TY - JOUR AU - Alijanpourotaghsara, Amirreza AU - Vessal, Arsalan AU - Alijanpour, Amirmasoud AU - Strelnikov, David AU - Piroska, Márton AU - Persely, Aliz AU - Jokkel, Zsófia AU - Szalontai, László AU - Forgo, Bianka AU - Kozák, Lajos Rudolf AU - Bekesy-Szabo, Adam AU - Maurovich-Horvat, Pál AU - Tárnoki, Dávid László AU - Tárnoki, Ádám Domonkos TI - Morphometric Analysis of Neocortical and Infratentorial Structures: Genetic and Environmental Insights from a Twin Neuroanatomical Study JF - MEDICINA-LITHUANIA J2 - MED LITH VL - 61 PY - 2025 IS - 2 PG - 18 SN - 1010-660X DO - 10.3390/medicina61020261 UR - https://m2.mtmt.hu/api/publication/35773338 ID - 35773338 AB - Background and Objective: Brain morphometry is shaped by a complex interplay of genetic and environmental factors, including physiological and neuropsychiatric conditions. These influences can vary across distinct brain regions, yet the precise contributions of genetics and environment to regional variation in healthy brains remain poorly understood. This study examines the heritability of specific brain structures to provide deeper insights into their development. Materials and Methods: We studied 118 healthy adult twins from the Hungarian Twin Registry using T1-weighted magnetic resonance imaging (T1W MRI) and the volBrain pipeline for structural measurements. Results: In all regions, monozygotic (MZ) twins showed a higher resemblance than dizygotic (DZ) twins in total brainstem and cerebellar volumes, with significant heritability (A: 90.5–92.6%) and minimal unique environmental effects (E: <1%). For supratentorial regions, regarding the total gray matter volume, all regions exhibited high heritability (A: 74.5–92.4%) and minimal environmental influence (E: <1.5%). In average cortical thickness analysis, the frontal lobe, temporal lobe, and pre-central gyrus were influenced by shared and unique environmental factors (C: 63–66.5%; E: 33.4–37%), whereas genetics were more prominent in the parietal lobe, occipital lobe, and post-central gyrus (A: 67.7–85%; E: 15–32.3%). Conclusions: Genetics strongly influence cortical gray matter volume in supratentorial regions (both total and regional), as well as the total brainstem volume and the total and cortical gray matter volumes of the cerebellum in infratentorial regions. This genetic influence extends to the average cortical thickness of the parietal lobe, post-central gyrus, and occipital lobe, while the frontal lobe, temporal lobe, and pre-central gyrus are more affected by environmental factors. These findings emphasize the importance of understanding region-specific genetic and environmental contributions to brain structure, which could guide personalized therapeutic and preventive strategies for neurological conditions. LA - English DB - MTMT ER - TY - JOUR AU - Vessal, Arsalan AU - Alijanpourotaghsara, Amirreza AU - Strelnikov, David AU - Persely, Aliz AU - Piroska, Márton AU - Alijanpour, A. AU - Jokkel, Zsófia AU - Szalontai, László AU - Forgo, B. AU - Kozák, Lajos Rudolf AU - Bekesy-Szabo, A. AU - Maurovich-Horvat, Pál AU - Tárnoki, Dávid László AU - Tárnoki, Ádám Domonkos TI - The interplay of genetic and environmental factors on the morphology of the limbic cortex and hippocampal subfields: Insights from an MRI twin study JF - PSYCHIATRY RESEARCH-NEUROIMAGING J2 - PSYCHIAT RES-NEUROIM VL - 345 PY - 2024 PG - 8 SN - 0925-4927 DO - 10.1016/j.pscychresns.2024.111909 UR - https://m2.mtmt.hu/api/publication/35472997 ID - 35472997 N1 - Medical Imaging Centre, Semmelweis University, Budapest1082, Hungary Department of Radiology, Faculty of Medicine and Health, Örebro University, Örebro, 702 81, Sweden Export Date: 28 January 2025 CODEN: PSREE Correspondence Address: Tarnoki, A.D.; Medical Imaging Centre, Budapest, Hungary; email: tarnoki2@gmail.com LA - English DB - MTMT ER - TY - GEN AU - Arsalan, Vessal AU - Strelnikov, David AU - Alijanpourotaghsara, Amirreza AU - Piroska, Márton AU - Szalontai, László AU - Forgó, Bianka AU - Jokkel, Zsófia AU - Persely, Aliz AU - Hernyes, Anita AU - Kozák, Lajos Rudolf AU - Szabó, Ádám György AU - Maurovich-Horvat, Pál AU - Tárnoki, Dávid László AU - Tárnoki, Ádám Domonkos TI - Genetic and environmental influences on limbic system grey matter structures: insights from an MRI twin study PY - 2023 UR - https://m2.mtmt.hu/api/publication/34055774 ID - 34055774 LA - English DB - MTMT ER - TY - JOUR AU - Sztipits, Tamás AU - Barabás, János Imre AU - Szalontai, László AU - Dubóczki, Zsolt AU - Budai, Barna AU - Geletey, Olivér Zsolt AU - Wettstein, Dániel AU - Mersich, Tamás TI - Virtuális érmodell vizsgálata laparoszkópos jobb hemicolectomia és komplett mesocolicus excisio esetében JF - ORVOSI HETILAP J2 - ORV HETIL VL - 164 PY - 2023 IS - 49 SP - 1938 EP - 1946 PG - 9 SN - 0030-6002 DO - 10.1556/650.2023.32925 UR - https://m2.mtmt.hu/api/publication/34353112 ID - 34353112 N1 - Országos Onkológiai Intézet, Daganatsebészeti Központ, Hasi Sebészeti Részleg, Budapest, Hungary Semmelweis Egyetem, Általános Orvostudományi Kar, Városmajori Szív- és Érgyógyászati Klinika, 3D Központ, Budapest, Hungary Országos Onkológiai Intézet, Onkológiai Képalkotó és Invazív Diagnosztikai Központ, Budapest, Hungary Országos Onkológiai Intézet, Molekuláris Genetikai Osztály, Budapest, Hungary Semmelweis Egyetem, Általános Orvostudományi Kar, Budapest, Hungary Ráth Gy. u. 7–9, Budapest, 1122, Hungary Cited By :1 Export Date: 3 May 2024 CODEN: ORHEA LA - Hungarian DB - MTMT ER - TY - JOUR AU - Alijanpourotaghsara, Amirreza AU - Strelnikov, David AU - Piroska, Márton AU - Szalontai, László AU - Forgo, Bianka AU - Jokkel, Zsófia AU - Persely, Aliz AU - Hernyes, Anita AU - Kozák, Lajos Rudolf AU - Szabó, Ádám György AU - Maurovich-Horvat, Pál AU - Tárnoki, Ádám Domonkos AU - Tárnoki, Dávid László TI - Genetic and Environmental Effects on the Development of White Matter Hyperintensities in a Middle Age Twin Population JF - MEDICINA-LITHUANIA J2 - MED LITH VL - 58 PY - 2022 IS - 10 PG - 11 SN - 1010-660X DO - 10.3390/medicina58101425 UR - https://m2.mtmt.hu/api/publication/33197558 ID - 33197558 N1 - Medical Imaging Centre, Semmelweis University, Budapest, 1082, Hungary Department of Radiology, Faculty of Medicine and Health, Örebro University, Örebro, 702 81, Sweden Export Date: 23 January 2024 Correspondence Address: Tarnoki, D.L.; Medical Imaging Centre, Hungary; email: tarnoki4@gmail.com AB - Introduction: White matter hyperintensities (WMH) indicate white matter brain lesions in magnetic resonance imaging (MRI), which can be used as a marker for brain aging and cerebrovascular and neurodegenerative disorders. Twin studies revealed substantial but not uniform WMH heritability in elderly twins. The objective of our study was to investigate the genetic and environmental components of WMH, as well as their importance in a healthy twin population, utilizing 3T MRI scanners in a middle-aged twin population. Methods: Brain MRI was performed on 120 healthy adult twins from the Hungarian Twin Registry on a 3T scanner (86 monozygotic, MZ and 34 dizygotic, DZ twins; median age 50 ± 26.5 years, 72.5% female and 27.5% male). The count of WMH on FLAIR images was calculated using an automated volumetry pipeline (volBrain) and human processing. The age- and sex-adjusted MZ and DZ intra-pair correlations were determined and the total variance was decomposed into genetic, shared and unique environmental components using structural equation modeling. Results: Age and sex-adjusted MZ intrapair correlations were higher than DZ correlations, indicating moderate genetic influence in each lesion (rMZ = 0.466, rDZ = -0.025 for total count; rMZ = 0.482, rDZ = 0.093 for deep white matter count; rMZ = 0.739, rDZ = 0.39 for infratentorial count; rMZ = 0.573, rDZ = 0.372 for cerebellar count and rMZ = 0.473, rDZ = 0.19 for periventricular count), indicating a moderate heritability (A = 40.3%, A = 45%, A = 72.7% and A = 55.5%and 47.2%, respectively). The rest of the variance was influenced by unique environmental effects (E between 27.3% and 59.7%, respectively). Conclusions: The number of WMH lesions is moderately influenced by genetic effects, particularly in the infratentorial region in middle-aged twins. These results suggest that the distribution of WMH in various brain regions is heterogeneous. LA - English DB - MTMT ER - TY - JOUR AU - Strelnikov, David AU - Alijanpourotaghsara, Amirreza AU - Piroska, Márton AU - Szalontai, László AU - Forgo, B. AU - Jokkel, Zsófia AU - Persely, Aliz AU - Hernyes, Anita AU - Kozák, Lajos Rudolf AU - Szabó, Ádám György AU - Maurovich-Horvat, Pál AU - Tárnoki, Dávid László AU - Tárnoki, Ádám Domonkos TI - Heritability of Subcortical Grey Matter Structures JF - MEDICINA-LITHUANIA J2 - MED LITH VL - 58 PY - 2022 IS - 11 PG - 14 SN - 1010-660X DO - 10.3390/medicina58111687 UR - https://m2.mtmt.hu/api/publication/33292143 ID - 33292143 LA - English DB - MTMT ER - TY - THES AU - Szalontai, László TI - THE MORPHOLOGY OF THE VERTEBROBASILAR SYSTEM PY - 2022 DO - 10.14753/SE.2022.2633 UR - https://m2.mtmt.hu/api/publication/34058009 ID - 34058009 LA - English DB - MTMT ER - TY - JOUR AU - Tárnoki, Ádám Domonkos AU - Szalontai, László AU - Fagnani, Corrado AU - Tárnoki, Dávid László AU - Lucatelli, Pierleone AU - Maurovich-Horvat, Pál AU - Jermendy, Ádám Levente AU - Kovács, Attila AU - Molnár, Andrea Ágnes AU - Godor, Erika AU - Fejér, Bence AU - Hernyes, Anita AU - Cirelli, Carlo AU - Fanelli, Fabrizio AU - Farina, Filippo AU - Baracchini, Claudio AU - Meneghetti, Giorgio AU - Gyarmathy, Anna V AU - Jermendy, György AU - Merkely, Béla Péter AU - Pucci, Giacomo AU - Schillaci, Giuseppe AU - Stazi, Maria A AU - Medda, Emanuela TI - Genetic and environmental factors on heart rate, mean arterial pressure and carotid intima media thickness. a longitudinal twin study TS - a longitudinal twin study JF - CARDIOLOGY JOURNAL J2 - CARDIOL J VL - 28 PY - 2021 IS - 3 SP - 431 EP - 438 PG - 8 SN - 1897-5593 DO - 10.5603/CJ.a2019.0089 UR - https://m2.mtmt.hu/api/publication/30828887 ID - 30828887 N1 - Medical Imaging Center, Semmelweis University, Budapest, Hungary Hungarian Twin Registry, Budapest, Hungary Italian Twin Registry, Center for Behavioural Sciences and Mental Health, Istituto Superiore di Sanità, Rome, Italy Vascular and Interventional Radiology Unit, Department of Radiological, Oncological and Anatomo-Pathological Sciences, Sapienza University of Rome, Italy MTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, Budapest, Hungary Department of Neurosciences, University of Padua School of Medicine, Padua, Italy Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States Third Department of Internal Medicine, Bajcsy Zsilinszky Hospital, Budapest, Hungary Università di Perugia, Unità di Medicina Interna, Ospedale “S. Maria”, Terni, Italy Struttura Complessa di Medicina Interna, Azienda Ospedaliero-Universitaria di Terni, Italy Cited By :3 Export Date: 23 January 2024 Correspondence Address: Szalontai, L.; Medical Imaging Center, 78/A Ulloi street, Hungary; email: laszlo.szalontai.med@gmail.com AB - Heart rate (HR), mean arterial pressure (MAP) and carotid intima-media thickness (cIMT) are moderately heritable cardiovascular traits, but the environmental effects on the longitudinal change of their heritability have never been investigated.368 Italian and Hungarian twins (107 monozygotic, 77 dizygotic) underwent oscillometric measurement and B-mode sonography of bilateral carotid arteries in 2009/10 and 2014. Within-individual/cross-study wave, cross-twin/within-study wave and cross-twin/cross-study wave correlations were estimated, and bivariate Cholesky models were fitted to decompose the total variance at each wave and covariance between study waves into additive genetic, shared and unique environmental components.For each trait, a moderate longitudinal stability was observed, with within-individual/cross-wave correlations of 0.42 (95% CI: 0.33-0.51) for HR, 0.34 (95% CI: 0.24-0.43) for MAP, and 0.23 (95% CI: 0.12-0.33) for cIMT. Cross-twin/cross-wave correlations in monozygotic pairs were all significant and substantially higher than the corresponding dizygotic correlations. Genetic continuity was the main source of longitudinal stability, with across-time genetic correlations of 0.52 (95% CI: 0.29-0.71) for HR, 0.56 (95% CI: 0.31-0.81) for MAP, and 0.36 (95% CI: 0.07-0.64) for cIMT. Overlapping genetic factors explained respectively 57%, 77%, and 68% of the longitudinal covariance of the HR, MAP and cIMT traits.Genetic factors have a substantial role in the longitudinal change of HR, MAP and cIMT; however, the influence of unique environmental factors remains relevant. Further studies should better elucidate whether epigenetic mechanisms have a role in influencing the stability of the investigated traits over time. LA - English DB - MTMT ER - TY - JOUR AU - Szalontai, László AU - Jokkel, Zsófia AU - Horváth, Tamás AU - Piroska, Márton AU - Forgo, Bianka AU - Oláh, Csaba Zsolt AU - Kostyal, Laszlo AU - Tárnoki, Dávid László AU - Tárnoki, Ádám Domonkos TI - Are the Morphological Indices of the Vertebrobasilar System Heritable? A Twin Study Based on 3D Reconstructed Models JF - MEDICINA-LITHUANIA J2 - MED LITH VL - 57 PY - 2021 IS - 2 PG - 10 SN - 1010-660X DO - 10.3390/medicina57020127 UR - https://m2.mtmt.hu/api/publication/31854293 ID - 31854293 N1 - Medical Imaging Centre, Semmelweis University, 78/A Üllői Street, Budapest, 1082, Hungary Oncologic Imaging Diagnostic Center, Department of Radiology, National Institute of Oncology, Ráth György Street 7-9, Budapest, 1122, Hungary HeartBit, Hűvösvölgyi Road 42, Budapest, 1021, Hungary Department of Radiology, Faculty of Medicine and Health, Örebro University, Södra Grev Rosengatan, Örebro, 701 85, Sweden Department of Neurosurgery, University of Debrecen, Nagyerdei Boulevard 98, Debrecen, 4032, Hungary Department of Radiology, Borsod County University Teaching Hospital, 72-76 Szentpéteri Gate, Miskolc, 3526, Hungary Cited By :3 Export Date: 23 January 2024 Correspondence Address: Szalontai, L.; Medical Imaging Centre, 78/A Üllői Street, Hungary; email: laszlo.szalontai.med@gmail.com Correspondence Address: Szalontai, L.; Oncologic Imaging Diagnostic Center, Ráth György Street 7-9, Hungary; email: laszlo.szalontai.med@gmail.com AB - Background and Objectives: The asymmetrical vertebral artery (VA) flow and diameter are common findings, which can result in an asymmetrical blood flow in the basilar artery (BA), leading to bending of the artery over time. This study investigated whether the variation of the different vertebrobasilar morphological indices that influence flow characteristics might be inherited. Materials and Methods: We analyzed 200 cerebral magnetic resonance imaging (MRI) scans of healthy Caucasian twins (100 pairs) who underwent time-of-flight MRI. From the scans, we reconstructed the 3D mesh of the posterior circulation from the start of the V4 segment to the basilar tip and subsequently analyzed the morphology of the vertebrobasilar system. The phenotypic covariances of the different morphological parameters were decomposed into heritability (A), shared (C), and unshared (E) environmental effects. Results: 39% of the twins had left dominant VA, while 32.5% had right dominant. In addition, 28.5% were classified as equal. The vertebral artery V4 segment diameter, curvature, and tortuosity were mainly influenced by shared (C) and unshared (E) environmental factors. A moderate heritability was found for the BA length (A: 63%; 95% CI: 45.7-75.2%; E: 37%; 95% CI: 24.8-54.3%) and volume (A: 60.1%; 95% CI: 42.4-73.2%; E: 39.9%; 95% CI: 26.8-57.6%), while the torsion of both arteries showed no heritability and were only influenced by the unshared environment. Conclusions: The length and volume of the BA show a moderate genetical influence. However, most of the measured morphological indices were influenced by shared and unshared factors, which highlight the role of the ever-changing hemodynamic influences shaping the geometry of the vertebrobasilar system. LA - English DB - MTMT ER - TY - JOUR AU - Hernyes, Anita AU - Piroska, Márton AU - Fejér, Bence AU - Szalontai, László AU - Szabó, Helga AU - Forgó, Bianka AU - Jermendy, Ádám Levente AU - Molnár, Andrea Ágnes AU - Maurovich-Horvat, Pál AU - Jermendy, György AU - Merkely, Béla Péter AU - Tárnoki, Dávid László AU - Tárnoki, Ádám Domonkos TI - Overlapping Genetic Background of Coronary Artery and Carotid/Femoral Atherosclerotic Calcification JF - MEDICINA-LITHUANIA J2 - MED LITH VL - 57 PY - 2021 IS - 3 PG - 18 SN - 1010-660X DO - 10.3390/medicina57030252 UR - https://m2.mtmt.hu/api/publication/31927234 ID - 31927234 N1 - Medical Imaging Centre, Semmelweis University, 78/A Üllői Street, Budapest, 1083, Hungary Medical Centre Hungarian Defence Forces, Central Radiological Diagnostic Department, 44 Róbert Károly Boulevard, Budapest, 1134, Hungary Department of Radiology, Faculty of Medicine and Health, Örebro University, Södra Grev Rosengatan, Örebro, 70185, Sweden Heart and Vascular Center, MTA-SE Cardiovascular Imaging Research Group, Semmelweis University, 18 Határőr Street, Budapest, 1122, Hungary 3rd Department of Internal Medicine, Bajcsy Zsilinszky Hospital and Clinic, 89-91 Maglódi Street, Budapest, 1106, Hungary Hungarian Twin Registry, 29 Erdélyi Street, Budapest, 1212, Hungary Cited By :2 Export Date: 5 February 2025 Correspondence Address: Tarnoki, A.D.; Medical Imaging Centre, 78/A Üllői Street, Hungary; email: tarnoki2@gmail.com Correspondence Address: Tarnoki, A.D.; Hungarian Twin Registry, 29 Erdélyi Street, Hungary; email: tarnoki2@gmail.com LA - English DB - MTMT ER -