@article{MTMT:34483970, title = {Points of Interest in the Chemistry of the Levomepromazine Drug Substance: Recycling of Undesired Enantiomer, Identification of New Phenothiazine Dimers, Synthesis of a Pharmacopeial Impurity, and an Unexpected Rearrangement}, url = {https://m2.mtmt.hu/api/publication/34483970}, author = {Poszávácz, László and Porcs-Makkay, Márta and Halász, Judit and Mórász, Tamás and Nagy, Tamás and Kátainé Fadgyas, Katalin and Simig, Gyula and Volk, Balázs}, doi = {10.1021/acs.oprd.3c00368}, journal-iso = {ORG PROCESS RES DEV}, journal = {ORGANIC PROCESS RESEARCH & DEVELOPMENT}, volume = {28}, unique-id = {34483970}, issn = {1083-6160}, year = {2024}, eissn = {1520-586X}, pages = {281-292}, orcid-numbers = {Simig, Gyula/0000-0002-2569-6476; Volk, Balázs/0000-0002-2019-1874} } @article{MTMT:33585454, title = {New, scalable process for the preparation of 5-acetyl-1H-pyrazole-3-carboxylic acid, a key intermediate of darolutamide}, url = {https://m2.mtmt.hu/api/publication/33585454}, author = {Poszávácz, László and Nagy, Tamás and Kátainé Fadgyas, Katalin and Volk, Balázs}, doi = {10.1055/a-2016-4337}, journal-iso = {SYNTHESIS-STUTTGART}, journal = {SYNTHESIS-STUTTGART}, volume = {55}, unique-id = {33585454}, issn = {0039-7881}, abstract = {A new, efficient process for the synthesis of 5-acetyl-1H-pyrazole-3-carboxylic acid, a versatile building block and the key intermediate of darolutamide, using diethyl pyrazole-3,5-dicarboxylate as the starting material is described. Contrary to the synthetic routes known from the literature, this procedure does not apply explosive diazo reagents, moreover it is simple and safe, thereby suitable for scale-up.}, year = {2023}, eissn = {1437-210X}, pages = {2061-2069}, orcid-numbers = {Volk, Balázs/0000-0002-2019-1874} } @misc{MTMT:33106268, title = {Az afizagabar gyógyszerjelölt molekula kulcsintermedierjének négylépéses áramlásos-kaszkád előállítása és az eljárás méretnövelése}, url = {https://m2.mtmt.hu/api/publication/33106268}, author = {Pethő, Bálint and Szilágyi, Gábor and Mengyel, Béla and Nagy, Tamás and Kátainé Fadgyas, Katalin and Volk, Balázs}, unique-id = {33106268}, year = {2022}, orcid-numbers = {Volk, Balázs/0000-0002-2019-1874} } @misc{MTMT:33106229, title = {„Semmi sem olyan egyszerű, mint amilyennek látszik”. Darolutamid intermedier generikus szemmel}, url = {https://m2.mtmt.hu/api/publication/33106229}, author = {Poszávácz, László and Szilágyi, Bence and Nagy, Tamás and Egyed, Attila and Kátainé Fadgyas, Katalin and Keserű, György Miklós and Mándity, István and Volk, Balázs}, unique-id = {33106229}, year = {2022}, orcid-numbers = {Mándity, István/0000-0003-2865-6143; Volk, Balázs/0000-0002-2019-1874} } @article{MTMT:31377458, title = {Rearrangement of o -(pivaloylaminomethyl)benzaldehydes: an experimental and computational study}, url = {https://m2.mtmt.hu/api/publication/31377458}, author = {Hargitai, Csilla Eszter and Koványiné Lax, Györgyi and Nagy, Tamás and Ábrányi-Balogh, Péter and Dancsó, András and Tóth, Gábor and Halász, Judit and Pandur, Angéla and Simig, Gyula and Volk, Balázs}, doi = {10.3762/bjoc.16.136}, journal-iso = {BEILSTEIN J ORG CHEM}, journal = {BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY}, volume = {16}, unique-id = {31377458}, issn = {1860-5397}, year = {2020}, eissn = {1860-5397}, pages = {1636-1648}, orcid-numbers = {Ábrányi-Balogh, Péter/0000-0002-9284-5160; Dancsó, András/0000-0001-8460-217X; Simig, Gyula/0000-0002-2569-6476; Volk, Balázs/0000-0002-2019-1874} } @CONFERENCE{MTMT:30885939, title = {Lombikból áramlásos reaktorba. a technológia váltásának lehetőségei a vortioxetin szintézisének példáján keresztül}, url = {https://m2.mtmt.hu/api/publication/30885939}, author = {Boros, Z. and Nagy-Győr, L. and Kátainé Fadgyas, Katalin and Kőhegyi, I. and Ling, István and Nagy, Tamás and Iványi, Z. and Oláh, M. and Ruzsics, Gy. and Temesi, O. and Volk, Balázs}, booktitle = {XLII. Kémiai előadói napok}, unique-id = {30885939}, year = {2019}, pages = {69}, orcid-numbers = {Volk, Balázs/0000-0002-2019-1874} } @article{MTMT:30808583, title = {Study on the Lithiation Reaction of 3-Diisopropylcarbamoyl-N-pivaloylphenylethylamine}, url = {https://m2.mtmt.hu/api/publication/30808583}, author = {Hargitai, Csilla Eszter and Nagy, Tamás and Halász, Judit and Simig, Gyula and Volk, Balázs}, doi = {10.3311/PPch.13770}, journal-iso = {PERIOD POLYTECH CHEM ENG}, journal = {PERIODICA POLYTECHNICA-CHEMICAL ENGINEERING}, volume = {63}, unique-id = {30808583}, issn = {0324-5853}, year = {2019}, eissn = {1587-3765}, pages = {629-635}, orcid-numbers = {Simig, Gyula/0000-0002-2569-6476; Volk, Balázs/0000-0002-2019-1874} } @article{MTMT:30687041, title = {Interesting transformations of methylenedioxy-substituted ortho-(pivaloylaminomethyl)benzaldehyde}, url = {https://m2.mtmt.hu/api/publication/30687041}, author = {Hargitai, Csilla Eszter and Koványiné Lax, Györgyi and Nagy, Tamás and Ábrányi-Balogh, Péter and Dancsó, András and Halász, Judit and Tóth, Gábor and Simig, Gyula and Volk, Balázs}, doi = {10.1007/s00706-019-02395-6}, journal-iso = {MONATSH CHEM}, journal = {MONATSHEFTE FUR CHEMIE}, volume = {150}, unique-id = {30687041}, issn = {0026-9247}, abstract = {Under acidic conditions, methylenedioxy-substituted ortho-(pivaloylaminomethyl)benzaldehyde underwent a surprising rearrangement reaction leading to the regioisomer of the starting compound as the major product and a dimer-type aldehyde as the minor one. The supposed reaction mechanisms are given below providing a feasible explanation for the formation of both products. Isoindole, proposed as the key intermediate for the formation of the products, was trapped in a Diels–Alder cycloaddition carried out with N-phenylmaleimide.}, year = {2019}, eissn = {1434-4475}, pages = {1121-1125}, orcid-numbers = {Dancsó, András/0000-0001-8460-217X; Simig, Gyula/0000-0002-2569-6476; Volk, Balázs/0000-0002-2019-1874} } @article{MTMT:30662166, title = {Continuous flow production in the final step of vortioxetine synthesis. Piperazine ring formation on a flow platform with a focus on productivity and scalability}, url = {https://m2.mtmt.hu/api/publication/30662166}, author = {Boros, Zoltán and Nagy-Győr, László and Kátainé Fadgyas, Katalin and Kőhegyi, Imre and Ling, István and Nagy, Tamás and Iványi, Zoltán and Oláh, Márk and Ruzsics, György and Temesi, Ottó and Volk, Balázs}, doi = {10.1007/s41981-019-00036-x}, journal-iso = {J FLOW CHEM}, journal = {JOURNAL OF FLOW CHEMISTRY}, volume = {9}, unique-id = {30662166}, issn = {2062-249X}, year = {2019}, eissn = {2063-0212}, pages = {101-103}, orcid-numbers = {Volk, Balázs/0000-0002-2019-1874} } @{MTMT:31616786, title = {PIMAVANSERIN SALTS USEFUL FOR THE PRODUCTION OF A PHARMACEUTICAL PREPARATION}, url = {https://m2.mtmt.hu/api/publication/31616786}, author = {TÓTHNÉ, LAURITZ Mária and VOLK, Balázs and KÁTAINÉ, FADGYAS Katalin and VARGA, Zoltán and Nagy, Tamás and DIETRICH, Ádám Dezső and Molnárné Samu, Erika and KESZTHELYI, Adrienn and RÁCZ, Norbert; and SZLÁVIK, László}, unique-id = {31616786}, year = {2018}, orcid-numbers = {VOLK, Balázs/0000-0002-2019-1874} }