TY - JOUR AU - Bak-Csiha, Sára AU - Hernyak, Marcell AU - Molnar, Agnes AU - Lőrincz, Hajnalka AU - Katkó, Mónika AU - Paragh, György AU - Bodor, Miklós AU - Harangi, Mariann AU - Sztanek, Ferenc AU - Berta, Eszter TI - Alpha-Lipoic Acid Treatment Reduces the Levels of Advanced End Glycation Products in Type 2 Diabetes Patients with Neuropathy JF - BIOMEDICINES J2 - BIOMEDICINES VL - 13 PY - 2025 IS - 2 PG - 16 SN - 2227-9059 DO - 10.3390/biomedicines13020438 UR - https://m2.mtmt.hu/api/publication/35804701 ID - 35804701 LA - English DB - MTMT ER - TY - JOUR AU - Borbásné Sebestyén, Veronika AU - Ujvárosy, Dóra AU - Ratku, Balázs AU - Lőrincz, Hajnalka AU - Bak-Csiha, Sára AU - Tari , Dóra AU - Majai, Gyöngyike AU - Somodi, Sándor AU - Szűcs, Gabriella AU - Harangi, Mariann AU - Szabó, Zoltán TI - Inflammatory Biomarkers and Lipid Parameters May Predict an Increased Risk for Atrial Arrhythmias in Patients with Systemic Sclerosis JF - BIOMEDICINES J2 - BIOMEDICINES VL - 13 PY - 2025 IS - 1 SP - 220 SN - 2227-9059 DO - 10.3390/biomedicines13010220 UR - https://m2.mtmt.hu/api/publication/35698744 ID - 35698744 AB - Background/Objectives: Autoimmune inflammation enhances the electrical instability of the atrial myocardium in patients with systemic sclerosis (SSc); thus, atrial arrhythmia risk is increased, which might be predicted by evaluating the P wave interval and dispersion of a 12-lead surface electrocardiogram (ECG). Methods: We examined 26 SSc patients and 36 healthy controls and measured the P wave interval and P wave dispersion of the 12-lead surface ECG in each patient. Furthermore, echocardiography and 24-hour Holter ECG were performed and levels of inflammatory laboratory parameters, including serum progranulin (PGRN), sVCAM-1, sICAM-1, leptin and C-reactive protein (CRP), were determined. Lipid parameters, such as Apo A-I, LDL-cholesterol (LDL-C), oxidized LDL (oxLDL) and the LDL and HDL subfractions were also evaluated. Results: The P wave interval showed a significant positive correlation with the levels of Apo A-I, LDL-C, CRP, sVCAM-1, sICAM-1 and leptin. The oxLDL level correlated positively with P wave dispersion. Of note, significant positive correlation was also found between the large HDL percentage and the P wave interval. Conclusions: Our results suggest that PGRN, sVCAM-1, sICAM-1, leptin, CRP, LDL-C and oxLDL, along with LDL and HDL subfractions, might have a role in atrial arrhythmogenesis in patients with SSc. LA - English DB - MTMT ER - TY - JOUR AU - Hernyák, M. AU - Tóth, L.I. AU - Bak-Csiha, Sára AU - Molnár, Ágnes AU - Lőrincz, Hajnalka AU - Paragh, György AU - Harangi, Mariann AU - Sztanek, Ferenc TI - Kallistatin as a Potential Marker of Therapeutic Response During Alpha-Lipoic Acid Treatment in Diabetic Patients with Sensorimotor Polyneuropathy JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 25 PY - 2024 IS - 24 SN - 1661-6596 DO - 10.3390/ijms252413276 UR - https://m2.mtmt.hu/api/publication/35677958 ID - 35677958 N1 - Division of Metabolism, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Debrecen, H-4032, Hungary Doctoral School of Health Sciences, University of Debrecen, Debrecen, H-4032, Hungary Institute of Health Studies, Faculty of Health Sciences, University of Debrecen, Debrecen, H-4032, Hungary ELKH-UD Vascular Pathophysiology Research Group 11003, University of Debrecen, Debrecen, H-4032, Hungary Export Date: 10 January 2025 Correspondence Address: Sztanek, F.; Division of Metabolism, Hungary; email: sztanek@belklinika.com Chemicals/CAS: intercellular adhesion molecule 1, 126547-89-5; metformin, 1115-70-4, 657-24-9; n(g),n(g) dimethylarginine, 30315-93-6; nitric oxide, 10102-43-9; thioctic acid, 1077-29-8, 2319-84-8, 62-46-4; vasculotropin, 127464-60-2 Manufacturers: Woerwag, Germany AB - Diabetic sensorimotor neuropathy (DSPN) is strongly associated with the extent of cellular oxidative stress and endothelial dysfunction in type 2 diabetes (T2DM). Alpha-lipoic acid (ALA) attenuates the progression of DSPN through its antioxidant and vasculoprotective effects. Kallistatin has antioxidant and anti-inflammatory properties. We aimed to evaluate changes in kallistatin levels and markers of endothelial dysfunction in patients with T2DM and DSPN following six months of treatment with 600 mg/day of ALA. A total of 54 patients with T2DM and DSPN and 24 control patients with T2DM but without neuropathy participated in this study. The serum concentrations of kallistatin, ICAM-1, VCAM-1, oxLDL, VEGF, ADMA, and TNF-alpha were measured by an ELISA. Peripheral sensory neuropathy was assessed with neuropathy symptom questionnaires and determination of the current perception threshold. After ALA treatment, the level of kallistatin significantly decreased, as well as the levels of TNF-alpha and ADMA. Changes in kallistatin levels were positively correlated with changes in oxLDL. The improvement in DSPN symptoms following ALA treatment showed a positive correlation with changes in kallistatin, VEGF, oxLDL, and ADMA levels. Based on our results, kallistatin could represent a potential new biomarker for assessing therapeutic response during ALA treatment in patients with DSPN. © 2024 by the authors. LA - English DB - MTMT ER - TY - JOUR AU - Berta, Eszter AU - Halmi, Sándor AU - Molnár, István AU - Hutkai, Dávid AU - Bak-Csiha, Sára AU - Bhattoa Harjit, Pál AU - Lőrincz, Hajnalka AU - Somodi, Sándor AU - Katkó, Mónika AU - Harangi, Mariann AU - Paragh, György AU - Nagy, Endre AU - Bodor, Miklós TI - Low Serum Fibroblast Growth Factor 21 Level and Its Altered Regulation by Thyroid Hormones in Patients with Hashimoto’s Thyroiditis on Levothyroxine Substitution JF - METABOLITES J2 - METABOLITES VL - 14 PY - 2024 IS - 10 SN - 2218-1989 DO - 10.3390/metabo14100565 UR - https://m2.mtmt.hu/api/publication/35597244 ID - 35597244 AB - Background/Objectives: Fibroblast growth factor 21 (FGF21) is a hormonal regulator of lipid and glucose metabolism exerting protection against atherosclerosis by multiple actions on the blood vessels, liver, and adipose tissues. We aimed to investigate serum FGF21 level and its relation to thyroid hormones and metabolic parameters among patients with Hashimoto’s thyroiditis (HT). Methods: Eighty patients with HT on levothyroxine treatment and eighty-two age- and BMI-matched adults without thyroid disease serving as controls were enrolled. Serum FGF21 concentrations were determined with an enzyme-linked immunosorbent assay. Results: Median serum FGF21 level was significantly lower in HT patients compared with controls (74.2 (33.4–148.3) pg/mL vs. 131.9 (44.8–236.3) pg/mL; p = 0.03). We found a positive correlation between FGF21 and age, triglyceride, total cholesterol, and low-density lipoprotein cholesterol in both groups, while thyroid stimulating hormone and C-reactive protein showed a positive correlation, and thyroxine had an inverse correlation with FGF21 only in control subjects. According to multiple regression analyses, thyroid status is the main predictor of FGF21 in healthy controls, while it is not a significant predictor of FGF21 among HT patients on levothyroxine supplementation therapy. Conclusions: Our results indicate that the physiological role of thyroid function in the regulation of FGF21 synthesis is impaired in HT patients, which may contribute to the metabolic alterations characteristic of HT patients. LA - English DB - MTMT ER - TY - JOUR AU - Lőrincz, Hajnalka AU - Bak-Csiha, Sára AU - Ratku, Balázs AU - Somodi, Sándor AU - Sztanek, Ferenc AU - Paragh, György AU - Harangi, Mariann TI - Associations between Serum Kallistatin Levels and Markers of Glucose Homeostasis, Inflammation, and Lipoprotein Metabolism in Patients with Type 2 Diabetes and Nondiabetic Obesity JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 25 PY - 2024 IS - 11 SP - 6264 SN - 1661-6596 DO - 10.3390/ijms25116264 UR - https://m2.mtmt.hu/api/publication/35059303 ID - 35059303 AB - Kallistatin is an endogenous serine proteinase inhibitor with various functions, including antioxidative, anti-inflammatory, and anti-atherosclerotic properties. To date, associations between kallistatin and lipoprotein subfractions are poorly investigated. In this study, we enrolled 62 obese patients with type 2 diabetes (T2D), 106 nondiabetic obese (NDO) subjects matched in gender, age, and body mass index, as well as 49 gender- and age-matched healthy, normal-weight controls. Serum kallistatin levels were measured with ELISA, and lipoprotein subfractions were analyzed using Lipoprint® (Quantimetrix Corp., Redondo Beach, CA, USA) gel electrophoresis. Kallistatin concentrations were significantly higher in T2D patients compared to NDO and control groups. We found significant positive correlations between very-low-density lipoprotein (VLDL), small high-density lipoprotein (HDL) subfractions, glucose, hemoglobin A1c (HbA1c), betatrophin, and kallistatin, while negative correlations were detected between mean low-density lipoprotein (LDL) size, large and intermediate HDL subfractions, and kallistatin in the whole study population. The best predictor of kallistatin was HbA1c in T2D patients, high-sensitivity C-reactive protein (hsCRP) and betatrophin in NDO patients, and hsCRP in controls. Our results indicate that kallistatin expression might be induced by persistent hyperglycemia in T2D, while in nondiabetic subjects, its production might be associated with systemic inflammation. The correlation of kallistatin with lipid subfractions may suggest its putative role in atherogenesis. LA - English DB - MTMT ER - TY - JOUR AU - Ratku, Balázs AU - Lőrincz, Hajnalka AU - Bak-Csiha, Sára AU - Sebestyén, Veronika AU - Berta, Eszter AU - Bodor, Miklós AU - Nagy, Endre AU - Szabó, Zoltán AU - Harangi, Mariann AU - Somodi, Sándor TI - Serum afamin and its implications in adult growth hormone deficiency: a prospective GH-withdrawal study JF - FRONTIERS IN ENDOCRINOLOGY J2 - FRONT ENDOCRINOL VL - 15 PY - 2024 SN - 1664-2392 DO - 10.3389/fendo.2024.1348046 UR - https://m2.mtmt.hu/api/publication/34564621 ID - 34564621 LA - English DB - MTMT ER - TY - JOUR AU - Lőrincz, Hajnalka AU - Bak-Csiha, Sára AU - Ratku, Balázs AU - Somodi, Sándor AU - Sztanek, Ferenc AU - Seres, Ildikó AU - Paragh, György AU - Harangi, Mariann TI - Gender-Dependent Associations between Serum Betatrophin Levels and Lipoprotein Subfractions in Diabetic and Nondiabetic Obese Patients JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 24 PY - 2023 IS - 22 SN - 1661-6596 DO - 10.3390/ijms242216504 UR - https://m2.mtmt.hu/api/publication/34483385 ID - 34483385 AB - Betatrophin, also known as angiopoietin-like protein 8 (ANGPTL8), mainly plays a role in lipid metabolism. To date, associations between betatrophin and lipoprotein subfractions are poorly investigated. For this study, 50 obese patients with type 2 diabetes (T2D) and 70 nondiabetic obese (NDO) subjects matched in gender, age, and body mass index (BMI) as well as 49 gender- and age-matched healthy, normal-weight controls were enrolled. Serum betatrophin levels were measured with ELISA, and lipoprotein subfractions were analyzed using Lipoprint gel electrophoresis. Betatrophin concentrations were found to be significantly higher in the T2D and NDO groups compared to the controls in all subjects and in females, but not in males. We found significant positive correlations between triglyceride, very low density lipoprotein (VLDL), large LDL (low density lipoprotein), small LDL, high density lipoprotein (HDL) -6-10 subfractions, and betatrophin, while negative correlations were detected between betatrophin and IDL, mean LDL size, and HDL-1-5. Proportion of small HDL was the best predictor of betatrophin in all subjects. Small LDL and large HDL subfractions were found to be the best predictors in females, while in males, VLDL was found to be the best predictor of betatrophin. Our results underline the significance of serum betatrophin measurement in the cardiovascular risk assessment of obese patients with and without T2D, but gender differences might be taken into consideration. LA - English DB - MTMT ER - TY - JOUR AU - Sztanek, Ferenc AU - Tóth, László AU - Molnár, Ágnes AU - Bak-Csiha, Sára AU - Szentpéteri, Anita AU - Lőrincz, Hajnalka AU - Nagy, Attila Csaba AU - Paragh, György AU - Harangi, Mariann TI - 520 $aA 2-es típusú cukorbetegségben (T2DM) az inzulinrezisztencia és az elhízás, valamint a kóros lipideltérések között JF - DIABETOLOGIA HUNGARICA J2 - DIABETOLOGIA HUNGARICA VL - 31 PY - 2023 IS - Suppl_1 SP - 71 EP - 72 PG - 2 SN - 1217-372X UR - https://m2.mtmt.hu/api/publication/34087449 ID - 34087449 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Lőrincz, Hajnalka AU - Ratku, Balázs AU - Bak-Csiha, Sára AU - Seres, Ildikó AU - Szabó, Zoltán AU - Katona, Éva Melitta AU - Paragh, György AU - Harangi, Mariann AU - Somodi, Sándor TI - Az organokinek szintjének vizsgálata elhízott 2-es típusú diabéteszes és elhízott nem diabéteszes betegekben JF - DIABETOLOGIA HUNGARICA J2 - DIABETOLOGIA HUNGARICA VL - 31 PY - 2023 IS - Suppl_1 SP - 48 EP - 49 PG - 2 SN - 1217-372X UR - https://m2.mtmt.hu/api/publication/34087371 ID - 34087371 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Bak-Csiha, Sára AU - Molnár, István AU - Halmi, Sándor AU - Hutkai, Dávid AU - Lőrincz, Hajnalka AU - Somodi, Sándor AU - Katkó, Mónika AU - Harangi, Mariann AU - Paragh, György AU - Nagy, Endre V. AU - Berta, Eszter AU - Bodor, Miklós TI - Advanced glycation end products and their soluble receptor (sRAGE) in patients with Hashimoto’s thyroiditis on levothyroxine substitution JF - FRONTIERS IN ENDOCRINOLOGY J2 - FRONT ENDOCRINOL VL - 14 PY - 2023 SN - 1664-2392 DO - 10.3389/fendo.2023.1187725 UR - https://m2.mtmt.hu/api/publication/34012307 ID - 34012307 LA - English DB - MTMT ER -