@article{MTMT:35728281, title = {Renal dysfunction contributes to deteriorated survival outcomes in patients with upper and lower gastrointestinal bleeding: insights from a cohort study of 1160 cases}, url = {https://m2.mtmt.hu/api/publication/35728281}, author = {Simon, Orsolya Anna and Frim, Levente and Borbásné Farkas, Kornélia and Sipos, Zoltán and Vörhendi, Nóra and Boros, Eszter and Pálinkás, Dániel and Teutsch, Brigitta and Kalló, Patrícia and Vass, Vivien and Szentesi, Andrea Ildikó and Hágendorn, Roland and Hegyi, Péter and Erőss, Bálint Mihály and Szabó, Imre}, doi = {10.1038/s41598-025-87969-7}, journal-iso = {SCI REP}, journal = {SCIENTIFIC REPORTS}, volume = {15}, unique-id = {35728281}, abstract = {Both acute kidney injury and chronic kidney disease are risk factors for many outcomes of gastrointestinal bleeding (GIB). These are associated with higher mortality, longer hospitalisation, and greater need for transfusion in case of overt GIB. Our study aimed to further evaluate the role of kidney function in several clinical outcomes of GIB patients. The Hungarian Gastrointestinal Bleeding Registry collected data on all-cause GIB between 2019 and 2022. A multi-level data-validation system provided high-quality data, which was retrospectively analysed. Numerous primary (in-hospital mortality, discharge, need for endoscopic intervention, in-hospital rebleeding, length of hospitalisation, need for emergency surgery, need for endoscopic examination and need for intensive care unit) and secondary (detection of Helicobacter pylori ( H. pylori ), recognition of cancer as the source of bleeding, need for any kind of transfusion or clotting factor, anticoagulation therapy) outcomes were observed. Descriptive statistical tools were used to summarize our data. Among others, estimated glomerular filtration rate (eGFR) (ml/min/1.73 m 2 ) was used as continuous variable, mean, standard deviation, median, interquartile range and minimum/maximum values were calculated. Reduced kidney function was associated with in-hospital mortality (eGFR: 42.63 ± 28.78 ml/min/1.73 m 2 vs. 57.08 ± 26.62 ml/min/1.73 m 2 , p < 0.001), need for red blood cells (RBC) transfusion (eGFR: 51.98 ± 27.90 ml/min/1.73 m 2 vs. 60.11 ± 25.06 ml/min/1.73 m 2 , p < 0.001) and clotting factor supplementation (eGFR: 47.40 ± 27.41 ml/min/1.73 m 2 vs. 56.68 ± 27.02 ml/min/1.73 m 2 , p < 0.001). Better eGFR values at admission were associated with discharge home after proper treatment, compared to any other outcome of the admission (eGFR: 58.12 ± 25.56 ml/min/1.73 m 2 vs. 50.23 ± 29.69 ml/min/1.73 m 2 , p < 0.001), H. pylori positivity (eGFR: 59.63 ± 25.24 ml/min/1.73 m 2 vs. 52.76 ± 25.44 ml/min/1.73 m 2 , p = 0.021) and the need for endoscopic intervention (eGFR: 58.65 ± 26.61 ml/min/1.73 m 2 vs. 54.31 ± 27.64 ml/min/1.73 m 2 , p = 0.008). At admission, patients with better eGFR than 36.64 ml/min/1.73 m 2 were discharged to their homes, mortality was higher with eGFR worse than 25.96 ml/min/1.73 m 2 , more RBC transfusion was needed if eGFR was lower than 49.61 ml/min/1.73 m 2 . Regulation of anticoagulation was examined extensively. Impaired kidney function at admission results higher in-hospital mortality in overt all-cause GIB and increases the need of RBC transfusion.}, year = {2025}, eissn = {2045-2322}, orcid-numbers = {Borbásné Farkas, Kornélia/0000-0002-5349-6527; Sipos, Zoltán/0000-0001-7845-8116; Boros, Eszter/0000-0002-7831-163X; Teutsch, Brigitta/0000-0002-9530-7886; Vass, Vivien/0009-0004-6099-426X; Szentesi, Andrea Ildikó/0000-0003-2097-6927; Hegyi, Péter/0000-0003-0399-7259; Erőss, Bálint Mihály/0000-0003-3658-8427} } @article{MTMT:35785849, title = {New machine-learning models outperform conventional risk assessment tools in Gastrointestinal bleeding}, url = {https://m2.mtmt.hu/api/publication/35785849}, author = {Boros, Eszter and Pintér, József and Molontay, Roland and Prószéky, Kristóf Gergely and Vörhendi, Nóra and Simon, Orsolya Anna and Teutsch, Brigitta and Pálinkás, Dániel and Frim, Levente and Tari, Edina and Gagyi, Endre and Szabó, Imre and Hágendorn, Roland and Vincze, Áron and Izbéki, Ferenc and Abonyi-Tóth, Zsolt and Szentesi, Andrea Ildikó and Vass, Vivien and Hegyi, Péter and Erőss, Bálint Mihály}, doi = {10.1038/s41598-025-90986-1}, journal-iso = {SCI REP}, journal = {SCIENTIFIC REPORTS}, volume = {15}, unique-id = {35785849}, abstract = {Rapid and accurate identification of high-risk acute gastrointestinal bleeding (GIB) patients is essential. We developed two machine-learning (ML) models to calculate the risk of in-hospital mortality in patients admitted due to overt GIB. We analyzed the prospective, multicenter Hungarian GIB Registry's data. The predictive performance of XGBoost and CatBoost machine-learning algorithms with the Glasgow-Blatchford (GBS), pre-endoscopic Rockall and ABC scores were compared. We evaluated our models using five-fold cross-validation, and performance was measured by area under receiver operating characteristic curve (AUC) analysis with 95% confidence intervals (CI). Overall, we included 1,021 patients in the analysis. In-hospital death occurred in 108 cases. The XGBoost and the CatBoost model identified patients who died with an AUC of 0.84 (CI:0.76-0.90; 0.77-0.90; respectively) in the internal validation set, whereas the GBS and pre-endoscopic Rockall clinical scoring system's performance was significantly lower, AUC values of 0.68 (CI:0.62-0.74) and 0.62 (CI:0.56-0.67), respectively. ABC score had an AUC of 0.77 (CI:0.71-0.83). The XGBoost model had a specificity of 0.96 (CI:0.92-0.98) at a sensitivity of 0.25 (CI:0.10-0.43) compared with the CatBoost model, which had a specificity of 0.74 (CI:0.66-0.83) at a sensitivity of 0.78 (CI:0.57-0.95). XGBoost and the CatBoost models evaluate the mortality risk of acute GI bleeding better, than the conventional risk assessment tools.}, year = {2025}, eissn = {2045-2322}, orcid-numbers = {Boros, Eszter/0000-0002-7831-163X; Molontay, Roland/0000-0002-0666-5279; Teutsch, Brigitta/0000-0002-9530-7886; Tari, Edina/0000-0002-8540-0614; Vincze, Áron/0000-0003-2217-7686; Abonyi-Tóth, Zsolt/0000-0002-5585-3313; Szentesi, Andrea Ildikó/0000-0003-2097-6927; Hegyi, Péter/0000-0003-0399-7259; Erőss, Bálint Mihály/0000-0003-3658-8427} } @article{MTMT:36097239, title = {New machine-learning models outperform conventional risk assessment tools int gastrointestinal bleeding}, url = {https://m2.mtmt.hu/api/publication/36097239}, author = {Boros, E and Prószéky, KG and Molontay, R and Vörhendi, Nóra and Simon, Orsolya Anna and Teutsch, B and Dániel, P and Frim, Levente and Abonyi-Tóth, Zsolt and Hegyi, Péter and Erőss, Bálint Mihály}, journal-iso = {ENDOSCOPY}, journal = {ENDOSCOPY}, volume = {57}, unique-id = {36097239}, issn = {0013-726X}, year = {2025}, eissn = {1438-8812}, pages = {S48-S49}, orcid-numbers = {Abonyi-Tóth, Zsolt/0000-0002-5585-3313; Hegyi, Péter/0000-0003-0399-7259; Erőss, Bálint Mihály/0000-0003-3658-8427} } @article{MTMT:36097331, title = {Effects of anticoagulation on diverticular bleeding - a retrospective review of 213 cases}, url = {https://m2.mtmt.hu/api/publication/36097331}, author = {Frim, Levente and Bokori, D and Simon, Orsolya Anna and Boros, E and Teutsch, B and Vörhendi, Nóra and Dániel, P and Tari, E and Hágendorn, Roland and Erőss, B and Szabó, Imre}, journal-iso = {ENDOSCOPY}, journal = {ENDOSCOPY}, volume = {57}, unique-id = {36097331}, issn = {0013-726X}, year = {2025}, eissn = {1438-8812}, pages = {S468-S469} } @article{MTMT:36097346, title = {Anticoagulation management after gastrointestinal bleeding: a cohort study of 236 patients}, url = {https://m2.mtmt.hu/api/publication/36097346}, author = {Dániel, P and Teutsch, B and Vörhendi, Nóra and Simon, Orsolya Anna and Boros, E and Frim, Levente and Hegyi, P and Gyökeres, T and Erőss, B}, journal-iso = {ENDOSCOPY}, journal = {ENDOSCOPY}, volume = {57}, unique-id = {36097346}, issn = {0013-726X}, year = {2025}, eissn = {1438-8812}, pages = {S525-S525} } @article{MTMT:36197187, title = {ANTICOAGULATION MANAGEMENT AFTER GASTROINTESTINAL BLEEDING: A COHORT STUDY OF 236 PATIENTS}, url = {https://m2.mtmt.hu/api/publication/36197187}, author = {Pálinkás, D. and Teutsch, Brigitta and Vörhendi, Nóra and Simon, Orsolya Anna and Boros, Eszter and Frim, Levente and Hegyi, P. and Gyökeres, T. and Erőss, B.}, journal-iso = {M GASZTROENT}, journal = {MAGYAR GASZTROENTEROLÓGIA}, volume = {11}, unique-id = {36197187}, issn = {1788-1145}, year = {2025}, pages = {97-98}, orcid-numbers = {Teutsch, Brigitta/0000-0002-9530-7886; Boros, Eszter/0000-0002-7831-163X} } @article{MTMT:36197239, title = {A VESEKÁROSODÁS HOZZÁJÁRUL A ROSSZABB TÚLÉLÉSI EREDMÉNYEKHEZ FELSŐ ÉS ALSÓ GASZTROINTESZTINÁLIS VÉRZÉSBEN SZENVEDŐ BETEGEKNÉL: EGY 1,160 ESETBŐL ÁLLÓ KOHORSZ TANULMÁNY EREDMÉNYEI}, url = {https://m2.mtmt.hu/api/publication/36197239}, author = {Simon, Orsolya Anna and Frim, Levente and Borbásné Farkas, Kornélia and Sipos, Zoltán and Vörhendi, Nóra and Boros, Eszter and Pálinkás, D. and Teutsch, Brigitta and Kalló, P. and Vass, V. and Szentesi, Andrea Ildikó and Hágendorn, Roland and Hegyi, Péter and Erőss, Bálint Mihály and Szabó, Imre}, journal-iso = {M GASZTROENT}, journal = {MAGYAR GASZTROENTEROLÓGIA}, volume = {11}, unique-id = {36197239}, issn = {1788-1145}, year = {2025}, pages = {102-103}, orcid-numbers = {Borbásné Farkas, Kornélia/0000-0002-5349-6527; Sipos, Zoltán/0000-0001-7845-8116; Boros, Eszter/0000-0002-7831-163X; Teutsch, Brigitta/0000-0002-9530-7886; Szentesi, Andrea Ildikó/0000-0003-2097-6927; Hegyi, Péter/0000-0003-0399-7259; Erőss, Bálint Mihály/0000-0003-3658-8427} } @misc{MTMT:36197551, title = {A VESEKÁROSODÁS HOZZÁJÁRUL A ROSSZABB TÚLÉLÉSI EREDMÉNYEKHEZ FELSŐ ÉS ALSÓ GASZTROINTESZTINÁLIS VÉRZÉSBEN SZENVEDŐ BETEGEKNÉL: EGY 1,160 ESETBŐL ÁLLÓ KOHORSZ TANULMÁNY EREDMÉNYEI.}, url = {https://m2.mtmt.hu/api/publication/36197551}, author = {Simon, Orsolya Anna and Frim, Levente and Borbásné Farkas, Kornélia and Sipos, Zoltán and Vörhendi, Nóra and Boros, Eszter and Pálinkás, D. and Teutsch, Brigitta and Kalló, P. and Vass, V. and Szentesi, Andrea Ildikó and Hágendorn, Roland and Hegyi, Péter and Erőss, Bálint Mihály and Szabó, Imre}, unique-id = {36197551}, year = {2025}, orcid-numbers = {Borbásné Farkas, Kornélia/0000-0002-5349-6527; Sipos, Zoltán/0000-0001-7845-8116; Boros, Eszter/0000-0002-7831-163X; Teutsch, Brigitta/0000-0002-9530-7886; Szentesi, Andrea Ildikó/0000-0003-2097-6927; Hegyi, Péter/0000-0003-0399-7259; Erőss, Bálint Mihály/0000-0003-3658-8427} } @article{MTMT:36435471, title = {VESEFUNKCIÓS LABORATÓRIUMI PARAMÉTEREK ELEMZÉSE FELSŐ ÉS ALSÓ GASZTROINTESZTINÁLIS VÉRZÉSBEN SZENVEDŐ BETEGEKNÉL: EGY 1160 ESETBŐL ÁLLÓ KOHORSZ TANULMÁNY EREDMÉNYEI}, url = {https://m2.mtmt.hu/api/publication/36435471}, author = {Simon, Orsolya Anna and Frim, Levente and Borbásné Farkas, Kornélia and Sipos, Zoltán and Vörhendi, Nóra and Boros, Eszter and Pálinkás, D. and Teutsch, B. and Kalló, P. and Vass, V. and Szentesi, Andrea Ildikó and Hágerdorn, R. and Hegyi, P. and Erőss, B. and Szabó, Imre}, journal-iso = {MBA}, journal = {MAGYAR BELORVOSI ARCHIVUM}, volume = {2025}, unique-id = {36435471}, issn = {0133-5464}, year = {2025}, pages = {345-346}, orcid-numbers = {Borbásné Farkas, Kornélia/0000-0002-5349-6527; Sipos, Zoltán/0000-0001-7845-8116; Boros, Eszter/0000-0002-7831-163X; Szentesi, Andrea Ildikó/0000-0003-2097-6927} } @misc{MTMT:36435550, title = {VESEFUNKCIÓS LABORATÓRIUMI PARAMÉTEREK ELEMZÉSE FELSŐ ÉS ALSÓ GASZTROINTESZTINÁLIS VÉRZÉSBEN SZENVEDŐ BETEGEKNÉL: EGY 1160 ESETBŐL ÁLLÓ KOHORSZ TANULMÁNY EREDMÉNYEI.}, url = {https://m2.mtmt.hu/api/publication/36435550}, author = {Simon, Orsolya Anna and Frim, Levente and Borbásné Farkas, Kornélia and Sipos, Zoltán and Vörhendi, Nóra and Boros, Eszter and Pálinkás, D. and Teutsch, B. and Kalló, P. and Vass, V. and Szentesi, A. and Hágendorn, Roland and Hegyi, P. and Erőss, B. and Szabó, Imre}, unique-id = {36435550}, year = {2025}, orcid-numbers = {Borbásné Farkas, Kornélia/0000-0002-5349-6527; Sipos, Zoltán/0000-0001-7845-8116; Boros, Eszter/0000-0002-7831-163X} }