@article{MTMT:34868573, title = {The Population-Based Hungarian Twin Registry. An Update.}, url = {https://m2.mtmt.hu/api/publication/34868573}, author = {Tárnoki, Dávid László and Piroska, Márton and Forgó, Bianka and Szabó, Helga and Zöldi, Luca and Melicher, Dóra and Metneki, Julia and Littvay, Levente and Tárnoki, Ádám Domonkos}, doi = {10.1017/thg.2024.15}, journal-iso = {TWIN RES HUM GENET}, journal = {TWIN RESEARCH AND HUMAN GENETICS}, volume = {27}, unique-id = {34868573}, issn = {1832-4274}, abstract = {Between 2006 and 2021, the Hungarian Twin Registry (HTR) operated a volunteer twin registry of all age groups (50% monozygotic [MZ], 50% dizygotic [DZ], 70% female, average age 34 ± 22 years), including 1044 twin pairs, 24 triplets and one quadruplet set. In 2021, the HTR transformed from a volunteer registry into a population-based one, and it was established in the Medical Imaging Centre of Semmelweis University in Budapest. Semmelweis University's innovation fund supported the development of information technology, a phone bank and voicemail infrastructure, administrative materials, and a new website was established where twins and their relatives (parent, foster parent or caregiver) can register. The HTR's biobank was also established: 157,751 individuals with a likely twin-sibling living in Hungary (77,042 twins, 1194 triplets, 20 quadruplets, and one quintuplet) were contacted between February and March of 2021 via sealed letters. Until November 20, 2022, 12,001 twin individuals and their parents or guardians (6724 adult twins, 3009 parents/guardians and 5277 minor twins) registered, mostly online. Based on simple self-reports, 37.6% of the registered adults were MZ twins and 56.8% were DZ; 1.12% were triplets and 4.5% were unidentified. Of the registered children, 22.3% were MZ, 72.7% were DZ, 1.93% were triplets, and 3.05% were unidentified. Of the registered twins, 59.9% were female (including both the adult and minor twins). The registration questionnaire consists of eight parts, including socio-demographic and anthropometric data, smoking habits and medical questions (diseases, operations, therapies). Hungary's twin registry has become the sole and largest population-based twin registry in Central Eastern Europe. This new resource will facilitate performing world-class modern genetic research.}, keywords = {Central Eastern Europe; genetic research; twin registry}, year = {2024}, eissn = {1839-2628}, pages = {115-119}, orcid-numbers = {Tárnoki, Dávid László/0000-0002-7001-7647; Piroska, Márton/0000-0002-6000-5044; Zöldi, Luca/0000-0003-4187-1673; Melicher, Dóra/0000-0003-4848-1424; Littvay, Levente/0000-0003-2022-6886; Tárnoki, Ádám Domonkos/0000-0001-5909-3780} } @CONFERENCE{MTMT:35434440, title = {Non-alcoholic fatty liver disease in discordant monozygotic twins.}, url = {https://m2.mtmt.hu/api/publication/35434440}, author = {Zöldi, Luca and Persely, Aliz and Piroska, M and Beszedics, B and Tárnoki, Ádám Domonkos and Tárnoki, Dávid László}, booktitle = {Abstract book of the Twins Congress 2023}, unique-id = {35434440}, year = {2023}, pages = {116-116}, orcid-numbers = {Zöldi, Luca/0000-0003-4187-1673; Tárnoki, Ádám Domonkos/0000-0001-5909-3780; Tárnoki, Dávid László/0000-0002-7001-7647} } @article{MTMT:34271363, title = {Analysis of Genetic and MRI Changes, Blood Markers, and Risk Factors in a Twin Pair Discordant of Progressive Supranuclear Palsy}, url = {https://m2.mtmt.hu/api/publication/34271363}, author = {Persely, Aliz and Beszedics, B. and Pálóczi, Krisztina and Piroska, Márton and Alijanpourotaghsara, Amirreza and Strelnikov, David and Vessal, A. and Szabó, Helga and Hernyes, Anita and Zöldi, Luca and Jokkel, Zsófia and Fekete, A. and Juhász, János and Makra, Nóra and Szabó, Dóra and Buzás, Edit Irén and Tárnoki, Ádám Domonkos and Tárnoki, Dávid László}, doi = {10.3390/medicina59101696}, journal-iso = {MED LITH}, journal = {MEDICINA-LITHUANIA}, volume = {59}, unique-id = {34271363}, issn = {1010-660X}, year = {2023}, eissn = {1648-9144}, orcid-numbers = {Pálóczi, Krisztina/0000-0001-7065-3582; Piroska, Márton/0000-0002-6000-5044; Strelnikov, David/0000-0002-5911-9335; Hernyes, Anita/0000-0001-5875-4006; Zöldi, Luca/0000-0003-4187-1673; Jokkel, Zsófia/0000-0002-5407-6540; Szabó, Dóra/0000-0002-8601-3923; Buzás, Edit Irén/0000-0002-3744-206X; Tárnoki, Ádám Domonkos/0000-0001-5909-3780; Tárnoki, Dávid László/0000-0002-7001-7647} } @article{MTMT:33951415, title = {Carotis-atherosclerosis ultrahangos fenotípusainak radiomikai vizsgálata a demencia tükrében}, url = {https://m2.mtmt.hu/api/publication/33951415}, author = {Mihály, Gergő and Persely, Aliz and Hernyes, Anita and Szabó, Gergely and Zöldi, Luca and Beszedics, Beatrix and Jokkel, Zsófia and Piroska, Márton and Tárnoki, Dávid László and Tárnoki, Ádám Domonkos}, journal-iso = {MAGYAR RADIOLÓGIA ONLINE}, journal = {MAGYAR RADIOLÓGIA ONLINE}, volume = {14}, unique-id = {33951415}, year = {2023}, eissn = {2063-9481}, pages = {4/1-12}, orcid-numbers = {Hernyes, Anita/0000-0001-5875-4006; Zöldi, Luca/0000-0003-4187-1673; Jokkel, Zsófia/0000-0002-5407-6540; Piroska, Márton/0000-0002-6000-5044; Tárnoki, Dávid László/0000-0002-7001-7647; Tárnoki, Ádám Domonkos/0000-0001-5909-3780} } @article{MTMT:33501803, title = {Utilizing Graphical Analysis of Chest Radiographs for Primary Screening of Osteoporosis}, url = {https://m2.mtmt.hu/api/publication/33501803}, author = {Saeki, Soichiro and Yamamoto, Kouichi and Tomizawa, Rie and Mészáros, Szilvia and Horváth, Csaba and Zöldi, Luca and Szabó, Helga and Tárnoki, Ádám Domonkos and Tárnoki, Dávid László and Ishida, Takayuki and Honda, Chika}, doi = {10.3390/medicina58121765}, journal-iso = {MED LITH}, journal = {MEDICINA-LITHUANIA}, volume = {58}, unique-id = {33501803}, issn = {1010-660X}, abstract = {Background and Objectives: Osteoporosis is a major risk of fractures, harming patients’ quality of life. Dual-energy X-ray absorptiometry (DXA), which can detect osteoporosis early, is too expensive to be conducted on a regular basis. Therefore, we aimed to evaluate a screening method using chest radiographs developed in Japan applied to another population. Materials and Methods: Fifty-five patients who had a chest radiograph and DXA and applied within three months of each test were recruited from the patient database of Semmelweis University (Budapest, Hungary). Graphical analysis of the chest radiographs was conducted to identify the ratio of the cortical bone in the clavicle of each patient. Two researchers performed the analysis, and multiple regression was conducted to determine the bone mineral density of each patient provided by DXA. Results: The Pearson correlation between two examiners’ determinations of the cortical bone ratio was 0.769 (p < 0.001). The multiple regression model proved to be statistically significant in identifying osteoporosis, but the model adopted for the Hungarian population was different compared to the Japanese population. Conclusions: This simple, economic Japanese graphical analysis method for chest radiographs may be feasible in detecting osteoporosis. Further studies with a larger population of patients with greater variety of ethnicity would be of value in improving the accuracy of this model.}, keywords = {Hungary; Japan; PREVENTION; bone mineral density; aging society; bone fractures}, year = {2022}, eissn = {1648-9144}, orcid-numbers = {Mészáros, Szilvia/0000-0002-4871-6986; Horváth, Csaba/0000-0002-0490-7932; Zöldi, Luca/0000-0003-4187-1673; Tárnoki, Ádám Domonkos/0000-0001-5909-3780; Tárnoki, Dávid László/0000-0002-7001-7647} } @article{MTMT:33291618, title = {The Relationship between Atherosclerosis and Gut Microbiome in Patients with Obstructive Sleep Apnoea}, url = {https://m2.mtmt.hu/api/publication/33291618}, author = {Szabó, Helga and Piroska, Márton and Hernyes, Anita and Zöldi, Luca and Juhász, János and Ligeti, Balázs and Makra, Nóra and Szabó, Dóra and Bikov, András and Kunos, Laszlo and Tárnoki, Ádám Domonkos and Tárnoki, Dávid László}, doi = {10.3390/app122211484}, journal-iso = {APPL SCI-BASEL}, journal = {APPLIED SCIENCES-BASEL}, volume = {12}, unique-id = {33291618}, abstract = {Background: Obstructive sleep apnoea (OSA) and gut dysbiosis are known risk factors for atherosclerosis. However, only very few studies have been focused on the relationship between OSA, atherosclerosis, and the intestinal microbiome, all in animal models. Methods: Twenty-two patients with OSA, 16 with and 6 without carotid atherosclerosis were involved in the study. After a diagnostic sleep examination, the intima media thickness (IMT) was measured and plaques were found using carotid ultrasound. Blood was also drawn for metabolic profile, and a stool sample was provided for 16S ribosomal RNA microbiome investigation. Results: An increased maximal common carotid artery (CCA) IMT was significantly associated with decreased phylum-level diversity. The level of Peptostreptococcaceae was significantly lower in atherosclerotic subjects. Some other candidate microbes appeared in the two groups at the genus level as well: Bilophila, Romboutsia, Slackia, and Veillonella in the non-atherosclerotic group; and Escherichia-Shigella, Prevotella, and Ruminococcaceae in the atherosclerotic group. Conclusions: This is the first pilot research to analyze the association between the gut microbiome and atherosclerosis in adult patients with OSA with and without carotid atherosclerosis. Dysbiosis and individual bacteria may contribute to the development of carotid atherosclerosis in patients with OSA. Further investigations are necessary to reveal a more precise background in a larger sample.}, year = {2022}, eissn = {2076-3417}, orcid-numbers = {Piroska, Márton/0000-0002-6000-5044; Hernyes, Anita/0000-0001-5875-4006; Zöldi, Luca/0000-0003-4187-1673; Szabó, Dóra/0000-0002-8601-3923; Bikov, András/0000-0002-8983-740X; Tárnoki, Ádám Domonkos/0000-0001-5909-3780; Tárnoki, Dávid László/0000-0002-7001-7647} } @article{MTMT:31974190, title = {Association between Gut Microbial Diversity and Carotid Intima-Media Thickness}, url = {https://m2.mtmt.hu/api/publication/31974190}, author = {Szabó, Helga and Hernyes, Anita and Piroska, Márton and Ligeti, Balázs and Fussy, Peter and Zöldi, Luca and Galyasz, Szonja and Makra, Nóra and Szabó, Dóra and Tárnoki, Ádám Domonkos and Tárnoki, Dávid László}, doi = {10.3390/medicina57030195}, journal-iso = {MED LITH}, journal = {MEDICINA-LITHUANIA}, volume = {57}, unique-id = {31974190}, issn = {1010-660X}, year = {2021}, eissn = {1648-9144}, orcid-numbers = {Hernyes, Anita/0000-0001-5875-4006; Piroska, Márton/0000-0002-6000-5044; Zöldi, Luca/0000-0003-4187-1673; Szabó, Dóra/0000-0002-8601-3923; Tárnoki, Ádám Domonkos/0000-0001-5909-3780; Tárnoki, Dávid László/0000-0002-7001-7647} } @article{MTMT:31206729, title = {Az arteria carotis communis intima-media komplex sajátosságainak vizsgálata ultrahanggal - Technikai megfontolások és korrelációk egyéb atherosclerosisra utaló változókkal.}, url = {https://m2.mtmt.hu/api/publication/31206729}, author = {Hernyes, Anita and Fejér, Bence and Szabó, Helga and Szalontai, László and Persely, Aliz and Fekete, Márton and Szily, Marcell and Jokkel, Zsófia and Debreceni, R and Gyulay, Kata Klára and Szabó, G and Zöldi, Luca and Tárnoki, Ádám Domonkos and Tárnoki, Dávid László}, doi = {10.5374/mro.2019.3.2}, journal-iso = {MAGYAR RADIOLÓGIA ONLINE}, journal = {MAGYAR RADIOLÓGIA ONLINE}, volume = {10}, unique-id = {31206729}, year = {2019}, eissn = {2063-9481}, pages = {2/1-10}, orcid-numbers = {Hernyes, Anita/0000-0001-5875-4006; Fejér, Bence/0000-0001-8751-7368; Szily, Marcell/0000-0003-3298-9231; Jokkel, Zsófia/0000-0002-5407-6540; Gyulay, Kata Klára/0000-0002-9355-1623; Zöldi, Luca/0000-0003-4187-1673; Tárnoki, Ádám Domonkos/0000-0001-5909-3780; Tárnoki, Dávid László/0000-0002-7001-7647} }