@article{MTMT:35472997, title = {The interplay of genetic and environmental factors on the morphology of the limbic cortex and hippocampal subfields: Insights from an MRI twin study}, url = {https://m2.mtmt.hu/api/publication/35472997}, author = {Vessal, Arsalan and Alijanpourotaghsara, Amirreza and Strelnikov, David and Persely, Aliz and Piroska, Márton and Alijanpour, A. and Jokkel, Zsófia and Szalontai, László and Forgo, B. and Kozák, Lajos Rudolf and Bekesy-Szabo, A. and Maurovich-Horvat, Pál and Tárnoki, Dávid László and Tárnoki, Ádám Domonkos}, doi = {10.1016/j.pscychresns.2024.111909}, journal-iso = {PSYCHIAT RES-NEUROIM}, journal = {PSYCHIATRY RESEARCH-NEUROIMAGING}, volume = {345}, unique-id = {35472997}, issn = {0925-4927}, year = {2024}, eissn = {1872-7506}, orcid-numbers = {Strelnikov, David/0000-0002-5911-9335; Piroska, Márton/0000-0002-6000-5044; Jokkel, Zsófia/0000-0002-5407-6540; Kozák, Lajos Rudolf/0000-0003-0368-3663; Maurovich-Horvat, Pál/0000-0003-0885-736X; Tárnoki, Dávid László/0000-0002-7001-7647; Tárnoki, Ádám Domonkos/0000-0001-5909-3780} } @article{MTMT:34353112, title = {Virtuális érmodell vizsgálata laparoszkópos jobb hemicolectomia és komplett mesocolicus excisio esetében}, url = {https://m2.mtmt.hu/api/publication/34353112}, author = {Sztipits, Tamás and Barabás, János Imre and Szalontai, László and Dubóczki, Zsolt and Budai, Barna and Geletey, Olivér Zsolt and Wettstein, Dániel and Mersich, Tamás}, doi = {10.1556/650.2023.32925}, journal-iso = {ORV HETIL}, journal = {ORVOSI HETILAP}, volume = {164}, unique-id = {34353112}, issn = {0030-6002}, year = {2023}, eissn = {1788-6120}, pages = {1938-1946}, orcid-numbers = {Sztipits, Tamás/0000-0003-2533-3904; Barabás, János Imre/0000-0002-4404-8730; Budai, Barna/0000-0001-9411-9202; Mersich, Tamás/0000-0001-9576-7121} } @misc{MTMT:34055774, title = {Genetic and environmental influences on limbic system grey matter structures: insights from an MRI twin study}, url = {https://m2.mtmt.hu/api/publication/34055774}, author = {Arsalan, Vessal and Strelnikov, David and Alijanpourotaghsara, Amirreza and Piroska, Márton and Szalontai, László and Forgó, Bianka and Jokkel, Zsófia and Persely, Aliz and Hernyes, Anita and Kozák, Lajos Rudolf and Szabó, Ádám György and Maurovich-Horvat, Pál and Tárnoki, Dávid László and Tárnoki, Ádám Domonkos}, unique-id = {34055774}, year = {2023}, orcid-numbers = {Strelnikov, David/0000-0002-5911-9335; Piroska, Márton/0000-0002-6000-5044; Jokkel, Zsófia/0000-0002-5407-6540; Hernyes, Anita/0000-0001-5875-4006; Kozák, Lajos Rudolf/0000-0003-0368-3663; Szabó, Ádám György/0000-0003-4014-3762; Maurovich-Horvat, Pál/0000-0003-0885-736X; Tárnoki, Dávid László/0000-0002-7001-7647; Tárnoki, Ádám Domonkos/0000-0001-5909-3780} } @mastersthesis{MTMT:34058009, title = {THE MORPHOLOGY OF THE VERTEBROBASILAR SYSTEM}, url = {https://m2.mtmt.hu/api/publication/34058009}, author = {Szalontai, László}, doi = {10.14753/SE.2022.2633}, unique-id = {34058009}, year = {2022} } @article{MTMT:33292143, title = {Heritability of Subcortical Grey Matter Structures}, url = {https://m2.mtmt.hu/api/publication/33292143}, author = {Strelnikov, David and Alijanpourotaghsara, Amirreza and Piroska, Márton and Szalontai, László and Forgo, B. and Jokkel, Zsófia and Persely, Aliz and Hernyes, Anita and Kozák, Lajos Rudolf and Szabó, Ádám György and Maurovich-Horvat, Pál and Tárnoki, Dávid László and Tárnoki, Ádám Domonkos}, doi = {10.3390/medicina58111687}, journal-iso = {MED LITH}, journal = {MEDICINA-LITHUANIA}, volume = {58}, unique-id = {33292143}, issn = {1010-660X}, year = {2022}, eissn = {1648-9144}, orcid-numbers = {Strelnikov, David/0000-0002-5911-9335; Piroska, Márton/0000-0002-6000-5044; Jokkel, Zsófia/0000-0002-5407-6540; Hernyes, Anita/0000-0001-5875-4006; Kozák, Lajos Rudolf/0000-0003-0368-3663; Szabó, Ádám György/0000-0003-4014-3762; Maurovich-Horvat, Pál/0000-0003-0885-736X; Tárnoki, Dávid László/0000-0002-7001-7647; Tárnoki, Ádám Domonkos/0000-0001-5909-3780} } @article{MTMT:33197558, title = {Genetic and Environmental Effects on the Development of White Matter Hyperintensities in a Middle Age Twin Population}, url = {https://m2.mtmt.hu/api/publication/33197558}, author = {Alijanpourotaghsara, Amirreza and Strelnikov, David and Piroska, Márton and Szalontai, László and Forgo, Bianka and Jokkel, Zsófia and Persely, Aliz and Hernyes, Anita and Kozák, Lajos Rudolf and Szabó, Ádám György and Maurovich-Horvat, Pál and Tárnoki, Ádám Domonkos and Tárnoki, Dávid László}, doi = {10.3390/medicina58101425}, journal-iso = {MED LITH}, journal = {MEDICINA-LITHUANIA}, volume = {58}, unique-id = {33197558}, issn = {1010-660X}, abstract = {Introduction: White matter hyperintensities (WMH) indicate white matter brain lesions in magnetic resonance imaging (MRI), which can be used as a marker for brain aging and cerebrovascular and neurodegenerative disorders. Twin studies revealed substantial but not uniform WMH heritability in elderly twins. The objective of our study was to investigate the genetic and environmental components of WMH, as well as their importance in a healthy twin population, utilizing 3T MRI scanners in a middle-aged twin population. Methods: Brain MRI was performed on 120 healthy adult twins from the Hungarian Twin Registry on a 3T scanner (86 monozygotic, MZ and 34 dizygotic, DZ twins; median age 50 ± 26.5 years, 72.5% female and 27.5% male). The count of WMH on FLAIR images was calculated using an automated volumetry pipeline (volBrain) and human processing. The age- and sex-adjusted MZ and DZ intra-pair correlations were determined and the total variance was decomposed into genetic, shared and unique environmental components using structural equation modeling. Results: Age and sex-adjusted MZ intrapair correlations were higher than DZ correlations, indicating moderate genetic influence in each lesion (rMZ = 0.466, rDZ = -0.025 for total count; rMZ = 0.482, rDZ = 0.093 for deep white matter count; rMZ = 0.739, rDZ = 0.39 for infratentorial count; rMZ = 0.573, rDZ = 0.372 for cerebellar count and rMZ = 0.473, rDZ = 0.19 for periventricular count), indicating a moderate heritability (A = 40.3%, A = 45%, A = 72.7% and A = 55.5%and 47.2%, respectively). The rest of the variance was influenced by unique environmental effects (E between 27.3% and 59.7%, respectively). Conclusions: The number of WMH lesions is moderately influenced by genetic effects, particularly in the infratentorial region in middle-aged twins. These results suggest that the distribution of WMH in various brain regions is heterogeneous.}, keywords = {TWINS; MRI; heritability; White matter hyperintensities; VolBrain}, year = {2022}, eissn = {1648-9144}, orcid-numbers = {Strelnikov, David/0000-0002-5911-9335; Piroska, Márton/0000-0002-6000-5044; Jokkel, Zsófia/0000-0002-5407-6540; Hernyes, Anita/0000-0001-5875-4006; Kozák, Lajos Rudolf/0000-0003-0368-3663; Szabó, Ádám György/0000-0003-4014-3762; Maurovich-Horvat, Pál/0000-0003-0885-736X; Tárnoki, Ádám Domonkos/0000-0001-5909-3780; Tárnoki, Dávid László/0000-0002-7001-7647} } @{MTMT:32832938, title = {Twin and family studies on epigenetics of autoimmune diseases}, url = {https://m2.mtmt.hu/api/publication/32832938}, author = {Jokkel, Zsófia and Piroska, Márton and Szalontai, László and Hernyes, Anita and Tárnoki, Dávid László and Tárnoki, Ádám Domonkos}, booktitle = {Twin and Family Studies of Epigenetics}, doi = {10.1016/B978-0-12-820951-6.00009-0}, unique-id = {32832938}, year = {2021}, pages = {169-191}, orcid-numbers = {Jokkel, Zsófia/0000-0002-5407-6540; Piroska, Márton/0000-0002-6000-5044; Hernyes, Anita/0000-0001-5875-4006; Tárnoki, Dávid László/0000-0002-7001-7647; Tárnoki, Ádám Domonkos/0000-0001-5909-3780} } @article{MTMT:32208631, title = {Laterality of deep white matter hyperintensities correlates with basilar artery bending and vertebral artery dominance}, url = {https://m2.mtmt.hu/api/publication/32208631}, author = {Szalontai, László and Jokkel, Zsófia and Horváth, Tamás and Forgo, Bianka and Kalina, Ildikó and Maurovich-Horvat, Pál and Auyang, Philip L and Zubair, M Mujeeb and Garami, Zsolt and Tárnoki, Dávid László and Tárnoki, Ádám Domonkos}, doi = {10.3325/cmj.2021.62.360}, journal-iso = {CROAT MED J}, journal = {CROATIAN MEDICAL JOURNAL}, volume = {62}, unique-id = {32208631}, issn = {0353-9504}, abstract = {To investigate whether vertebrobasilar geometry contributes to the presence, severity, and laterality of white matter hyperintensities (WMH).We retrospectively reviewed 290 cerebral scans of patients who underwent time-of-flight and fluid-attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI) between 2017 and 2018. WMH were counted, localized, and grouped according to laterality on the FLAIR sequence. A 3D mesh of the posterior circulation was reconstructed (with ITK SNAP software) and the morphology of the vertebrobasilar system analyzed with an in-house software written in Python.Patients were assigned into a group with WMH (n=204) and a group without WMH (n=86). The severity of WMH burden was mainly affected by age and hypertension, while the localization of the WMH (or laterality) was mainly affected by the vertebrobasilar system morphology. Basilar artery morphology only affected the parieto-occipital region significantly if both posterior communicating arteries were hypoplastic or absent. The dominant vertebral artery and basilar artery curve had an opposite directional relationship.An unequal vertebral artery flow is an important hemodynamic contributor to basilar bending. Increased basilar artery curvature and increased infratentorial WMH burden may signal inadequate blood flow and predict cerebrovascular events.}, keywords = {BASILAR ARTERY; Retrospective Studies; Magnetic Resonance Imaging; white matter; vertebral artery}, year = {2021}, eissn = {1332-8166}, pages = {360-366}, orcid-numbers = {Jokkel, Zsófia/0000-0002-5407-6540; Horváth, Tamás/0000-0003-3038-8643; Kalina, Ildikó/0000-0002-2647-9123; Maurovich-Horvat, Pál/0000-0003-0885-736X; Tárnoki, Dávid László/0000-0002-7001-7647; Tárnoki, Ádám Domonkos/0000-0001-5909-3780} } @article{MTMT:31927234, title = {Overlapping Genetic Background of Coronary Artery and Carotid/Femoral Atherosclerotic Calcification}, url = {https://m2.mtmt.hu/api/publication/31927234}, author = {Hernyes, Anita and Piroska, Márton and Fejér, Bence and Szalontai, László and Szabó, Helga and Forgó, Bianka and Jermendy, Ádám Levente and Molnár, Andrea Ágnes and Maurovich-Horvat, Pál and Jermendy, Gyorgy and Merkely, Béla Péter and Tárnoki, Dávid László and Tárnoki, Ádám Domonkos}, doi = {10.3390/medicina57030252}, journal-iso = {MED LITH}, journal = {MEDICINA-LITHUANIA}, volume = {57}, unique-id = {31927234}, issn = {1010-660X}, year = {2021}, eissn = {1648-9144}, orcid-numbers = {Hernyes, Anita/0000-0001-5875-4006; Piroska, Márton/0000-0002-6000-5044; Fejér, Bence/0000-0001-8751-7368; Forgó, Bianka/0000-0003-0627-1795; Jermendy, Ádám Levente/0000-0001-8295-0840; Maurovich-Horvat, Pál/0000-0003-0885-736X; Jermendy, Gyorgy/0000-0001-5596-7831; Merkely, Béla Péter/0000-0001-6514-0723; Tárnoki, Dávid László/0000-0002-7001-7647; Tárnoki, Ádám Domonkos/0000-0001-5909-3780} } @article{MTMT:31854293, title = {Are the Morphological Indices of the Vertebrobasilar System Heritable? A Twin Study Based on 3D Reconstructed Models}, url = {https://m2.mtmt.hu/api/publication/31854293}, author = {Szalontai, László and Jokkel, Zsófia and Horváth, Tamás and Piroska, Márton and Forgo, Bianka and Oláh, Csaba Zsolt and Kostyal, Laszlo and Tárnoki, Dávid László and Tárnoki, Ádám Domonkos}, doi = {10.3390/medicina57020127}, journal-iso = {MED LITH}, journal = {MEDICINA-LITHUANIA}, volume = {57}, unique-id = {31854293}, issn = {1010-660X}, abstract = {Background and Objectives: The asymmetrical vertebral artery (VA) flow and diameter are common findings, which can result in an asymmetrical blood flow in the basilar artery (BA), leading to bending of the artery over time. This study investigated whether the variation of the different vertebrobasilar morphological indices that influence flow characteristics might be inherited. Materials and Methods: We analyzed 200 cerebral magnetic resonance imaging (MRI) scans of healthy Caucasian twins (100 pairs) who underwent time-of-flight MRI. From the scans, we reconstructed the 3D mesh of the posterior circulation from the start of the V4 segment to the basilar tip and subsequently analyzed the morphology of the vertebrobasilar system. The phenotypic covariances of the different morphological parameters were decomposed into heritability (A), shared (C), and unshared (E) environmental effects. Results: 39% of the twins had left dominant VA, while 32.5% had right dominant. In addition, 28.5% were classified as equal. The vertebral artery V4 segment diameter, curvature, and tortuosity were mainly influenced by shared (C) and unshared (E) environmental factors. A moderate heritability was found for the BA length (A: 63%; 95% CI: 45.7-75.2%; E: 37%; 95% CI: 24.8-54.3%) and volume (A: 60.1%; 95% CI: 42.4-73.2%; E: 39.9%; 95% CI: 26.8-57.6%), while the torsion of both arteries showed no heritability and were only influenced by the unshared environment. Conclusions: The length and volume of the BA show a moderate genetical influence. However, most of the measured morphological indices were influenced by shared and unshared factors, which highlight the role of the ever-changing hemodynamic influences shaping the geometry of the vertebrobasilar system.}, keywords = {heritability; twin study; 3D vascular reconstruction; basilar artery curve; vertebral artery dominance}, year = {2021}, eissn = {1648-9144}, orcid-numbers = {Jokkel, Zsófia/0000-0002-5407-6540; Horváth, Tamás/0000-0003-3038-8643; Piroska, Márton/0000-0002-6000-5044; Tárnoki, Dávid László/0000-0002-7001-7647; Tárnoki, Ádám Domonkos/0000-0001-5909-3780} }