TY  - JOUR
AU  - Rostás, Róbert
AU  - Fekete, István
AU  - Horváth, László
AU  - Márton, Sándor József
AU  - Fekete, Klára
TI  - Correlation of single-fiber electromyography studies and functional status in patients with amyotrophic lateral sclerosis
JF  - OPEN MEDICINE
J2  - OPEN MED-WARSAW
VL  - 19
PY  - 2024
IS  - 1
SN  - 2391-5463
DO  - 10.1515/med-2024-0990
UR  - https://m2.mtmt.hu/api/publication/35159904
ID  - 35159904
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Rostás, Róbert
AU  - Fekete, István
AU  - Horváth, László
AU  - Fekete, Klára
TI  - Blink Reflex Examination in Patients with Amyotrophic Lateral Sclerosis Compared to Diseases Affecting the Peripheral Nervous System and Healthy Controls
JF  - BRAIN SCIENCES
J2  - BRAIN SCI
VL  - 13
PY  - 2023
IS  - 10
SP  - 1384
SN  - 2076-3425
DO  - 10.3390/brainsci13101384
UR  - https://m2.mtmt.hu/api/publication/34201625
ID  - 34201625
AB  - Amyotrophic lateral sclerosis (ALS) is a fatal form of neuromuscular disease. The aim of this study was to assess changes in the blink reflex (BR) parameters as a valid and easy-to-use tool in ALS patients. We assessed the BR test in patients with a definitive diagnosis of ALS, healthy volunteers, and patients with diseases affecting the peripheral nervous system. The BR was studied in 29 patients who met the Awaji criteria. Latencies were compared with our healthy controls (N = 50) and other diseases of the peripheral nervous system (N = 61). The ALS Functional Rating Scale—Revised (ALSFRS-R) was used to evaluate functional status. Significantly prolonged R2i and R2c latencies were found in the ALS group compared with the healthy control group (p < 0.001). The latencies of R1, R2i, R2c were all increased in the bulbar subtype compared to the limb-onset subtype (p < 0.05). According to our results, BR examination might be a promising tool to monitor the course of the disease or serve as a prognostic biomarker in patients with ALS, but it should be assessed in further studies. The abnormalities detected through BR might help perform earlier interventions in ALS patients and might be useful in other diseases affecting the peripheral nervous system.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Csikai, Enikő
AU  - Andrejkovics, Mónika
AU  - Balajthy-Hidegh, B.
AU  - Hofgárt, Gergely
AU  - Kardos, L.
AU  - Diószegi, Á.
AU  - Rostás, Róbert
AU  - Kovács, Katalin Réka
AU  - Csongrádi, Éva
AU  - Csiba, László
TI  - Influence of angiotensin-converting enzyme inhibition on reversibility of alterations in arterial wall and cognitive performance associated with early hypertension: A follow-up study
JF  - MEDICINE
J2  - MEDICINE
VL  - 98
PY  - 2019
IS  - 34
PG  - 9
SN  - 0025-7974
DO  - 10.1097/MD.0000000000016966
UR  - https://m2.mtmt.hu/api/publication/30808466
ID  - 30808466
AB  - The importance of optimal blood pressure control for preventing or reducing the impairment of vascular and cognitive functions is well known. However, the reversibility of early alterations in vascular and cognitive functions through antihypertensive agents is under-investigated. In this study, we evaluated the influence of 3 months of angiotensin-converting enzyme (ACE) inhibition treatment on the morphological and functional arterial wall and cognitive performance changes in 30 newly diagnosed primary hypertensive patients.Common carotid intima-media thickness (IMT) and brachial artery flow-mediated dilatation (FMD) were detected by ultrasonography. Arterial stiffness indicated by augmentation index (AIx) and pulse wave velocity (PWV) was assessed by arteriography. Cognitive functions were assessed by neuropsychological examination.The executive function overall score was significantly higher at 3-month follow-up than at baseline (median, 0.233 (IQR, 0.447) vs -0.038 (0.936); P = .001). Three-month ACE inhibition did not produce significant improvement in IMT, FMD, AIx and PWV values. Significant negative associations were revealed between IMT and complex attention (r = -0.598, P = .0008), executive function (r = -0.617, P = .0005), and immediate memory (r = -0.420, P = .026) overall scores at follow-up. AIx had significant negative correlations with complex attention (r = -0.568, P = .001), executive function (r = -0.374, P = .046), and immediate memory (r = -0.507, P = .005). PWV correlated significantly and negatively with complex attention (r = -0.490, P = .007).Timely and effective antihypertensive therapy with ACE inhibitors has significant beneficial effects on cognitive performance in as few as 3 months. Early ACE inhibition may have an important role in the reversal of initial impairments of cognitive function associated with hypertension-induced vascular alterations.
LA  - English
DB  - MTMT
ER  -