter/0000-0003-4355-8103; Balog, Piroska/0000-0001-5025-8649; Bódizs, Róbert/0000-0001-5341-060X; Ujma, Przemyslaw Péter/0000-0002-7981-3009; Stauder, Adrienne/0000-0002-0358-3657; Kovács, Illés/0000-0001-5763-0482; Vokó, Zoltán/0000-0002-1004-1848; Takács, István/0000-0002-7810-4833; Vásárhelyi, Barna/0000-0003-0055-7346; Torzsa, Péter/0000-0002-8148-4961; Ferdinandy, Péter/0000-0002-6424-6806; Benyó, Zoltán/0000-0001-6015-0359; Szabó, Attila/0000-0001-7321-9861; Bednárikné Dörnyei, Gabriella/0000-0001-7007-6252; Kellermayer, Miklós/0000-0002-5553-6553; Merkely, Béla Péter/0000-0001-6514-0723} } @article{MTMT:34217068, title = {Comparative analysis of health status and health service utilization patterns among rural and urban elderly populations in Hungary: a study on the challenges of unhealthy aging}, url = {https://m2.mtmt.hu/api/publication/34217068}, author = {Kovács, Nóra and Pikó, Péter and Juhász, Attila and Nagy, Csilla and Oroszi, Beatrix and Ungvári, Zoltán István and Ádány, Róza}, doi = {10.1007/s11357-023-00926-y}, journal-iso = {GEROSCIENCE}, journal = {GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)}, volume = {46}, unique-id = {34217068}, issn = {2509-2715}, abstract = {The demographic transition poses a significant challenge for health systems, especially in Central and Eastern European (CEE) countries, where the healthcare needs of aging populations are on the rise. This study aimed to describe and compare the health status and utilization of health services among the elderly residing in urban and rural areas of the most deprived region in Hungary. A comprehensive health survey was conducted in 2022, involving a randomly selected sample of 443 older adults (>= 65 years) in Northeast Hungary. Multivariable logistic regression models adjusting for age, sex, education, financial status, chronic diseases, and activity limitations were used to investigate the association between type of residence and health service use. Among the study participants, 62.3% were female, 38.3% attained primary education, 12.5% reported a bad or very bad financial situation and 52.6% lived in urban areas. Overall, 24% of the elderly rated their health as very good or good (27.8% in urban and 19.7% in rural areas), while 57.8% (52.6% and 63.5% in urban and rural areas) reported limitations in daily activities. Compared to urban residents, rural residents reported lower rates of dentist visits (p = 0.006), specialist visits (p = 0.028), faecal occult blood testing (p < 0.001), colorectal cancer screening with colonoscopy (p = 0.014), and breast cancer screening (p = 0.035), and a higher rate of blood pressure measurement (p = 0.042). Multivariable models indicated that urban residence was positively associated with faecal occult blood testing (OR = 2.32, p = 0.014), but negatively associated with blood pressure (OR = 0.42, p = 0.017) and blood glucose measurements (OR = 0.48, p = 0.009). These findings highlight the influence of residence on health service utilization among older adults in Hungary. Further comprehensive studies are needed to better understand the health needs of the elderly population and to develop policies aimed at promoting healthy aging in CEE countries.}, year = {2024}, eissn = {2509-2723}, pages = {2017-2031}, orcid-numbers = {Oroszi, Beatrix/0000-0001-8915-0336; Ungvári, Zoltán István/0000-0002-6035-6039} } @article{MTMT:34768299, title = {1289TiP LANTERN study: A multi-omics digital human avatar for integrating precision medicine into clinical practice for lung cancer patients}, url = {https://m2.mtmt.hu/api/publication/34768299}, author = {Bria, E. and Lococo, F. and Boldrini, L. and Evangelista, J. and Flamini, S. and Minucci, A. and Troost, E.G.C. and Ádány, Róza and Farré, N. and Öztürk, E. and Urbani, A. and Trisolini, R. and Giordano, A. and Rindi, G. and Sala, E. and Valentini, V. and Boccia, S. and Margaritora, S. and Scambia, G. and Tortora, G.}, doi = {10.1016/j.annonc.2023.09.3083}, journal-iso = {ANN ONCOL}, journal = {ANNALS OF ONCOLOGY}, volume = {34}, unique-id = {34768299}, issn = {0923-7534}, year = {2023}, eissn = {1569-8041}, pages = {S743-S744} } @article{MTMT:34764897, title = {Heavy metals in recorded and unrecorded spirits}, url = {https://m2.mtmt.hu/api/publication/34764897}, author = {Szűcs, Sándor and Muhollari, Teuta and Baranyai, Edina and Nagy, Attila Csaba and Ádány, Róza and Sándor, J. and McKee, M. and Pál, László}, journal-iso = {TOXICOL LETT}, journal = {TOXICOLOGY LETTERS}, volume = {384}, unique-id = {34764897}, issn = {0378-4274}, year = {2023}, eissn = {1879-3169}, pages = {S285-S285}, orcid-numbers = {Nagy, Attila Csaba/0000-0002-0554-7350} } @{MTMT:34721579, title = {Az ENSZ és a WHO szerepvállalása a népegészségügy területén, alapvető dokumentumok - Agenda 2030, kapcsolódó WHO dokumentumok}, url = {https://m2.mtmt.hu/api/publication/34721579}, author = {Ádány, Róza and Ungvári, Zoltán István}, booktitle = {Megelőző orvostan és népegészségtan}, unique-id = {34721579}, year = {2023}, pages = {17-20}, orcid-numbers = {Ungvári, Zoltán István/0000-0002-6035-6039} } @{MTMT:34721420, title = {A prevenció és szintjei}, url = {https://m2.mtmt.hu/api/publication/34721420}, author = {Ádány, Róza and Ungvári, Zoltán István}, booktitle = {Megelőző orvostan és népegészségtan}, unique-id = {34721420}, year = {2023}, pages = {15-16}, orcid-numbers = {Ungvári, Zoltán István/0000-0002-6035-6039} } @{MTMT:34721334, title = {A népegészségügy története, fejlődése}, url = {https://m2.mtmt.hu/api/publication/34721334}, author = {Ádány, Róza and Ungvári, Zoltán István}, booktitle = {Megelőző orvostan és népegészségtan}, unique-id = {34721334}, year = {2023}, pages = {4-9}, orcid-numbers = {Ungvári, Zoltán István/0000-0002-6035-6039} } @{MTMT:34721313, title = {A népegészségügy fő funkciói}, url = {https://m2.mtmt.hu/api/publication/34721313}, author = {Ádány, Róza and Ungvári, Zoltán István}, booktitle = {Megelőző orvostan és népegészségtan}, unique-id = {34721313}, year = {2023}, pages = {1-1}, orcid-numbers = {Ungvári, Zoltán István/0000-0002-6035-6039} }