@article{MTMT:34155138,
	title = {Nanoformulation of Therapeutic Enzymes: A Short Review},
	url = {https://m2.mtmt.hu/api/publication/34155138},
	author = {Tóth, Gergő Dániel and Koplányi, Gábor and Kenéz, Balázs and Balogh Weiser, Diána},
	doi = {10.3311/PPch.22826},
	journal-iso = {PERIOD POLYTECH CHEM ENG},
	journal = {PERIODICA POLYTECHNICA-CHEMICAL ENGINEERING},
	volume = {67},
	unique-id = {34155138},
	issn = {0324-5853},
	abstract = {Enzyme replacement therapy (ERT) is a therapeutic approach that involves the administration of specific enzymes to the patient in order to correct metabolic defects caused by enzyme deficiency. The formulation of ERTs involves the production, purification, and formulation of the enzyme into a stable and biologically active drug product, often using recombinant DNA technology. Non-systemic ERTs often involve the immobilization of the enzyme on a carrier, such as hydrogels, liposomes, or nanoparticles. ERT holds great promise for the treatment of a wide range of genetic disorders, and its success regarding lysosomal storage diseases, such as Fabry disease, Gaucher disease, and Pompe disease has paved the way for the development of similar therapies for other genetic disorders too.},
	year = {2023},
	eissn = {1587-3765},
	pages = {624-635},
	orcid-numbers = {Koplányi, Gábor/0000-0002-3791-1057; Balogh Weiser, Diána/0000-0002-9957-1203}
}

@article{MTMT:33740967,
	title = {Combined Nanofibrous Face Mask: Co-Formulation of Lipases and Antibiotic Agent by Electrospinning Technique},
	url = {https://m2.mtmt.hu/api/publication/33740967},
	author = {Balogh Weiser, Diána and Molnár, Alexandra and Tóth, Gergő Dániel and Koplányi, Gábor and Szemes, József and Decsi, Balázs and Katona, Gábor and Salamah, Maryana and Ender, Ferenc and Kovács, Anita and Berkó, Szilvia and Budai-Szűcs, Mária and Balogh, György Tibor},
	doi = {10.3390/pharmaceutics15041174},
	journal-iso = {PHARMACEUTICS},
	journal = {PHARMACEUTICS},
	volume = {15},
	unique-id = {33740967},
	issn = {1999-4923},
	abstract = {The application of enzyme-based therapies has received significant attention in modern drug development. Lipases are one of the most versatile enzymes that can be used as therapeutic agents in basic skin care and medical treatment related to excessive sebum production, acne, and inflammation. The traditional formulations available for skin treatment, such as creams, ointments or gels, are widely applied; however, their use is not always accompanied by good drug penetration properties, stability, or patient adherence. Nanoformulated drugs offer the possibility of combining enzymatic and small molecule formulations, making them a new and exciting alternative in this field. In this study polymeric nanofibrous matrices made of polyvinylpyrrolidone and polylactic acid were developed, entrapping lipases from Candida rugosa and Rizomucor miehei and antibiotic compound nadifloxacin. The effect of the type of polymers and lipases were investigated, and the nanofiber formation process was optimized to provide a promising alternative in topical treatment. Our experiments have shown that entrapment by electrospinning induced two orders of magnitude increase in the specific enzyme activity of lipases. Permeability investigations indicated that all lipase-loaded nanofibrous masks were capable of delivering nadifloxacin to the human epidermis, confirming the viability of electrospinning as a formulation method for topical skin medications.},
	keywords = {PROTEIN; Therapy; EFFICACY; ENZYMATIC RESOLUTION; LIPASE; acne vulgaris; Electrospinning; nanoformulation; Skin treatment; Immobilized lipase; nano mask},
	year = {2023},
	eissn = {1999-4923},
	orcid-numbers = {Balogh Weiser, Diána/0000-0002-9957-1203; Koplányi, Gábor/0000-0002-3791-1057; Katona, Gábor/0000-0003-1564-4813; Kovács, Anita/0000-0001-5593-1329; Berkó, Szilvia/0000-0002-3842-8876; Budai-Szűcs, Mária/0000-0001-5187-5702; Balogh, György Tibor/0000-0003-3347-1880}
}

@article{MTMT:32242806,
	title = {Entrapment of Phenylalanine Ammonia-Lyase in Nanofibrous Polylactic Acid Matrices by Emulsion Electrospinning},
	url = {https://m2.mtmt.hu/api/publication/32242806},
	author = {Koplányi, Gábor and Bell, Evelin and Molnár, Zsófia Klára and Tóth, Gergő Dániel and Józó, Muriel and Szilágyi, András Ferenc and Ender, Ferenc and Pukánszky, Béla and Vértessy, Beáta (Grolmuszné) and Poppe, László and Balogh Weiser, Diána},
	doi = {10.3390/catal11101149},
	journal-iso = {CATALYSTS},
	journal = {CATALYSTS},
	volume = {11},
	unique-id = {32242806},
	year = {2021},
	eissn = {2073-4344},
	orcid-numbers = {Koplányi, Gábor/0000-0002-3791-1057; Szilágyi, András Ferenc/0000-0001-6898-1755; Ender, Ferenc/0000-0003-3800-5707; Poppe, László/0000-0002-8358-1378; Balogh Weiser, Diána/0000-0002-9957-1203}
}

@article{MTMT:32082348,
	title = {Nanofibrous Formulation of Cyclodextrin Stabilized Lipases for Efficient Pancreatin Replacement Therapies},
	url = {https://m2.mtmt.hu/api/publication/32082348},
	author = {Tóth, Gergő Dániel and Nochta-Kazsoki, Adrienn Katalin and Gyarmati, Benjámin Sándor and Szilágyi, András Ferenc and Vasvári, Gábor and Katona, Gábor and Szente, Lajos and Zelkó, Romána and Poppe, László and Balogh Weiser, Diána and Balogh, György Tibor},
	doi = {10.3390/pharmaceutics13070972},
	journal-iso = {PHARMACEUTICS},
	journal = {PHARMACEUTICS},
	volume = {13},
	unique-id = {32082348},
	issn = {1999-4923},
	year = {2021},
	eissn = {1999-4923},
	orcid-numbers = {Nochta-Kazsoki, Adrienn Katalin/0000-0002-0611-3124; Szilágyi, András Ferenc/0000-0001-6898-1755; Katona, Gábor/0000-0003-1564-4813; Zelkó, Romána/0000-0002-5419-9137; Poppe, László/0000-0002-8358-1378; Balogh Weiser, Diána/0000-0002-9957-1203; Balogh, György Tibor/0000-0003-3347-1880}
}

@article{MTMT:30819582,
	title = {Conservation of the biocatalytic activity of whole yeast cells by supported sol-gel entrapment for efficient acyloin condensation},
	url = {https://m2.mtmt.hu/api/publication/30819582},
	author = {Nagy-Győr, László and Farkas, Emese and Lăcătuș, Mihai and Tóth, Gergő Dániel and Incze, Dániel János and Hornyánszky, Gábor and Erdélyiné Bódai, Viktória and Paizs, Csaba and Poppe, László and Balogh Weiser, Diána},
	doi = {10.3311/PPch.14645},
	journal-iso = {PERIOD POLYTECH CHEM ENG},
	journal = {PERIODICA POLYTECHNICA-CHEMICAL ENGINEERING},
	volume = {64},
	unique-id = {30819582},
	issn = {0324-5853},
	abstract = {In this study, an efficient and generally applicable 2nd generation sol-gel entrapment method was developed for immobilization of yeast cells. Cells of Lodderomyces elongisporus, Candida norvegica, Debaryomyces fabryi, Pichia carsonii strains in admixture with hollow silica microspheres support were immobilized in sol-gel matrix obtained from polycondensation of tetraethoxysilane. As biocatalysts in the selective acyloin condensation of benzaldehyde catalyzed by pyruvate decarboxylase of the yeast, the novel immobilized whole-cell preparations were compared to other states of the cells such as freshly harvested wet cell paste, lyophilized cells and sol-gel entrapped preparations without hollow silica microspheres support. Reusability and storability studies designated this novel 2nd generation sol-gel method as a promising alternative for solid formulation of whole-cells bypassing expensive and difficult downstream steps while providing easy-to-handle and stable biocatalysts with long-term preservation of the biocatalytic activity.},
	year = {2020},
	eissn = {1587-3765},
	pages = {153-161},
	orcid-numbers = {Paizs, Csaba/0000-0002-7403-7098; Poppe, László/0000-0002-8358-1378; Balogh Weiser, Diána/0000-0002-9957-1203}
}