TY - JOUR AU - Szabó, Johanna Petra AU - Hajnal, Boglárka Zsófia AU - Sákovics, Anna AU - Erőss, Loránd AU - Fabó, Dániel TI - Intracortical mechanisms of after-discharges elicited by intracranial 50 Hz stimulation of epileptic patients JF - IDEGGYÓGYÁSZATI SZEMLE PROCEEDINGS / CLINICAL NEUROSCIENCE PROCEEDINGS J2 - IDEGGYÓGY SZEMLE PROC VL - 9 PY - 2024 IS - 6 SP - 257 EP - 258 PG - 2 SN - 2498-6240 UR - https://m2.mtmt.hu/api/publication/35501668 ID - 35501668 LA - English DB - MTMT ER - TY - JOUR AU - Hajnal, Boglárka Zsófia AU - Szabó, Johanna Petra AU - Tóth, Emília AU - Keller, Corey J AU - Wittner, Lucia AU - Mehta, Ashesh D AU - Erőss, Loránd AU - Ulbert, István AU - Fabó, Dániel AU - Entz, László TI - Author Correction. Assessment of heat stress contributing factors in the indoor environment among vulnerable populations in Klang Valley using principal component analysis (PCA). TS - Assessment of heat stress contributing factors in the indoor environment among vulnerable populations in Klang Valley using principal component analysis (PCA). JF - SCIENTIFIC REPORTS J2 - SCI REP VL - 14 PY - 2024 IS - 1 PG - 1 SN - 2045-2322 DO - 10.1038/s41598-024-76651-z UR - https://m2.mtmt.hu/api/publication/35470005 ID - 35470005 LA - English DB - MTMT ER - TY - JOUR AU - Hajnal, Boglárka Zsófia AU - Szabó, Johanna Petra AU - Tóth, Emília AU - Keller, Corey J AU - Wittner, Lucia AU - Mehta, Ashesh D AU - Erőss, Loránd AU - Ulbert, István AU - Fabó, Dániel AU - Entz, László TI - Intracortical mechanisms of single pulse electrical stimulation (SPES) evoked excitations and inhibitions in humans. JF - SCIENTIFIC REPORTS J2 - SCI REP VL - 14 PY - 2024 IS - 1 PG - 17 SN - 2045-2322 DO - 10.1038/s41598-024-62433-0 UR - https://m2.mtmt.hu/api/publication/35050690 ID - 35050690 N1 - Export Date: 30 October 2024 Correspondence Address: Fabó, D.; Epilepsy Center, Hungary; email: fabo.daniel@gmail.com AB - Cortico-cortical evoked potentials (CCEPs) elicited by single-pulse electric stimulation (SPES) are widely used to assess effective connectivity between cortical areas and are also implemented in the presurgical evaluation of epileptic patients. Nevertheless, the cortical generators underlying the various components of CCEPs in humans have not yet been elucidated. Our aim was to describe the laminar pattern arising under SPES evoked CCEP components (P1, N1, P2, N2, P3) and to evaluate the similarities between N2 and the downstate of sleep slow waves. We used intra-cortical laminar microelectrodes (LMEs) to record CCEPs evoked by 10 mA bipolar 0.5 Hz electric pulses in seven patients with medically intractable epilepsy implanted with subdural grids. Based on the laminar profile of CCEPs, the latency of components is not layer-dependent, however their rate of appearance varies across cortical depth and stimulation distance, while the seizure onset zone does not seem to affect the emergence of components. Early neural excitation primarily engages middle and deep layers, propagating to the superficial layers, followed by mainly superficial inhibition, concluding in a sleep slow wave-like inhibition and excitation sequence. LA - English DB - MTMT ER - TY - GEN AU - Jordán, Zsófia AU - Pető, Nóra AU - Sákovics, Anna AU - Hajnal, Boglárka Zsófia AU - Szabó, Johanna Petra AU - Ujvári, Ákos AU - Kelemen, Anna AU - Fabó, Dániel TI - Long-term results with the novel anti-seizure medication, cenobamate, in a single center in Hungary PY - 2023 UR - https://m2.mtmt.hu/api/publication/34428213 ID - 34428213 LA - English DB - MTMT ER - TY - JOUR AU - Fabó, Dániel AU - Bokodi, Virág AU - Szabó, Johanna Petra AU - Tóth, Emília AU - Salami, Pariya AU - Keller, Corey J AU - Hajnal, Boglárka Zsófia AU - Thesen, Thomas AU - Devinsky, Orrin AU - Doyle, Werner AU - Mehta, Ashesh AU - Madsen, Joseph AU - Eskandar, Emad AU - Erőss, Loránd AU - Ulbert, István AU - Halgren, Eric AU - Cash, Sydney S TI - The role of superficial and deep layers in the generation of high frequency oscillations and interictal epileptiform discharges in the human cortex JF - SCIENTIFIC REPORTS J2 - SCI REP VL - 13 PY - 2023 IS - 1 PG - 17 SN - 2045-2322 DO - 10.1038/s41598-022-22497-2 UR - https://m2.mtmt.hu/api/publication/34019088 ID - 34019088 N1 - Epilepsy Unit, Department of Neurology, National Institute of Mental Health, Neurology and Neurosurgery, Amerikai Út 57. 1145, Budapest, Hungary Roska Tamás Doctoral School of Sciences and Technologies, Budapest, Hungary János Szentágothai Doctoral School of Neurosciences, Budapest, Hungary Department of Neurology, University of Texas, McGovern Medical School, Houston, TX, United States Epilepsy Division, Department of Neurology, Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States Department of Psychiatry and Behavioral Sciences, Stanford University Medical Center, Stanford, CA, United States VA Palo Alto Health Care System, Palo Alto, CA, United States Comprehensive Epilepsy Center, New York University School of Medicine, New York, NY, United States Department of Biomedical Sciences, College of Medicine, University of Houston, Houston, TX, United States Department of Neurosurgery, Zucker School of Medicine at Hofstra/Northwell and Feinstein Institute for Medical Research, Manhasset, NY, United States The Children’s Hospital, Boston, MA, United States Massachusetts General Hospital Neurosurgery Research, Boston, MA, United States Department of Functional Neurosurgery, National Institute of Mental Health, Neurology and Neurosurgery, Budapest, Hungary Institute of Psychology, Eötvös Loránd Research Network, Budapest, Hungary Department of Radiology, Neurosciences and Psychiatry, University of California, San Diego, San Diego, CA, United States Export Date: 30 October 2023 Correspondence Address: Fabo, D.; Epilepsy Unit, Amerikai Út 57. 1145, Hungary; email: fabo@oiti.hu Correspondence Address: Cash, S.S.; Epilepsy Division, United States; email: scash@mgh.harvard.edu AB - Describing intracortical laminar organization of interictal epileptiform discharges (IED) and high frequency oscillations (HFOs), also known as ripples. Defining the frequency limits of slow and fast ripples. We recorded potential gradients with laminar multielectrode arrays (LME) for current source density (CSD) and multi-unit activity (MUA) analysis of interictal epileptiform discharges IEDs and HFOs in the neocortex and mesial temporal lobe of focal epilepsy patients. IEDs were observed in 20/29, while ripples only in 9/29 patients. Ripples were all detected within the seizure onset zone (SOZ). Compared to hippocampal HFOs, neocortical ripples proved to be longer, lower in frequency and amplitude, and presented non-uniform cycles. A subset of ripples (≈ 50%) co-occurred with IEDs, while IEDs were shown to contain variable high-frequency activity, even below HFO detection threshold. The limit between slow and fast ripples was defined at 150 Hz, while IEDs' high frequency components form clusters separated at 185 Hz. CSD analysis of IEDs and ripples revealed an alternating sink-source pair in the supragranular cortical layers, although fast ripple CSD appeared lower and engaged a wider cortical domain than slow ripples MUA analysis suggested a possible role of infragranularly located neural populations in ripple and IED generation. Laminar distribution of peak frequencies derived from HFOs and IEDs, respectively, showed that supragranular layers were dominated by slower (< 150 Hz) components. Our findings suggest that cortical slow ripples are generated primarily in upper layers while fast ripples and associated MUA in deeper layers. The dissociation of macro- and microdomains suggests that microelectrode recordings may be more selective for SOZ-linked ripples. We found a complex interplay between neural activity in the neocortical laminae during ripple and IED formation. We observed a potential leading role of cortical neurons in deeper layers, suggesting a refined utilization of LMEs in SOZ localization. LA - English DB - MTMT ER - TY - JOUR AU - Szabó, Johanna Petra AU - Hajnal, Boglárka Zsófia AU - Sákovics, Anna AU - Erőss, Loránd AU - Fabó, Dániel TI - Spectral analysis of after-discharges elicited by intracranial 50 Hz stimulation of epileptic patients JF - BRAIN STIMULATION J2 - BRAIN STIMUL VL - 16 PY - 2023 IS - 1 SP - 335 EP - 335 PG - 1 SN - 1935-861X DO - 10.1016/j.brs.2023.01.632 UR - https://m2.mtmt.hu/api/publication/33649610 ID - 33649610 LA - English DB - MTMT ER - TY - JOUR AU - Pető, Nóra AU - Jordán, Zsófia AU - Hajnal, Boglárka Zsófia AU - Ujvari, A. AU - Kelemen, Anna AU - Fabó, Dániel TI - Long-term results with the novel anti-seizure medication, cenobamate, in a single centre in Hungary JF - EUROPEAN JOURNAL OF NEUROLOGY J2 - EUR J NEUROL VL - 29 PY - 2022 SP - 733 EP - 733 PG - 1 SN - 1351-5101 UR - https://m2.mtmt.hu/api/publication/34428168 ID - 34428168 LA - English DB - MTMT ER - TY - CONF AU - Tóth, Estilla Zsófia AU - Szabó, Gyöngyvér Felicia AU - Kandrács, Ágnes AU - Molnár, Orsolya Noémi AU - Nagy, Gábor AU - Bagó, Attila György AU - Fabó, Dániel AU - Hajnal, Boglárka Zsófia AU - Rácz, Bence AU - Wittner, Lucia AU - Ulbert, István AU - Tóth, Kinga TI - Perisomatic inhibition and its relation to epilepsy and to synchrony generation in the human neocortex T2 - International Neuroscience Meeting, Budapest 2022 PY - 2022 UR - https://m2.mtmt.hu/api/publication/33632094 ID - 33632094 LA - English DB - MTMT ER - TY - JOUR AU - Hajnal, Boglárka Zsófia AU - Entz, László AU - Tóth, Emília AU - Wittner, Lucia AU - Ulbert, István AU - Erőss, Loránd AU - Fabó, Dániel TI - A humán agykéreg elektromos ingerlésével kiváltott válaszok alatti lokális hálózati és egysejt-szintű aktivitásváltozásainak vizsgálata JF - IDEGGYÓGYÁSZATI SZEMLE PROCEEDINGS / CLINICAL NEUROSCIENCE PROCEEDINGS J2 - IDEGGYÓGY SZEMLE PROC VL - 7 PY - 2022 IS - 1 SP - 18 SN - 2498-6240 UR - https://m2.mtmt.hu/api/publication/33075628 ID - 33075628 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Éltes, Tímea AU - Hajnal, Boglárka Zsófia AU - Kamondi, Anita TI - Concealment of Allergic Reactions to Alteplase by Face Masks in Non-Communicating Acute Stroke Patients. A Warning Call to Improve Our Physical Examination Practices during the COVID-19 Pandemic TS - A Warning Call to Improve Our Physical Examination Practices during the COVID-19 Pandemic JF - TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE J2 - TOHOKU J EXP MED VL - 257 PY - 2022 IS - 2 SP - 157 EP - 161 PG - 5 SN - 0040-8727 DO - 10.1620/tjem.2022.J027 UR - https://m2.mtmt.hu/api/publication/32801245 ID - 32801245 LA - English DB - MTMT ER -