TY - JOUR AU - Tárnoki, Dávid László AU - Piroska, Márton AU - Forgó, Bianka AU - Szabó, Helga AU - Zöldi, Luca AU - Melicher, Dóra AU - Metneki, Julia AU - Littvay, Levente AU - Tárnoki, Ádám Domonkos TI - The Population-Based Hungarian Twin Registry. An Update. TS - An Update. JF - TWIN RESEARCH AND HUMAN GENETICS J2 - TWIN RES HUM GENET VL - 27 PY - 2024 IS - 2 SP - 115 EP - 119 PG - 5 SN - 1832-4274 DO - 10.1017/thg.2024.15 UR - https://m2.mtmt.hu/api/publication/34868573 ID - 34868573 AB - Between 2006 and 2021, the Hungarian Twin Registry (HTR) operated a volunteer twin registry of all age groups (50% monozygotic [MZ], 50% dizygotic [DZ], 70% female, average age 34 ± 22 years), including 1044 twin pairs, 24 triplets and one quadruplet set. In 2021, the HTR transformed from a volunteer registry into a population-based one, and it was established in the Medical Imaging Centre of Semmelweis University in Budapest. Semmelweis University's innovation fund supported the development of information technology, a phone bank and voicemail infrastructure, administrative materials, and a new website was established where twins and their relatives (parent, foster parent or caregiver) can register. The HTR's biobank was also established: 157,751 individuals with a likely twin-sibling living in Hungary (77,042 twins, 1194 triplets, 20 quadruplets, and one quintuplet) were contacted between February and March of 2021 via sealed letters. Until November 20, 2022, 12,001 twin individuals and their parents or guardians (6724 adult twins, 3009 parents/guardians and 5277 minor twins) registered, mostly online. Based on simple self-reports, 37.6% of the registered adults were MZ twins and 56.8% were DZ; 1.12% were triplets and 4.5% were unidentified. Of the registered children, 22.3% were MZ, 72.7% were DZ, 1.93% were triplets, and 3.05% were unidentified. Of the registered twins, 59.9% were female (including both the adult and minor twins). The registration questionnaire consists of eight parts, including socio-demographic and anthropometric data, smoking habits and medical questions (diseases, operations, therapies). Hungary's twin registry has become the sole and largest population-based twin registry in Central Eastern Europe. This new resource will facilitate performing world-class modern genetic research. LA - English DB - MTMT ER - TY - CONF AU - Zöldi, Luca AU - Persely, Aliz AU - Piroska, M AU - Beszedics, B AU - Tárnoki, Ádám Domonkos AU - Tárnoki, Dávid László TI - Non-alcoholic fatty liver disease in discordant monozygotic twins. T2 - Abstract book of the Twins Congress 2023 C1 - Budapest PY - 2023 SP - 116 EP - 116 PG - 1 UR - https://m2.mtmt.hu/api/publication/35434440 ID - 35434440 LA - English DB - MTMT ER - TY - JOUR AU - Persely, Aliz AU - Beszedics, B. AU - Pálóczi, Krisztina AU - Piroska, Márton AU - Alijanpourotaghsara, Amirreza AU - Strelnikov, David AU - Vessal, A. AU - Szabó, Helga AU - Hernyes, Anita AU - Zöldi, Luca AU - Jokkel, Zsófia AU - Fekete, A. AU - Juhász, János AU - Makra, Nóra AU - Szabó, Dóra AU - Buzás, Edit Irén AU - Tárnoki, Ádám Domonkos AU - Tárnoki, Dávid László TI - Analysis of Genetic and MRI Changes, Blood Markers, and Risk Factors in a Twin Pair Discordant of Progressive Supranuclear Palsy JF - MEDICINA-LITHUANIA J2 - MED LITH VL - 59 PY - 2023 IS - 10 PG - 18 SN - 1010-660X DO - 10.3390/medicina59101696 UR - https://m2.mtmt.hu/api/publication/34271363 ID - 34271363 N1 - Medical Imaging Centre, Semmelweis University, Budapest, 1082, Hungary Neurology Department, Medical Centre Hungarian Defence Forces, Budapest, 1134, Hungary Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, 1085, Hungary Central Radiological Diagnostic Department, Medical Centre Hungarian Defence Forces, Budapest, 1134, Hungary Institute of Medical Microbiology, Semmelweis University, Budapest, 1085, Hungary Faculty of Information Technology and Bionics, Pazmany Peter Catholic University, Budapest, 1085, Hungary Export Date: 23 January 2024 Correspondence Address: Tarnoki, D.L.; Medical Imaging Centre, Hungary; email: tarnoki4@gmail.com Chemicals/CAS: Biomarkers LA - English DB - MTMT ER - TY - JOUR AU - Mihály, Gergő AU - Persely, Aliz AU - Hernyes, Anita AU - Szabó, Gergely AU - Zöldi, Luca AU - Beszedics, Beatrix AU - Jokkel, Zsófia AU - Piroska, Márton AU - Tárnoki, Dávid László AU - Tárnoki, Ádám Domonkos TI - Carotis-atherosclerosis ultrahangos fenotípusainak radiomikai vizsgálata a demencia tükrében JF - MAGYAR RADIOLÓGIA ONLINE J2 - MAGYAR RADIOLÓGIA ONLINE VL - 14 PY - 2023 IS - 1 SP - 4/1 EP - 12 PG - 12 SN - 2063-9481 UR - https://m2.mtmt.hu/api/publication/33951415 ID - 33951415 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Saeki, Soichiro AU - Yamamoto, Kouichi AU - Tomizawa, Rie AU - Mészáros, Szilvia AU - Horváth, Csaba AU - Zöldi, Luca AU - Szabó, Helga AU - Tárnoki, Ádám Domonkos AU - Tárnoki, Dávid László AU - Ishida, Takayuki AU - Honda, Chika TI - Utilizing Graphical Analysis of Chest Radiographs for Primary Screening of Osteoporosis JF - MEDICINA-LITHUANIA J2 - MED LITH VL - 58 PY - 2022 IS - 12 PG - 8 SN - 1010-660X DO - 10.3390/medicina58121765 UR - https://m2.mtmt.hu/api/publication/33501803 ID - 33501803 N1 - Center Hospital of the National Center for Global Health and Medicine, Tokyo, 162-8655, Japan Department of Global and Innovative Medicine, Graduate School of Medicine, Osaka University, Osaka, 565-0871, Japan Department of Radiological Sciences, Faculty of Health Sciences, Morinomiya University of Medical Sciences, Osaka, 559-8611, Japan Center for Twin Research, Graduate School of Medicine, Osaka University, Osaka, 565-0871, Japan School of Nursing, Graduate School of Nursing, Osaka Metropolitan University, Osaka, 545-8585, Japan Department of Internal Medicine and Oncology, Semmelweis University, Budapest, 1082, Hungary Medical Imaging Centre, Semmelweis University, Budapest, 1082, Hungary Department of Medical Physics & Engineering, Graduate School of Medicine, Osaka University, Osaka, 565-0871, Japan Department of Public Health Nursing, Shiga University of Medical Science, Otsu, 520-2192, Japan Export Date: 23 January 2024 Correspondence Address: Saeki, S.; Center Hospital of the National Center for Global Health and MedicineJapan; email: sosaeki@hosp.ncgm.go.jp Correspondence Address: Honda, C.; Center for Twin Research, Japan; email: chikah@belle.shiga-med.ac.jp AB - Background and Objectives: Osteoporosis is a major risk of fractures, harming patients’ quality of life. Dual-energy X-ray absorptiometry (DXA), which can detect osteoporosis early, is too expensive to be conducted on a regular basis. Therefore, we aimed to evaluate a screening method using chest radiographs developed in Japan applied to another population. Materials and Methods: Fifty-five patients who had a chest radiograph and DXA and applied within three months of each test were recruited from the patient database of Semmelweis University (Budapest, Hungary). Graphical analysis of the chest radiographs was conducted to identify the ratio of the cortical bone in the clavicle of each patient. Two researchers performed the analysis, and multiple regression was conducted to determine the bone mineral density of each patient provided by DXA. Results: The Pearson correlation between two examiners’ determinations of the cortical bone ratio was 0.769 (p < 0.001). The multiple regression model proved to be statistically significant in identifying osteoporosis, but the model adopted for the Hungarian population was different compared to the Japanese population. Conclusions: This simple, economic Japanese graphical analysis method for chest radiographs may be feasible in detecting osteoporosis. Further studies with a larger population of patients with greater variety of ethnicity would be of value in improving the accuracy of this model. LA - English DB - MTMT ER - TY - JOUR AU - Szabó, Helga AU - Piroska, Márton AU - Hernyes, Anita AU - Zöldi, Luca AU - Juhász, János AU - Ligeti, Balázs AU - Makra, Nóra AU - Szabó, Dóra AU - Bikov, András AU - Kunos, Laszlo AU - Tárnoki, Ádám Domonkos AU - Tárnoki, Dávid László TI - The Relationship between Atherosclerosis and Gut Microbiome in Patients with Obstructive Sleep Apnoea JF - APPLIED SCIENCES-BASEL J2 - APPL SCI-BASEL VL - 12 PY - 2022 IS - 22 PG - 18 SN - 2076-3417 DO - 10.3390/app122211484 UR - https://m2.mtmt.hu/api/publication/33291618 ID - 33291618 N1 - Medical Imaging Centre, Semmelweis University, Budapest, 1082, Hungary Central Radiological Diagnostic Department, Medical Centre Hungarian Defence Forces, Budapest, 1134, Hungary Institute of Medical Microbiology, Semmelweis University, Budapest, 1085, Hungary Faculty of Information Technology and Bionics, Pazmany Peter Catholic University, Budapest, 1085, Hungary North West Lung Centre, Wythenshawe Hospital, Manchester University Foundation Trust, Manchester, M23 9LT, United Kingdom Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, The University of Manchester, Manchester, M13 9NT, United Kingdom Institute of Pulmonology, Torokbalint, 2045, Hungary Cited By :1 Export Date: 20 July 2023 Correspondence Address: Tarnoki, D.L.; Medical Imaging Centre, Hungary; email: tarnoki4@gmail.com Funding details: Manchester Biomedical Research Centre, BRC Funding details: Magyar Tudományos Akadémia, MTA, ÚNKP-20-5 Funding details: Nemzeti Kutatási, Fejlesztési és Innovaciós Alap, NKFIA Funding details: Magyarország Kormánya, OTKA 138055 Funding details: Innovációs és Technológiai Minisztérium Funding details: Magyar Tüdőgyógyász Társaság, MTT Funding text 1: This research was funded by the Semmelweis Science and Innovation Fund—Research and Development Application; Hungarian Respiratory Society—Scientific Research Application; Dean’s Fund—Research Application between Theoretical and Clinical Institutes; Bólyai scholarship of the Hungarian Academy of Sciences; ÚNKP-20-5 and ÚNKP-21-5 New National Excellence Program of the Ministry for Innovation and Technology, from the source of the National Research, Development, and Innovation Fund. The bioinformatics analysis was supported by the Hungarian Government grant OTKA 138055 (Large scale surveying of bacteriophages in the human microbiome with pangenomic and machine learning approaches). Funding text 2: The Samsung ultrasound equipment was provided by Sonarmed Ltd., a Samsung Medison representative. Colleagues of the Medical Imaging Centre and Institute of Medical Microbiology, Semmelweis University, provided administrative and technical support. The authors are grateful to Electro-oxygen for providing equipment for this study and Monika Banlaky for her support with the sleep tests as well as Peter Fussy and Szonja Galyasz for their help during the microbiome measurements, and Bianka Forgo, Marcell Szily and Daniel Tamas Kovacs for their help in the OSA study. Andras Bikov is supported by the NIHR Manchester BRC. AB - Background: Obstructive sleep apnoea (OSA) and gut dysbiosis are known risk factors for atherosclerosis. However, only very few studies have been focused on the relationship between OSA, atherosclerosis, and the intestinal microbiome, all in animal models. Methods: Twenty-two patients with OSA, 16 with and 6 without carotid atherosclerosis were involved in the study. After a diagnostic sleep examination, the intima media thickness (IMT) was measured and plaques were found using carotid ultrasound. Blood was also drawn for metabolic profile, and a stool sample was provided for 16S ribosomal RNA microbiome investigation. Results: An increased maximal common carotid artery (CCA) IMT was significantly associated with decreased phylum-level diversity. The level of Peptostreptococcaceae was significantly lower in atherosclerotic subjects. Some other candidate microbes appeared in the two groups at the genus level as well: Bilophila, Romboutsia, Slackia, and Veillonella in the non-atherosclerotic group; and Escherichia-Shigella, Prevotella, and Ruminococcaceae in the atherosclerotic group. Conclusions: This is the first pilot research to analyze the association between the gut microbiome and atherosclerosis in adult patients with OSA with and without carotid atherosclerosis. Dysbiosis and individual bacteria may contribute to the development of carotid atherosclerosis in patients with OSA. Further investigations are necessary to reveal a more precise background in a larger sample. LA - English DB - MTMT ER - TY - JOUR AU - Szabó, Helga AU - Hernyes, Anita AU - Piroska, Márton AU - Ligeti, Balázs AU - Fussy, Peter AU - Zöldi, Luca AU - Galyasz, Szonja AU - Makra, Nóra AU - Szabó, Dóra AU - Tárnoki, Ádám Domonkos AU - Tárnoki, Dávid László TI - Association between Gut Microbial Diversity and Carotid Intima-Media Thickness JF - MEDICINA-LITHUANIA J2 - MED LITH VL - 57 PY - 2021 IS - 3 PG - 11 SN - 1010-660X DO - 10.3390/medicina57030195 UR - https://m2.mtmt.hu/api/publication/31974190 ID - 31974190 N1 - Medical Imaging Centre, Semmelweis University, Budapest, 1082, Hungary Central Radiological Diagnostic Department, Medical Centre Hungarian Defence Forces, Budapest, 1134, Hungary Institute of Medical Microbiology, Semmelweis University, Budapest, 1089, Hungary Faculty of Information Technology and Bionics, Pazmany Peter Catholic University, Budapest, 1088, Hungary Faculty of Medicine, Semmelweis University, Budapest, 1085, Hungary Cited By :15 Export Date: 23 January 2024 Correspondence Address: Szabo, H.; Medical Imaging Centre, Hungary; email: szabo.helga@semmelweis-univ.hu Correspondence Address: Szabo, H.; Central Radiological Diagnostic Department, Hungary; email: szabo.helga@semmelweis-univ.hu Chemicals/CAS: RNA, Ribosomal, 16S LA - English DB - MTMT ER - TY - JOUR AU - Hernyes, Anita AU - Fejér, Bence AU - Szabó, Helga AU - Szalontai, László AU - Persely, Aliz AU - Fekete, Márton AU - Szily, Marcell AU - Jokkel, Zsófia AU - Debreceni, R AU - Gyulay, Kata Klára AU - Szabó, G AU - Zöldi, Luca AU - Tárnoki, Ádám Domonkos AU - Tárnoki, Dávid László TI - Az arteria carotis communis intima-media komplex sajátosságainak vizsgálata ultrahanggal - Technikai megfontolások és korrelációk egyéb atherosclerosisra utaló változókkal. JF - MAGYAR RADIOLÓGIA ONLINE J2 - MAGYAR RADIOLÓGIA ONLINE VL - 10 PY - 2019 IS - 3 SP - 2/1 EP - 10 PG - 10 SN - 2063-9481 DO - 10.5374/mro.2019.3.2 UR - https://m2.mtmt.hu/api/publication/31206729 ID - 31206729 N1 - Ellenőrizve teljes szöveg alapján GT LA - Hungarian DB - MTMT ER -