TY - JOUR AU - Román, Ádám TI - A személyre szabott medicina fejlődése, története JF - KALEIDOSCOPE: MŰVELŐDÉS- TUDOMÁNY- ÉS ORVOSTÖRTÉNETI FOLYÓIRAT J2 - KALEIDOSCOPE VL - 13 PY - 2023 IS - 26 SP - 361 EP - 369 PG - 9 SN - 2062-2597 DO - 10.17107/KH.2023.26.19 UR - https://m2.mtmt.hu/api/publication/34144148 ID - 34144148 AB - Today, personalised medicine is gaining ground. This article attempts to present the history of the development of this system from its beginnings to the main technological milestones. However, the evolution of personalised medicine is still ongoing. Newer and newer research and technological developments are aiming to make healthcare increasingly personalised, which may in the future allow for even more effective treatment and prevention of diseases. Personalised medicine is one of the most promising areas in healthcare, but it faces many challenges in the 21st century. LA - Hungarian DB - MTMT ER - TY - JOUR AU - Henn, László AU - Szabó, Anikó AU - Imre, László AU - Román, Ádám AU - Ábrahám, Andrea AU - Vedelek, Balázs AU - Nánási, Péter Pál AU - Boros, Imre Miklós TI - Alternative linker histone permits fast paced nuclear divisions in early Drosophila embryo JF - NUCLEIC ACIDS RESEARCH J2 - NUCLEIC ACIDS RES VL - 48 PY - 2020 IS - 16 SP - 9007 EP - 9018 PG - 12 SN - 0305-1048 DO - 10.1093/nar/gkaa624 UR - https://m2.mtmt.hu/api/publication/31397830 ID - 31397830 AB - In most animals, the start of embryogenesis requires specific histones. In Drosophila linker histone variant BigH1 is present in early embryos. To uncover the specific role of this alternative linker histone at early embryogenesis, we established fly lines in which domains of BigH1 have been replaced partially or completely with that of H1. Analysis of the resulting Drosophila lines revealed that at normal temperature somatic H1 can substitute the alternative linker histone, but at low temperature the globular and C-terminal domains of BigH1 are essential for embryogenesis. In the presence of BigH1 nucleosome stability increases and core histone incorporation into nucleosomes is more rapid, while nucleosome spacing is unchanged. Chromatin formation in the presence of BigH1 permits the fast-paced nuclear divisions of the early embryo. We propose a model which explains how this specific linker histone ensures the rapid nucleosome reassembly required during quick replication cycles at the start of embryogenesis. LA - English DB - MTMT ER -