TY - JOUR AU - Vessal, Arsalan AU - Alijanpourotaghsara, Amirreza AU - Strelnikov, David AU - Persely, Aliz AU - Piroska, Márton AU - Alijanpour, A. AU - Jokkel, Zsófia AU - Szalontai, László AU - Forgo, B. AU - Kozák, Lajos Rudolf AU - Bekesy-Szabo, A. AU - Maurovich-Horvat, Pál AU - Tárnoki, Dávid László AU - Tárnoki, Ádám Domonkos TI - The interplay of genetic and environmental factors on the morphology of the limbic cortex and hippocampal subfields: Insights from an MRI twin study JF - PSYCHIATRY RESEARCH-NEUROIMAGING J2 - PSYCHIAT RES-NEUROIM VL - 345 PY - 2024 PG - 8 SN - 0925-4927 DO - 10.1016/j.pscychresns.2024.111909 UR - https://m2.mtmt.hu/api/publication/35472997 ID - 35472997 LA - English DB - MTMT ER - TY - JOUR AU - Sztipits, Tamás AU - Barabás, János Imre AU - Szalontai, László AU - Dubóczki, Zsolt AU - Budai, Barna AU - Geletey, Olivér Zsolt AU - Wettstein, Dániel AU - Mersich, Tamás TI - Virtuális érmodell vizsgálata laparoszkópos jobb hemicolectomia és komplett mesocolicus excisio esetében JF - ORVOSI HETILAP J2 - ORV HETIL VL - 164 PY - 2023 IS - 49 SP - 1938 EP - 1946 PG - 9 SN - 0030-6002 DO - 10.1556/650.2023.32925 UR - https://m2.mtmt.hu/api/publication/34353112 ID - 34353112 N1 - Országos Onkológiai Intézet, Daganatsebészeti Központ, Hasi Sebészeti Részleg, Budapest, Hungary Semmelweis Egyetem, Általános Orvostudományi Kar, Városmajori Szív- és Érgyógyászati Klinika, 3D Központ, Budapest, Hungary Országos Onkológiai Intézet, Onkológiai Képalkotó és Invazív Diagnosztikai Központ, Budapest, Hungary Országos Onkológiai Intézet, Molekuláris Genetikai Osztály, Budapest, Hungary Semmelweis Egyetem, Általános Orvostudományi Kar, Budapest, Hungary Ráth Gy. u. 7–9, Budapest, 1122, Hungary Cited By :1 Export Date: 3 May 2024 CODEN: ORHEA LA - Hungarian DB - MTMT ER - TY - GEN AU - Arsalan, Vessal AU - Strelnikov, David AU - Alijanpourotaghsara, Amirreza AU - Piroska, Márton AU - Szalontai, László AU - Forgó, Bianka AU - Jokkel, Zsófia AU - Persely, Aliz AU - Hernyes, Anita AU - Kozák, Lajos Rudolf AU - Szabó, Ádám György AU - Maurovich-Horvat, Pál AU - Tárnoki, Dávid László AU - Tárnoki, Ádám Domonkos TI - Genetic and environmental influences on limbic system grey matter structures: insights from an MRI twin study PY - 2023 UR - https://m2.mtmt.hu/api/publication/34055774 ID - 34055774 LA - English DB - MTMT ER - TY - THES AU - Szalontai, László TI - THE MORPHOLOGY OF THE VERTEBROBASILAR SYSTEM PY - 2022 DO - 10.14753/SE.2022.2633 UR - https://m2.mtmt.hu/api/publication/34058009 ID - 34058009 LA - English DB - MTMT ER - TY - JOUR AU - Strelnikov, David AU - Alijanpourotaghsara, Amirreza AU - Piroska, Márton AU - Szalontai, László AU - Forgo, B. AU - Jokkel, Zsófia AU - Persely, Aliz AU - Hernyes, Anita AU - Kozák, Lajos Rudolf AU - Szabó, Ádám György AU - Maurovich-Horvat, Pál AU - Tárnoki, Dávid László AU - Tárnoki, Ádám Domonkos TI - Heritability of Subcortical Grey Matter Structures JF - MEDICINA-LITHUANIA J2 - MED LITH VL - 58 PY - 2022 IS - 11 PG - 14 SN - 1010-660X DO - 10.3390/medicina58111687 UR - https://m2.mtmt.hu/api/publication/33292143 ID - 33292143 LA - English DB - MTMT ER - TY - JOUR AU - Alijanpourotaghsara, Amirreza AU - Strelnikov, David AU - Piroska, Márton AU - Szalontai, László AU - Forgo, Bianka AU - Jokkel, Zsófia AU - Persely, Aliz AU - Hernyes, Anita AU - Kozák, Lajos Rudolf AU - Szabó, Ádám György AU - Maurovich-Horvat, Pál AU - Tárnoki, Ádám Domonkos AU - Tárnoki, Dávid László TI - Genetic and Environmental Effects on the Development of White Matter Hyperintensities in a Middle Age Twin Population JF - MEDICINA-LITHUANIA J2 - MED LITH VL - 58 PY - 2022 IS - 10 PG - 11 SN - 1010-660X DO - 10.3390/medicina58101425 UR - https://m2.mtmt.hu/api/publication/33197558 ID - 33197558 N1 - Medical Imaging Centre, Semmelweis University, Budapest, 1082, Hungary Department of Radiology, Faculty of Medicine and Health, Örebro University, Örebro, 702 81, Sweden Export Date: 23 January 2024 Correspondence Address: Tarnoki, D.L.; Medical Imaging Centre, Hungary; email: tarnoki4@gmail.com AB - Introduction: White matter hyperintensities (WMH) indicate white matter brain lesions in magnetic resonance imaging (MRI), which can be used as a marker for brain aging and cerebrovascular and neurodegenerative disorders. Twin studies revealed substantial but not uniform WMH heritability in elderly twins. The objective of our study was to investigate the genetic and environmental components of WMH, as well as their importance in a healthy twin population, utilizing 3T MRI scanners in a middle-aged twin population. Methods: Brain MRI was performed on 120 healthy adult twins from the Hungarian Twin Registry on a 3T scanner (86 monozygotic, MZ and 34 dizygotic, DZ twins; median age 50 ± 26.5 years, 72.5% female and 27.5% male). The count of WMH on FLAIR images was calculated using an automated volumetry pipeline (volBrain) and human processing. The age- and sex-adjusted MZ and DZ intra-pair correlations were determined and the total variance was decomposed into genetic, shared and unique environmental components using structural equation modeling. Results: Age and sex-adjusted MZ intrapair correlations were higher than DZ correlations, indicating moderate genetic influence in each lesion (rMZ = 0.466, rDZ = -0.025 for total count; rMZ = 0.482, rDZ = 0.093 for deep white matter count; rMZ = 0.739, rDZ = 0.39 for infratentorial count; rMZ = 0.573, rDZ = 0.372 for cerebellar count and rMZ = 0.473, rDZ = 0.19 for periventricular count), indicating a moderate heritability (A = 40.3%, A = 45%, A = 72.7% and A = 55.5%and 47.2%, respectively). The rest of the variance was influenced by unique environmental effects (E between 27.3% and 59.7%, respectively). Conclusions: The number of WMH lesions is moderately influenced by genetic effects, particularly in the infratentorial region in middle-aged twins. These results suggest that the distribution of WMH in various brain regions is heterogeneous. LA - English DB - MTMT ER - TY - CHAP AU - Jokkel, Zsófia AU - Piroska, Márton AU - Szalontai, László AU - Hernyes, Anita AU - Tárnoki, Dávid László AU - Tárnoki, Ádám Domonkos ED - Shuai, Li ED - John, Hopper TI - Twin and family studies on epigenetics of autoimmune diseases T2 - Twin and Family Studies of Epigenetics PB - Elsevier CY - Online kiadás CY - London SN - 9780128209516 PY - 2021 SP - 169 EP - 191 PG - 23 DO - 10.1016/B978-0-12-820951-6.00009-0 UR - https://m2.mtmt.hu/api/publication/32832938 ID - 32832938 LA - English DB - MTMT ER - TY - JOUR AU - Szalontai, László AU - Jokkel, Zsófia AU - Horváth, Tamás AU - Forgo, Bianka AU - Kalina, Ildikó AU - Maurovich-Horvat, Pál AU - Auyang, Philip L AU - Zubair, M Mujeeb AU - Garami, Zsolt AU - Tárnoki, Dávid László AU - Tárnoki, Ádám Domonkos TI - Laterality of deep white matter hyperintensities correlates with basilar artery bending and vertebral artery dominance JF - CROATIAN MEDICAL JOURNAL J2 - CROAT MED J VL - 62 PY - 2021 IS - 4 SP - 360 EP - 366 PG - 7 SN - 0353-9504 DO - 10.3325/cmj.2021.62.360 UR - https://m2.mtmt.hu/api/publication/32208631 ID - 32208631 AB - To investigate whether vertebrobasilar geometry contributes to the presence, severity, and laterality of white matter hyperintensities (WMH).We retrospectively reviewed 290 cerebral scans of patients who underwent time-of-flight and fluid-attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI) between 2017 and 2018. WMH were counted, localized, and grouped according to laterality on the FLAIR sequence. A 3D mesh of the posterior circulation was reconstructed (with ITK SNAP software) and the morphology of the vertebrobasilar system analyzed with an in-house software written in Python.Patients were assigned into a group with WMH (n=204) and a group without WMH (n=86). The severity of WMH burden was mainly affected by age and hypertension, while the localization of the WMH (or laterality) was mainly affected by the vertebrobasilar system morphology. Basilar artery morphology only affected the parieto-occipital region significantly if both posterior communicating arteries were hypoplastic or absent. The dominant vertebral artery and basilar artery curve had an opposite directional relationship.An unequal vertebral artery flow is an important hemodynamic contributor to basilar bending. Increased basilar artery curvature and increased infratentorial WMH burden may signal inadequate blood flow and predict cerebrovascular events. LA - English DB - MTMT ER - TY - JOUR AU - Hernyes, Anita AU - Piroska, Márton AU - Fejér, Bence AU - Szalontai, László AU - Szabó, Helga AU - Forgó, Bianka AU - Jermendy, Ádám Levente AU - Molnár, Andrea Ágnes AU - Maurovich-Horvat, Pál AU - Jermendy, Gyorgy AU - Merkely, Béla Péter AU - Tárnoki, Dávid László AU - Tárnoki, Ádám Domonkos TI - Overlapping Genetic Background of Coronary Artery and Carotid/Femoral Atherosclerotic Calcification JF - MEDICINA-LITHUANIA J2 - MED LITH VL - 57 PY - 2021 IS - 3 PG - 18 SN - 1010-660X DO - 10.3390/medicina57030252 UR - https://m2.mtmt.hu/api/publication/31927234 ID - 31927234 LA - English DB - MTMT ER - TY - JOUR AU - Szalontai, László AU - Jokkel, Zsófia AU - Horváth, Tamás AU - Piroska, Márton AU - Forgo, Bianka AU - Oláh, Csaba Zsolt AU - Kostyal, Laszlo AU - Tárnoki, Dávid László AU - Tárnoki, Ádám Domonkos TI - Are the Morphological Indices of the Vertebrobasilar System Heritable? A Twin Study Based on 3D Reconstructed Models JF - MEDICINA-LITHUANIA J2 - MED LITH VL - 57 PY - 2021 IS - 2 PG - 10 SN - 1010-660X DO - 10.3390/medicina57020127 UR - https://m2.mtmt.hu/api/publication/31854293 ID - 31854293 N1 - Medical Imaging Centre, Semmelweis University, 78/A Üllői Street, Budapest, 1082, Hungary Oncologic Imaging Diagnostic Center, Department of Radiology, National Institute of Oncology, Ráth György Street 7-9, Budapest, 1122, Hungary HeartBit, Hűvösvölgyi Road 42, Budapest, 1021, Hungary Department of Radiology, Faculty of Medicine and Health, Örebro University, Södra Grev Rosengatan, Örebro, 701 85, Sweden Department of Neurosurgery, University of Debrecen, Nagyerdei Boulevard 98, Debrecen, 4032, Hungary Department of Radiology, Borsod County University Teaching Hospital, 72-76 Szentpéteri Gate, Miskolc, 3526, Hungary Cited By :3 Export Date: 23 January 2024 Correspondence Address: Szalontai, L.; Medical Imaging Centre, 78/A Üllői Street, Hungary; email: laszlo.szalontai.med@gmail.com Correspondence Address: Szalontai, L.; Oncologic Imaging Diagnostic Center, Ráth György Street 7-9, Hungary; email: laszlo.szalontai.med@gmail.com AB - Background and Objectives: The asymmetrical vertebral artery (VA) flow and diameter are common findings, which can result in an asymmetrical blood flow in the basilar artery (BA), leading to bending of the artery over time. This study investigated whether the variation of the different vertebrobasilar morphological indices that influence flow characteristics might be inherited. Materials and Methods: We analyzed 200 cerebral magnetic resonance imaging (MRI) scans of healthy Caucasian twins (100 pairs) who underwent time-of-flight MRI. From the scans, we reconstructed the 3D mesh of the posterior circulation from the start of the V4 segment to the basilar tip and subsequently analyzed the morphology of the vertebrobasilar system. The phenotypic covariances of the different morphological parameters were decomposed into heritability (A), shared (C), and unshared (E) environmental effects. Results: 39% of the twins had left dominant VA, while 32.5% had right dominant. In addition, 28.5% were classified as equal. The vertebral artery V4 segment diameter, curvature, and tortuosity were mainly influenced by shared (C) and unshared (E) environmental factors. A moderate heritability was found for the BA length (A: 63%; 95% CI: 45.7-75.2%; E: 37%; 95% CI: 24.8-54.3%) and volume (A: 60.1%; 95% CI: 42.4-73.2%; E: 39.9%; 95% CI: 26.8-57.6%), while the torsion of both arteries showed no heritability and were only influenced by the unshared environment. Conclusions: The length and volume of the BA show a moderate genetical influence. However, most of the measured morphological indices were influenced by shared and unshared factors, which highlight the role of the ever-changing hemodynamic influences shaping the geometry of the vertebrobasilar system. LA - English DB - MTMT ER -