TY - JOUR AU - Shahmohammadi, Sayeh AU - Orsy, György AU - Forró, Enikő TI - Lipase-catalyzed Strategies for the Preparation of Key Intermediates for the Synthesis of the Taxol Side Chain JF - MINI-REVIEWS IN ORGANIC CHEMISTRY J2 - MINI-REV ORG CHEM VL - 23 PY - 2026 IS - 1 SP - 1 EP - 9 PG - 9 SN - 1570-193X DO - 10.2174/0118756298317278240913071521 UR - https://m2.mtmt.hu/api/publication/36203475 ID - 36203475 LA - English DB - MTMT ER - TY - JOUR AU - Orsy, György AU - Shahmohammadi, Sayeh AU - Forró, Enikő TI - A Sustainable Green Enzymatic Method for Amide Bond Formation JF - MOLECULES J2 - MOLECULES VL - 28 PY - 2023 IS - 15 PG - 11 SN - 1431-5157 DO - 10.3390/molecules28155706 UR - https://m2.mtmt.hu/api/publication/34082152 ID - 34082152 N1 - Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös u. 6, Szeged, H-6720, Hungary Stereochemistry Research Group, Eötvös Loránd Research Network, University of Szeged, Eötvös u. 6, Szeged, H-6720, Hungary Export Date: 28 August 2023 CODEN: MOLEF Correspondence Address: Forró, E.; Institute of Pharmaceutical Chemistry, Eötvös u. 6, Hungary; email: forro.eniko@szte.hu Funding details: TKP-2021-EGA-32 Funding details: Hungarian Scientific Research Fund, OTKA, K-138871 Funding text 1: The authors’ thanks are due to the Hungarian Research Foundation (OTKA No. K-138871), the Ministry of Human Capacities, Hungary (grant TKP-2021-EGA-32). AB - A sustainable enzymatic strategy for the preparation of amides by using Candida antarctica lipase B as the biocatalyst and cyclopentyl methyl ether as a green and safe solvent was devised. The method is simple and efficient and it produces amides with excellent conversions and yields without the need for intensive purification steps. The scope of the reaction was extended to the preparation of 28 diverse amides using four different free carboxylic acids and seven primary and secondary amines, including cyclic amines. This enzymatic methodology has the potential to become a green and industrially reliable process for direct amide synthesis. LA - English DB - MTMT ER - TY - JOUR AU - Nghi, Hoang Thao AU - Shahmohammadi, Sayeh AU - Ebrahimi, Kourosh H. TI - Ancient complexes of iron and sulfur modulate oncogenes and oncometabolism JF - CURRENT OPINION IN CHEMICAL BIOLOGY J2 - CURR OPIN CHEM BIOL VL - 76 PY - 2023 PG - 8 SN - 1367-5931 DO - 10.1016/j.cbpa.2023.102338 UR - https://m2.mtmt.hu/api/publication/34320436 ID - 34320436 AB - Inorganic complexes of iron and sulfur, that is, iron-sulfur [FeS] clusters, have played a fundamental role in life on Earth since the prebiotic period. These clusters were involved in elemen-tary reactions leading to the emergence of life and, since then, gained function in processes, such as respiration, replication, transcription, and the immune response. We discuss how three [FeS] proteins involved in the innate immune response play a role in oncogene expression/function and oncometabolism. Our analysis highlights the importance of future research into understanding the [FeS] clusters' roles in cancer progression and proliferation. The outcomes of these studies will help identify new targets and develop new anticancer therapeutics. LA - English DB - MTMT ER - TY - JOUR AU - Németi, Gábor AU - Berkecz, Róbert AU - Shahmohammadi, Sayeh AU - Forró, Enikő AU - Lindner, Wolfgang AU - Péter, Antal AU - Ilisz, István TI - Enantioselective high-performance liquid chromatographic separation of fluorinated ß- phenylalanine derivatives utilizing Cinchona alkaloid-based ion-exchanger chiral stationary phases. Enantioselective separation of fluorinated ß-phenylalanine derivatives TS - Enantioselective separation of fluorinated ß-phenylalanine derivatives JF - JOURNAL OF CHROMATOGRAPHY A J2 - J CHROMATOGR A VL - 1670 PY - 2022 PG - 10 SN - 0021-9673 DO - 10.1016/j.chroma.2022.462974 UR - https://m2.mtmt.hu/api/publication/32741660 ID - 32741660 N1 - Institute of Pharmaceutical Analysis, Interdisciplinary Excellence Centre, University of Szeged, H-6720 Szeged, Somogyi u. 4, Hungary Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös u. 6, Szeged, H-6720, Hungary Department of Analytical Chemistry, University of Vienna, Währinger Strasse 38, Vienna, 1090, Austria Cited By :1 Export Date: 21 June 2023 CODEN: JCRAE Correspondence Address: Ilisz, I.; Institute of Pharmaceutical Analysis, Somogyi B. u. 4, Hungary; email: ilisz.istvan@szte.hu Chemicals/CAS: acetonitrile, 75-05-8; methanol, 67-56-1; phenylalanine, 3617-44-5, 63-91-2; Cinchona Alkaloids; Methanol; Phenylalanine Funding details: Nemzeti Kutatási, Fejlesztési és Innovaciós Alap, NKFIA Funding details: Innovációs és Technológiai Minisztérium Funding details: National Research, Development and Innovation Office, K129049, K137607, TKP2021-EGA-32 Funding text 1: This work was supported by National Research, Development and Innovation Office-NKFIA through projects K137607 and K129049. Project no. TKP2021-EGA-32 has been implemented with the support provided by the Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund, financed under the TKP2021-EGA funding scheme. LA - English DB - MTMT ER - TY - JOUR AU - Shahmohammadi, Sayeh AU - Faragó, Tünde AU - Palkó, Márta AU - Forró, Enikő TI - Green Strategies for the Preparation of Enantiomeric 5–8-Membered Carbocyclic β-Amino Acid Derivatives through CALB-Catalyzed Hydrolysis JF - MOLECULES J2 - MOLECULES VL - 27 PY - 2022 IS - 8 PG - 11 SN - 1431-5157 DO - 10.3390/molecules27082600 UR - https://m2.mtmt.hu/api/publication/32787510 ID - 32787510 N1 - Institute of Pharmaceutical Chemistry, Interdisciplinary Excellence Center, Faculty of Pharmacy, University of Szeged, Szeged, H-6720, Hungary MTA-SZTE Stereochemistry Research Group, Hungarian Academy of Sciences, Szeged, H-6720, Hungary Export Date: 4 June 2023 CODEN: MOLEF Correspondence Address: Forró, E.; Institute of Pharmaceutical Chemistry, Hungary; email: forro.eniko@szte.hu Chemicals/CAS: amino acid, 65072-01-7; Amino Acids; Esters; Fungal Proteins; Solvents Funding details: 2.3.2-15-2016-00014, EFOP 3.6.3-VEKOP-16-2017-00009 Funding details: Hungarian Scientific Research Fund, OTKA, K129049, K138871 Funding details: National Research, Development and Innovation Office Funding text 1: Funding: The authors thank the Hungarian Scientific Research Council (OTKA, K129049 and K138871) and the Ministry of National Economy, National Research, Development and Innovation Office (GINOP, 2.3.2-15-2016-00014) and (EFOP 3.6.3-VEKOP-16-2017-00009) for financial support. LA - English DB - MTMT ER - TY - JOUR AU - Tanács, Dániel AU - Berkecz, Róbert AU - Shahmohammadi, Sayeh AU - Forró, Enikő AU - Armstrong, Daniel W. AU - Péter, Antal AU - Ilisz, István TI - Macrocyclic glycopeptides- and derivatized cyclofructan-based chiral stationary phases for the enantioseparation of fluorinated ß-phenylalanine analogs JF - JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS J2 - J PHARMACEUT BIOMED ANAL VL - 219 PY - 2022 PG - 9 SN - 0731-7085 DO - 10.1016/j.jpba.2022.114912 UR - https://m2.mtmt.hu/api/publication/32936379 ID - 32936379 N1 - Funding Agency and Grant Number: National Research, Development and Innovation Office-NKFIA [K137607, K129049, TKP2021-EGA-32]; Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund [TKP2021-EGA] Funding text: Acknowledgments This work was supported by National Research, Development and Innovation Office-NKFIA through projects K137607 and K129049. Project no. TKP2021-EGA-32 has been implemented with the support provided by the Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund, financed under the TKP2021-EGA funding scheme. LA - English DB - MTMT ER - TY - CONF AU - Tanács, Dániel AU - Berkecz, Róbert AU - Shahmohammadi, Sayeh AU - Forró, Enikő AU - Daniel, W. Armstrong AU - Péter, Antal AU - Ilisz, István ED - Felinger, Attila TI - Liquid Chromatographic Enantioseparation of Fluorinated ß-Phenylalanine Analogs Utilizing Superficially Porous Particles T2 - 33rd International Symposium on Chromatography – ISC 2022 PB - Hungarian Society for Separation Sciences C1 - Budapest SN - 9786155270741 PY - 2022 PG - 1 UR - https://m2.mtmt.hu/api/publication/33551486 ID - 33551486 LA - English DB - MTMT ER - TY - CONF AU - Shahmohammadi, Sayeh AU - Faragó, Tünde AU - Palkó, Márta AU - Forró, Enikő TI - Green enzymatic strategies for the preparation of enantiomeric carbocyclic beta-amino acid derivatives T2 - GreenCat 2022 Book of Abstracts PY - 2022 PG - 1 UR - https://m2.mtmt.hu/api/publication/33672957 ID - 33672957 LA - English DB - MTMT ER - TY - THES AU - Shahmohammadi, Sayeh TI - New enzymatic strategies for the preparation of pharmaceutically important enantiomeric β-amino acid derivatives PB - Szegedi Tudományegyetem PY - 2022 SP - 52 SN - 9798381082999 DO - 10.14232/phd.11328 UR - https://m2.mtmt.hu/api/publication/34118001 ID - 34118001 AB - The present Ph.D. work has been planned to accomplish two major goals. In view of the significance of fluorine-substituted compounds, the first aim was to synthesize a selection of (±)-β-amino carboxylic ester hydrochloride salts 3a–e, then to generate an appropriate lipase-catalyzed method for their resolution through hydrolysis, furnishing enantiopure new β-fluorophenyl-substituted β-amino acids (S)-5a–e and unreacted β-amino esters (R)-4a–e. The second objective of my work was a comparative investigation of different green strategies and then to build an environmentally benign CALB-catalyzed hydrolysis of cis carbocyclic amino esters 6–9. LA - English DB - MTMT ER - TY - JOUR AU - Shahmohammadi, Sayeh AU - Fülöp, Ferenc AU - Forró, Enikő TI - Efficient Synthesis of New Fluorinated β-Amino Acid Enantiomers through Lipase-Catalyzed Hydrolysis JF - MOLECULES J2 - MOLECULES VL - 25 PY - 2020 IS - 24 PG - 11 SN - 1431-5157 DO - 10.3390/molecules25245990 UR - https://m2.mtmt.hu/api/publication/31862790 ID - 31862790 N1 - Institute of Pharmaceutical Chemistry, University of Szeged, Szeged, H-6720, Hungary Stereochemistry Research Group of the Hungarian Academy of Sciences, University of Szeged, Szeged, H-6720, Hungary Cited By :4 Export Date: 6 March 2023 CODEN: MOLEF Correspondence Address: Forró, E.; Institute of Pharmaceutical Chemistry, Hungary; email: forro.eniko@pharm.u-szeged.hu Chemicals/CAS: amino acid, 65072-01-7; fluorine, 7782-41-4; triacylglycerol lipase, 9001-62-1; Amino Acids; Fluorine; Lipase Funding details: 2.3.2-15-2016-00014 Funding details: Hungarian Scientific Research Fund, OTKA, K129049 Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFIH Funding text 1: Funding: The authors thank the Hungarian Scientific Research Council (OTKA, K129049) and the Ministry of National Economy, National Research, Development and Innovation Office (GINOP, 2.3.2-15-2016-00014) for financial support. LA - English DB - MTMT ER -