@article{MTMT:32952219, title = {Perineural Capsaicin Treatment Inhibits Collateral Sprouting of Intact Cutaneous Nociceptive Afferents}, url = {https://m2.mtmt.hu/api/publication/32952219}, author = {Sántha, Péter and Lakatos, Szandra and Horváth, Ágnes Judit and Dux, Mária and Jancsó, Gábor}, doi = {10.3390/biomedicines10061326}, journal-iso = {BIOMEDICINES}, journal = {BIOMEDICINES}, volume = {10}, unique-id = {32952219}, abstract = {Perineural treatment of peripheral nerves with capsaicin produces a long-lasting selective regional thermo- and chemo-analgesia and elimination of the neurogenic inflammatory response involving degeneration of nociceptive afferent fibers. In this study, we examined longitudinal changes in mustard oil-induced sensory neurogenic vasodilatation and plasma extravasation following perineural capsaicin treatment of the rat saphenous nerve utilizing scanning laser Doppler imaging and vascular labeling with colloidal silver. Capsaicin treatment resulted in a marked decrease in mustard oil-induced vasodilatation in the skin area served by the saphenous nerve. Repeated imaging of the vasodilatatory response showed no recovery for at least 7 weeks. However, following transection and ligation of the capsaicin-treated saphenous nerve, a substantial recovery of the vasodilatatory response was observed, suggesting a reinnervation of the chemodenervated skin area by collateral sprouting of neighboring intact sciatic nerve afferents. Elimination of the recovered vascular reaction by capsaicin treatment of the sciatic nerve supported this conclusion. Similar results have been obtained by using the vascular labeling technique. These findings indicate an inhibitory effect of persisting cutaneous nerve fibers on the collateral sprouting of intact nerve fibers into the chemodenervated skin area. These observations may bear implications for the development of sensory disturbances following peripheral nerve injuries.}, keywords = {NEUROGENIC INFLAMMATION; TRPA1; collateral sprouting; capsaicin TRPV1; scanning laser Doppler perfusion imaging}, year = {2022}, eissn = {2227-9059}, orcid-numbers = {Sántha, Péter/0000-0003-0552-0358; Horváth, Ágnes Judit/0000-0003-3964-0729; Dux, Mária/0000-0002-9941-8188; Jancsó, Gábor/0000-0002-0496-3416} } @article{MTMT:32821108, title = {Bal kamrai rotációs eltérések kezelt hypopituitarizmusban – Eredmények a háromdimenziós speckle-tracking MAGYAR-Path Tanulmányból = Left ventricular rotational abnormalities in treated hypopituitarism – Insights from the three-dimensional speckle-tracking echocardiographic MAGYAR-Path Study}, url = {https://m2.mtmt.hu/api/publication/32821108}, author = {Kormányos, Árpád and Gyenes, Nándor and Horváth, Ágnes Judit and Ambrus, Nóra and Lengyel, Csaba Attila and Valkusz, Zsuzsanna and Nemes, Attila}, journal-iso = {CARDIOL HUNG}, journal = {CARDIOLOGIA HUNGARICA}, volume = {52}, unique-id = {32821108}, issn = {0133-5596}, year = {2022}, eissn = {1588-0230}, pages = {C187-C187}, orcid-numbers = {Kormányos, Árpád/0000-0002-7052-2184; Horváth, Ágnes Judit/0000-0003-3964-0729; Lengyel, Csaba Attila/0000-0002-0434-0067; Valkusz, Zsuzsanna/0000-0003-1928-6160; Nemes, Attila/0000-0002-7570-6214} } @article{MTMT:32158714, title = {Is treated hypopituitarism associated with increased left ventricular strains?—Detailed analysis from the three-dimensional speckle-tracking echocardiographic MAGYAR-Path Study}, url = {https://m2.mtmt.hu/api/publication/32158714}, author = {Nemes, Attila and Kormányos, Árpád and Gyenes, Nándor and Ambrus, Nóra and Horváth, Ágnes Judit and Lengyel, Csaba Attila and Valkusz, Zsuzsanna}, doi = {10.21037/qims-21-113}, journal-iso = {QUANT IMAG MED SURG (QUIMS)}, journal = {QUANTITATIVE IMAGING IN MEDICINE AND SURGERY}, volume = {12}, unique-id = {32158714}, issn = {2223-4292}, year = {2022}, eissn = {2223-4306}, pages = {838-845}, orcid-numbers = {Nemes, Attila/0000-0002-7570-6214; Kormányos, Árpád/0000-0002-7052-2184; Horváth, Ágnes Judit/0000-0003-3964-0729; Lengyel, Csaba Attila/0000-0002-0434-0067; Valkusz, Zsuzsanna/0000-0003-1928-6160} } @misc{MTMT:32477077, title = {A COVID-19 SÚLYOSSÁGÁT ELŐRE JELZIK AZ ELSŐ ELLÁTÁS SORÁN MÉRT KLINIKAI TÜNETEK ÉS PARAMÉTEREK – EGYCENTRUMOS, RETROSPEKTÍV KLINIKAI VIZSGÁLAT}, url = {https://m2.mtmt.hu/api/publication/32477077}, author = {Németh, Balázs and Inczefi, Orsolya and Iglói, Gábor and Ollé, Georgina and Dani, Kristóf Tamás and Fejes, Imola and Horváth, Ágnes Judit and Illés, Dóra and Greff, Dorottya and Christofi, Alexandros and Szalatnyai, Bálint and Roczkov, Anett and Tajti, Máté and Laczkó, Edit and Riesz, Tamás János and Éberhardt, Gábor and Kiss, Nóra Ágnes and Kiss, Tamás and Visnyovszki, Ádám and Nagy, Nóra and Orosz, László and Farkas, Attila and Sepp, Krisztián and Róka, Richárd László}, unique-id = {32477077}, year = {2021}, orcid-numbers = {Németh, Balázs/0000-0001-5338-7577; Inczefi, Orsolya/0000-0001-7974-1263; Horváth, Ágnes Judit/0000-0003-3964-0729; Sepp, Krisztián/0000-0001-9400-5213} } @article{MTMT:32470212, title = {Left Ventricular Rotational Abnormalities in Treated Hypopituitarism: Insights From the Three-Dimensional Speckle-Tracking Echocardiographic MAGYAR-Path Study}, url = {https://m2.mtmt.hu/api/publication/32470212}, author = {Kormányos, Árpád and Gyenes, Nándor and Horváth, Ágnes Judit and Ambrus, Nóra and Lengyel, Csaba Attila and Valkusz, Zsuzsanna and Nemes, Attila}, doi = {10.3389/fcvm.2021.703146}, journal-iso = {FRONT CARDIOVASC MED}, journal = {FRONTIERS IN CARDIOVASCULAR MEDICINE}, volume = {8}, unique-id = {32470212}, issn = {2297-055X}, year = {2021}, eissn = {2297-055X}, orcid-numbers = {Kormányos, Árpád/0000-0002-7052-2184; Horváth, Ágnes Judit/0000-0003-3964-0729; Lengyel, Csaba Attila/0000-0002-0434-0067; Valkusz, Zsuzsanna/0000-0003-1928-6160; Nemes, Attila/0000-0002-7570-6214} } @article{MTMT:31345040, title = {Longitudinal Study of Functional Reinnervation of the Denervated Skin by Collateral Sprouting of Peptidergic Nociceptive Nerves Utilizing Laser Doppler Imaging}, url = {https://m2.mtmt.hu/api/publication/31345040}, author = {Lakatos, Szandra and Jancsó, Gábor and Horváth, Ágnes Judit and Kisné Dobos, Ildikó and Sántha, Péter}, doi = {10.3389/fphys.2020.00439}, journal-iso = {FRONT PHYSIOL}, journal = {FRONTIERS IN PHYSIOLOGY}, volume = {11}, unique-id = {31345040}, abstract = {Restitution of cutaneous sensory function is accomplished by neural regenerative processes of distinct mechanisms following peripheral nerve lesions. Although methods available for the study of functional cutaneous nerve regeneration are specific and accurate, they are unsuitable for the longitudinal follow-up of the temporal and spatial aspects of the reinnervation process. Therefore, the aim of this study was to develop a new, non-invasive approach for the longitudinal examination of cutaneous nerve regeneration utilizing the determination of changes in the sensory neurogenic vasodilatatory response, a salient feature of calcitonin gene-related peptide-containing nociceptive afferent nerves, with scanning laser Doppler flowmetry. Scanning laser Doppler imaging was applied to measure the intensity and spatial extent of sensory neurogenic vasodilatation elicited by the application of mustard oil onto the dorsal skin of the rat hindpaw. Mustard oil induced reproducible and uniform increases in skin perfusion reaching maximum values at 2-4 min after application whereafter the blood flow gradually returned to control level after about 8-10 min. Transection and ligation of the saphenous nerve largely eliminated the vasodilatatory response in the medial aspect of the dorsal skin of the hindpaw. In the 2 nd to 4 th weeks after injury, the mustard oil-induced vasodilatatory reaction gradually recovered. Since regeneration of the saphenous nerve was prevented, the recovery of the vasodilatatory response may be accounted for by the collateral sprouting of neighboring intact sciatic afferent nerve fibers. This was supported by the elimination of the vasodilatatory response in both the saphenous and sciatic innervation territories following local treatment of the sciatic nerve with capsaicin to defunctionalize nociceptive afferent fibers. The present findings demonstrate that this novel technique utilizing scanning laser Doppler flowmetry to quantitatively measure cutaneous sensory neurogenic vasodilatation, a vascular response mediated by peptidergic nociceptive nerves, is a reliable non-invasive approach for the longitudinal study of nerve regeneration in the skin.}, keywords = {NOCICEPTION; TRPV1; TRPA1; nerve injury; Sensory innervation; Scanning laser Doppler flowmetry; collateral sprouting; cutaneous vasodilatation}, year = {2020}, eissn = {1664-042X}, orcid-numbers = {Jancsó, Gábor/0000-0002-0496-3416; Horváth, Ágnes Judit/0000-0003-3964-0729; Sántha, Péter/0000-0003-0552-0358} }