TY  - JOUR
AU  - Simon, Orsolya Anna
AU  - Frim, Levente
AU  - Borbásné Farkas, Kornélia
AU  - Sipos, Zoltán
AU  - Vörhendi, Nóra
AU  - Boros, Eszter
AU  - Pálinkás, Dániel
AU  - Teutsch, Brigitta
AU  - Kalló, Patrícia
AU  - Vass, Vivien
AU  - Szentesi, Andrea Ildikó
AU  - Hágendorn, Roland
AU  - Hegyi, Péter
AU  - Erőss, Bálint Mihály
AU  - Szabó, Imre
TI  - Renal dysfunction contributes to deteriorated survival outcomes in patients with upper and lower gastrointestinal bleeding: insights from a cohort study of 1160 cases
JF  - SCIENTIFIC REPORTS
J2  - SCI REP
VL  - 15
PY  - 2025
IS  - 1
PG  - 11
SN  - 2045-2322
DO  - 10.1038/s41598-025-87969-7
UR  - https://m2.mtmt.hu/api/publication/35728281
ID  - 35728281
N1  - First Department of Medicine, Medical School, University of Pécs, Ifjúság Útja 13, Pécs, 7624, Hungary            
            Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary            
            Institute of Bioanalysis, Medical School, University of Pécs, Pécs, Hungary            
            Centre for Translational Medicine, Semmelweis University, Budapest, Hungary            
            Institute of Pancreatic Diseases, Semmelweis University, Budapest, Hungary            
            Internal Medicine, Hospital and Clinics of Siófok, Siófok, Hungary            
            First Department of Internal Medicine, St. George University Teaching Hospital of County Fejér, Székesfehérvár, Hungary            
            Department of Gastroenterology, Central Hospital of Northern Pest - Military Hospital, Budapest, Hungary            
            Department of Radiology, Medical Imaging Centre, Semmelweis University, Budapest, Hungary            
            Department of Primary Health Care, Department of Family Medicine, Medical School, University of Pécs, Pécs, Hungary            
            Export Date: 25 February 2025; Correspondence Address: O.A. Simon; First Department of Medicine, Medical School, University of Pécs, Pécs, Ifjúság Útja 13, 7624, Hungary; email: simon.orsolya@pte.hu
AB  - Both acute kidney injury and chronic kidney disease are risk factors for many outcomes of gastrointestinal bleeding (GIB). These are associated with higher mortality, longer hospitalisation, and greater need for transfusion in case of overt GIB. Our study aimed to further evaluate the role of kidney function in several clinical outcomes of GIB patients. The Hungarian Gastrointestinal Bleeding Registry collected data on all-cause GIB between 2019 and 2022. A multi-level data-validation system provided high-quality data, which was retrospectively analysed. Numerous primary (in-hospital mortality, discharge, need for endoscopic intervention, in-hospital rebleeding, length of hospitalisation, need for emergency surgery, need for endoscopic examination and need for intensive care unit) and secondary (detection of Helicobacter pylori ( H. pylori ), recognition of cancer as the source of bleeding, need for any kind of transfusion or clotting factor, anticoagulation therapy) outcomes were observed. Descriptive statistical tools were used to summarize our data. Among others, estimated glomerular filtration rate (eGFR) (ml/min/1.73 m 2 ) was used as continuous variable, mean, standard deviation, median, interquartile range and minimum/maximum values were calculated. Reduced kidney function was associated with in-hospital mortality (eGFR: 42.63 ± 28.78 ml/min/1.73 m 2 vs. 57.08 ± 26.62 ml/min/1.73 m 2 , p < 0.001), need for red blood cells (RBC) transfusion (eGFR: 51.98 ± 27.90 ml/min/1.73 m 2 vs. 60.11 ± 25.06 ml/min/1.73 m 2 , p < 0.001) and clotting factor supplementation (eGFR: 47.40 ± 27.41 ml/min/1.73 m 2 vs. 56.68 ± 27.02 ml/min/1.73 m 2 , p < 0.001). Better eGFR values at admission were associated with discharge home after proper treatment, compared to any other outcome of the admission (eGFR: 58.12 ± 25.56 ml/min/1.73 m 2 vs. 50.23 ± 29.69 ml/min/1.73 m 2 , p < 0.001), H. pylori positivity (eGFR: 59.63 ± 25.24 ml/min/1.73 m 2 vs. 52.76 ± 25.44 ml/min/1.73 m 2 , p = 0.021) and the need for endoscopic intervention (eGFR: 58.65 ± 26.61 ml/min/1.73 m 2 vs. 54.31 ± 27.64 ml/min/1.73 m 2 , p = 0.008). At admission, patients with better eGFR than 36.64 ml/min/1.73 m 2 were discharged to their homes, mortality was higher with eGFR worse than 25.96 ml/min/1.73 m 2 , more RBC transfusion was needed if eGFR was lower than 49.61 ml/min/1.73 m 2 . Regulation of anticoagulation was examined extensively. Impaired kidney function at admission results higher in-hospital mortality in overt all-cause GIB and increases the need of RBC transfusion.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Boros, Eszter
AU  - Pintér, József
AU  - Molontay, Roland
AU  - Prószéky, Kristóf Gergely
AU  - Vörhendi, Nóra
AU  - Simon, Orsolya Anna
AU  - Teutsch, Brigitta
AU  - Pálinkás, Dániel
AU  - Frim, Levente
AU  - Tari, Edina
AU  - Gagyi, Endre
AU  - Szabó, Imre
AU  - Hágendorn, Roland
AU  - Vincze, Áron
AU  - Izbéki, Ferenc
AU  - Abonyi-Tóth, Zsolt
AU  - Szentesi, Andrea Ildikó
AU  - Vass, Vivien
AU  - Hegyi, Péter
AU  - Erőss, Bálint Mihály
TI  - New machine-learning models outperform conventional risk assessment tools in Gastrointestinal bleeding
JF  - SCIENTIFIC REPORTS
J2  - SCI REP
VL  - 15
PY  - 2025
IS  - 1
PG  - 10
SN  - 2045-2322
DO  - 10.1038/s41598-025-90986-1
UR  - https://m2.mtmt.hu/api/publication/35785849
ID  - 35785849
AB  - Rapid and accurate identification of high-risk acute gastrointestinal bleeding (GIB) patients is essential. We developed two machine-learning (ML) models to calculate the risk of in-hospital mortality in patients admitted due to overt GIB. We analyzed the prospective, multicenter Hungarian GIB Registry's data. The predictive performance of XGBoost and CatBoost machine-learning algorithms with the Glasgow-Blatchford (GBS), pre-endoscopic Rockall and ABC scores were compared. We evaluated our models using five-fold cross-validation, and performance was measured by area under receiver operating characteristic curve (AUC) analysis with 95% confidence intervals (CI). Overall, we included 1,021 patients in the analysis. In-hospital death occurred in 108 cases. The XGBoost and the CatBoost model identified patients who died with an AUC of 0.84 (CI:0.76-0.90; 0.77-0.90; respectively) in the internal validation set, whereas the GBS and pre-endoscopic Rockall clinical scoring system's performance was significantly lower, AUC values of 0.68 (CI:0.62-0.74) and 0.62 (CI:0.56-0.67), respectively. ABC score had an AUC of 0.77 (CI:0.71-0.83). The XGBoost model had a specificity of 0.96 (CI:0.92-0.98) at a sensitivity of 0.25 (CI:0.10-0.43) compared with the CatBoost model, which had a specificity of 0.74 (CI:0.66-0.83) at a sensitivity of 0.78 (CI:0.57-0.95). XGBoost and the CatBoost models evaluate the mortality risk of acute GI bleeding better, than the conventional risk assessment tools.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Boros, E
AU  - Prószéky, KG
AU  - Molontay, R
AU  - Vörhendi, Nóra
AU  - Simon, Orsolya Anna
AU  - Teutsch, B
AU  - Dániel, P
AU  - Frim, Levente
AU  - Abonyi-Tóth, Zsolt
AU  - Hegyi, Péter
AU  - Erőss, Bálint Mihály
TI  - New machine-learning models outperform conventional risk assessment tools int gastrointestinal bleeding
JF  - ENDOSCOPY
J2  - ENDOSCOPY
VL  - 57
PY  - 2025
IS  - S02
SP  - S48
EP  - S49
PG  - 2
SN  - 0013-726X
UR  - https://m2.mtmt.hu/api/publication/36097239
ID  - 36097239
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Frim, Levente
AU  - Bokori, D
AU  - Simon, Orsolya Anna
AU  - Boros, E
AU  - Teutsch, B
AU  - Vörhendi, Nóra
AU  - Dániel, P
AU  - Tari, E
AU  - Hágendorn, Roland
AU  - Erőss, B
AU  - Szabó, Imre
TI  - Effects of anticoagulation on diverticular bleeding - a retrospective review of 213 cases
JF  - ENDOSCOPY
J2  - ENDOSCOPY
VL  - 57
PY  - 2025
IS  - S02
SP  - S468
EP  - S469
PG  - 2
SN  - 0013-726X
UR  - https://m2.mtmt.hu/api/publication/36097331
ID  - 36097331
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Dániel, P
AU  - Teutsch, B
AU  - Vörhendi, Nóra
AU  - Simon, Orsolya Anna
AU  - Boros, E
AU  - Frim, Levente
AU  - Hegyi, P
AU  - Gyökeres, T
AU  - Erőss, B
TI  - Anticoagulation management after gastrointestinal bleeding: a cohort study of 236 patients
JF  - ENDOSCOPY
J2  - ENDOSCOPY
VL  - 57
PY  - 2025
IS  - S02
SP  - S525
EP  - S525
PG  - 1
SN  - 0013-726X
UR  - https://m2.mtmt.hu/api/publication/36097346
ID  - 36097346
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Pálinkás, D.
AU  - Teutsch, Brigitta
AU  - Vörhendi, Nóra
AU  - Simon, Orsolya Anna
AU  - Boros, Eszter
AU  - Frim, Levente
AU  - Hegyi, P.
AU  - Gyökeres, T.
AU  - Erőss, B.
TI  - ANTICOAGULATION MANAGEMENT AFTER GASTROINTESTINAL BLEEDING: A COHORT STUDY OF 236 PATIENTS
JF  - MAGYAR GASZTROENTEROLÓGIA
J2  - M GASZTROENT
VL  - 11
PY  - 2025
IS  - Supplementum 1
SP  - 97
EP  - 98
PG  - 2
SN  - 1788-1145
UR  - https://m2.mtmt.hu/api/publication/36197187
ID  - 36197187
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Simon, Orsolya Anna
AU  - Frim, Levente
AU  - Borbásné Farkas, Kornélia
AU  - Sipos, Zoltán
AU  - Vörhendi, Nóra
AU  - Boros, Eszter
AU  - Pálinkás, D.
AU  - Teutsch, Brigitta
AU  - Kalló, P.
AU  - Vass, V.
AU  - Szentesi, Andrea Ildikó
AU  - Hágendorn, Roland
AU  - Hegyi, Péter
AU  - Erőss, Bálint Mihály
AU  - Szabó, Imre
TI  - A VESEKÁROSODÁS HOZZÁJÁRUL A ROSSZABB TÚLÉLÉSI EREDMÉNYEKHEZ FELSŐ ÉS ALSÓ GASZTROINTESZTINÁLIS VÉRZÉSBEN SZENVEDŐ BETEGEKNÉL: EGY 1,160 ESETBŐL ÁLLÓ KOHORSZ TANULMÁNY EREDMÉNYEI
JF  - MAGYAR GASZTROENTEROLÓGIA
J2  - M GASZTROENT
VL  - 11
PY  - 2025
IS  - Suplementum 1
SP  - 102
EP  - 103
PG  - 2
SN  - 1788-1145
UR  - https://m2.mtmt.hu/api/publication/36197239
ID  - 36197239
LA  - Hungarian
DB  - MTMT
ER  - 

TY  - GEN
AU  - Simon, Orsolya Anna
AU  - Frim, Levente
AU  - Borbásné Farkas, Kornélia
AU  - Sipos, Zoltán
AU  - Vörhendi, Nóra
AU  - Boros, Eszter
AU  - Pálinkás, D.
AU  - Teutsch, Brigitta
AU  - Kalló, P.
AU  - Vass, V.
AU  - Szentesi, Andrea Ildikó
AU  - Hágendorn, Roland
AU  - Hegyi, Péter
AU  - Erőss, Bálint Mihály
AU  - Szabó, Imre
TI  - A VESEKÁROSODÁS HOZZÁJÁRUL A ROSSZABB TÚLÉLÉSI EREDMÉNYEKHEZ FELSŐ ÉS ALSÓ GASZTROINTESZTINÁLIS VÉRZÉSBEN SZENVEDŐ BETEGEKNÉL: EGY 1,160 ESETBŐL ÁLLÓ KOHORSZ TANULMÁNY EREDMÉNYEI.
PY  - 2025
UR  - https://m2.mtmt.hu/api/publication/36197551
ID  - 36197551
LA  - Hungarian
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Simon, Orsolya Anna
AU  - Frim, Levente
AU  - Borbásné Farkas, Kornélia
AU  - Sipos, Zoltán
AU  - Vörhendi, Nóra
AU  - Boros, Eszter
AU  - Pálinkás, D.
AU  - Teutsch, B.
AU  - Kalló, P.
AU  - Vass, V.
AU  - Szentesi, Andrea Ildikó
AU  - Hágerdorn, R.
AU  - Hegyi, P.
AU  - Erőss, B.
AU  - Szabó, Imre
TI  - VESEFUNKCIÓS LABORATÓRIUMI PARAMÉTEREK ELEMZÉSE FELSŐ ÉS ALSÓ GASZTROINTESZTINÁLIS VÉRZÉSBEN SZENVEDŐ BETEGEKNÉL: EGY 1160 ESETBŐL ÁLLÓ KOHORSZ TANULMÁNY EREDMÉNYEI
JF  - MAGYAR BELORVOSI ARCHIVUM
J2  - MBA
VL  - 2025
PY  - 2025
IS  - 5-6
SP  - 345
EP  - 346
PG  - 2
SN  - 0133-5464
UR  - https://m2.mtmt.hu/api/publication/36435471
ID  - 36435471
LA  - Hungarian
DB  - MTMT
ER  - 

TY  - GEN
AU  - Simon, Orsolya Anna
AU  - Frim, Levente
AU  - Borbásné Farkas, Kornélia
AU  - Sipos, Zoltán
AU  - Vörhendi, Nóra
AU  - Boros, Eszter
AU  - Pálinkás, D.
AU  - Teutsch, B.
AU  - Kalló, P.
AU  - Vass, V.
AU  - Szentesi, A.
AU  - Hágendorn, Roland
AU  - Hegyi, P.
AU  - Erőss, B.
AU  - Szabó, Imre
TI  - VESEFUNKCIÓS LABORATÓRIUMI PARAMÉTEREK ELEMZÉSE FELSŐ ÉS ALSÓ GASZTROINTESZTINÁLIS VÉRZÉSBEN SZENVEDŐ BETEGEKNÉL: EGY 1160 ESETBŐL ÁLLÓ KOHORSZ TANULMÁNY EREDMÉNYEI.
PY  - 2025
UR  - https://m2.mtmt.hu/api/publication/36435550
ID  - 36435550
LA  - Hungarian
DB  - MTMT
ER  -