@article{MTMT:34720489,
	title = {Reviewing critical TRPM2 variants through a structure-function lens},
	url = {https://m2.mtmt.hu/api/publication/34720489},
	author = {Tóth, Ádám Viktor and Bartók, Ádám},
	doi = {10.1016/j.jbiotec.2024.02.017},
	journal-iso = {J BIOTECHNOL},
	journal = {JOURNAL OF BIOTECHNOLOGY},
	volume = {385},
	unique-id = {34720489},
	issn = {0168-1656},
	year = {2024},
	eissn = {1873-4863},
	pages = {49-57},
	orcid-numbers = {Bartók, Ádám/0000-0002-1232-5246}
}

@article{MTMT:34431632,
	title = {High-throughput ligand profile characterization in novel cell lines expressing seven heterologous insect olfactory receptors for the detection of volatile plant biomarkers},
	url = {https://m2.mtmt.hu/api/publication/34431632},
	author = {Zboray, Katalin and Tóth, Ádám Viktor and Miskolczi, Tímea D. and Pesti, Krisztina and Casanova, Emilio and Kreidl, Emanuel and Mike, Árpád and Szenes, Áron and Sági, László and Lukács, Péter},
	doi = {10.1038/s41598-023-47455-4},
	journal-iso = {SCI REP},
	journal = {SCIENTIFIC REPORTS},
	volume = {13},
	unique-id = {34431632},
	issn = {2045-2322},
	abstract = {Agriculturally important crop plants emit a multitude of volatile organic compounds (VOCs), which are excellent indicators of their health status and their interactions with pathogens and pests. In this study, we have developed a novel cellular olfactory panel for detecting fungal pathogen-related VOCs we had identified in the field, as well as during controlled inoculations of several crop plants. The olfactory panel consists of seven stable HEK293 cell lines each expressing a functional Drosophila olfactory receptor as a biosensing element along with GCaMP6, a fluorescent calcium indicator protein. An automated 384-well microplate reader was used to characterize the olfactory receptor cell lines for their sensitivity to reference VOCs. Subsequently, we profiled a set of 66 VOCs on all cell lines, covering a concentration range from 1 to 100 μM. Results showed that 49 VOCs (74.2%) elicited a response in at least one olfactory receptor cell line. Some VOCs activated the cell lines even at nanomolar (ppb) concentrations. The interaction profiles obtained here will support the development of biosensors for agricultural applications. Additionally, the olfactory receptor proteins can be purified from these cell lines with sufficient yields for further processing, such as structure determination or integration with sensor devices.},
	year = {2023},
	eissn = {2045-2322},
	orcid-numbers = {Mike, Árpád/0000-0002-9095-8161}
}

@article{MTMT:32676587,
	title = {Automated patch-clamp with automated analysis: extracting compound-specific, concentration-independent biophysical properties of inhibition for sodium channel inhibitors},
	url = {https://m2.mtmt.hu/api/publication/32676587},
	author = {Mike, Árpád and Pesti, Krisztina and Földi, Mátyás Csaba and Tóth, Ádám Viktor and Zboray, Katalin and Lukács, Péter},
	doi = {10.1016/j.bpj.2021.11.2238},
	journal-iso = {BIOPHYS J},
	journal = {BIOPHYSICAL JOURNAL},
	volume = {121},
	unique-id = {32676587},
	issn = {0006-3495},
	year = {2022},
	eissn = {1542-0086},
	pages = {92-92},
	orcid-numbers = {Mike, Árpád/0000-0002-9095-8161}
}

@article{MTMT:32468284,
	title = {An Advanced Automated Patch Clamp Protocol Design to Investigate Drug—Ion Channel Binding Dynamics},
	url = {https://m2.mtmt.hu/api/publication/32468284},
	author = {Lukács, Péter and Pesti, Krisztina and Földi, Mátyás Csaba and Zboray, Katalin and Tóth, Ádám Viktor and Papp, Gábor and Mike, Árpád},
	doi = {10.3389/fphar.2021.738260},
	journal-iso = {FRONT PHARMACOL},
	journal = {FRONTIERS IN PHARMACOLOGY},
	volume = {12},
	unique-id = {32468284},
	year = {2021},
	eissn = {1663-9812},
	orcid-numbers = {Papp, Gábor/0000-0001-5038-678X; Mike, Árpád/0000-0002-9095-8161}
}

@article{MTMT:32218209,
	title = {Characterization of Compound-Specific, Concentration-Independent Biophysical Properties of Sodium Channel Inhibitor Mechanism of Action Using Automated Patch-Clamp Electrophysiology},
	url = {https://m2.mtmt.hu/api/publication/32218209},
	author = {Pesti, Krisztina and Földi, Mátyás Csaba and Zboray, Katalin and Tóth, Ádám Viktor and Lukács, Péter and Mike, Árpád},
	doi = {10.3389/fphar.2021.738460},
	journal-iso = {FRONT PHARMACOL},
	journal = {FRONTIERS IN PHARMACOLOGY},
	volume = {12},
	unique-id = {32218209},
	year = {2021},
	eissn = {1663-9812},
	orcid-numbers = {Mike, Árpád/0000-0002-9095-8161}
}

@article{MTMT:31821613,
	title = {The mechanism of non-blocking inhibition of sodium channels revealed by conformation-selective photolabeling},
	url = {https://m2.mtmt.hu/api/publication/31821613},
	author = {Földi, Mátyás Csaba and Pesti, Krisztina and Zboray, Katalin and Tóth, Ádám Viktor and Hegedűs, Tamás and Málnási Csizmadia, András and Lukács, Péter and Mike, Árpád},
	doi = {10.1111/bph.15365},
	journal-iso = {BR J PHARMACOL},
	journal = {BRITISH JOURNAL OF PHARMACOLOGY},
	volume = {178},
	unique-id = {31821613},
	issn = {0007-1188},
	abstract = {Sodium channel inhibitors can be used to treat hyperexcitability-related diseases, including epilepsies, pain syndromes, neuromuscular disorders, and cardiac arrhythmias. The applicability of these drugs is limited by their nonspecific effect on physiological function. They act mainly by sodium channel block and in addition by modulation of channel kinetics. While channel block inhibits healthy and pathological tissue equally, modulation can preferentially inhibit pathological activity. An ideal drug designed to target the sodium channels of pathological tissue would act predominantly by modulation. Thus far, no such drug has been described.Patch-clamp experiments with ultra-fast solution exchange and photolabeling-coupled electrophysiology were applied to describe the unique mechanism of riluzole on Nav1.4 sodium channels. In silico docking experiments were used to study the molecular details of binding.We present evidence that riluzole acts predominantly by non-blocking modulation. We propose that, being a relatively small molecule, riluzole is able to stay bound to the binding site, but nonetheless stay off the conduction pathway, by residing in one of the fenestrations. We demonstrate how this mechanism can be recognized.Our results identify riluzole as the prototype of this new class of sodium channel inhibitors. Drugs of this class are expected to selectively prevent hyperexcitability, while having minimal effect on cells firing at a normal rate from a normal resting potential.},
	keywords = {EPILEPSY; PAIN; BINDING SITES; Sodium Channels; ARRHYTHMIAS; riluzole; local anesthetics},
	year = {2021},
	eissn = {1476-5381},
	pages = {1200-1217},
	orcid-numbers = {Hegedűs, Tamás/0000-0002-0331-9629; Málnási Csizmadia, András/0000-0002-2430-8398; Mike, Árpád/0000-0002-9095-8161}
}

@article{MTMT:31196565,
	title = {What Makes a Compound a Sodium Channel Inhibitor},
	url = {https://m2.mtmt.hu/api/publication/31196565},
	author = {Tóth, Ádám Viktor and Lukács, Péter and Mike, Árpád},
	doi = {10.1016/j.bpj.2019.11.3132},
	journal-iso = {BIOPHYS J},
	journal = {BIOPHYSICAL JOURNAL},
	volume = {118},
	unique-id = {31196565},
	issn = {0006-3495},
	year = {2020},
	eissn = {1542-0086},
	pages = {577A-577A},
	orcid-numbers = {Mike, Árpád/0000-0002-9095-8161}
}

@article{MTMT:31180515,
	title = {Development of a Smell Biosensor System for Early Detection of Plant Diseases},
	url = {https://m2.mtmt.hu/api/publication/31180515},
	author = {Miskolczi, Tímea Dóra and Zboray, Katalin and Keszőcze, Anikó Zsófia and Quddoos, Zainab and Ambrózy, Zsuzsanna and Hamow, Kamirán Áron and Tóth, Ádám Viktor and Sági, László and Szelényi, Magdolna Olívia and Radványi, Dalma and Földi, Mátyás Csaba and Molnár, Béla Péter and Pesti, Krisztina and Mike, Árpád and Lukács, Péter},
	doi = {10.1016/j.bpj.2019.11.1774},
	journal-iso = {BIOPHYS J},
	journal = {BIOPHYSICAL JOURNAL},
	volume = {118},
	unique-id = {31180515},
	issn = {0006-3495},
	year = {2020},
	eissn = {1542-0086},
	pages = {315A-315A},
	orcid-numbers = {Hamow, Kamirán Áron/0000-0002-7089-1078; Mike, Árpád/0000-0002-9095-8161}
}