TY - JOUR AU - Tóth, Luca AU - Czigler, András AU - Horváth, Péter AU - Szarka, Nikolett AU - Környei, Bálint Soma AU - Tóth, Arnold AU - Schwarcz, Attila AU - Ungvári, Zoltán István AU - Büki, András AU - Tóth, Péter József TI - The effect of mild traumatic brain injury on cerebral microbleeds in aging JF - FRONTIERS IN AGING NEUROSCIENCE J2 - FRONT AGING NEUROSCI VL - 13 PY - 2021 PG - 7 SN - 1663-4365 DO - 10.3389/fnagi.2021.717391 UR - https://m2.mtmt.hu/api/publication/32172268 ID - 32172268 AB - A traumatic brain injury (TBI) induces the formation of cerebral microbleeds (CMBs), which are associated with cognitive impairments, psychiatric disorders, and gait dysfunctions in patients. Elderly people frequently suffer TBIs, especially mild brain trauma (mTBI). Interestingly, aging is also an independent risk factor for the development of CMBs. However, how TBI and aging may interact to promote the development of CMBs is not well established. In order to test the hypothesis that an mTBI exacerbates the development of CMBs in the elderly, we compared the number and cerebral distribution of CMBs and assessed them by analysing susceptibility weighted (SW) MRI in young (25 ± 10 years old, n = 18) and elder (72 ± 7 years old, n = 17) patients after an mTBI and in age-matched healthy subjects (young: 25 ± 6 years old, n = 20; aged: 68 ± 5 years old, n = 23). We found significantly more CMBs in elder patients after an mTBI compared with young patients; however, we did not observe a significant difference in the number of cerebral microhemorrhages between aged and aged patients with mTBI. The majority of CMBs were found supratentorially (lobar and basal ganglion). The lobar distribution of supratentorial CMBs showed that aging enhances the formation of parietal and occipital CMBs after mTBIs. This suggests that aging and mTBIs do not synergize in the induction of the development of CMBs, and that the different distribution of mTBI-induced CMBs in aged patients may lead to specific age-related clinical characteristics of mTBIs. LA - English DB - MTMT ER - TY - JOUR AU - Tamás, Viktória AU - Sebestyén, Gabriella AU - Nagy, Szilvia Anett AU - Horváth, Péter AU - Mérei, Ákos AU - Tomaiuolo, Francesco AU - Raffa, Giovanni AU - Germanó, Antonino Francesco AU - Büki, András TI - Provocation and prediction of visual peripersonal neglect-like symptoms in preoperative planning and during awake brain surgery JF - ACTA NEUROCHIRURGICA J2 - ACTA NEUROCHIR VL - 163 PY - 2021 SP - 1941 EP - 1947 PG - 7 SN - 0001-6268 DO - 10.1007/s00701-021-04822-2 UR - https://m2.mtmt.hu/api/publication/31954808 ID - 31954808 AB - Neglect is a severe neuropsychological/neurological deficit that usually develops due to lesions of the posterior inferior parietal area of the right hemisphere and is characterized by a lack of attention to the left side. Our case is a proven right-handed, 30-year-old female patient with a low-grade glioma, which was located in the temporo-opercular region and also in the superior temporal gyrus of the right hemisphere. Upon presurgical planning, the motor, language, and visuospatial functions were mapped. In order to achieve this, the protocol for routine magnetic resonance imaging and navigated transcranial magnetic stimulation has been expanded, accordingly. LA - English DB - MTMT ER - TY - JOUR AU - Tóth, Luca AU - Czigler, András AU - Horváth, Péter AU - Környei, Bálint Soma AU - Szarka, Nikolett AU - Schwarcz, Attila AU - Ungvári, Zoltán István AU - Büki, András AU - Tóth, Péter József TI - Traumatic brain injury-induced cerebral microbleeds in the elderly JF - GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE) J2 - GEROSCIENCE VL - 43 PY - 2021 IS - 1 SP - 125 EP - 136 PG - 12 SN - 2509-2715 DO - 10.1007/s11357-020-00280-3 UR - https://m2.mtmt.hu/api/publication/31620181 ID - 31620181 AB - Traumatic brain injury (TBI) was shown to lead to the development of cerebral microbleeds (CMBs), which are associated with long term cognitive decline and gait disturbances in patients. The elderly is one of the most vulnerable parts of the population to suffer TBI. Importantly, ageing is known to exacerbate microvascular fragility and to promote the formation of CMBs. In this overview, the effect of ageing is discussed on the development and characteristics of TBI-related CMBs, with special emphasis on CMBs associated with mild TBI. Four cases of TBI-related CMBs are described to illustrate the concept that ageing exacerbates the deleterious microvascular effects of TBI and that similar brain trauma may induce more CMBs in old patients than in young ones. Recommendations are made for future prospective studies to establish the mechanistic effects of ageing on the formation of CMBs after TBI, and to determine long-term consequences of CMBs on clinically relevant outcome measures including cognitive performance, gait and balance function. LA - English DB - MTMT ER - TY - CHAP AU - Horváth, Péter AU - Verma, K. AU - Valadka, A.B. ED - Eapen, Blessen C ED - Cifu, David X TI - Acute emergency management of traumatic brain injury T2 - Brain Injury Medicine: Board Review PB - Elsevier SN - 9780323653855 T3 - Brain Injury Medicine: Board Review PY - 2020 SP - 84and88.e1 DO - 10.1016/B978-0-323-65385-5.00019-6 UR - https://m2.mtmt.hu/api/publication/33740792 ID - 33740792 LA - English DB - MTMT ER - TY - JOUR AU - Büki, András AU - Barzó, Pál AU - Demeter, B AU - Kanizsai, Péter László AU - Ezer, Erzsébet AU - Tóth, Péter József AU - Horváth, Péter AU - Varga, Csaba TI - Baleseti agysérültek ellátásának irányelvei - 2017 JF - IDEGGYOGYASZATI SZEMLE / CLINICAL NEUROSCIENCE J2 - IDEGGYOGY SZEMLE VL - 70 PY - 2017 IS - 7-8 SP - 223 EP - 245 PG - 23 SN - 0019-1442 DO - 10.18071/isz.70.0223 UR - https://m2.mtmt.hu/api/publication/3262835 ID - 3262835 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Szarka, Nikolett AU - Amrein, Krisztina AU - Horváth, Péter AU - Ivic, Ivan AU - Czeiter, Endre AU - Büki, András AU - Koller, Ákos AU - Tóth, Péter József TI - HYPERTENSION-INDUCED ENHANCED MYOGENIC CONSTRICTION OF CEREBRAL ARTERIES IS PRESERVED AFTER TRAUMATIC BRAIN INJURY. JF - JOURNAL OF NEUROTRAUMA J2 - J NEUROTRAUM VL - 34 PY - 2017 IS - 14 SP - 2315 EP - 2319 PG - 5 SN - 0897-7151 DO - 10.1089/neu.2016.4962 UR - https://m2.mtmt.hu/api/publication/3195505 ID - 3195505 AB - Traumatic brain injury (TBI) was shown to impair pressure-induced myogenic response of cerebral arteries, which is associated with vascular and neural dysfunction and increased mortality of TBI patients. Hypertension was shown to enhance myogenic tone of cerebral arteries via increased vascular production of 20-hydroxyeicosatrienoic acid (HETE). This adaptive mechanism protects brain tissue form pressure/volume overload, but it can also lead to increased susceptibility to cerebral ischemia. Although both effects may potentiate the detrimental vascular consequences of TBI, it is not known how hypertension modulates the effect of TBI on myogenic responses of cerebral vessels. We hypothesized that in hypertensive rats, the enhanced myogenic cerebrovascular response is preserved after TBI. Thus, we investigated the myogenic responses of isolated middle cerebral arteries (MCA) of normotensive and spontaneously hypertensive rats (SHR) after severe impact acceleration diffuse brain injury. TBI diminished myogenic constriction of MCAs isolated from normotensive rats, whereas the 20-HETE-mediated enhanced myogenic response of MCAs isolated from SHRs was not affected by TBI. These results suggest that the optimal cerebral perfusion pressure values and vascular signaling pathways can be different and thus should be targeted differently in normotensive and hypertensive patients following TBI. LA - English DB - MTMT ER -