TY - JOUR AU - Sántha, Péter AU - Lakatos, Szandra AU - Horváth, Ágnes Judit AU - Dux, Mária AU - Jancsó, Gábor TI - Perineural Capsaicin Treatment Inhibits Collateral Sprouting of Intact Cutaneous Nociceptive Afferents JF - BIOMEDICINES J2 - BIOMEDICINES VL - 10 PY - 2022 IS - 6 PG - 12 SN - 2227-9059 DO - 10.3390/biomedicines10061326 UR - https://m2.mtmt.hu/api/publication/32952219 ID - 32952219 AB - Perineural treatment of peripheral nerves with capsaicin produces a long-lasting selective regional thermo- and chemo-analgesia and elimination of the neurogenic inflammatory response involving degeneration of nociceptive afferent fibers. In this study, we examined longitudinal changes in mustard oil-induced sensory neurogenic vasodilatation and plasma extravasation following perineural capsaicin treatment of the rat saphenous nerve utilizing scanning laser Doppler imaging and vascular labeling with colloidal silver. Capsaicin treatment resulted in a marked decrease in mustard oil-induced vasodilatation in the skin area served by the saphenous nerve. Repeated imaging of the vasodilatatory response showed no recovery for at least 7 weeks. However, following transection and ligation of the capsaicin-treated saphenous nerve, a substantial recovery of the vasodilatatory response was observed, suggesting a reinnervation of the chemodenervated skin area by collateral sprouting of neighboring intact sciatic nerve afferents. Elimination of the recovered vascular reaction by capsaicin treatment of the sciatic nerve supported this conclusion. Similar results have been obtained by using the vascular labeling technique. These findings indicate an inhibitory effect of persisting cutaneous nerve fibers on the collateral sprouting of intact nerve fibers into the chemodenervated skin area. These observations may bear implications for the development of sensory disturbances following peripheral nerve injuries. LA - English DB - MTMT ER - TY - JOUR AU - Kormányos, Árpád AU - Gyenes, Nándor AU - Horváth, Ágnes Judit AU - Ambrus, Nóra AU - Lengyel, Csaba Attila AU - Valkusz, Zsuzsanna AU - Nemes, Attila TI - Bal kamrai rotációs eltérések kezelt hypopituitarizmusban – Eredmények a háromdimenziós speckle-tracking MAGYAR-Path Tanulmányból = Left ventricular rotational abnormalities in treated hypopituitarism – Insights from the three-dimensional speckle-tracking echocardiographic MAGYAR-Path Study JF - CARDIOLOGIA HUNGARICA J2 - CARDIOL HUNG VL - 52 PY - 2022 IS - Suppl. C SP - C187 EP - C187 PG - 1 SN - 0133-5596 UR - https://m2.mtmt.hu/api/publication/32821108 ID - 32821108 LA - English DB - MTMT ER - TY - JOUR AU - Nemes, Attila AU - Kormányos, Árpád AU - Gyenes, Nándor AU - Ambrus, Nóra AU - Horváth, Ágnes Judit AU - Lengyel, Csaba Attila AU - Valkusz, Zsuzsanna TI - Is treated hypopituitarism associated with increased left ventricular strains?—Detailed analysis from the three-dimensional speckle-tracking echocardiographic MAGYAR-Path Study JF - QUANTITATIVE IMAGING IN MEDICINE AND SURGERY J2 - QUANT IMAG MED SURG (QUIMS) VL - 12 PY - 2022 IS - 1 SP - 838 EP - 845 PG - 8 SN - 2223-4292 DO - 10.21037/qims-21-113 UR - https://m2.mtmt.hu/api/publication/32158714 ID - 32158714 N1 - Export Date: 22 November 2021 Correspondence Address: Nemes, A.; Department of Medicine, Semmelweis street 8, P.O. Box 427, Hungary; email: nemes.attila@med.u-szeged.hu LA - English DB - MTMT ER - TY - GEN AU - Németh, Balázs AU - Inczefi, Orsolya AU - Iglói, Gábor AU - Ollé, Georgina AU - Dani, Kristóf Tamás AU - Fejes, Imola AU - Horváth, Ágnes Judit AU - Illés, Dóra AU - Greff, Dorottya AU - Christofi, Alexandros AU - Szalatnyai, Bálint AU - Roczkov, Anett AU - Tajti, Máté AU - Laczkó, Edit AU - Riesz, Tamás János AU - Éberhardt, Gábor AU - Kiss, Nóra Ágnes AU - Kiss, Tamás AU - Visnyovszki, Ádám AU - Nagy, Nóra AU - Orosz, László AU - Farkas, Attila AU - Sepp, Krisztián AU - Róka, Richárd László TI - A COVID-19 SÚLYOSSÁGÁT ELŐRE JELZIK AZ ELSŐ ELLÁTÁS SORÁN MÉRT KLINIKAI TÜNETEK ÉS PARAMÉTEREK – EGYCENTRUMOS, RETROSPEKTÍV KLINIKAI VIZSGÁLAT PY - 2021 UR - https://m2.mtmt.hu/api/publication/32477077 ID - 32477077 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Kormányos, Árpád AU - Gyenes, Nándor AU - Horváth, Ágnes Judit AU - Ambrus, Nóra AU - Lengyel, Csaba Attila AU - Valkusz, Zsuzsanna AU - Nemes, Attila TI - Left Ventricular Rotational Abnormalities in Treated Hypopituitarism: Insights From the Three-Dimensional Speckle-Tracking Echocardiographic MAGYAR-Path Study JF - FRONTIERS IN CARDIOVASCULAR MEDICINE J2 - FRONT CARDIOVASC MED VL - 8 PY - 2021 PG - 7 SN - 2297-055X DO - 10.3389/fcvm.2021.703146 UR - https://m2.mtmt.hu/api/publication/32470212 ID - 32470212 LA - English DB - MTMT ER - TY - JOUR AU - Lakatos, Szandra AU - Jancsó, Gábor AU - Horváth, Ágnes Judit AU - Kisné Dobos, Ildikó AU - Sántha, Péter TI - Longitudinal Study of Functional Reinnervation of the Denervated Skin by Collateral Sprouting of Peptidergic Nociceptive Nerves Utilizing Laser Doppler Imaging JF - FRONTIERS IN PHYSIOLOGY J2 - FRONT PHYSIOL VL - 11 PY - 2020 PG - 10 SN - 1664-042X DO - 10.3389/fphys.2020.00439 UR - https://m2.mtmt.hu/api/publication/31345040 ID - 31345040 AB - Restitution of cutaneous sensory function is accomplished by neural regenerative processes of distinct mechanisms following peripheral nerve lesions. Although methods available for the study of functional cutaneous nerve regeneration are specific and accurate, they are unsuitable for the longitudinal follow-up of the temporal and spatial aspects of the reinnervation process. Therefore, the aim of this study was to develop a new, non-invasive approach for the longitudinal examination of cutaneous nerve regeneration utilizing the determination of changes in the sensory neurogenic vasodilatatory response, a salient feature of calcitonin gene-related peptide-containing nociceptive afferent nerves, with scanning laser Doppler flowmetry. Scanning laser Doppler imaging was applied to measure the intensity and spatial extent of sensory neurogenic vasodilatation elicited by the application of mustard oil onto the dorsal skin of the rat hindpaw. Mustard oil induced reproducible and uniform increases in skin perfusion reaching maximum values at 2-4 min after application whereafter the blood flow gradually returned to control level after about 8-10 min. Transection and ligation of the saphenous nerve largely eliminated the vasodilatatory response in the medial aspect of the dorsal skin of the hindpaw. In the 2 nd to 4 th weeks after injury, the mustard oil-induced vasodilatatory reaction gradually recovered. Since regeneration of the saphenous nerve was prevented, the recovery of the vasodilatatory response may be accounted for by the collateral sprouting of neighboring intact sciatic afferent nerve fibers. This was supported by the elimination of the vasodilatatory response in both the saphenous and sciatic innervation territories following local treatment of the sciatic nerve with capsaicin to defunctionalize nociceptive afferent fibers. The present findings demonstrate that this novel technique utilizing scanning laser Doppler flowmetry to quantitatively measure cutaneous sensory neurogenic vasodilatation, a vascular response mediated by peptidergic nociceptive nerves, is a reliable non-invasive approach for the longitudinal study of nerve regeneration in the skin. LA - English DB - MTMT ER -