TY - JOUR AU - Borbásné Sebestyén, Veronika AU - Ratku, Balázs AU - Ujvárosy, Dóra AU - Lőrincz, Hajnalka AU - Tari , Dóra AU - Végh, Lilla AU - Majai, Gyöngyike AU - Somodi, Sándor AU - Páll, Dénes AU - Szűcs, Gabriella AU - Harangi, Mariann AU - Szabó, Zoltán TI - Progranulin, sICAM-1, and sVCAM-1 May Predict an Increased Risk for Ventricular Arrhythmias in Patients with Systemic Sclerosis JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 25 PY - 2024 IS - 13 SP - 7380 SN - 1661-6596 DO - 10.3390/ijms25137380 UR - https://m2.mtmt.hu/api/publication/35146359 ID - 35146359 AB - In systemic sclerosis (SSc), fibrosis of the myocardium along with ongoing autoimmune inflammation can alter the electric function of the cardiac myocytes, which may increase the risk for ventricular arrhythmias and sudden cardiac death. We analyzed the electrocardiographic (ECG) variables describing ventricular repolarization such as QT interval, QT dispersion (QTd), T wave peak-to-end interval (Tpe), and arrhythmogeneity index (AIX) of 26 patients with SSc and 36 healthy controls. Furthermore, echocardiographic and laboratory parameters were examined, with a focus on inflammatory proteins like C-reactive ptotein (CRP), soluble intracellular adhesion molecule-1 (sICAM-1), soluble vascular adhesion molecule-1 (sVCAM-1), and progranulin (PGRN). The CRP, sICAM-1, and sVCAM-1 levels were positively correlated with the length of the QT interval. Although the serum PGRN levels were not increased in the SSc group compared to the controls, in SSc patients, the PGRN levels were positively correlated with the QT interval and the AIX. According to our results, we conclude that there may be a potential association between autoimmune inflammation and the risk for ventricular arrhythmias in patients with SSc. We emphasize that the measurement of laboratory parameters of inflammatory activity including CRP, PGRN, sVCAM-1, and sICAM-1 could be helpful in the prediction of sudden cardiac death in patients with SSc. LA - English DB - MTMT ER - TY - JOUR AU - Lőrincz, Hajnalka AU - Bak-Csiha, Sára AU - Ratku, Balázs AU - Somodi, Sándor AU - Sztanek, Ferenc AU - Paragh, György AU - Harangi, Mariann TI - Associations between Serum Kallistatin Levels and Markers of Glucose Homeostasis, Inflammation, and Lipoprotein Metabolism in Patients with Type 2 Diabetes and Nondiabetic Obesity JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 25 PY - 2024 IS - 11 SP - 6264 SN - 1661-6596 DO - 10.3390/ijms25116264 UR - https://m2.mtmt.hu/api/publication/35059303 ID - 35059303 AB - Kallistatin is an endogenous serine proteinase inhibitor with various functions, including antioxidative, anti-inflammatory, and anti-atherosclerotic properties. To date, associations between kallistatin and lipoprotein subfractions are poorly investigated. In this study, we enrolled 62 obese patients with type 2 diabetes (T2D), 106 nondiabetic obese (NDO) subjects matched in gender, age, and body mass index, as well as 49 gender- and age-matched healthy, normal-weight controls. Serum kallistatin levels were measured with ELISA, and lipoprotein subfractions were analyzed using Lipoprint® (Quantimetrix Corp., Redondo Beach, CA, USA) gel electrophoresis. Kallistatin concentrations were significantly higher in T2D patients compared to NDO and control groups. We found significant positive correlations between very-low-density lipoprotein (VLDL), small high-density lipoprotein (HDL) subfractions, glucose, hemoglobin A1c (HbA1c), betatrophin, and kallistatin, while negative correlations were detected between mean low-density lipoprotein (LDL) size, large and intermediate HDL subfractions, and kallistatin in the whole study population. The best predictor of kallistatin was HbA1c in T2D patients, high-sensitivity C-reactive protein (hsCRP) and betatrophin in NDO patients, and hsCRP in controls. Our results indicate that kallistatin expression might be induced by persistent hyperglycemia in T2D, while in nondiabetic subjects, its production might be associated with systemic inflammation. The correlation of kallistatin with lipid subfractions may suggest its putative role in atherogenesis. LA - English DB - MTMT ER - TY - JOUR AU - Ratku, Balázs AU - Lőrincz, Hajnalka AU - Bak-Csiha, Sára AU - Sebestyén, Veronika AU - Berta, Eszter AU - Bodor, Miklós AU - Nagy, Endre AU - Szabó, Zoltán AU - Harangi, Mariann AU - Somodi, Sándor TI - Serum afamin and its implications in adult growth hormone deficiency: a prospective GH-withdrawal study JF - FRONTIERS IN ENDOCRINOLOGY J2 - FRONT ENDOCRINOL VL - 15 PY - 2024 SN - 1664-2392 DO - 10.3389/fendo.2024.1348046 UR - https://m2.mtmt.hu/api/publication/34564621 ID - 34564621 LA - English DB - MTMT ER - TY - JOUR AU - Lőrincz, Hajnalka AU - Ratku, Balázs AU - Ötvös, T. AU - Szentpéteri, Anita AU - Seres, Ildikó AU - Paragh, György AU - Harangi, Mariann AU - Somodi, Sándor TI - CORRELATIONS BETWEEN SERUM AFAMIN AND LIPID PARAMETERS IN OBESE TYPE 2 DIABETIC PATIENTS JF - ATHEROSCLEROSIS J2 - ATHEROSCLEROSIS VL - 379 PY - 2023 IS - S1 SP - S104 EP - S104 SN - 0021-9150 UR - https://m2.mtmt.hu/api/publication/34732660 ID - 34732660 LA - English DB - MTMT ER - TY - JOUR AU - Lőrincz, Hajnalka AU - Bak-Csiha, Sára AU - Ratku, Balázs AU - Somodi, Sándor AU - Sztanek, Ferenc AU - Seres, Ildikó AU - Paragh, György AU - Harangi, Mariann TI - Gender-Dependent Associations between Serum Betatrophin Levels and Lipoprotein Subfractions in Diabetic and Nondiabetic Obese Patients JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 24 PY - 2023 IS - 22 SN - 1661-6596 DO - 10.3390/ijms242216504 UR - https://m2.mtmt.hu/api/publication/34483385 ID - 34483385 AB - Betatrophin, also known as angiopoietin-like protein 8 (ANGPTL8), mainly plays a role in lipid metabolism. To date, associations between betatrophin and lipoprotein subfractions are poorly investigated. For this study, 50 obese patients with type 2 diabetes (T2D) and 70 nondiabetic obese (NDO) subjects matched in gender, age, and body mass index (BMI) as well as 49 gender- and age-matched healthy, normal-weight controls were enrolled. Serum betatrophin levels were measured with ELISA, and lipoprotein subfractions were analyzed using Lipoprint gel electrophoresis. Betatrophin concentrations were found to be significantly higher in the T2D and NDO groups compared to the controls in all subjects and in females, but not in males. We found significant positive correlations between triglyceride, very low density lipoprotein (VLDL), large LDL (low density lipoprotein), small LDL, high density lipoprotein (HDL) -6-10 subfractions, and betatrophin, while negative correlations were detected between betatrophin and IDL, mean LDL size, and HDL-1-5. Proportion of small HDL was the best predictor of betatrophin in all subjects. Small LDL and large HDL subfractions were found to be the best predictors in females, while in males, VLDL was found to be the best predictor of betatrophin. Our results underline the significance of serum betatrophin measurement in the cardiovascular risk assessment of obese patients with and without T2D, but gender differences might be taken into consideration. LA - English DB - MTMT ER - TY - JOUR AU - Ratku, Balázs AU - Sebestyén, Veronika AU - Szelesné Árokszállási, Andrea AU - Erdei, Annamária AU - Berta, Eszter AU - Szabó, Zoltán AU - Bodor, Miklós AU - Nagy, Endre AU - Somodi, Sándor TI - A felnőttkori növekedésihormon-hiány szív- és érrendszeri szövődményei JF - ORVOSI HETILAP J2 - ORV HETIL VL - 164 PY - 2023 IS - 41 SP - 1616 EP - 1627 PG - 12 SN - 0030-6002 DO - 10.1556/650.2023.32890 UR - https://m2.mtmt.hu/api/publication/34280731 ID - 34280731 AB - A növekedési hormon–inzulinszerű növekedési faktor-1 (GH–IGF-1-) tengely jelentős szerepet tölt be a cardiovascularis rendszer fiziológiás működésének fenntartásában. Az elmúlt évtizedek kutatási eredményei alapján a GH–IGF-1-tengely részt vesz a perifériás ellenállás szabályozásában, és hozzájárul a normális szívizomtömeg és balkamra-funkció megtartásához. A GH–IGF-1-tengely érfalprotektív funkciói az atherosclerosis ellenében hatnak. Ellentétben a gyermekkori GH-hiánnyal, amelynél a betegség egyértelmű biológiai következménye a gyermek növekedésbeli visszamaradása, a felnőttkori növekedésihormon-hiánynak (adult growth hormone deficiency – AGHD) nincsenek specifikus tünetei. Az AGHD klinikai megjelenését a cardiovascularis rizikótényezők halmozódása jellemzi, amely miatt a klinikai kép leginkább a metabolicus szindrómához hasonlítható. Újabb kutatások AGHD esetében a tradicionális rizikótényezők mellett krónikus kisfokú gyulladás, prothromboticus állapot és oxidatív stressz jelenlétére is rámutattak, amelyek szintén közrejátszhatnak a fokozott kardiometabolikus rizikó kialakulásában. A tartós GH-szubsztitúció AGHD-betegek esetében a lipidprofil jelentős javulását eredményezi, és kedvező hatással van a testösszetételre, a szívizomtömegre, az endothelfunkcióra, valamint az újonnan felismert, nem tradicionális rizikótényezőkre is. A betegséggel összefüggő fokozott mortalitás a mai felfogás szerint multikauzális, és nem vezethető vissza csupán a GH hiányára. A kedvezőtlen mortalitásért az etiológia, az alkalmazott kezelés és az egyéb hypophysishormon-hiányok kezelésének nehézsége is felelős lehet. Mindazonáltal hypopituitarismus esetében optimális, a GH-pótlást is magában foglaló hormonszubsztitúcióval az átlagpopulációéhoz közelítő mortalitás érhető el. Orv Hetil. 2023; 164(41): 1616–1627. LA - Hungarian DB - MTMT ER - TY - JOUR AU - Lőrincz, Hajnalka AU - Ratku, Balázs AU - Bak-Csiha, Sára AU - Seres, Ildikó AU - Szabó, Zoltán AU - Katona, Éva Melitta AU - Paragh, György AU - Harangi, Mariann AU - Somodi, Sándor TI - Az organokinek szintjének vizsgálata elhízott 2-es típusú diabéteszes és elhízott nem diabéteszes betegekben JF - DIABETOLOGIA HUNGARICA J2 - DIABETOLOGIA HUNGARICA VL - 31 PY - 2023 IS - Suppl_1 SP - 48 EP - 49 PG - 2 SN - 1217-372X UR - https://m2.mtmt.hu/api/publication/34087371 ID - 34087371 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Lőrincz, Hajnalka AU - Ratku, Balázs AU - Bak-Csiha, Sára AU - Seres, Ildikó AU - Szabó, Zoltán AU - Paragh, György AU - Harangi, Mariann AU - Somodi, Sándor TI - Impaired Organokine Regulation in Non-Diabetic Obese Subjects: Halfway to the Cardiometabolic Danger Zone JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 24 PY - 2023 IS - 4 PG - 13 SN - 1661-6596 DO - 10.3390/ijms24044115 UR - https://m2.mtmt.hu/api/publication/33671118 ID - 33671118 AB - Altered organokine expression contributes to increased cardiometabolic risk in obesity. Our aim was to evaluate the associations of serum afamin with glucose homeostasis, atherogenic dyslipidemia, and other adipokines in severe obesity to clarify the early metabolic alterations. 106 non-diabetic obese (NDO) subjects and 62 obese patients with type 2 diabetes matched for age, gender, and body mass index (BMI) were enrolled in this study. We compared their data with 49 healthy, lean controls. Serum afamin and retinol-binding protein 4 (RBP4), as well as plasma plasminogen activator inhibitor-1 (PAI-1), were measured with ELISA, and lipoprotein subfractions were analyzed using Lipoprint gel electrophoresis. Afamin and PAI-1 found to be significantly higher in the NDO and T2M group (p < 0.001 and p < 0.001, respectively) than in the controls. In contrast, RBP4 was unexpectedly lower in the NDO and T2DM group compared to controls (p < 0.001). Afamin showed negative correlations with mean LDL size and RBP4, but positive correlations with anthropometric, glucose/lipid parameters, and PAI-1 in both the overall patients and the in NDO + T2DM groups. BMI, glucose, intermediate HDL, and small HDL were predictors of afamin. Afamin may serve as a biomarker for the severity of cardiometabolic disturbances in obesity. The complexity of organokine patterns in NDO subjects draws attention to the diverse spectrum of obesity-related comorbidities. LA - English DB - MTMT ER - TY - JOUR AU - Lőrincz, Hajnalka AU - Somodi, Sándor AU - Ratku, Balázs AU - Harangi, Mariann AU - Paragh, György TI - Crucial Regulatory Role of Organokines in Relation to Metabolic Changes in Non-Diabetic Obesity JF - METABOLITES J2 - METABOLITES VL - 13 PY - 2023 IS - 2 SP - 270 SN - 2218-1989 DO - 10.3390/metabo13020270 UR - https://m2.mtmt.hu/api/publication/33670887 ID - 33670887 AB - Obesity is characterized by an excessive accumulation of fat leading to a plethora of medical complications, including coronary artery disease, hypertension, type 2 diabetes mellitus or impaired glucose tolerance and dyslipidemia. Formerly, several physiological roles of organokines, including adipokines, hepatokines, myokines and gut hormones have been described in obesity, especially in the regulation of glucose and lipid metabolism, insulin sensitivity, oxidative stress, and low-grade inflammation. The canonical effect of these biologically active peptides and proteins may serve as an intermediate regulatory level that connects the central nervous system and the endocrine, autocrine, and paracrine actions of organs responsible for metabolic and inflammatory processes. Better understanding of the function of this delicately tuned network may provide an explanation for the wide range of obesity phenotypes with remarkable inter-individual differences regarding comorbidities and therapeutic responses. The aim of this review is to demonstrate the role of organokines in the lipid and glucose metabolism focusing on the obese non-diabetic subgroup. We also discuss the latest findings about sarcopenic obesity, which has recently become one of the most relevant metabolic disturbances in the aging population. LA - English DB - MTMT ER - TY - CHAP AU - Ratku, Balázs AU - Lőrincz, Hajnalka AU - Barth, Anita AU - Somodi, Sándor ED - Rusinné Fedor, Anita ED - Tóth, Dalma ED - Zakor-Broda, Rita TI - Az afamin, mint potenciális biomarker az elhízott betegek és a 2-es típusú cukorbetegek gondozásában T2 - XIV. Nemzetközi Nyíregyházi Doktorandusz és Posztdoktori Konferencia PB - Debreceni Egyetem Egészségtudományi Kar CY - Nyíregyháza SN - 9789634904755 PY - 2022 SP - 55 UR - https://m2.mtmt.hu/api/publication/33574927 ID - 33574927 LA - Hungarian DB - MTMT ER -