TY  - JOUR
AU  - Jójárt, Boldizsár
AU  - Resál, Tamás
AU  - Kata, Diána
AU  - Molnár, Tünde
AU  - Bacsur, Péter
AU  - Szabó, Viktória
AU  - Varga, Árpád
AU  - Szántó, Kata Judit
AU  - Pallagi, Petra
AU  - Földesi, Imre
AU  - Molnár, Tamás
AU  - Maléth, József
AU  - Farkas, Klaudia
TI  - P421 The faecal biomarker LDN-051 is a novel tool for monitoring disease activity and therapeutic response in Inflammatory Bowel Diseases
JF  - JOURNAL OF CROHNS & COLITIS
J2  - J CROHNS COLITIS
VL  - 18
PY  - 2024
IS  - Supplement_1
SP  - i869
EP  - i869
PG  - 1
SN  - 1873-9946
DO  - 10.1093/ecco-jcc/jjad212.0551
UR  - https://m2.mtmt.hu/api/publication/34538603
ID  - 34538603
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Jójárt, Boldizsár
AU  - Csákány-Papp, Noémi
AU  - Laub, H
AU  - Vasas, Béla
AU  - Barta, B
AU  - Szabó, Viktória
AU  - Bagyánszki, Mária
AU  - Mándity, I
AU  - Heltovics, G
AU  - Pallagi, Petra
AU  - Maléth, József
TI  - P072 LDN-071, a novel first-in-class amino acid-based PAI-1 inhibitor, significantly reduces the severity of experimental colitis in mice
JF  - JOURNAL OF CROHNS & COLITIS
J2  - J CROHNS COLITIS
VL  - 18
PY  - 2024
IS  - Supplement_1
SP  - i342
EP  - i342
PG  - 1
SN  - 1873-9946
DO  - 10.1093/ecco-jcc/jjad212.0202
UR  - https://m2.mtmt.hu/api/publication/34538600
ID  - 34538600
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Jójárt, Boldizsár
AU  - Resál, Tamás
AU  - Kata, Diána
AU  - Molnár, Tünde
AU  - Bacsur, Péter
AU  - Szabó, Viktória
AU  - Varga, Árpád
AU  - Szántó, Kata Judit
AU  - Pallagi, Petra
AU  - Földesi, Imre
AU  - Molnár, Tamás
AU  - Maléth, József
AU  - Farkas, Klaudia
TI  - Plasminogen activator inhibitor 1 is a novel faecal biomarker for monitoring disease activity and therapeutic response in inflammatory bowel diseases
JF  - JOURNAL OF CROHNS & COLITIS
J2  - J CROHNS COLITIS
VL  - 18
PY  - 2024
IS  - 3
SP  - 392
EP  - 405
PG  - 14
SN  - 1873-9946
DO  - 10.1093/ecco-jcc/jjad160
UR  - https://m2.mtmt.hu/api/publication/34167015
ID  - 34167015
N1  - Ladon Therapeutics Ltd, Szeged, Hungary            
            Department of Medicine, University of Szeged, Szeged, Hungary            
            ELKH-USZ Momentum Epithelial Cell Signaling and Secretion Research Group, University of Szeged, Szeged, Hungary            
            HCEMM-USZ Molecular Gastroenterology Research Group, University of Szeged, Szeged, Hungary            
            Faculty of Medicine, Institute of Laboratory Medicine, University of Szeged, Szeged, Hungary            
            Export Date: 8 April 2024            
            Correspondence Address: Maléth, J.; HAS-USZ Momentum Epithelial Cell Signalling and Secretion Research Group, Hungary; email: maleth.jozsef@med.uszeged.hu            
            Correspondence Address: Farkas, K.; HAS-USZ Momentum Epithelial Cell Signalling and Secretion Research Group, Hungary            
            Chemicals/CAS: adalimumab, 331731-18-1, 1446410-95-2; azathioprine, 446-86-6, 55774-33-9; budesonide, 51333-22-3, 51372-29-3; cyclosporine, 59865-13-3, 63798-73-2, 79217-60-0; infliximab, 170277-31-3; mesalazine, 89-57-6; plasminogen activator inhibitor 1, 140208-23-7; tofacitinib, 477600-75-2, 540737-29-9; ustekinumab, 815610-63-0, 949907-93-1; vedolizumab, 943609-66-3; Biomarkers; Plasminogen Activator Inhibitor 1            
            Tradenames: 201170, Greiner; ab269373, Abcam; ChemiDoc MP, Biorad; GraphPad 9.5.0, Graphpad; iScript cDNA Synthesis Kit, Biorad; MedCalc Software 20.211, MedCalc; Multiskan FC, Thermo; NucleoSpin RNA Plus Kit, Macherey            
            Manufacturers: Abcam; Biorad; Carl Zeiss; Graphpad; Greiner; Macherey; MedCalc; Thermo
AB  - Crohn's disease and ulcerative colitis require lifelong treatment and patient monitoring. Current biomarkers have several limitations, therefore, there is an unmet need to identify novel biomarkers in inflammatory bowel disease (IBD). Previously, the role of plasminogen activator inhibitor 1 (PAI-1) was established in the pathogenesis of IBD and suggested as a potential biomarker. Therefore, we aimed to comprehensively analyze the selectivity of PAI-1 in IBD, its correlation with the disease activity, and its potential to predict therapeutic response.Blood, colon biopsy, organoid cultures (OC), and faecal samples were used from active and inactive IBD patients and control subjects. Serpin E1 gene expressions and PAI-1 protein levels and localization in serum, biopsy, and fecal samples were evaluated by qRT-PCR, ELISA, and immunostaining, respectively.The study population comprised 132 IBD patients (56 CD and 76 UC) and 40 non-IBD patients. We demonstrated that the serum, mucosal, and faecal PAI-1 concentration is elevated in IBD patients, showing clinical and endoscopic activity. In responders (decrease of eMayo≥3 in UC; or SES-CD>50% in CD), the initial PAI-1 level decreased significantly upon successful therapy. OCs derived from active IBD patients produced higher concentrations of PAI-1 than the controls, suggesting that epithelial cells could be a source of PAI-1. Moreover, faecal PAI-1 selectively increases in active IBD but not other organic gastrointestinal diseases.The serum, mucosal, and faecal PAI-1 concentration correlates with the disease activity and therapeutic response in IBD, suggesting that PAI-1 could be utilized as a novel non-invasive, disease-specific faecal biomarker in the patient follow-up.
LA  - English
DB  - MTMT
ER  - 

TY  - GEN
AU  - Szabó, Viktória
AU  - Csákány-Papp, Noémi
AU  - Görög, Marietta
AU  - Madácsy, Tamara
AU  - Varga, Árpád
AU  - Kiss, Aletta Kata
AU  - Tél, Bálint
AU  - Jójárt, Boldizsár
AU  - Crul, Tim
AU  - Dudás, Krisztina Márta
AU  - Bagyánszki, Mária
AU  - Bódi, Nikolett
AU  - Ayaydin, Ferhan
AU  - Jee, Shyam
AU  - Tiszlavicz, László
AU  - Stauderman, Kenneth
AU  - Hebbar, Sudarshan
AU  - Pallagi, Petra
AU  - Maléth, József
TI  - Orai1 calcium channel inhibition prevents progression of chronic pancreatitis
PY  - 2023
UR  - https://m2.mtmt.hu/api/publication/34687647
ID  - 34687647
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Szabó, Viktória
AU  - Csákány-Papp, Noémi
AU  - Görög, Marietta
AU  - Madácsy, Tamara
AU  - Varga, Árpád
AU  - Kiss, AK
AU  - Tél, Bálint
AU  - Jójárt, Boldizsár
AU  - Crul, Tim
AU  - Dudás, Krisztina Márta
AU  - Bagyánszki, M
AU  - Bódi, N
AU  - Ayaydin, F
AU  - Jee, S
AU  - Tiszlavicz, L
AU  - Stauderman, K
AU  - Hebbar, S
AU  - Pallagi, Petra
AU  - Maléth, József
TI  - ORAI1 CALCIUM CHANNEL INHIBITION PREVENTS PROGRESSION OF RECURRENT ACUTE AND CHRONIC PANCREATITIS
JF  - UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
J2  - UEG JOURNAL
VL  - 11
PY  - 2023
IS  - Suppl 8
SP  - 66
EP  - 66
PG  - 1
SN  - 2050-6406
UR  - https://m2.mtmt.hu/api/publication/34687430
ID  - 34687430
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Molnár, Tamás
AU  - Szabó, Viktória
AU  - Jójárt, Boldizsár
AU  - Csákány-Papp, Noémi
AU  - Pallagi, Petra
AU  - Maléth, József
TI  - PLASMINOGEN ACTIVATOR INHIBITOR 1 A POTENTIAL NEW THERAPEUTIC TARGET IN THE TREATMENT OF CHRONIC PANCREATITIS
JF  - UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
J2  - UEG JOURNAL
VL  - 11
PY  - 2023
IS  - Suppl 8
SP  - 463
EP  - 463
PG  - 1
SN  - 2050-6406
UR  - https://m2.mtmt.hu/api/publication/34687367
ID  - 34687367
LA  - English
DB  - MTMT
ER  - 

TY  - GEN
AU  - Szabó, Viktória
AU  - Csákány-Papp, Noémi
AU  - Görög, Marietta
AU  - Madácsy, Tamara
AU  - Varga, Árpád
AU  - Kiss, Aletta Kata
AU  - Tél, Bálint
AU  - Jójárt, Boldizsár
AU  - Crul, Tim
AU  - Dudás, Krisztina Márta
AU  - Bagyánszki, Mária
AU  - Bódi, Nikolett
AU  - Ayaydin, Ferhan
AU  - Shyam, Jee
AU  - Tiszlavicz, László
AU  - Stauderman, Kenneth
AU  - Hebbar, Sudarshan
AU  - Pallagi, Petra
AU  - Maléth, József
TI  - The inhibition of Orai1 calcium channel reduces the progression of chronic pancreatitis
PY  - 2023
SP  - 1
UR  - https://m2.mtmt.hu/api/publication/34672053
ID  - 34672053
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Molnár, Tünde
AU  - Szabó, Viktória
AU  - Jójárt, Boldizsár
AU  - Csákány-Papp, Noémi
AU  - Pallagi, Petra
AU  - Maléth, József
TI  - Determining the role of Serpin E1/PAI-1 in the development and progression of chronic pancreatitis
JF  - PANCREATOLOGY
J2  - PANCREATOLOGY
VL  - 23
PY  - 2023
SP  - e65
SN  - 1424-3903
DO  - 10.1016/j.pan.2023.06.568
UR  - https://m2.mtmt.hu/api/publication/34633221
ID  - 34633221
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Jójárt, Boldizsár
AU  - Resál, Tamás
AU  - Kata, Diána
AU  - Molnár, Tünde
AU  - Bacsur, Péter
AU  - Szabó, Viktória
AU  - Varga, Árpád
AU  - Szántó, Kata Judit
AU  - Földesi, Imre
AU  - Molnár, Tamás
AU  - Maléth, József
AU  - Farkas, Klaudia
TI  - LDN-051 a novel fecal biomarker for monitoring disease activity and therapeutic response in inflammatory bowel diseases – results of a phase 2 clinical trial
JF  - UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
J2  - UEG JOURNAL
VL  - 11
PY  - 2023
IS  - S8
SP  - 291
EP  - 292
PG  - 2
SN  - 2050-6406
UR  - https://m2.mtmt.hu/api/publication/34593890
ID  - 34593890
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Jójárt, Boldizsár
AU  - Csákány-Papp, Noémi
AU  - H., Laub
AU  - Vasas, Béla
AU  - Barta, Bence Pál
AU  - Szabó, Viktória
AU  - Bagyánszki, Mária
AU  - I., Mándity
AU  - G., Heltovics
AU  - Pallagi, Petra
AU  - Maléth, József
TI  - LDN-071, a novel first-in-class peptide-based plasminogen activator inhibitor 1, significantly reduces the severity of experimental colitis in mic
JF  - UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
J2  - UEG JOURNAL
VL  - 11
PY  - 2023
IS  - S8
SP  - 209
EP  - 2010
PG  - 1802
SN  - 2050-6406
UR  - https://m2.mtmt.hu/api/publication/34593826
ID  - 34593826
LA  - English
DB  - MTMT
ER  -